Biomarkers and methods of diagnosing and prognosing mild traumatic brain injuries

ABSTRACT

The invention provides biomarkers and methods for determining the risk of a subject for developing mild traumatic brain injuries (mTBI). In some aspects, the methods of the invention also determine the fitness of a subject for participating in an activity with increased chances of receiving a head impact. Some embodiments of the invention are directed to kits for determining the risk of a subject for developing mTBI or the fitness of a subject for participating in an activity with increased chances of receiving a head impact.

RELATED APPLICATION DATA

This application is the U.S. National Stage of International Application No. PCT/US2016/024588 filed on Mar. 28, 2016, which claims priority to and the benefit of U.S. Provisional Application No. 62/139,328 filed on Mar. 27, 2015, the contents of each of which are hereby incorporated by reference in their entireties.

FIELD OF THE INVENTION

The present invention is related to biomarkers and methods for determining the risk of a subject for developing mild traumatic brain injuries (mTBI). In some aspects, embodiments of the invention are directed to kits and apparatuses.

BACKGROUND OF THE INVENTION

Despite significant benefits to the physical, mental, and social development of adolescents and young adults participating athletics, sport-related injuries are a significant risk in this population. Particularly, playing contact sports such as football and hockey involves a significant risk of brain injury due to impact to the head. During such physical activity, the head or other body part of the individual is often subjected to direct contact to the head, which results in impact to the skull and brain of the individual as well as movement of the head or body part itself. Sport-related concussion is the most commonly cited athletic injury in the lay and professional literature during the past decade. These injuries are a significant public health issue because of concerns with the developing brain following head trauma, recurrent and cumulative effects of concussion, recovery following concussion, as well as more global issues concerning academic performance and psychosocial issues.

The Center for Disease Control and Prevention (CDC) estimates estimated that 1.6 to 3.8 million sport-related concussion injuries occurring annually and that the incidence of sports-related mild traumatic brain injury (mTBI) approaches 300,000 annually in the United States. It is not uncommon that a typical range of concussions per year for a football team of 90 players is 4-6 (7%) and for a hockey team with 28 players is 6 (21%). In rugby, concussion can affect as many as 40% of players on a team each year. Approximately a third of these injuries occur in football. Head injuries accounted for 13.3% of all football injuries to boys and 4.4% of all soccer injuries to both boys and girls in a large study of high school sports injuries. Approximately 62,800 mTBI cases occur annually among high school varsity athletes, with football accounting for about 63% of cases. Concussions in hockey affect 10% of the athletes and make up 12%-14% of all injuries.

The CDC statistics on mTBI does not even include such incidences in the United States Armed Forces. In the army, the incidence of TBI in the armed forces is around 20,000 annually, and for the Navy, Airforce, and the Marines, the incidence of TBI for each branch is around 2,500 annually.

Concussions, particularly when repeated multiple times, significantly threaten the long-term health of the person. The health care costs associated with mTBI in sports are estimated to be in the hundreds of millions annually. The National Center for Injury Prevention and Control considers sports-related traumatic brain injury (mild and severe) an important public health problem because of the high incidence of these injuries, the relative youth of those being injured with possible long term disability, and the danger of cumulative effects from repeat incidences.

Sport-related concussion has been linked to various markers of health, including an increase in symptom reports, cognitive deficits, balance impairments, as well as depression, mood disturbances, sleep disturbances, and attention/concentration issues, which are all mediators that may affect one's perception of their quality of life. While there have been great strides in the evaluation of clinical assessment tools for evaluating the concussed athlete, concussion remains a clinical diagnosis based primarily on self-reported signs and symptoms, cognitive deficits, and balance impairments. These tools are helpful in tracking recovery post-injury, but they rely on self-reporting by an individual who is motivate to remain participating in sport and lack the sensitivity to be a diagnostic tool.

The health risks of subsequent head impact increases significantly, for example subsequent impacts following an initial concussion (mTBI) may be 4-6 times more likely to result in a second, often more severe, brain injury. Although increased brain tissue strain, pressure waves, and pressure gradients within the skull have been linked with specific brain injury mechanisms, much remains unknown about the response of the brain to head impacts. There is even less known about the correspondence between specific impact forces and injury, particularly with respect to injuries caused by repeated exposure to impact forces of a lower level than those that result in a catastrophic injury or fatality.

Detecting changes that are a direct result of head impact and mild traumatic brain injury are challenging. Conventional imaging techniques are usually insufficient to identify damage associated with mTBI. However, the presence of lingering symptoms indicates that functional changes resulting from repeated and/or acute exposure to head impact do occur and can typically last several days. These functional changes possibly result from structural damage to torn axons and synaptic connections and inflammation. Therefore, there is an opportunity to detect either physical injury and/or repair processes going on in the brain as a head impact that do not result in a concussion diagnosis or only result in mTBI. Unfortunately, there is limited data on the molecular changes associated with mTBI or from the effect repeated head impacts that do not result in a diagnosis of concussion such as those that occur during routine practices and games of contact sports.

SUMMARY OF THE INVENTION

Embodiments of the invention provide methods for determining the risk of a subject for developing mTBI. The methods comprise obtaining a biological sample from a subject; measuring the biological sample for an amount of at least one biomarker selected from the group consisting of the biomarkers selected from biomarkers listed in any one of Tables 1-53; and comparing the amount of the at least biomarker with the amount of the at least one biomarker in a control biological sample, wherein a change in the amount of the at least one biomarker from the subject compared with the control is indicative of the subject having an increased risk for mTBI.

Embodiments of the invention further provides methods for determining the fitness of a subject for participating in an activity with increased chances of receiving a head impact comprising: obtaining a biological sample from a subject; measuring the biological sample for an amount of at least one biomarker selected from biomarkers listed in any one of Tables 1-53; and comparing the amount of the at least one biomarker with the amount of the at least one biomarker in a control sample; and wherein a change in the amount of the at least one biomarker from the subject compared with the control is indicative of the subject being unfit for participating in the activity with increased chances of receiving a head impact.

The amount of the at least one biomarker is preferably the amount of biomarkers' extracellular RNA expression in the biological sample. Some implementations of the methods of the invention comprise measuring the biological sample for for an amount of at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least ten, at least eleven, at least twelve, at least thirteen, at least fourteen, at least fifteen, at least sixteen, at least seventeen, at least eighteen, at least nineteen, or at least twenty biomarkers selected from biomarkers listed in any one of Tables 1-53.

In some embodiments, the methods of the invention provide that a subject has an increased risk for developing mTBI or is not fit for participating in an activity with increased chances of receiving a head impact when the change in amount of the amount of at least one biomarker selected from biomarkers listed in any one of Tables 6-32 and 53 corresponds with the indicated change in expression of the at least one biomarker shown in Tables 6-32 and 53.

In some aspects, the biological sample is obtained after the subject has received a head impact incident, for example within 48 hours, within 24 hours, within 12 hours, or within 6 hours of the subject having had a head impact incident or is suspected of having a head impact incident.

The invention also provides kits for determining the risk of a subject for developing mTBI or for determining the fitness of a subject for participating in an activity with increased chances of receiving a head impact, wherein the kits detect the expression of at least one biomarker selected from the biomarkers listed in any one of Tables 1-53. In some embodiments, the kit comprises a primer or probe that specifically determines the expression level of at least one biomarker selected from any one of Tables 6-53 in the subject. The kits may further comprise a dataset comprising the expression level of the at least one biomarker in normal subjects and/or a control sample.

The kits may further comprise instructions listing the direction of change in the expression of the at least one biomarker in the subject in relation to the dataset or the control that demonstrates the subject has increased risk of the subject for developing mTBI. In some embodiments, the direction of change in the expression corresponds to the changes as depicted in any one of Tables 6-53.

In some embodiments, the kits determine the probability score for a subject's exposure to potentially injurious head impact. Such kits comprise a primer or probe that specifically determines the expression level of at least one biomarker selected from any one of Tables 31 and 32 and a control sample or a dataset comprising the expression level of the at least one biomarker in normal subjects. Correlating the change in the expression of the at least one biomarker with the changes as depicted in any one of Tables 31 and 32 determines the subject's probability score for a subject's risk for concussion.

Additional objectives, advantages and novel features will be set forth in the description which follows or will become apparent to those skilled in the art upon examination of the drawings and detailed description which follows.

DETAILED DESCRIPTION

As used herein, the verb “comprise” as is used in this description and in the claims and its conjugations are used in its non-limiting sense to mean that items following the word are included, but items not specifically mentioned are not excluded. In addition, reference to an element by the indefinite article “a” or “an” does not exclude the possibility that more than one of the elements are present, unless the context clearly requires that there is one and only one of the elements. The indefinite article article “a” or “an” thus usually means “at least one.”

As used herein, the term “subject” or “patient” refers to any vertebrate including, without limitation, humans and other primates (e.g., chimpanzees and other apes and monkey species), farm animals (e.g., cattle, sheep, pigs, goats and horses), domestic mammals (e.g., dogs and cats), laboratory animals (e.g., rodents such as mice, rats, and guinea pigs), and birds (e.g., domestic, wild and game birds such as chickens, turkeys and other gallinaceous birds, ducks, geese, and the like). In some implementations, the subject may be a mammal, preferrably a human.

As used herein, the term “acute head injury” refers to head injury received by subjects who do not have a history chronic cumulative head impact exposure. For example, the subject may play non-contract sports.

As used herein, the term “biological sample” or “biofluid” includes blood samples, salivary samples, and urine samples. However, other biological samples are also contemplated, for example, cerebral spinal fluid samples, plasma samples, and tear samples. Thus biological sample, as used herein, refers to biological fluids (biofluids) of the subject.

As used herein, the term “head impact,” refers generally to measurable impact to the head. Determination that head impact has occurred may, for example, be based on readings from protective headgear, such as helmets made by Riddell (Chicago, Ill., USA).

As used herein, the term “expression” in relation to biomarkers refers both genetic expression and protein expression. Measuring genetic expression includes measuring the expression of DNA and/or RNA, including measuring non-coding RNA molecules, such as microRNAs. Such measurements include measuring extracellular RNA expression. Measuring protein expression includes measuring the presence of whole proteins and/or peptides. For RNA expression, a biomarker is considered expressed if a sample has at least 10 read counts of the mRNA.

As referenced herein, ENSEMBL ID described contain the sequences of ENSEMBL 75, Gencode release 19, the contents of which are incorporated herein.

The invention relates to the discovery that subjects who are contact sports athletes (e.g. football or baseball players) and subject who are not contact sports athletes (e.g. track and field athletes or swimmers) have unique transcriptomes. The invention also relates to the discovery that the transcriptomes of contact sports athletes who recently had or did not have any head impact incidents are unique. Furthermore, the uniqueness of the transcriptome can distinguish based on the force of the head impact (as measured by linear or rotational acceleration or an impact score such as HITsp from helmets made by Riddell), the number of hits, and the frequency of the head impact. Thus, the invention provides biomarkers for determining the risk of a subject for developing mTBI and for concussion. In some aspects, the disclosed biomarkers have been found to be significant in at least four comparisons.

Table 1 lists the biomarkers that differentiate (based on linear regression analysis, differential expression analysis, or random forest algorithm) various case and control samples. For linear regression, simple linear regression was performed where the players' impact data from the helmets were regressed were on the gene expression measured in counts which have been normalized for sequencing depth between the samples. The impact data from the helmets are the total number of all head impacts sustained by the player in the game (Total Hits or the number of hits), the highest impact sustained by the player in the game, where the impact can be measured by linear acceleration sustained by the head (Max_Lin_acc), the rotational acceleration (Max_Rot_acc) and a combined score of the location of impact, linear and rotational acceleration (HITsp), and the sum of all impacts sustained by the player in the game (Cum_Lin_acc, Cum_Rot_acc, or Cum HITsp). Genes with a |slope|>0.1 and a p-value <0.05 were considered significant and included in Table 1. In some aspects, the biomarkers of Table 1 were determined based comparisons between the following pairs of samples:

-   -   A subject who is a contact sport athlete and experienced the         most forceful head impact (Max_HITsp) and the subject's         baseline;     -   Subjects who are contact sport athletes and experienced the most         forceful head impact (Max_HITsp) and subjects who are contact         sport athletes and experienced the least forceful head impact         (Min_HITsp);     -   Subjects who are contact sport athletes and experienced the most         forceful head impact (Max_HITsp) and subjects with normal         exposure to head impact (e.g. athletes who do not play contact         sports) (Track_field_control);     -   A subject who is a contact sport athlete and experienced the         least forceful head impact (Min_HITsp) and the subject's         baseline;     -   A subject who is a contact sport athlete and experienced the         most frequent head impact (Max_freq_hits) and the subject's         baseline;     -   Subject who are contact sport athletes and experienced the most         frequent head impact (Max_freq_hits) and subjects who are a         contact sport athletes and experienced the least frequent head         impact (Min_freq_hits);     -   Subjects who are contact sport athletes and experienced the most         frequent head impact (Max_freq_hits) and subjects with normal         exposure to head impact (e.g. athletes who do not play contact         sports) (Track_field_control);     -   Subjects who experienced most frequent head impact         (Max_freq_hits) and the subject's baseline or subjects who are         not contact sport athletes (Track_field_control);     -   A subject who is a contact sport athlete and experienced the         least frequent head impact (Min_freq_hits) and the subject's         baseline;     -   Subjects who experienced the least frequent head impact         (Min_freq_hits) and the subject's baseline or subjects who are         not contact sport athletes (Track_field_control);     -   Subjects who are contact sport athletes (baseline) and subjects         who are not contact sport athletes (Track_field_control);     -   A subject who is a contact sport athlete and experienced the         least forceful head impact (Min_HITsp) and the subject's         baseline;     -   Subjects who experienced least forceful head impact (Min_HITsp)         and the subject's baseline or subjects who are not contact sport         athletes (Track_field_control);     -   Subjects with mild exposure to potentially injurious head impact         (probability score of 0-0.1) and subjects with least exposure to         potentially injurious head impact (probability score of 0);     -   Subjects with moderate exposure potentially injurious head         impact (probability score of 0.1-0.5) and subjects with least         exposure potentially injurious head impact (probability score of         0);     -   Subjects with moderate exposure potentially injurious head         impact (probability score of 0.1-0.5) and subjects with mild         exposure potentially injurious head impact (probability score of         0-0.1);     -   Subjects with high exposure potentially injurious head impact         (probability score of >0.5) and subjects with least exposure         potentially injurious head impact (probability score of 0);     -   Subjects with high exposure potentially injurious head impact         (probability score of >0.5) and subjects with mild exposure         potentially injurious head impact (probability score of 0-0.1);         and     -   Subjects with high exposure potentially injurious head impact         (probability score of >0.5) and subject with moderate exposure         potentially injurious head impact (probability score of         0.1-0.5).         In comparisons using the probability score for risk of         concussion, the scores are calculated using the linear and         rotational acceleration was studied previously by Rowson et. al         (“Brain Injury Prediction: Assessing the Combined Probability of         Concussion Using Linear and Rotational Head Acceleration.” Ann         of Biomed. Engg 2013).

Table 2 list the biomarkers that are differentially expressed, regardless of whether the biological sample is from blood, urine, or saliva, that can be used for determining the risk of a subject for developing mTBI and for concussion, Table 3 is a subset of the biomarkers that are differentially expressed in blood samples. Table 4 is a subset of the biomarkers that are differentially expressed in saliva samples. Table 5 is a subset of the biomarkers that are differentially expressed urine samples.

Tables 6-15 lists the significant genes from linear regression analysis with year 1 and year 2 samples. The analysis was performed with two levels of stringency: (1) only those genes which had measurable expression in at least 50% of the samples (Expr in 0.5 samples) and (2) only those genes which had expression in at least 80% of the samples (Expr in 0.8 samples). Genes with a |slope|>0.1 and a p-value<0.05 were considered significant. Tables 6-11 contain the significant genes in plasma samples. Tables 12-15 list the significant genes in urine samples.

Accordingly, the invention provides methods for determining the risk of a subject for developing mTBI. The methods comprise obtaining a biological sample from a subject; measuring the biological sample for an amount of at least one biomarker selected from the group consisting of the biomarkers listed in any one of Tables 1-15; and comparing the amount of the at least one biomarker in the biological sample with the amount of the at least one biomarker in a control sample, wherein a change in the amount of the at least one biomarker from the subject compared with the control sample is indicative of the subject being at an increased risk for developing mTBI. In some aspects, the biomarkers detect the risk of developing mTBI after a head impact incident.

The invention also provides methods for determining the fitness of a subject for participating in an activity with increased chances of receiving a head impact. The methods comprise obtaining a biological sample from a subject; measuring the biological sample for an amount of at least one biomarker selected from the group consisting of the biomarkers listed in any one of Tables 1-15; and comparing the amount of the at least one biomarker with the amount of the at least one biomarker in a control sample, wherein a change in the amount of the at least one biomarker from the subject compared with the control is indicative of the subject being unfit for participating in the activity with increased chances of receiving a head impact.

In some aspects, the methods of the invention further comprises determining, based on the biomarker measurement, whether the subject should be hospitalized for the head impact incident, whether the subject should be monitored while continuing or halting the activity that resulted in the head impact, or the whether the subject incurred no significant increases in risk for developing mTBI due to the head impact incident.

In some aspects, measuring the biological sample of the methods of the invention comprises measuring the biological sample for an amount of at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least ten, at least eleven, at least twelve, at least thirteen, at least fourteen, at least fifteen, at least sixteen, at least seventeen, at least eighteen, at least nineteen, or at least twenty biomarkers selected from the group consisting of the biomarkers listed in any one of Tables 1-15.

In some embodiments of the invention, the biological sample from a subject is obtained after known head impact, for example head impact that is detected by helmet, such as one by Riddell. In some aspects, the biological sample may be collected immediately after known head impact or within one hour, three hours, six hours, eight hours, 12 hours, 18 hours, 24 hours, or 48 hours after known head impact or the time of suspected head impact incident. The biological sample may also be collected at least one hour, at least three hours, at least six, at least eight hours, at least 12 hours, at least 18 hours, or at least 24 hours after known head impact the time of suspected head impact incident.

In some implementations, the control sample is the baseline sample of the subject. The baseline sample of the subject may be collected prior the immediate head trauma, which may or may not reflect a history of frequent head impacts, such as in athletes playing contact sports. For example, the baseline sample of a football player collected before the start of the athlete's competitive season or during the practice week may reflect a baseline comprising changes due to the subject having a history of frequent head impacts. Though if the baseline sample of a football player were collected before the start of the athlete's first competitive season or if the baseline sample were from a subject not participating in contact sports, the baseline sample would not reflect a baseline comprising such changes.

In other implementations, the control sample is not the baseline sample of the subject. For example, the control sample may be a matched sample (for example by age and sex) from a different subject or a predicted control sample calculated from the general population. The predicted control sample may be further made representative by characterizing the general population by age. Thus prepubescent athletes and post-pubescent athletes would have separate predicted control samples. The representative sample for the general population of post-pubescent athletes may be further refined by sex and additional age brackets, for example, for a population of males between the ages of 18 to 24, females between the ages of 18 to 24, males between the ages of 25 to 30, females between the ages of 25 to 30, males between the ages of 30 to 40, or females between the ages of 30 to 40.

Methods for measuring the biological sample for an amount of at least one biomarker are well established in the art. Such methods include detection of the at least one biomarker by reacting the biological sample with primers to detect gene expression or reaction the biological sample with antibodies to detect protein expression. Particular methods for measuring the biological sample for an amount of at least one biomarker include PCR, real-time PCR, immunoassays, gene or protein arrays, and western blotting. In some implementations, detection of protein biomarkers in the biological sample may be through mass spectrometry, protein arrays, antibody arrays, ELISA, and other forms of immunoassays.

When more than one biomarker is measured, the determination of the risk of a subject for developing mTBI may be based on a uniform increase in the expression of a set of biomarkers selected from the biomarkers listed in any one of Tables 1-53, a uniform decrease in the expression of a set of biomarkers selected from the biomarkers listed in any one of Tables 1-53, or a combination of increased expression of some biomarkers listed in any one of Tables 1-53 and decrease expression of other biomarkers listed in any one of Tables 1-53.

For example, an increased risk may be reflected by the detection of increased expression in the measured biomarkers. An increased risk may also be reflected by the detection of decreased expression in the measured biomarkers. An increased risk may additionally be reflected by the detection of decreased expression in some of the measured biomarkers in combination with the detection of increased expression in the other measured biomarkers. In some implementations, the determination of the risk of a subject for developing mTBI may be based a combination of biomarker listed in any one of Tables 1-53 having increased expression, decreased expression, and no change in expression.

Gradations of risk may also be determined by comparing the amount of the at least one biomarker in the biological sample with the amount of the at least one biomarker in a control sample. The magnitude of the change in expression is correlated to increased or decreased risk of the subject developing mTBI. The combination of particularly changes or lack of change in the expression of biomarker is also correlated is correlated to increased or decreased risk of the subject developing mTBI.

The invention further encompasses kits for determining the risk of a subject for developing mTBI or for determining the fitness of a subject for participating in an activity with increased chances of receiving a head impact, wherein the kits detect the expression of at least one biomarker selected from the biomarkers listed in any one of Tables 1-53. In some embodiments, the kit comprises a primer or probe that specifically determines the expression level of at least one biomarker selected from any one of Tables 1-53 in the subject. In some implementations, the probe is covalently attached to the surface of a solid support. The kits may further comprise a dataset comprising the expression level of the at least one biomarker in normal subjects and/or a control sample.

The kits may further comprise instructions listing the direction of change in the expression of the at least one biomarker in the subject in relation to the dataset or the control that demonstrates the subject has increased risk of the subject for developing mTBI. In some embodiments, the direction of change in the expression corresponds to the changes as depicted in any one of Tables 6-53.

In some embodiments, the kits determine the probability of a subject's exposure to potentially injurious head impact, for example least exposure (probability score of 0), mild exposure (probability score of 0-0.1), moderate exposure (probability score of 0.1-0.5), and high exposure (probability score of >0.5). Such kits comprise a primer or probe that specifically determines the expression level of at least one biomarker selected from Table 32 or 33 and a control sample or a dataset comprising the expression level of the at least one biomarker in normal subjects. Correlating the change in the expression of the at least one biomarker with the changes as depicted in Table 32 or 33 determines the subject's probability score exposure to potentially injurious head impact.

In some aspects, the kits provide rapid onsite determination of the risk of a subject for developing mTBI. An example of such a kit comprises a detection agent for at least one biomarker at least one biomarker selected from the group consisting of the biomarkers listed in any one of Tables 1-53 and reagents facilitating the detection of the at least one biomarker. The detection agent may be antibodies that recognize the at least one biomarker, which can be fluorescence-conjugated. The detection agent may also be a nucleotide sequence that recognize the at least one biomarker. Reagents facilitating the detection of the at least one biomarker by using the aforementioned detection agents are well known in the art. In some embodiments, the kits may comprise a DNA polymerase and a buffer.

EXAMPLES

It should be understood that while particular embodiments have been illustrated and described, various modifications can be made thereto without departing from the spirit and scope of the invention as will be apparent to those skilled in the art. Such changes and modifications are within the scope and teachings of this invention as defined in the claims appended hereto.

1. Identification of Biomarkers for Determining the Risk for Developing mTBI or Concussion

A. Sample Collection:

Samples of saliva, urine and blood were collected from players on youth, high school, and collegiate football players and matched non-contact athletes. The samples were collected at baseline (prior to the first contact practice) and once each week of the season (from summer training camp to the Pac-12 championship game at the end of the season). Post-season, return to baseline, samples were also collected and stored. In order to correlate molecular changes with head impact exposure, the athletes were outfitted with the Riddell Sideline Response System (SRS) (U.S. patent application Ser. No. 13/603,319), which recorded the magnitude and frequency of every head impact during each practice and game in one season. Head injury samples were generally collected as soon after the head injury as possible. In cases were the samples were labeled “previous day,” the samples were collected a day after a game took place. Thus the samples were collected a day after a head impact incident or suspected time of a head impact incident.

B. Sample Selection for RNASeq:

Sample selection for RNA sequencing was carried based on the following criteria:

-   -   a) Players who were hit more frequently between two sample         collections/games than others. These constitute the groups         Max_freq_hits and Min_freq_hits respectively. The number of hits         between two games/sample collections range from 128-200 for the         Max_freq_hits and 2-20 for the Min_freq_hits groups         respectively.     -   b) Players who were hit with a high impact as evidenced by the         HITSp values from the helmet data between two sample         collections/games than others. These constitute the groups         Max_hitsp and Min_hitsp respectively. The HITsp values take into         account the linear and rotational acceleration and the location         of impact amongst others. The HITsp values range from 120-200         for the Max_hitsp and 15-30 for the Min_hitsp groups         respectively.     -   c) The baselines for the aforementioned players and other         non-footballer athletes (track and field, swimmers, wrestlers,         etc.) were sequenced.         2. Verification of Biomarkers for Determining the Risk for         Developing mTBI or Concussion

A. Analysis Methodology for Differential Expression

The sequenced samples were aligned to the human genome (Gencode release 19, ENSEMBL 75) using the Spliced Transcripts Alignment to a Reference (STAR) softwarel. The aligned reads were then counted for gene features using htseq-count. The output from htseq-count, which is a list of genes and their corresponding counts for each sample, is then analyzed for differential expression by DESeq2. DESeq2 estimates variance-mean dependence in count data arising from the htseq-count in this case, and tests for differential expression based on a model using the negative binomial distribution. The raw counts for the samples were normalized using the median ratio method, which is used by the DESeq2 software by default to minimize the effect of large expression outliers across the samples. Only samples with a sufficient number of coding genes discovered (>10,000 coding genes with at least 10 counts) were allowed for further analysis.

The three major steps in the DESeq2 software are a) estimation of size factors; b) estimation of dispersion; and c) negative binomial GLM fitting and Wald statistics.

For year 1 samples, pairwise comparisons were performed for Max_freq_hits/Max_HITsp versus their baselines and Min_freq_hits/Min_HITsp. Comparisons were also made with non-footballer controls. Only genes with an adjusted p-value of less than 0.05 and a log 2foldchange >+2 or <−2 were deemed to be significantly over-expressed and under-expressed respectively for each pairwise comparison. This analysis was carried out for all three biofluids, namely blood, urine and saliva, separately owing to the difference in the constitution of the exRNA (extracellular RNA) present in them. Tables 16-26 depict the fold change in the expression of these markers in the pairwise comparisons. Positive values indicate increased expression while negative values indicate decreased expression.

Table 16 lists the markers that are differentially expressed when the blood sample of subjects who experienced most forceful head impact (Max_HITsp) as compared to the subject's baseline, subjects who experienced least forceful head impact (Min_HITsp), or subjects who are not contact sports athletes (Track_field_control). Table 17 lists markers that are differentially expressed when the urine or saliva sample of subjects who experienced most forceful head impact (Max_HITsp) as compared to the subject's baseline or subjects who are not contact sports athletes (Track_field_control).

Table 18 lists markers that are differentially expressed when the blood sample of subjects who experienced most frequent head impact (Max_freq_hits) are compared to the subjects' baseline or subjects who are not contact sports athletes (Track_field_control). Table 19 lists markers that are differentially expressed when the urine sample of subjects who experienced most frequent head impacts (Max_freq_hits) are compared to the subjects' baseline, subjects with least frequent head impacts (Min_freq_hits), or subjects who are not contact sports athletes (Track_field_control). Table 20 lists markers that are differentially expressed when the saliva sample of subjects who experienced most frequent head impact (Max_freq_hits) are compared to the subjects' baseline or subjects who experienced least frequent head impact (Min_freq_h its).

Table 21 lists markers that are differentially expressed when the blood sample of subjects who experienced least forceful head impact (Min_HITsp) are compared to the subject's baseline or subjects who are not contact sports athletes (Track_field_control). Table 22 lists markers that are differentially expressed when the urine sample of subjects who experienced least forceful head impact (Min_HITsp) are compared to subjects who are not contact sports athletes (Track_field_control).

Table 23 lists markers that are differentially expressed when the blood sample of subjects who experienced frequent head impact (Min_freq_hits) are compared to the subjects' baseline or subjects who are not contact sports athletes (Track_field_control). Table 24 lists markers that are differentially expressed when the urine sample of subjects who experienced frequent head impact (Min_freq_hits) are compared to the subjects who are not contact sports athletes (Track_field_control).

Table 25 lists markers that are differentially expressed when the baseline blood sample of subjects who are contact sport athletes (baseline) are compared to subjects who are not contact sports athletes (Track_field_control). Table 26 lists markers that are differentially expressed when the baseline urine sample of subjects who are contact sport athletes (baseline) are compared to the subjects who are not contact sports athletes (Track_field_control).

Another analysis was carried for the combination of year 1 and years 2 samples. In year 2, there were 240 samples sequenced in all for small RNA, which consisted of 91 plasma and 149 urine samples. The cut-off employed for sample selection was that each sample has at least 7500 protein coding genes with at least 10 read counts. Since no new saliva samples were sequenced from year 2, the analyses are restricted to plasma and urine only. All the analyses conducted were with respect to the player's hit data on the previous day. The analysis for the combination of year 1 and year 2 samples was performed in two ways.

The first way comprises dividing the sample set by sample source into various categories based on a single measurement: Number of hits sustained on the previous day or the highest impact sustained on the previous day (HITsp). The categories here are:

SI no Case Control 1 Max_hitsp Min_hitsp 2 Max_hitsp Baseline 3 Min_hitsp Baseline 4 High_freq_hits Low_freq_hits 5 High_freq_hits Baseline 6 Low_freq_hits Baseline Max_HITsp represents players who sustain a hit greater than or equal to 85 the previous day. Min_HITsp represents payers who sustain a hit less than or equal to 30 the previous day. High_freq_hits represents players who were hit greater than or equal to 60 times the previous day. Low_freq_hits represents players who were hit less than or equal to 15 times the previous day. Baseline represents sample acquired from players before the season began. Concussion represents players with a diagnosed concussion.

Tables 27-30 list the differentially expressed biomarkers based on the above comparisons and depict the fold change in the expression of these markers in the pairwise comparisons. Positive values indicate increased expression while negative values indicate decreased expression.

Table 27 lists a subset of markers that are differentially expressed in plasma when considering the frequency of head impact. Table 28 lists a subset of markers that are differentially expressed in plasma when considering the level of head impact. The listed markers in Tables 27 and 28 are significant in at least four differential expression comparisons. Table 29 lists markers that are differentially expressed in urine when considering the frequency of head impact. Table 30 lists markers that are differentially expressed in urine when considering the level of head impact.

The second way comprises weighting each impact sustained the previous day by the linear and rotational acceleration for each impact to determine the probability for concussion using the algorithms of Rowson et. al (“Brain Injury Prediction: Assessing the Combined Probability of Concussion Using Linear and Rotational Head Acceleration.” Ann of Biomed. Engg 2013). The methods of Rowson et al. was used to determine risk of exposure associated with each impact. Briefly, each impact sustained by the player is given a probability score that informs the risk of exposure to potentially injurious impacts. These probabilities are summed up for the previous day hit data to get a cumulative risk score. The players are then categorized as 0 (least risk: baseline samples), 1 (risk between 0-0.1), 2 (0.1-0.5) and 3 (0.5 and above). Differential expression analysis was then conducted for the following categories:

SI no Case Control 1 3 0 2 3 1 3 3 2 4 2 0 5 2 1 6 1 0

The above analysis therefore takes into account the number of impacts sustained by the player the previous day along with their corresponding impact information (linear and rotational acceleration associated with each hit). Tables 31 and 32 lists differentially expressed biomarkers based on the above comparisons in plasma and urine samples, respectively, and depict the fold change in the expression of these markers in the pairwise comparisons. Positive values indicate increased expression while negative values indicate decreased expression. The listed markers in Table 31 are a subset of differentially expressed biomarkers that are significant in at least four differential expression comparisons.

B. Analysis Methodology for Linear Regression

Simple linear regression was performed in year 1 and years 2 samples where the players' impact data from the helmets, in seven categories, were regressed up on the RNA expression. The categories are: the total number of all head impacts sustained by the player in the game (Total Hits), the highest impact sustained by the player in the game, where the impact can be measured by linear acceleration sustained by the head (Max_Lin_acc), the rotational acceleration (Max_Rot_acc), and a combined score of the location of impact, linear and rotational acceleration (HITsp) (Max HITsp), and sum of all impacts sustained by the player in the game (Cum_Lin_acc, Cum_Rot_acc, and Cum HITsp). These data were regressed on the gene expression measured in counts which have been normalized for sequencing depth between the samples.

The analysis was performed with two levels of stringency, firstly with only those genes which had measurable expression in at least 50% of the samples (Expr in 0.5 samples) and secondly with only those genes which had expression in at least 80% of the samples (Expr in 0.8 samples). Genes with a |slope|>0.1 and a p-value <0.05 were considered significant. Here expressed is defined as having at least 10 read counts of the mRNA. Tables 6-15 disclose the significant biomarkers from linear regression.

C. Methodology for Random Forest Machine Learning Algorithm

To arrive at the smallest set of genes that could comprehensively discriminate between cases and controls, random forests machine learning algorithm was used. Random forest is a machine learning technique for classification and regression which instead of using all predictors (genes) and all individuals (samples) to make a single classification tree, it uses a forest of many trees each based on a random selection of predictors and individuals. Each tree is fit using a bootstrap sample of data drawn with replacement and grown until each node is pure. The trees all act as weak classifiers and when there are ˜10,000 weak classifiers, the average result from all these classifiers give a robust and accurate estimate of the data. Random forest gives us a set of genes ranked by their importance or discriminating power between the samples—case or control. This is especially useful when dealing with a large set of genes which are significantly differentially expressed or when too few are differentially expressed.

Tables 33-53 present the set of the genes that discriminate between various cases and controls using blood samples and urine samples. Tables 33 and 34 list markers that discriminate between contact sport athletes and non-contact sports athletes from their blood and urine samples, respectively. Tables 35-39 list the markers that differentiate subjects who had the most frequent head impact by using blood and urine samples. Tables 40-45 list markers that differentiate subjects who had the most forciful head impact from the subject by using blood and urine samples. Tables 46-49 lists the markers that differentiate subjects who had the least frequent head impact by using blood and urine samples. Tables 50-52 list the markers that differentiate subjects who had the lest frequent head impact by using blood and urine samples. Table 53 lists markers with expression that is significant different across the different biological samples.

Elevations or reductions in the expression of these RNA indicate frequent head contact and might increase risk for injury. In some implementations, an expression profile wherein the changes in marker expression completely corresponds with the changes depicted in Table 53 is indicative of the subject being at increased risk for mTBI. Though in other implementations, just decreased expression of ENSG00000113889, ENSG00000164825, ENSG00000165685, ENSG00000169344, ENSG00000184908, and ENSG00000270103 or just increased expression of ENSG00000125652, ENSG00000145113, ENSG00000153802, ENSG00000196352, ENSG00000197674, ENSG00000206652, ENSG00000210194, ENSG00000230140, ENSG00000254325, ENSG00000258406, ENSG00000267706, ENSG00000269364, and ENSG00000271043 is indicative of the subject being at increased risk for mTBI. Accordingly, in some embodiments, a change in the expression of at least 6 markers listed in Table 53 is indicative of the subject being at increased risk for mTBI.

TABLE 1 Hgnc Ensembl ID symbol Description ENSG00000004864 SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 [Source:HGNC Symbol;Acc:HGNC:10983] ENSG00000005175 RPAP3 RNA polymerase II associated protein 3 [Source:HGNC Symbol;Acc:HGNC:26151] ENSG00000005249 PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta [Source:HGNC Symbol;Acc:HGNC:9392] ENSG00000005961 ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [Source:HGNC Symbol;Acc:HGNC:6138] ENSG00000006432 MAP3K9 mitogen-activated protein kinase kinase kinase 9 [Source:HGNC Symbol;Acc:HGNC:6861] ENSG00000006715 VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:12713] ENSG00000010318 PHF7 PHD finger protein 7 [Source:HGNC Symbol;Acc:HGNC:18458] ENSG00000011275 RNF216 ring finger protein 216 [Source:HGNC Symbol;Acc:HGNC:21698] ENSG00000011638 TMEM159 transmembrane protein 159 [Source:HGNC Symbol;Acc:HGNC:30136] ENSG00000012779 ALOX5 arachidonate 5-lipoxygenase [Source:HGNC Symbol;Acc:HGNC:435] ENSG00000013016 EHD3 EH-domain containing 3 [Source:HGNC Symbol;Acc:HGNC:3244] ENSG00000025293 PHF20 PHD finger protein 20 [Source:HGNC Symbol;Acc:HGNC:16098] ENSG00000029725 RABEP1 rabaptin, RAB GTPase binding effector protein 1 [Source:HGNC Symbol;Acc:HGNC:17677] ENSG00000031003 FAM13B family with sequence similarity 13, member B [Source:HGNC Symbol;Acc:HGNC:1335] ENSG00000034677 RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:13432] ENSG00000035403 VCL vinculin [Source:HGNC Symbol;Acc:HGNC:12665] ENSG00000041353 RAB27B RAB27B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9767] ENSG00000044090 CUL7 cullin 7 [Source:HGNC Symbol;Acc:HGNC:21024] ENSG00000048405 ZNF800 zinc finger protein 800 [Source:HGNC Symbol;Acc:HGNC:27267] ENSG00000064012 CASP8 caspase 8, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:HGNC:1509] ENSG00000064102 ASUN asunder spermatogenesis regulator [Source:HGNC Symbol;Acc:HGNC:20174] ENSG00000064313 TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)- associated factor, 150 kDa [Source:HGNC Symbol;Acc:HGNC:11536] ENSG00000065054 SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 [Source:HGNC Symbol;Acc:HGNC:11076] ENSG00000066322 ELOVL1 ELOVL fatty acid elongase 1 [Source:HGNC Symbol;Acc:HGNC:14418] ENSG00000067369 TP53BP1 tumor protein p53 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11999] ENSG00000068796 KIF2A kinesin heavy chain member 2A [Source:HGNC Symbol;Acc:HGNC:6318] ENSG00000070190 DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides [Source:HGNC Symbol;Acc:HGNC:16500] ENSG00000074755 ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 [Source:HGNC Symbol;Acc:HGNC:29027] ENSG00000075624 ACTB actin, beta [Source:HGNC Symbol;Acc:HGNC:132] ENSG00000078124 ACER3 alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC:16066] ENSG00000079459 FDFT1 farnesyl-diphosphate farnesyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3629] ENSG00000080608 KIAA0020 KIAA0020 [Source:HGNC Symbol;Acc:HGNC:29676] ENSG00000081087 OSTM1 osteopetrosis associated transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:21652] ENSG00000081320 STK17B serine/threonine kinase 17b [Source:HGNC Symbol;Acc:HGNC:11396] ENSG00000081791 KIAA0141 KIAA0141 [Source:HGNC Symbol;Acc:HGNC:28969] ENSG00000081803 CADPS2 Ca++-dependent secretion activator 2 [Source:HGNC Symbol;Acc:HGNC:16018] ENSG00000087494 PTHLH parathyroid hormone-like hormone [Source:HGNC Symbol;Acc:HGNC:9607] ENSG00000100023 PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 [Source:HGNC Symbol;Acc:HGNC:9261] ENSG00000100181 TPTEP1 transmembrane phosphatase with tensin homology pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43648] ENSG00000100345 MYH9 myosin, heavy chain 9, non-muscle [Source:HGNC Symbol;Acc:HGNC:7579] ENSG00000100580 TMED8 transmembrane emp24 protein transport domain containing 8 [Source:HGNC Symbol;Acc:HGNC:18633] ENSG00000100592 DAAM1 dishevelled associated activator of morphogenesis 1 [Source:HGNC Symbol;Acc:HGNC:18142] ENSG00000101210 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 [Source:HGNC Symbol;Acc:HGNC:3192] ENSG00000102243 VGLL1 vestigial-like family member 1 [Source:HGNC Symbol;Acc:HGNC:20985] ENSG00000102572 STK24 serine/threonine kinase 24 [Source:HGNC Symbol;Acc:HGNC:11403] ENSG00000102804 TSC22D1 TSC22 domain family, member 1 [Source:HGNC Symbol;Acc:HGNC:16826] ENSG00000103194 USP10 ubiquitin specific peptidase 10 [Source:HGNC Symbol;Acc:HGNC:12608] ENSG00000103569 AQP9 aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] ENSG00000104447 TRPS1 trichorhinophalangeal syndrome I [Source:HGNC Symbol;Acc:HGNC:12340] ENSG00000105186 ANKRD27 ankyrin repeat domain 27 (VPS9 domain) [Source:HGNC Symbol;Acc:HGNC:25310] ENSG00000105778 AVL9 AVL9 homolog (S. cerevisiase) [Source:HGNC Symbol;Acc:HGNC:28994] ENSG00000106615 RHEB Ras homolog enriched in brain [Source:HGNC Symbol;Acc:HGNC:10011] ENSG00000107438 PDLIM1 PDZ and LIM domain 1 [Source:HGNC Symbol;Acc:HGNC:2067] ENSG00000107669 ATE1 arginyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:782] ENSG00000108094 CUL2 cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] ENSG00000108389 MTMR4 myotubularin related protein 4 [Source:HGNC Symbol;Acc:HGNC:7452] ENSG00000108883 EFTUD2 elongation factor Tu GTP binding domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30858] ENSG00000109084 TMEM97 transmembrane protein 97 [Source:HGNC Symbol;Acc:HGNC:28106] ENSG00000109272 PF4V1 platelet factor 4 variant 1 [Source:HGNC Symbol;Acc:HGNC:8862] ENSG00000109320 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [Source:HGNC Symbol;Acc:HGNC:7794] ENSG00000109854 HTATIP2 HIV-1 Tat interactive protein 2, 30 kDa [Source:HGNC Symbol;Acc:HGNC:16637] ENSG00000110002 VWA5A von Willebrand factor A domain containing 5A [Source:HGNC Symbol;Acc:HGNC:6658] ENSG00000110060 PUS3 pseudouridylate synthase 3 [Source:HGNC Symbol;Acc:HGNC:25461] ENSG00000110906 KCTD10 potassium channel tetramerization domain containing 10 [Source:HGNC Symbol;Acc:HGNC:23236] ENSG00000111215 PRR4 proline rich 4 (lacrimal) [Source:HGNC Symbol;Acc:HGNC:18020] ENSG00000111237 VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:14340] ENSG00000111348 ARHGDIB Rho GDP dissociation inhibitor (GDI) beta [Source:HGNC Symbol;Acc:HGNC:679] ENSG00000112118 MCM3 minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] ENSG00000112541 PDE10A phosphodiesterase 10A [Source:HGNC Symbol;Acc:HGNC:8772] ENSG00000112561 TFEB transcription factor EB [Source:HGNC Symbol;Acc:HGNC:11753] ENSG00000112893 MAN2A1 mannosidase, alpha, class 2A, member 1 [Source:HGNC Symbol;Acc:HGNC:6824] ENSG00000113494 PRLR prolactin receptor [Source:HGNC Symbol;Acc:HGNC:9446] ENSG00000113649 TCERG1 transcription elongation regulator 1 [Source:HGNC Symbol;Acc:HGNC:15630] ENSG00000113658 SMAD5 SMAD family member 5 [Source:HGNC Symbol;Acc:HGNC:6771] ENSG00000114013 CD86 CD86 molecule [Source:HGNC Symbol;Acc:HGNC:1705] ENSG00000114166 KAT2B K(lysine) acetyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:8638] ENSG00000114638 UPK1B uroplakin 1B [Source:HGNC Symbol;Acc:HGNC:12578] ENSG00000114805 PLCH1 phospholipase C, eta 1 [Source:HGNC Symbol;Acc:HGNC:29185] ENSG00000115159 GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) [Source:HGNC Symbol;Acc:HGNC:4456] ENSG00000115641 FHL2 four and a half LIM domains 2 [Source:HGNC Symbol;Acc:HGNC:3703] ENSG00000116117 PARD3B par-3 family cell polarity regulator beta [Source:HGNC Symbol;Acc:HGNC:14446] ENSG00000116191 RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 [Source:HGNC Symbol;Acc:HGNC:30279] ENSG00000116580 GON4L gon-4-like (C. elegans) [Source:HGNC Symbol;Acc:HGNC:25973] ENSG00000116984 MTR 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] ENSG00000117335 CD46 CD46 molecule, complement regulatory protein [Source:HGNC Symbol;Acc:HGNC:6953] ENSG00000117461 PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [Source:HGNC Symbol;Acc:HGNC:8981] ENSG00000119242 CCDC92 coiled-coil domain containing 92 [Source:HGNC Symbol;Acc:HGNC:29563] ENSG00000119684 MLH3 mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128] ENSG00000119888 EPCAM epithelial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:11529] ENSG00000119943 PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 [Source:HGNC Symbol;Acc:HGNC:23517] ENSG00000120586 NA NA ENSG00000120690 ELF1 E74-like factor 1 (ets domain transcription factor) [Source:HGNC Symbol;Acc:HGNC:3316] ENSG00000120889 TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [Source:HGNC Symbol;Acc:HGNC:11905] ENSG00000121594 CD80 CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700] ENSG00000121989 ACVR2A activin A receptor, type IIA [Source:HGNC Symbol;Acc:HGNC:173] ENSG00000122779 TRIM24 tripartite motif containing 24 [Source:HGNC Symbol;Acc:HGNC:11812] ENSG00000125676 THOC2 THO complex 2 [Source:HGNC Symbol;Acc:HGNC:19073] ENSG00000125945 ZNF436 zinc finger protein 436 [Source:HGNC Symbol;Acc:HGNC:20814] ENSG00000127588 GNG13 guanine nucleotide binding protein (G protein), gamma 13 [Source:HGNC Symbol;Acc:HGNC:14131] ENSG00000127947 PTPN12 protein tyrosine phosphatase, non-receptor type 12 [Source:HGNC Symbol;Acc:HGNC:9645] ENSG00000127952 STYXL1 serine/threonine/tyrosine interacting-like 1 [Source:HGNC Symbol;Acc:HGNC:18165] ENSG00000128245 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta [Source:HGNC Symbol;Acc:HGNC:12853] ENSG00000128266 GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide [Source:HGNC Symbol;Acc:HGNC:4395] ENSG00000128383 APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A [Source:HGNC Symbol;Acc:HGNC:17343] ENSG00000129315 CCNT1 cyclin T1 [Source:HGNC Symbol;Acc:HGNC:1599] ENSG00000129353 SLC44A2 solute carrier family 44 (choline transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:17292] ENSG00000129422 MTUS1 microtubule associated tumor suppressor 1 [Source:HGNC Symbol;Acc:HGNC:29789] ENSG00000130600 H19 H19, imprinted maternally expressed transcript (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:4713] ENSG00000132530 XAF1 XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] ENSG00000133116 KL klotho [Source:HGNC Symbol;Acc:HGNC:6344] ENSG00000133136 GNG5P2 guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:24826] ENSG00000133606 MKRN1 makorin ring finger protein 1 [Source:HGNC Symbol;Acc:HGNC:7112] ENSG00000134265 NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma [Source:HGNC Symbol;Acc:HGNC:7642] ENSG00000134627 PIWIL4 piwi-like RNA-mediated gene silencing 4 [Source:HGNC Symbol;Acc:HGNC:18444] ENSG00000135365 PHF21A PHD finger protein 21A [Source:HGNC Symbol;Acc:HGNC:24156] ENSG00000135521 LTV1 LTV1 ribosome biogenesis factor [Source:HGNC Symbol;Acc:HGNC:21173] ENSG00000135677 GNS glucosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4422] ENSG00000135828 RNASEL ribonuclease L (2′,5′-oligoisoadenylate synthetase-dependent) [Source:HGNC Symbol;Acc:HGNC:10050] ENSG00000135966 TGFBRAP1 transforming growth factor, beta receptor associated protein 1 [Source:HGNC Symbol;Acc:HGNC:16836] ENSG00000136193 SCRN1 secernin 1 [Source:HGNC Symbol;Acc:HGNC:22192] ENSG00000136457 CHAD chondroadherin [Source:HGNC Symbol;Acc:HGNC:1909] ENSG00000136689 IL1RN interleukin 1 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:6000] ENSG00000136715 SAP130 Sin3A-associated protein, 130 kDa [Source:HGNC Symbol;Acc:HGNC:29813] ENSG00000136738 STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Source:HGNC Symbol;Acc:HGNC:11357] ENSG00000136861 CDK5RAP2 CDK5 regulatory subunit associated protein 2 [Source:HGNC Symbol;Acc:HGNC:18672] ENSG00000136872 ALDOB aldolase B, fructose-bisphosphate [Source:HGNC Symbol;Acc:HGNC:417] ENSG00000136925 TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30087] ENSG00000137073 UBAP2 ubiquitin associated protein 2 [Source:HGNC Symbol;Acc:HGNC:14185] ENSG00000139055 ERP27 endoplasmic reticulum protein 27 [Source:HGNC Symbol;Acc:HGNC:26495] ENSG00000139192 TAPBPL TAP binding protein-like [Source:HGNC Symbol;Acc:HGNC:30683] ENSG00000140299 BNIP2 BCL2/adenovirus E1B 19 kDa interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:1083] ENSG00000140374 ETFA electron-transfer-flavoprotein, alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:3481] ENSG00000140740 UQCRC2 ubiquinol-cytochrome c reductase core protein II [Source:HGNC Symbol;Acc:HGNC:12586] ENSG00000140750 ARHGAP17 Rho GTPase activating protein 17 [Source:HGNC Symbol;Acc:HGNC:18239] ENSG00000141076 CIRH1A cirrhosis, autosomal recessive 1A (cirhin) [Source:HGNC Symbol;Acc:HGNC:1983] ENSG00000141179 PCTP phosphatidylcholine transfer protein [Source:HGNC Symbol;Acc:HGNC:8752] ENSG00000141194 OR4D1 olfactory receptor, family 4, subfamily D, member 1 [Source:HGNC Symbol;Acc:HGNC:8293] ENSG00000142669 SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 [Source:HGNC Symbol;Acc:HGNC:15568] ENSG00000143179 UCK2 uridine-cytidine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12562] ENSG00000143409 FAM63A family with sequence similarity 63, member A [Source:HGNC Symbol;Acc:HGNC:25648] ENSG00000145439 CBR4 carbonyl reductase 4 [Source:HGNC Symbol;Acc:HGNC:25891] ENSG00000146192 FGD2 FYVE, RhoGEF and PH domain containing 2 [Source:HGNC Symbol;Acc:HGNC:3664] ENSG00000147183 CPXCR1 CPX chromosome region, candidate 1 [Source:HGNC Symbol;Acc:HGNC:2332] ENSG00000147394 ZNF185 zinc finger protein 185 (LIM domain) [Source:HGNC Symbol;Acc:HGNC:12976] ENSG00000147419 CCDC25 coiled-coil domain containing 25 [Source:HGNC Symbol;Acc:HGNC:25591] ENSG00000147606 SLC26A7 solute carrier family 26 (anion exchanger), member 7 [Source:HGNC Symbol;Acc:HGNC:14467] ENSG00000148396 SEC16A SEC16 homolog A (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:29006] ENSG00000148498 PARD3 par-3 family cell polarity regulator [Source:HGNC Symbol;Acc:HGNC:16051] ENSG00000148840 PPRC1 peroxisome proliferator-activated receptor gamma, coactivator- related 1 [Source:HGNC Symbol;Acc:HGNC:30025] ENSG00000148848 ADAM12 ADAM metallopeptidase domain 12 [Source:HGNC Symbol;Acc:HGNC:190] ENSG00000148908 RGS10 regulator of G-protein signaling 10 [Source:HGNC Symbol;Acc:HGNC:9992] ENSG00000150054 MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) [Source:HGNC Symbol;Acc:HGNC:26542] ENSG00000150093 ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, M5K12) [Source:HGNC Symbol;Acc:HGNC:6153] ENSG00000152127 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl- glucosaminyltransferase [Source:HGNC Symbol;Acc:HGNC:7049] ENSG00000152457 DCLRE1C DNA cross-link repair 1C [Source:HGNC Symbol;Acc:HGNC:17642] ENSG00000152601 MBNL1 muscleblind-like splicing regulator 1 [Source:HGNC Symbol;Acc:HGNC:6923] ENSG00000153071 DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:2662] ENSG00000155827 RNF20 ring finger protein 20, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:10062] ENSG00000155903 RASA2 RAS p21 protein activator 2 [Source:HGNC Symbol;Acc:HGNC:9872] ENSG00000156650 KAT6B K(lysine) acetyltransferase 6B [Source:HGNC Symbol;Acc:HGNC:17582] ENSG00000158710 TAGLN2 transgelin 2 [Source:HGNC Symbol;Acc:HGNC:11554] ENSG00000158856 DMTN dematin actin binding protein [Source:HGNC Symbol;Acc:HGNC:3382] ENSG00000159186 ENSG00000159231 CBR3 carbonyl reductase 3 [Source:HGNC Symbol;Acc:HGNC:1549] ENSG00000159256 MORC3 MORC family CW-type zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:23572] ENSG00000159267 HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) [Source:HGNC Symbol;Acc:HGNC:4976] ENSG00000159840 ZYX zyxin [Source:HGNC Symbol;Acc:HGNC:13200] ENSG00000160094 ZNF362 zinc finger protein 362 [Source:HGNC Symbol;Acc:HGNC:18079] ENSG00000160584 SIK3 SIK family kinase 3 [Source:HGNC Symbol;Acc:HGNC:29165] ENSG00000160917 CPSF4 cleavage and polyadenylation specific factor 4, 30 kDa [Source:HGNC Symbol;Acc:HGNC:2327] ENSG00000161533 ACOX1 acyl-CoA oxidase 1, palmitoyl [Source:HGNC Symbol;Acc:HGNC:119] ENSG00000162105 SHANK2 SH3 and multiple ankyrin repeat domains 2 [Source:HGNC Symbol;Acc:HGNC:14295] ENSG00000162236 STX5 syntaxin 5 [Source:HGNC Symbol;Acc:HGNC:11440] ENSG00000162434 JAK1 Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] ENSG00000162722 TRIM58 tripartite motif containing 58 [Source:HGNC Symbol;Acc:HGNC:24150] ENSG00000162817 C1orf115 chromosome 1 open reading frame 115 [Source:HGNC Symbol;Acc:HGNC:25873] ENSG00000163029 SMC6 structural maintenance of chromosomes 6 [Source:HGNC Symbol;Acc:HGNC:20466] ENSG00000163602 RYBP RING1 and YY1 binding protein [Source:HGNC Symbol;Acc:HGNC:10480] ENSG00000163793 DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma [Source:HGNC Symbol;Acc:HGNC:24844] ENSG00000163993 S100P S100 calcium binding protein P [Source:HGNC Symbol;Acc:HGNC:10504] ENSG00000164056 SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) [Source:HGNC Symbol;Acc:HGNC:11269] ENSG00000164124 TMEM144 transmembrane protein 144 [Source:HGNC Symbol;Acc:HGNC:25633] ENSG00000164134 NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit [Source:HGNC Symbol;Acc:HGNC:30782] ENSG00000164181 ELOVL7 ELOVL fatty acid elongase 7 [Source:HGNC Symbol;Acc:HGNC:26292] ENSG00000164237 CMBL carboxymethylenebutenolidase homolog (Pseudomonas) [Source:HGNC Symbol;Acc:HGNC:25090] ENSG00000164266 SPINK1 serine peptidase inhibitor, Kazal type 1 [Source:HGNC Symbol;Acc:HGNC:11244] ENSG00000164305 CASP3 caspase 3, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:HGNC:1504] ENSG00000164402 8-Sep septin 8 [Source:HGNC Symbol;Acc:HGNC:16511] ENSG00000164691 TAGAP T-cell activation RhoGTPase activating protein [Source:HGNC Symbol;Acc:HGNC:15669] ENSG00000164808 SPIDR scaffolding protein involved in DNA repair [Source:HGNC Symbol;Acc:HGNC:28971] ENSG00000165406 8-Mar membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:23356] ENSG00000165819 METTL3 methyltransferase like 3 [Source:HGNC Symbol;Acc:HGNC:17563] ENSG00000165841 CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 [Source:HGNC Symbol;Acc:HGNC:2621] ENSG00000166086 JAM3 junctional adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:15532] ENSG00000166387 PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) [Source:HGNC Symbol;Acc:HGNC:9250] ENSG00000166428 PLD4 phospholipase D family, member 4 [Source:HGNC Symbol;Acc:HGNC:23792] ENSG00000166478 ZNF143 zinc finger protein 143 [Source:HGNC Symbol;Acc:HGNC:12928] ENSG00000166579 NDEL1 nudE neurodevelopment protein 1-like 1 [Source:HGNC Symbol;Acc:HGNC:17620] ENSG00000166963 MAP1A microtubule-associated protein 1A [Source:HGNC Symbol;Acc:HGNC:6835] ENSG00000167230 NA NA ENSG00000167257 RNF214 ring finger protein 214 [Source:HGNC Symbol;Acc:HGNC:25335] ENSG00000167258 CDK12 cyclin-dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224] ENSG00000167491 GATAD2A GATA zinc finger domain containing 2A [Source:HGNC Symbol;Acc:HGNC:29989] ENSG00000167671 UBXN6 UBX domain protein 6 [Source:HGNC Symbol;Acc:HGNC:14928] ENSG00000167693 NXN nucleoredoxin [Source:HGNC Symbol;Acc:HGNC:18008] ENSG00000167740 CYB5D2 cytochrome b5 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28471] ENSG00000168067 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [Source:HGNC Symbol;Acc:HGNC:6864] ENSG00000168394 TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [Source:HGNC Symbol;Acc:HGNC:43] ENSG00000168992 OR7E102P olfactory receptor, family 7, subfamily E, member 102 pseudogene [Source:HGNC Symbol;Acc:HGNC:15043] ENSG00000170049 KCNAB3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 [Source:HGNC Symbol;Acc:HGNC:6230] ENSG00000170485 NPAS2 neuronal PAS domain protein 2 [Source:HGNC Symbol;Acc:HGNC:7895] ENSG00000170606 HSPA4 heat shock 70 kDa protein 4 [Source:HGNC Symbol;Acc:HGNC:5237] ENSG00000170802 FOXN2 forkhead box N2 [Source:HGNC Symbol;Acc:HGNC:5281] ENSG00000171794 UTF1 undifferentiated embryonic cell transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12634] ENSG00000172183 ISG20 interferon stimulated exonuclease gene 20 kDa [Source:HGNC Symbol;Acc:HGNC:6130] ENSG00000172476 RAB40A RAB40A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:18283] ENSG00000172594 SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A [Source:HGNC Symbol;Acc:HGNC:17389] ENSG00000172769 OR5B3 olfactory receptor, family 5, subfamily B, member 3 [Source:HGNC Symbol;Acc:HGNC:8324] ENSG00000173210 ABLIM3 actin binding LIM protein family, member 3 [Source:HGNC Symbol;Acc:HGNC:29132] ENSG00000173728 C1orf100 chromosome 1 open reading frame 100 [Source:HGNC Symbol;Acc:HGNC:30435] ENSG00000175224 ATG13 autophagy related 13 [Source:HGNC Symbol;Acc:HGNC:29091] ENSG00000175602 CCDC85B coiled-coil domain containing 85B [Source:HGNC Symbol;Acc:HGNC:24926] ENSG00000176043 ENSG00000176928 GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 [Source:HGNC Symbol;Acc:HGNC:17973] ENSG00000177125 ZBTB34 zinc finger and BTB domain containing 34 [Source:HGNC Symbol;Acc:HGNC:31446] ENSG00000177200 CHD9 chromodomain helicase DNA binding protein 9 [Source:HGNC Symbol;Acc:HGNC:25701] ENSG00000177602 GSG2 germ cell associated 2 (haspin) [Source:HGNC Symbol;Acc:HGNC:19682] ENSG00000177628 GBA glucosidase, beta, acid [Source:HGNC Symbol;Acc:HGNC:4177] ENSG00000177685 CRACR2B calcium release activated channel regulator 2B [Source:HGNC Symbol;Acc:HGNC:28703] ENSG00000177853 ZNF518A zinc finger protein 518A [Source:HGNC Symbol;Acc:HGNC:29009] ENSG00000178222 RNF212 ring finger protein 212 [Source:HGNC Symbol;Acc:HGNC:27729] ENSG00000179914 ITLN1 intelectin 1 (galactofuranose binding) [Source:HGNC Symbol;Acc:HGNC:18259] ENSG00000180488 FAM73A family with sequence similarity 73, member A [Source:HGNC Symbol;Acc:HGNC:24741] ENSG00000180694 TMEM64 transmembrane protein 64 [Source:HGNC Symbol;Acc:HGNC:25441] ENSG00000181227 ENSG00000182393 IFNL1 interferon, lambda 1 [Source:HGNC Symbol;Acc:HGNC:18363] ENSG00000182446 NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:18261] ENSG00000182606 TRAK1 trafficking protein, kinesin binding 1 [Source:HGNC Symbol;Acc:HGNC:29947] ENSG00000183346 C10orf107 chromosome 10 open reading frame 107 [Source:HGNC Symbol;Acc:HGNC:28678] ENSG00000184108 TRIML1 tripartite motif family-like 1 [Source:HGNC Symbol;Acc:HGNC:26698] ENSG00000184319 RPL23AP82 ribosomal protein L23a pseudogene 82 [Source:HGNC Symbol;Acc:HGNC:33730] ENSG00000184602 SNN stannin [Source:HGNC Symbol;Acc:HGNC:11149] ENSG00000184674 NA NA ENSG00000185008 ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:10250] ENSG00000185187 SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [Source:HGNC Symbol;Acc:HGNC:30575] ENSG00000185296 ENSG00000186038 HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic [Source:HGNC Symbol;Acc:HGNC:24005] ENSG00000186298 PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme [Source:HGNC Symbol;Acc:HGNC:9283] ENSG00000186453 FAM228A family with sequence similarity 228, member A [Source:HGNC Symbol;Acc:HGNC:34418] ENSG00000187109 NAP1L1 nucleosome assembly protein 1-like 1 [Source:HGNC Symbol;Acc:HGNC:7637] ENSG00000187689 AMTN amelotin [Source:HGNC Symbol;Acc:HGNC:33188] ENSG00000187990 NA NA ENSG00000188060 RAB42 RAB42, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:28702] ENSG00000188536 HBA2 hemoglobin, alpha 2 [Source:HGNC Symbol;Acc:HGNC:4824] ENSG00000189339 SLC35E2B solute carrier family 35, member E2B [Source:HGNC Symbol;Acc:HGNC:33941] ENSG00000189403 HMGB1 high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983] ENSG00000196116 TDRD7 tudor domain containing 7 [Source:HGNC Symbol;Acc:HGNC:30831] ENSG00000196565 HBG2 hemoglobin, gamma G [Source:HGNC Symbol;Acc:HGNC:4832] ENSG00000196782 MAML3 mastermind-like 3 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:16272] ENSG00000197170 PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Source:HGNC Symbol;Acc:HGNC:9557] ENSG00000197417 SHPK sedoheptulokinase [Source:HGNC Symbol;Acc:HGNC:1492] ENSG00000197568 HHLA3 HERV-H LTR-associating 3 [Source:HGNC Symbol;Acc:HGNC:4906] ENSG00000197753 LHFPL5 lipoma HMGIC fusion partner-like 5 [Source:HGNC Symbol;Acc:HGNC:21253] ENSG00000198466 ZNF587 zinc finger protein 587 [Source:HGNC Symbol;Acc:HGNC:30955] ENSG00000198478 SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 [Source:HGNC Symbol;Acc:HGNC:15567] ENSG00000198682 PAPSS2 3′-phosphoadenosine 5′-phosphosulfate synthase 2 [Source:HGNC Symbol;Acc:HGNC:8604] ENSG00000198712 MT-CO2 mitochondrially encoded cytochrome c oxidase II [Source:HGNC Symbol;Acc:HGNC:7421] ENSG00000198787 OR4D12P olfactory receptor, family 4, subfamily D, member 12 pseudogene [Source:HGNC Symbol;Acc:HGNC:19587] ENSG00000198818 SFT2D1 SFT2 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21102] ENSG00000198829 SUCNR1 succinate receptor 1 [Source:HGNC Symbol;Acc:HGNC:4542] ENSG00000198840 MT-ND3 mitochondrially encoded NADH dehydrogenase 3 [Source:HGNC Symbol;Acc:HGNC:7458] ENSG00000198938 MT-CO3 mitochondrially encoded cytochrome c oxidase III [Source:HGNC Symbol;Acc:HGNC:7422] ENSG00000199287 NA NA ENSG00000199470 Small nucleolar RNA SNORA64/SNORA10 family [Source:RFAM;Acc:RF00264] ENSG00000200492 Small nucleolar RNA U3 [Source:RFAM;Acc:RF00012] ENSG00000200510 NA NA ENSG00000200702 Y RNA [Source:RFAM;Acc:RF00019] ENSG00000200753 Small nucleolar RNA SNORD56 [Source:RFAM;Acc:RF00275] ENSG00000200783 RN7SKP180 RNA, 7SK small nuclear pseudogene 180 [Source:HGNC Symbol;Acc:HGNC:45904] ENSG00000201271 RNU1-112P RNA, U1 small nuclear 112, pseudogene [Source:HGNC Symbol;Acc:HGNC:48454] ENSG00000201955 RNY3P1 RNA, Ro-associated Y3 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:42477] ENSG00000203426 NA NA ENSG00000203691 NA NA ENSG00000203849 NA NA ENSG00000204250 LINC00587 long intergenic non-protein coding RNA 587 [Source:HGNC Symbol;Acc:HGNC:31372] ENSG00000204310 AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:324] ENSG00000204389 HSPA1A heat shock 70 kDa protein 1A [Source:HGNC Symbol;Acc:HGNC:5232] ENSG00000206053 HN1L hematological and neurological expressed 1-like [Source:HGNC Symbol;Acc:HGNC:14137] ENSG00000206637 Small nucleolar RNA SNORA70 [Source:RFAM;Acc:RF00156] ENSG00000206848 RNU6-890P RNA, U6 small nuclear 890, pseudogene [Source:HGNC Symbol;Acc:HGNC:47853] ENSG00000207712 MIR627 microRNA 627 [Source:HGNC Symbol;Acc:HGNC:32883] ENSG00000209082 MT-TL1 mitochondrially encoded tRNA leucine 1 (UUA/G) [Source:HGNC Symbol;Acc:HGNC:7490] ENSG00000210049 MT-TF mitochondrially encoded tRNA phenylalanine [Source:HGNC Symbol;Acc:HGNC:7481] ENSG00000210077 MT-TV mitochondrially encoded tRNA valine [Source:HGNC Symbol;Acc:HGNC:7500] ENSG00000210107 MT-TQ mitochondrially encoded tRNA glutamine [Source:HGNC Symbol;Acc:HGNC:7495] ENSG00000210140 MT-TC mitochondrially encoded tRNA cysteine [Source:HGNC Symbol;Acc:HGNC:7477] ENSG00000210156 MT-TK mitochondrially encoded tRNA lysine [Source:HGNC Symbol;Acc:HGNC:7489] ENSG00000210176 MT-TH mitochondrially encoded tRNA histidine [Source:HGNC Symbol;Acc:HGNC:7487] ENSG00000210191 MT-TL2 mitochondrially encoded tRNA leucine 2 (CUN) [Source:HGNC Symbol;Acc:HGNC:7491] ENSG00000210194 MT-TE mitochondrially encoded tRNA glutamic acid [Source:HGNC Symbol;Acc:HGNC:7479] ENSG00000210195 MT-TT mitochondrially encoded tRNA threonine [Source:HGNC Symbol;Acc:HGNC:7499] ENSG00000210196 MT-TP mitochondrially encoded tRNA proline [Source:HGNC Symbol;Acc:HGNC:7494] ENSG00000211538 MIR501 microRNA 501 [Source:HGNC Symbol;Acc:HGNC:32135] ENSG00000211967 IGHV3-53 immunoglobulin heavy variable 3-53 [Source:HGNC Symbol;Acc:HGNC:5610] ENSG00000212338 Small nucleolar RNA SNORA67 [Source:RFAM;Acc:RF00272] ENSG00000212564 RNU6-1326P RNA, U6 small nuclear 1326, pseudogene [Source:HGNC Symbol;Acc:HGNC:48289] ENSG00000213014 VN2R17P vomeronasal 2 receptor 17 pseudogene [Source:HGNC Symbol;Acc:HGNC:33223] ENSG00000213023 SYT3 synaptotagmin III [Source:HGNC Symbol;Acc:HGNC:11511] ENSG00000213048 OR5S1P olfactory receptor, family 5, subfamily S, member 1 pseudogene [Source:HGNC Symbol;Acc:HGNC:15040] ENSG00000213144 ENSG00000213401 MAGEA12 melanoma antigen family A, 12 [Source:HGNC Symbol;Acc:HGNC:6799] ENSG00000213516 RBMXL1 RNA binding motif protein, X-linked-like 1 [Source:HGNC Symbol;Acc:HGNC:25073] ENSG00000213626 LBH limb bud and heart development [Source:HGNC Symbol;Acc:HGNC:29532] ENSG00000214049 UCA1 urothelial cancer associated 1 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:37126] ENSG00000215030 RPL13P12 ribosomal protein L13 pseudogene 12 [Source:HGNC Symbol;Acc:HGNC:35701] ENSG00000215089 KRT18P11 keratin 18 pseudogene 11 [Source:HGNC Symbol;Acc:HGNC:6431] ENSG00000215271 HOMEZ homeobox and leucine zipper encoding [Source:HGNC Symbol;Acc:HGNC:20164] ENSG00000215834 FMO9P flavin containing monooxygenase 9 pseudogene [Source:HGNC Symbol;Acc:HGNC:32210] ENSG00000217557 ENSG00000219188 CACYBPP3 calcyclin binding protein pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:45124] ENSG00000219368 ZNF299P zinc finger protein 299, pseudogene [Source:HGNC Symbol;Acc:HGNC:13088] ENSG00000220505 EIF4EBP2P3 eukaryotic translation initiation factor 4E binding protein 2 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:49318] ENSG00000221083 Small nucleolar RNA SNORA77 [Source:RFAM;Acc:RF00599] ENSG00000221096 NA NA ENSG00000221291 ENSG00000222036 POTEG POTE ankyrin domain family, member G [Source:HGNC Symbol;Acc:HGNC:33896] ENSG00000222524 RN7SKP109 RNA, 7SK small nuclear pseudogene 109 [Source:HGNC Symbol;Acc:HGNC:45833] ENSG00000223026 RN7SKP247 RNA, 7SK small nuclear pseudogene 247 [Source:HGNC Symbol;Acc:HGNC:45971] ENSG00000223554 ENSG00000223783 ENSG00000223881 ENSG00000224288 ENSG00000224418 STK24-AS1 STK24 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:39935] ENSG00000224618 ENSG00000224924 LINC00320 long intergenic non-protein coding RNA 320 [Source:HGNC Symbol;Acc:HGNC:19690] ENSG00000225112 ENSG00000225181 ENSG00000225216 ENSG00000225630 MTND2P28 MT-ND2 pseudogene 28 [Source:HGNC Symbol;Acc:HGNC:42129] ENSG00000225785 ENSG00000225906 ENSG00000225972 MTND1P23 MT-ND1 pseudogene 23 [Source:HGNC Symbol;Acc:HGNC:42092] ENSG00000226104 NA NA ENSG00000226272 ARHGAP26-AS1 ARHGAP26 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40792] ENSG00000226659 ENSG00000226801 OSTCP8 oligosaccharyltransferase complex subunit pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:42869] ENSG00000226939 ENSG00000226981 ABHD17AP6 abhydrolase domain containing 17A pseudogene 6 [Source:HGNC Symbol;Acc:HGNC:34044] ENSG00000227011 C17orf112 chromosome 17 open reading frame 112 [Source:HGNC Symbol;Acc:HGNC:42963] ENSG00000227159 DDX11L16 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 16 [Source:HGNC Symbol;Acc:HGNC:37115] ENSG00000227274 ENSG00000227438 ENSG00000227468 ENSG00000227593 ENSG00000227676 LINC01068 long intergenic non-protein coding RNA 1068 [Source:HGNC Symbol;Acc:HGNC:49106] ENSG00000227790 ENSG00000227970 NR1H5P nuclear receptor subfamily 1, group H, member 5, pseudogene [Source:HGNC Symbol;Acc:HGNC:32673] ENSG00000228253 MT-ATP8 mitochondrially encoded ATP synthase 8 [Source:HGNC Symbol;Acc:HGNC:7415] ENSG00000228513 ENSG00000228648 ENSG00000229031 ENSG00000229196 ENSG00000229338 ENSG00000229344 ENSG00000229485 KSR1P1 kinase suppressor of ras 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44977] ENSG00000229775 ENSG00000230019 YWHAQP9 YWHAQ pseudogene 9 [Source:HGNC Symbol;Acc:HGNC:37688] ENSG00000230022 FNTAP2 farnesyltransferase, CAAX box, alpha pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:3784] ENSG00000230495 ENSG00000230515 ENSG00000230528 NOS2P3 nitric oxide synthase 2 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:35124] ENSG00000230589 IMP3P1 IMP3 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:49385] ENSG00000230645 ENSG00000230867 ENSG00000231680 ENSG00000231682 ENSG00000231957 GNAI2P2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:45110] ENSG00000232111 ENSG00000232120 ENSG00000232491 ENSG00000232578 ENSG00000232650 ENSG00000233265 MICF MHC class I polypeptide-related sequence F (pseudogene) [Source:HGNC Symbol;Acc:HGNC:16801] ENSG00000233545 CYCSP33 cytochrome c, somatic pseudogene 33 [Source:HGNC Symbol;Acc:HGNC:24407] ENSG00000233614 DDX11L10 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 10 [Source:HGNC Symbol;Acc:HGNC:14125] ENSG00000233643 ENSG00000234113 ENSG00000234420 ZNF37BP zinc finger protein 37B, pseudogene [Source:HGNC Symbol;Acc:HGNC:13103] ENSG00000234456 MAGI2-AS3 MAGI2 antisense RNA 3 [Source:HGNC Symbol;Acc:HGNC:40862] ENSG00000234619 RPL7P11 ribosomal protein L7 pseudogene 11 [Source:HGNC Symbol;Acc:HGNC:35667] ENSG00000234683 ENSG00000234713 ENSG00000234723 ENSG00000234724 HDAC1P1 histone deacetylase 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:45190] ENSG00000234975 FTH1P2 ferritin, heavy polypeptide 1 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:3989] ENSG00000235147 ENSG00000235154 ENSG00000235186 ENSG00000235902 ENSG00000235938 NA NA ENSG00000236090 LDHAP3 lactate dehydrogenase A pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:6538] ENSG00000236852 ENSG00000236876 TMSB4XP1 thymosin beta 4, X-linked pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:11883] ENSG00000237256 PGAM3P phosphoglycerate mutase 3, pseudogene [Source:HGNC Symbol;Acc:HGNC:16557] ENSG00000237356 ENSG00000237621 OR9A1P olfactory receptor, family 9, subfamily A, member 1 pseudogene [Source:HGNC Symbol;Acc:HGNC:8486] ENSG00000237731 RNGTTP1 RNA guanylyltransferase and 5′-phosphatase pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:39652] ENSG00000237973 MIR6723 microRNA 6723 [Source:HGNC Symbol;Acc:HGNC:50152] ENSG00000238083 LRRC37A2 leucine rich repeat containing 37, member A2 [Source:HGNC Symbol;Acc:HGNC:32404] ENSG00000238460 ENSG00000238617 NA NA ENSG00000238754 Small nucleolar RNA U109 [Source:RFAM;Acc:RF01233] ENSG00000238763 NA NA ENSG00000238858 NA NA ENSG00000239011 NA NA ENSG00000239072 NA NA ENSG00000239073 NA NA ENSG00000239547 RN7SL843P RNA, 7SL, cytoplasmic 843, pseudogene [Source:HGNC Symbol;Acc:HGNC:46859] ENSG00000239617 ENSG00000239791 ENSG00000240286 MEAF6P1 MYST/Esa1-associated factor 6 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:42660] ENSG00000240545 RN7SL492P RNA, 7SL, cytoplasmic 492, pseudogene [Source:HGNC Symbol;Acc:HGNC:46508] ENSG00000240808 ENSG00000241468 ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 [Source:HGNC Symbol;Acc:HGNC:848] ENSG00000241656 UBA52P7 ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:36615] ENSG00000241757 RN7SL714P RNA, 7SL, cytoplasmic 714, pseudogene [Source:HGNC Symbol;Acc:HGNC:46730] ENSG00000241945 PWP2 PWP2 periodic tryptophan protein homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:9711] ENSG00000241954 ENSG00000242716 NA NA ENSG00000243136 RN7SL22P RNA, 7SL, cytoplasmic 22, pseudogene [Source:HGNC Symbol;Acc:HGNC:46038] ENSG00000243290 IGKV1-12 immunoglobulin kappa variable 1-12 [Source:HGNC Symbol;Acc:HGNC:5730] ENSG00000243370 RN7SL775P RNA, 7SL, cytoplasmic 775, pseudogene [Source:HGNC Symbol;Acc:HGNC:46791] ENSG00000243824 ENSG00000244414 CFHR1 complement factor H-related 1 [Source:HGNC Symbol;Acc:HGNC:4888] ENSG00000244734 HBB hemoglobin, beta [Source:HGNC Symbol;Acc:HGNC:4827] ENSG00000244921 ENSG00000248360 LINC00504 long intergenic non-protein coding RNA 504 [Source:HGNC Symbol;Acc:HGNC:43555] ENSG00000248538 ENSG00000248891 ENSG00000248898 ENSG00000249072 ENSG00000249307 LINC01088 long intergenic non-protein coding RNA 1088 [Source:HGNC Symbol;Acc:HGNC:49148] ENSG00000249429 ENSG00000249465 RBMXP4 RNA binding motif protein, X-linked pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:34028] ENSG00000249941 ENSG00000250067 YJEFN3 YjeF N-terminal domain containing 3 [Source:HGNC Symbol;Acc:HGNC:24785] ENSG00000250256 ENSG00000250347 ENSG00000250360 ENSG00000250392 ENSG00000250461 ENSG00000250508 ENSG00000250519 ENSG00000250612 ENSG00000250770 ENSG00000251062 ENSG00000251354 ENSG00000251751 RN7SKP46 RNA, 7SK small nuclear pseudogene 46 [Source:HGNC Symbol;Acc:HGNC:45770] ENSG00000251983 RN7SKP157 RNA, 7SK small nuclear pseudogene 157 [Source:HGNC Symbol;Acc:HGNC:45881] ENSG00000252164 RNA5SP282 RNA, 5S ribosomal pseudogene 282 [Source:HGNC Symbol;Acc:HGNC:43182] ENSG00000252180 NA NA ENSG00000252343 RNU2-34P RNA, U2 small nuclear 34, pseudogene [Source:HGNC Symbol;Acc:HGNC:48527] ENSG00000252497 RPPH1-2P ribonuclease P RNA component H1, 2 pseudogene [Source:HGNC Symbol;Acc:HGNC:47029] ENSG00000252596 NA NA ENSG00000252670 NA NA ENSG00000252672 NA NA ENSG00000252863 RNU6-1183P RNA, U6 small nuclear 1183, pseudogene [Source:HGNC Symbol;Acc:HGNC:48146] ENSG00000252904 Small nucleolar RNA SNORA76 [Source:RFAM;Acc:RF00598] ENSG00000253008 MIR2355 microRNA 2355 [Source:HGNC Symbol;Acc:HGNC:38328] ENSG00000253377 ENSG00000253603 ENSG00000253729 PRKDC protein kinase, DNA-activated, catalytic polypeptide [Source:HGNC Symbol;Acc:HGNC:9413] ENSG00000253780 IGHVIII-2-1 immunoglobulin heavy variable (III)-2-1 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:5695] ENSG00000253784 ENSG00000253849 ENSG00000254070 ENSG00000254273 ENSG00000254683 SNRPCP6 small nuclear ribonucleoprotein polypeptide C pseudogene 6 [Source:HGNC Symbol;Acc:HGNC:49821] ENSG00000254845 NA NA ENSG00000255003 CYCSP28 cytochrome c, somatic pseudogene 28 [Source:HGNC Symbol;Acc:HGNC:24402] ENSG00000255031 ENSG00000255408 PCDHA3 protocadherin alpha 3 [Source:HGNC Symbol;Acc:HGNC:8669] ENSG00000256257 CACNA1C-IT2 CACNA1C intronic transcript 2 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:41313] ENSG00000256972 ENSG00000257004 ENSG00000257519 ENSG00000257723 CHCHD3P2 coiled-coil-helix-coiled-coil-helix domain containing 3 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:44698] ENSG00000257777 ENSG00000257915 GLULP5 glutamate-ammonia ligase (glutamine synthetase) pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:37989] ENSG00000258088 ENSG00000258273 ENSG00000258642 ENSG00000258790 KIAA0391 KIAA0391 [Source:HGNC Symbol;Acc:HGNC:19958] ENSG00000258828 KRT8P2 keratin 8 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:20282] ENSG00000258845 ENSG00000259045 ENSG00000259047 ENSG00000259145 NA NA ENSG00000259411 HNRNPA1P45 heterogeneous nuclear ribonucleoprotein Al pseudogene 45 [Source:HGNC Symbol;Acc:HGNC:48775] ENSG00000259418 ENSG00000259479 SORD2P sorbitol dehydrogenase 2, pseudogene [Source:HGNC Symbol;Acc:HGNC:49919] ENSG00000259588 ENSG00000259604 ENSG00000259761 ENSG00000259802 ENSG00000260198 ENSG00000260229 ENSG00000260282 EIF4EBP2P2 eukaryotic translation initiation factor 4E binding protein 2 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:49317] ENSG00000261340 ENSG00000261665 TUBA8P2 tubulin, alpha 8 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:44569] ENSG00000263253 ENSG00000263435 ENSG00000263493 NA NA ENSG00000263542 ENSG00000263740 RN7SL4P RNA, 7SL, cytoplasmic 4, pseudogene [Source:HGNC Symbol;Acc:HGNC:10039] ENSG00000263774 ENSG00000263929 NA NA ENSG00000264235 ENSG00000264296 ENSG00000264386 MIR4513 microRNA 4513 [Source:HGNC Symbol;Acc:HGNC:41855] ENSG00000264439 ENSG00000264469 ENSG00000264910 RN7SL525P RNA, 7SL, cytoplasmic 525, pseudogene [Source:HGNC Symbol;Acc:HGNC:46541] ENSG00000265334 ENSG00000265408 ENSG00000265565 MIR3143 microRNA 3143 [Source:HGNC Symbol;Acc:HGNC:38284] ENSG00000265946 ENSG00000266187 RN7SL480P RNA, 7SL, cytoplasmic 480, pseudogene [Source:HGNC Symbol;Acc:HGNC:46496] ENSG00000266399 ENSG00000266596 NA NA ENSG00000266603 NA NA ENSG00000266667 ENSG00000266941 ENSG00000267513 ENSG00000267650 ENSG00000267670 ENSG00000268230 ENSG00000268357 VN1R81P vomeronasal 1 receptor 81 pseudogene [Source:HGNC Symbol;Acc:HGNC:37401] ENSG00000268995 VN1R82P vomeronasal 1 receptor 82 pseudogene [Source:HGNC Symbol;Acc:HGNC:37402] ENSG00000269028 MTRNR2L12 MT-RNR2-like 12 [Source:HGNC Symbol;Acc:HGNC:37169] ENSG00000269069 ENSG00000270371 ENSG00000270377 ENSG00000270457 ENSG00000270496 BNIP3P7 BCL2/adenovirus E1B 19 kDa interacting protein 3 pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:49101] ENSG00000270680 ENSG00000270683 FAM71BP1 family with sequence similarity 71, member B pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:49805] ENSG00000270798 ENSG00000271361 HTATSF1P2 HIV-1 Tat specific factor 1 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:38586] ENSG00000271415 ENSG00000272468 ENSG00000272626 ENSG00000273154

TABLE 2 All biological sample sources collected in year 1: blood, urine, and saliva Ensembl_ID HGNC_symbol Description ENSG00000178172 SPINK6 serine peptidase inhibitor, Kazal type 6 [Source:HGNC Symbol;Acc:HGNC:29486] ENSG00000204566 C10orf115 chromosome 10 open reading frame 115 [Source:HGNC Symbol;Acc:HGNC:31449] ENSG00000223881 ENSG00000237027 ENSG00000243075 RN7SL519P RNA, 7SL, cytoplasmic 519, pseudogene [Source:HGNC Symbol;Acc:HGNC:46535] ENSG00000256721 CACNA1C-IT3 CACNA1C intronic transcript 3 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:41314] ENSG00000268280 NA NA ENSG00000273185 ENSG00000260265 ENSG00000256915 ENSG00000236559 ENSG00000258406 ENSG00000212297 RNU6-821P RNA, U6 small nuclear 821, pseudogene [Source:HGNC Symbol;Acc:HGNC:47784] ENSG00000230140 ENSG00000068366 ACSL4 acyl-CoA synthetase long-chain family member 4 [Source:HGNC Symbol;Acc:HGNC:3571] ENSG00000175879 HOXD8 homeobox D8 [Source:HGNC Symbol;Acc:HGNC:5139] ENSG00000210194 MT-TE mitochondrially encoded tRNA glutamic acid [Source:HGNC Symbol;Acc:HGNC:7479] ENSG00000206652 RNU1-1 RNA, U1 small nuclear 1 [Source:HGNC Symbol;Acc:HGNC:10120] ENSG00000219074 SOD1P1 superoxide dismutase 1, soluble pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:45134] ENSG00000232833 NA NA ENSG00000270878 ENSG00000234629 WDR82P1 WD repeat domain 82 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:32447] ENSG00000236641 ENSG00000206172 HBA1 hemoglobin, alpha 1 [Source:HGNC Symbol;Acc:HGNC:4823] ENSG00000228857 ENSG00000257718 ENSG00000253759 IGHV3-57 immunoglobulin heavy variable 3-57 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:5612] ENSG00000259770 ENSG00000264280 NA NA ENSG00000200087 SNORA73B small nucleolar RNA, H/ACA box 73B [Source:HGNC Symbol;Acc:HGNC:10116] ENSG00000206634 SNORA22 small nucleolar RNA, H/ACA box 22 [Source:HGNC Symbol;Acc:HGNC:32612] ENSG00000239002 SCARNA10 small Cajal body-specific RNA 10 [Source:HGNC Symbol;Acc:HGNC:32567] ENSG00000185640 KRT79 keratin 79 [Source:HGNC Symbol;Acc:HGNC:28930] ENSG00000184261 KCNK12 potassium channel, subfamily K, member 12 [Source:HGNC Symbol;Acc:HGNC:6274] ENSG00000237181 ENSG00000222040 NA NA ENSG00000168993 CPLX1 complexin 1 [Source:HGNC Symbol;Acc:HGNC:2309] ENSG00000169683 LRRC45 leucine rich repeat containing 45 [Source:HGNC Symbol;Acc:HGNC:28302] ENSG00000258991 DUX4L19 double homeobox 4 like 19 [Source:HGNC Symbol;Acc:HGNC:37718] ENSG00000196911 KPNA5 karyopherin alpha 5 (importin alpha 6) [Source:HGNC Symbol;Acc:HGNC:6398] ENSG00000171612 SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 [Source:HGNC Symbol;Acc:HGNC:29681] ENSG00000265933 LINC00668 long intergenic non-protein coding RNA 668 [Source:HGNC Symbol;Acc:HGNC:44328] ENSG00000154822 PLCL2 phospholipase C-like 2 [Source:HGNC Symbol;Acc:HGNC:9064] ENSG00000109536 FRG1 FSHD region gene 1 [Source:HGNC Symbol;Acc:HGNC:3954] ENSG00000047662 FAM184B family with sequence similarity 184, member B [Source:HGNC Symbol;Acc:HGNC:29235] ENSG00000062524 LTK leukocyte receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6721] ENSG00000109680 TBC1D19 TBC1 domain family, member 19 [Source:HGNC Symbol;Acc:HGNC:25624] ENSG00000112992 NNT nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863] ENSG00000119523 ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase [Source:HGNC Symbol;Acc:HGNC:23159] ENSG00000127990 SGCE sarcoglycan, epsilon [Source:HGNC Symbol;Acc:HGNC:10808] ENSG00000132825 PPP1R3D protein phosphatase 1, regulatory subunit 3D [Source:HGNC Symbol;Acc:HGNC:9294] ENSG00000135637 CCDC142 coiled-coil domain containing 142 [Source:HGNC Symbol;Acc:HGNC:25889] ENSG00000152465 NMT2 N-myristoyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:7858] ENSG00000160993 ALKBH4 alkB, alkylation repair homolog 4 (E. coli) [Source:HGNC Symbol;Acc:HGNC:21900] ENSG00000164078 MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [Source:HGNC Symbol;Acc:HGNC:7381] ENSG00000167524 uncharacterized serine/threonine-protein kinase SgK494 [Source:EntrezGene;Acc:124923] ENSG00000171243 SOSTDC1 sclerostin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21748] ENSG00000173212 MAB21L3 mab-21-like 3 (C. elegans) [Source:HGNC Symbol;Acc:HGNC:26787] ENSG00000177947 ODF3 outer dense fiber of sperm tails 3 [Source:HGNC Symbol;Acc:HGNC:19905] ENSG00000196123 KIAA0895L KIAA0895-like [Source:HGNC Symbol;Acc:HGNC:34408] ENSG00000223358 EHHADH-AS1 EHHADH antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44133] ENSG00000226742 HSBP1L1 heat shock factor binding protein 1-like 1 [Source:HGNC Symbol;Acc:HGNC:37243] ENSG00000233393 ENSG00000237037 NDUFA6-AS1 NDUFA6 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:45273] ENSG00000255537 ENSG00000258705 ENSG00000157593 SLC35B2 solute carrier family 35 (adenosine 3′-phospho 5′- phosphosulfate transporter), member B2 [Source:HGNC Symbol;Acc:HGNC:16872] ENSG00000160588 MPZL3 myelin protein zero-like 3 [Source:HGNC Symbol;Acc:HGNC:27279] ENSG00000170044 ZPLD1 zona pellucida-like domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27022] ENSG00000198382 UVRAG UV radiation resistance associated [Source:HGNC Symbol;Acc:HGNC:12640] ENSG00000131732 ZCCHC9 zinc finger, CCHC domain containing 9 [Source:HGNC Symbol;Acc:HGNC:25424] ENSG00000141582 CBX4 chromobox homolog 4 [Source:HGNC Symbol;Acc:HGNC:1554] ENSG00000162591 MEGF6 multiple EGF-like-domains 6 [Source:HGNC Symbol;Acc:HGNC:3232] ENSG00000206149 HERC2P9 hect domain and RLD 2 pseudogene 9 [Source:HGNC Symbol;Acc:HGNC:30495] ENSG00000070950 RAD18 RAD18 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:18278] ENSG00000100299 ARSA arylsulfatase A [Source:HGNC Symbol;Acc:HGNC:713] ENSG00000259959 ENSG00000075336 TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:25010] ENSG00000088833 NSFL1C NSFL1 (p97) cofactor (p47) [Source:HGNC Symbol;Acc:HGNC:15912] ENSG00000104756 KCTD9 potassium channel tetramerization domain containing 9 [Source:HGNC Symbol;Acc:HGNC:22401] ENSG00000152763 WDR78 WD repeat domain 78 [Source:HGNC Symbol;Acc:HGNC:26252] ENSG00000138346 DNA2 DNA replication helicase/nuclease 2 [Source:HGNC Symbol;Acc:HGNC:2939] ENSG00000144909 OSBPL11 oxysterol binding protein-like 11 [Source:HGNC Symbol;Acc:HGNC:16397] ENSG00000199237 RNU6-834P RNA, U6 small nuclear 834, pseudogene [Source:HGNC Symbol;Acc:HGNC:47797] ENSG00000254014 ENSG00000172201 ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein [Source:HGNC Symbol;Acc:HGNC:5363] ENSG00000214772 ENSG00000253469 ENSG00000235858 ENSG00000244060 RPS2P41 ribosomal protein S2 pseudogene 41 [Source:HGNC Symbol;Acc:HGNC:36357] ENSG00000250535 STK19B serine/threonine kinase 19B, pseudogene [Source:HGNC Symbol;Acc:HGNC:21668] ENSG00000120699 EXOSC8 exosome component 8 [Source:HGNC Symbol;Acc:HGNC:17035] ENSG00000163577 E1F5A2 eukaryotic translation initiation factor 5A2 [Source:HGNC Symbol;Acc:HGNC:3301] ENSG00000164114 MAP9 microtubule-associated protein 9 [Source:HGNC Symbol;Acc:HGNC:26118] ENSG00000180708 OR10K2 olfactory receptor, family 10, subfamily K, member 2 [Source:HGNC Symbol;Acc:HGNC:14826] ENSG00000221571 RNU6ATAC35P RNA, U6atac small nuclear 35, pseudogene [Source:HGNC Symbol;Acc:HGNC:46934] ENSG00000226471 ENSG00000228445 UGT1A2P UDP glucuronosyltransferase 1 family, polypeptide A2 pseudogene [Source:HGNC Symbol;Acc:HGNC:12534] ENSG00000228695 CES1P1 carboxylesterase 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:18546] ENSG00000229571 PRAMEF26 PRAME family member 26 [Source:HGNC Symbol;Acc:HGNC:49178] ENSG00000230205 ENSG00000251634 ENSG00000255040 ENSG00000256660 CLEC12B C-type lectin domain family 12, member B [Source:HGNC Symbol;Acc:HGNC:31966] ENSG00000270423 ENSG00000272729 ENSG00000223963 PRKRIRP8 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:39572] ENSG00000259431 THTPA thiamine triphosphatase [Source:HGNC Symbol;Acc:HGNC:18987] ENSG00000224682 SOCS5P2 suppressor of cytokine signaling 5 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:44598] ENSG00000250437 ENSG00000258590 NBEAP1 neurobeachin pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:1007] ENSG00000060762 MPC1 mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606] ENSG00000120306 CYSTM1 cysteine-rich transmembrane module containing 1 [Source:HGNC Symbol;Acc:HGNC:30239] ENSG00000164825 DEFB1 defensin, beta 1 [Source:HGNC Symbol;Acc:HGNC:2766] ENSG00000165685 TMEM52B transmembrane protein 52B [Source:HGNC Symbol;Acc:HGNC:26438] ENSG00000169344 UMOD uromodulin [Source:HGNC Symbol;Acc:HGNC:12559] ENSG00000184908 CLCNKB chloride channel, voltage-sensitive Kb [Source:HGNC Symbol;Acc:HGNC:2027] ENSG00000185275 CD24P4 CD24 molecule pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:1649] ENSG00000197061 HIST1H4C histone cluster 1, H4c [Source:HGNC Symbol;Acc:HGNC:4787] ENSG00000205795 CYS1 cystin 1 [Source:HGNC Symbol;Acc:HGNC:18525] ENSG00000210127 MT-TA mitochondrially encoded tRNA alanine [Source:HGNC Symbol;Acc:HGNC:7475] ENSG00000269900 RMRP RNA component of mitochondrial RNA processing endoribonuclease [Source:HGNC Symbol;Acc:HGNC:10031] ENSG00000270103 RNU11 RNA, U11 small nuclear [Source:HGNC Symbol;Acc:HGNC:10108] ENSG00000104327 CALB1 calbindin 1, 28 kDa [Source:HGNC Symbol;Acc:HGNC:1434] ENSG00000113889 KNG1 kininogen 1 [Source:HGNC Symbol;Acc:HGNC:6383] ENSG00000107485 GATA3 GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] ENSG00000008438 PGLYRP1 peptidoglycan recognition protein 1 [Source:HGNC Symbol;Acc:HGNC:8904] ENSG00000105647 P1K3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Source:HGNC Symbol;Acc:HGNC:8980] ENSG00000116032 GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B [Source:HGNC Symbol;Acc:HGNC:16768] ENSG00000122862 SRGN serglycin [Source:HGNC Symbol;Acc:HGNC:9361] ENSG00000128645 HOXD1 homeobox D1 [Source:HGNC Symbol;Acc:HGNC:5132] ENSG00000134809 TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:11814] ENSG00000138207 RBP4 retinol binding protein 4, plasma [Source:HGNC Symbol;Acc:HGNC:9922] ENSG00000143546 S100A8 S100 calcium binding protein A8 [Source:HGNC Symbol;Acc:HGNC:10498] ENSG00000160181 TFF2 trefoil factor 2 [Source:HGNC Symbol;Acc:HGNC:11756] ENSG00000161992 PRR35 proline rich 35 [Source:HGNC Symbol;Acc:HGNC:14139] ENSG00000163209 SPRR3 small proline-rich protein 3 [Source:HGNC Symbol;Acc:HGNC:11268] ENSG00000164729 SLC35G3 solute carrier family 35, member G3 [Source:HGNC Symbol;Acc:HGNC:26848] ENSG00000165799 RNASE7 ribonuclease, RNase A family, 7 [Source:HGNC Symbol;Acc:HGNC:19278] ENSG00000168746 C20orf62 chromosome 20 open reading frame 62 [Source:HGNC Symbol;Acc:HGNC:16195] ENSG00000173915 USMG5 up-regulated during skeletal muscle growth 5 homolog (mouse) [Source:HGNC Symbol;Acc:HGNC:30889] ENSG00000175197 DDIT3 DNA-damage-inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] ENSG00000175283 DOLK dolichol kinase [Source:HGNC Symbol;Acc:HGNC:23406] ENSG00000176125 UFSP1 UFM1-specific peptidase 1 (non-functional) [Source:HGNC Symbol;Acc:HGNC:33821] ENSG00000179751 SYCN syncollin [Source:HGNC Symbol;Acc:HGNC:18442] ENSG00000181499 OR6T1 olfactory receptor, family 6, subfamily T, member 1 [Source:HGNC Symbol;Acc:HGNC:14848] ENSG00000187186 HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015 [Source:UniProtKB/TrEMBL;Acc:B7Z3J9] ENSG00000187808 SOWAHD sosondowah ankyrin repeat domain family member D [Source:HGNC Symbol;Acc:HGNC:32960] ENSG00000194297 RNU1-75P RNA, U1 small nuclear 75, pseudogene [Source:HGNC Symbol;Acc:HGNC:48417] ENSG00000197674 OR51C1P olfactory receptor, family 51, subfamily C, member 1 pseudogene [Source:HGNC Symbol;Acc:HGNC:15191] ENSG00000198518 NA NA ENSG00000199212 RNU105C RNA, U105C small nucleolar [Source:HGNC Symbol;Acc:HGNC:10104] ENSG00000199378 Y RNA [Source:RFAM;Acc:RF00019] ENSG00000199536 RNU6-315P RNA, U6 small nuclear 315, pseudogene [Source:HGNC Symbol;Acc:HGNC:47278] ENSG00000200131 RN7SKP77 RNA, 7SK small nuclear pseudogene 77 [Source:HGNC Symbol;Acc:HGNC:45801] ENSG00000200408 RNA5SP74 RNA, 5S ribosomal pseudogene 74 [Source:HGNC Symbol;Acc:HGNC:42851] ENSG00000201098 RNY1 RNA, Ro-associated Y1 [Source:HGNC Symbol;Acc:HGNC:10242] ENSG00000201640 RN7SKP28 RNA, 7SK small nuclear pseudogene 28 [Source:HGNC Symbol;Acc:HGNC:45752] ENSG00000201984 Y RNA [Source:RFAM;Acc:RF00019] ENSG00000203616 RHOT1P2 ras homolog family member T1 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:37838] ENSG00000204444 APOM apolipoprotein M [Source:HGNC Symbol;Acc:HGNC:13916] ENSG00000204544 MUC21 mucin 21, cell surface associated [Source:HGNC Symbol;Acc:HGNC:21661 ] ENSG00000205559 CHKB-AS1 CHKB antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:40146] ENSG00000207010 RNU6-1295P RNA, U6 small nuclear 1295, pseudogene [Source:HGNC Symbol;Acc:HGNC:48258] ENSG00000212497 RNA5SP465 RNA, 5S ribosomal pseudogene 465 [Source:HGNC Symbol;Acc:HGNC:43365] ENSG00000213343 RPL21P18 ribosomal protein L21 pseudogene 18 [Source:HGNC Symbol;Acc:HGNC:28362] ENSG00000213871 TAF9BP1 TAF9B RNA polymerase II, TATA box binding protein (TBP)- associated factor, 31 kDa pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:30687] ENSG00000213896 ENSG00000214070 ENSG00000214381 LINC00488 long intergenic non-protein coding RNA 488 [Source:HGNC Symbol;Acc:HGNC:32675] ENSG00000214759 ENSG00000215043 GLULP6 glutamate-ammonia ligase (glutamine synthetase) pseudogene 6 [Source:HGNC Symbol;Acc:HGNC:37990] ENSG00000215481 BCRP3 breakpoint cluster region pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:1016] ENSG00000216966 ENSG00000218180 SLC25A5P7 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:513] ENSG00000218803 GSTM2P1 glutathione S-transferase mu 2 (muscle) pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:38009] ENSG00000222281 RN7SKP111 RNA, 7SK small nuclear pseudogene 111 [Source:HGNC Symbol;Acc:HGNC:45835] ENSG00000222460 RN7SKP271 RNA, 7SK small nuclear pseudogene 271 [Source:HGNC Symbol;Acc:HGNC:45995] ENSG00000222678 RN7SKP213 RNA, 7SK small nuclear pseudogene 213 [Source:HGNC Symbol;Acc:HGNC:45937] ENSG00000222985 RNU2-14P RNA, U2 small nuclear 14, pseudogene [Source:HGNC Symbol;Acc:HGNC:48507] ENSG00000223581 ENSG00000223916 ENSG00000225770 ENSG00000226403 ENSG00000226868 ENSG00000227401 RPL37P1 ribosomal protein L37 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:16337] ENSG00000227415 ENSG00000227646 STEAP2-AS1 STEAP2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40820] ENSG00000227704 ENSG00000227818 ENSG00000227864 ARL5AP1 ADP-ribosylation factor-like 5A pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43933] ENSG00000228366 ENSG00000228436 ENSG00000229242 ENSG00000229313 ENSG00000229376 CICP3 capicua transcriptional repressor pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:37742] ENSG00000229925 ENSG00000229932 YWHAZP3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:31101] ENSG00000230696 ENSG00000230706 ENSG00000230710 LINC00332 long intergenic non-protein coding RNA 332 [Source:HGNC Symbol;Acc:HGNC:42049] ENSG00000231937 ENSG00000232015 HSPE1P25 heat shock 10 kDa protein 1 pseudogene 25 [Source:HGNC Symbol;Acc:HGNC:49344] ENSG00000232464 ENSG00000232524 ENSG00000232658 ENSG00000233558 ENSG00000235573 ENSG00000235578 ENSG00000235942 LCE6A late cornified envelope 6A [Source:HGNC Symbol;Acc:HGNC:31824] ENSG00000236209 ENSG00000236751 LINC01186 long intergenic non-protein coding RNA 1186 [Source:HGNC Symbol;Acc:HGNC:49573] ENSG00000236824 BCYRN1 brain cytoplasmic RNA 1 [Source:HGNC Symbol;Acc:HGNC:1022] ENSG00000237213 RPL23AP22 ribosomal protein L23a pseudogene 22 [Source:HGNC Symbol;Acc:HGNC:35505] ENSG00000237979 ENSG00000237991 RPL35P1 ribosomal protein L35 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:36695] ENSG00000238073 RBMY2HP RNA binding motif protein, Y-linked, family 2, member H pseudogene [Source:HGNC Symbol;Acc:HGNC:23893] ENSG00000238337 NA NA ENSG00000238609 RNU7-94P RNA, U7 small nuclear 94 pseudogene [Source:HGNC Symbol;Acc:HGNC:45628] ENSG00000239126 NA NA ENSG00000239183 SNORA84 small nucleolar RNA, H/ACA box 84 [Source:HGNC Symbol;Acc:HGNC:33615] ENSG00000239196 NA NA ENSG00000239272 RPL21P10 ribosomal protein L21 pseudogene 10 [Source:HGNC Symbol;Acc:HGNC:19795] ENSG00000239542 RN7SL399P RNA, 7SL, cytoplasmic 399, pseudogene [Source:HGNC Symbol;Acc:HGNC:46415] ENSG00000239857 GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:21690] ENSG00000240803 RN7SL231P RNA, 7SL, cytoplasmic 231, pseudogene [Source:HGNC Symbol;Acc:HGNC:46247] ENSG00000242229 RPS3API4 ribosomal protein 53a pseudogene 14 [Source:HGNC Symbol;Acc:HGNC:35715] ENSG00000243004 ENSG00000243974 VTI1BP1 vesicle transport through interaction with t-SNAREs 1B pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43727] ENSG00000244063 ENSG00000244260 ENSG00000244582 RPL21P120 ribosomal protein L21 pseudogene 120 [Source:HGNC Symbol;Acc:HGNC:35743] ENSG00000248240 ENSG00000248370 ENSG00000248834 MARK2P5 MAP/microtubule affinity-regulating kinase 2 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:39796] ENSG00000248890 HHIP-AS1 HHIP antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44182] ENSG00000249014 HMGN2P4 high mobility group nucleosomal binding domain 2 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:33567] ENSG00000249256 ATP5LP3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit g, pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:13216] ENSG00000249942 ENSG00000250120 PCDHA10 protocadherin alpha 10 [Source:HGNC Symbol;Acc:HGNC:8664] ENSG00000250234 ENSG00000250411 ENSG00000251445 ENSG00000251583 ENSG00000252350 RPPH1-3P ribonuclease P RNA component HI, 3 pseudogene [Source:HGNC Symbol;Acc:HGNC:47030] ENSG00000252376 RNA5SP395 RNA, 5S ribosomal pseudogene 395 [Source:HGNC Symbol;Acc:HGNC:43295] ENSG00000252396 RN7SKP195 RNA, 7SK small nuclear pseudogene 195 [Source:HGNC Symbol;Acc:HGNC:45919] ENSG00000252731 ENSG00000253112 ENSG00000253292 MIOXP1 myo-inositol oxygenase pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:50748] ENSG00000253560 ENSG00000253597 NA NA ENSG00000253882 ENSG00000253892 ENSG00000253920 IGLV3-31 immunoglobulin lambda variable 3-31 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:5913] ENSG00000254057 ENSG00000254082 ENSG00000254086 ENSG00000254260 ENSG00000254389 RHPN1-AS1 RHPN1 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:28457] ENSG00000254509 ENSG00000254832 OR4A40P olfactory receptor, family 4, subfamily A, member 40 pseudogene [Source:HGNC Symbol;Acc:HGNC:31259] ENSG00000255038 ENSG00000255142 ENSG00000256037 MRPL40P1 mitochondrial ribosomal protein L40 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44532] ENSG00000257022 ENSG00000257241 ENSG00000257292 ENSG00000257476 ENSG00000257640 ENSG00000257803 ENSG00000258225 ENSG00000258379 ENSG00000258486 RN7SL1 RNA, 7SL, cytoplasmic 1 [Source:HGNC Symbol;Acc:HGNC:10038] ENSG00000259035 ENSG00000259211 ENSG00000259564 ENSG00000260077 ENSG00000260571 BNIP3P5 BCL2/adenovirus E1B 19 kDa interacting protein 3 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:39658] ENSG00000260601 ENSG00000261916 ENSG00000261996 ENSG00000262001 DLGAP1-AS2 DLGAP1 antisense RNA 2 [Source:HGNC Symbol;Acc:HGNC:28146] ENSG00000262313 ENSG00000265713 ENSG00000266021 NA NA ENSG00000267142 ENSG00000267363 ENSG00000267493 CIRBP-AS1 CIRBP antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:28588] ENSG00000267706 ENSG00000268582 ENSG00000268798 ENSG00000269364 LINC01233 long intergenic non-protein coding RNA 1233 [Source:HGNC Symbol;Acc:HGNC:49756] ENSG00000269815 ENSG00000270010 ENSG00000270188 MTRNR2L11 MT-RNR2-like 11 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:37168] ENSG00000270708 ENSG00000271225 ENSG00000271365 ENSG00000271581 ENSG00000271767 NA NA ENSG00000272870 ENSG00000273106 ENSG00000273327 OR6L2P olfactory receptor, family 6, subfamily L, member 2 pseudogene [Source:HGNC Symbol;Acc:HGNC:15125] ENSG00000125652 ALKBH7 alkB, alkylation repair homolog 7 (E. coli) [Source:HGNC Symbol;Acc:HGNC:21306] ENSG00000127528 KLF2 Kruppel-like factor 2 [Source:HGNC Symbol;Acc:HGNC:6347] ENSG00000170891 CYTL1 cytokine-like 1 [Source:HGNC Symbol;Acc:HGNC:24435] ENSG00000185130 HIST1H2BL histone cluster 1, H2b1[Source:HGNC Symbol;Acc:HGNC:4748] ENSG00000224172 ENSG00000227125 ENSG00000233115 FAM90A11P family with sequence similarity 90, member All, pseudogene [Source:HGNC Symbol;Acc:HGNC:32259] ENSG00000255079 ENSG00000267762 ENSG00000271029 ENSG00000150201 FXYD4 FXYD domain containing ion transport regulator 4 [Source:HGNC Symbol;Acc:HGNC:4028] ENSG00000211698 TRGV4 T cell receptor gamma variable 4 [Source:HGNC Symbol;Acc:HGNC:12289] ENSG00000217643 PTGES3P2 prostaglandin E synthase 3 (cytosolic) pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:43822] ENSG00000244734 HBB hemoglobin, beta [Source:HGNC Symbol;Acc:HGNC:4827] ENSG00000254325 ENSG00000163739 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [Source:HGNC Symbol;Acc:HGNC:4602] ENSG00000215004 MESTP4 mesoderm specific transcript pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:38554] ENSG00000230312 ENSG00000230799 ENSG00000242770 ENSG00000254638 ENSG00000258676 ENSG00000234519 ENSG00000236495 ENSG00000216629 OR2W4P olfactory receptor, family 2, subfamily W, member 4 pseudogene [Source:HGNC Symbol;Acc:HGNC:15071] ENSG00000259108 ENSG00000198868 MIR4461 microRNA 4461 [Source:HGNC Symbol;Acc:HGNC:41656] ENSG00000086666 ZFAND6 zinc finger, AN1-type domain 6 [Source:HGNC Symbol;Acc:HGNC:30164] ENSG00000129562 DAD1 defender against cell death 1 [Source:HGNC Symbol;Acc:HGNC:2664] ENSG00000165480 SKA3 spindle and kinetochore associated complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:20262] ENSG00000210196 MT-TP mitochondrially encoded tRNA proline [Source:HGNC Symbol;Acc:HGNC:7494] ENSG00000214114 MYCBP MYC binding protein [Source:HGNC Symbol;Acc:HGNC:7554] ENSG00000259834 potassium voltage-gated channel, shaker-related subfamily, member 3 [Source:EntrezGene;Acc:3738] ENSG00000007306 CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 [Source:HGNC Symbol;Acc:HGNC:1819] ENSG00000043462 LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76 kDa) [Source:HGNC Symbol;Acc:HGNC:6529] ENSG00000057657 PRDM1 PR domain containing 1, with ZNF domain [Source:HGNC Symbol;Acc:HGNC:9346] ENSG00000059728 MXD1 MAX dimerization protein 1 [Source:HGNC Symbol;Acc:HGNC:6761] ENSG00000101336 HCK HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840] ENSG00000103569 AQP9 aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] ENSG00000120738 EGR1 early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] ENSG00000122861 PLAU plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] ENSG00000123395 ATG101 autophagy related 101 [Source:HGNC Symbol;Acc:HGNC:25679] ENSG00000140279 DUOX2 dual oxidase 2 [Source:HGNC Symbol;Acc:HGNC:13273] ENSG00000140678 ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) [Source:HGNC Symbol;Acc:HGNC:6152] ENSG00000140749 IGSF6 immunoglobulin superfamily, member 6 [Source:HGNC Symbol;Acc:HGNC:5953] ENSG00000145113 MUC4 mucin 4, cell surface associated [Source:HGNC Symbol;Acc:HGNC:7514] ENSG00000147180 ZNF711 zinc finger protein 711 [Source:HGNC Symbol;Acc:HGNC:13128] ENSG00000169429 CXCL8 chemokine (C-X-C motif) ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025] ENSG00000171223 JUNB jun B proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6205] ENSG00000188215 DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 [Source:HGNC Symbol;Acc:HGNC:28734] ENSG00000196352 CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) [Source:HGNC Symbol;Acc:HGNC:2665] ENSG00000212443 SNORA53 small nucleolar RNA, H/ACA box 53 [Source:HGNC Symbol;Acc:HGNC:32646] ENSG00000223880 LINC01078 long intergenic non-protein coding RNA 1078 [Source:HGNC Symbol;Acc:HGNC:49121] ENSG00000227056 RPL6P2 ribosomal protein L6 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:35964] ENSG00000231259 ENSG00000232990 MTATP6P7 mitochondrially encoded ATP synthase 6 pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:44581] ENSG00000241983 RN7SL566P RNA, 7SL, cytoplasmic 566, pseudogene [Source:HGNC Symbol;Acc:HGNC:46582] ENSG00000249588 ENSG00000254124 EEF1A1P37 eukaryotic translation elongation factor 1 alpha 1 pseudogene 37 [Source:HGNC Symbol;Acc:HGNC:37915] ENSG00000264462 MIR3648-1 microRNA 3648-1 [Source:HGNC Symbol;Acc:HGNC:38941] ENSG00000268543

TABLE 3 Some biomarkers differentially expressed in blood samples Ensembl_ID HGNC_symbol Description ENSG00000086666 ZFAND6 zinc finger, AN1-type domain 6 [Source:HGNC Symbol;Acc:HGNC:30164] ENSG00000129562 DAD1 defender against cell death 1 [Source:HGNC Symbol;Acc:HGNC:2664] ENSG00000165480 SKA3 spindle and kinetochore associated complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:20262] ENSG00000168993 CPLX1 complexin 1 [Source:HGNC Symbol;Acc:HGNC:2309] ENSG00000169683 LRRC45 leucine rich repeat containing 45 [Source:HGNC Symbol;Acc:HGNC:28302] ENSG00000172201 ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein [Source:HGNC Symbol;Acc:HGNC:5363] ENSG00000178172 SPINK6 serine peptidase inhibitor, Kazal type 6 [Source:HGNC Symbol;Acc:HGNC:29486] ENSG00000184261 KCNK12 potassium channel, subfamily K, member 12 [Source:HGNC Symbol;Acc:HGNC:6274] ENSG00000185640 KRT79 keratin 79 [Source:HGNC Symbol;Acc:HGNC:28930] ENSG00000204566 C10orf115 chromosome 10 open reading frame 115 [Source:HGNC Symbol;Acc:HGNC:31449] ENSG00000210196 MT-TP mitochondrially encoded tRNA proline [Source:HGNC Symbol;Acc:HGNC:7494] ENSG00000212297 RNU6-821P RNA, U6 small nuclear 821, pseudogene [Source:HGNC Symbol;Acc:HGNC:47784] ENSG00000214114 MYCBP MYC binding protein [Source:HGNC Symbol;Acc:HGNC:7554] ENSG00000214772 ENSG00000222040 NA NA ENSG00000223881 ENSG00000230140 ENSG00000235858 ENSG00000236559 ENSG00000237027 ENSG00000237181 ENSG00000243075 RN7SL519P RNA, 7SL, cytoplasmic 519, pseudogene [Source:HGNC Symbol;Acc:HGNC:46535] ENSG00000244060 RPS2P41 ribosomal protein S2 pseudogene 41 [Source:HGNC Symbol;Acc:HGNC:36357] ENSG00000250535 STK19B serine/threonine kinase 19B, pseudogene [Source:HGNC Symbol;Acc:HGNC:21668] ENSG00000253469 ENSG00000256721 CACNA1C-IT3 CACNA1C intronic transcript 3 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:41314] ENSG00000256915 ENSG00000258406 ENSG00000258991 DUX4L19 double homeobox 4 like 19 [Source:HGNC Symbol;Acc:HGNC:37718] ENSG00000259834 potassium voltage-gated channel, shaker-related subfamily, member 3 [Source:EntrezGene;Acc:3738] ENSG00000260265 ENSG00000268280 NA NA ENSG00000273185

TABLE 4 Some biomarkers differentially expressed in saliva samples Ensembl_ID HGNC_symbol Description ENSG00000120699 EXOSC8 exosome component 8 [Source:HGNC Symbol;Acc:HGNC:17035] ENSG00000163577 EIF5A2 eukaryotic translation initiation factor 5A2 [Source:HGNC Symbol;Acc:HGNC:3301] ENSG00000164114 MAP9 microtubule-associated protein 9 [Source:HGNC Symbol;Acc:HGNC:26118] ENSG00000180708 OR10K2 olfactory receptor, family 10, subfamily K, member 2 [Source:HGNC Symbol;Acc:HGNC:14826] ENSG00000221571 RNU6ATAC35P RNA, U6atac small nuclear 35, pseudogene [Source:HGNC Symbol;Acc:HGNC:46934] ENSG00000223963 PRKRIRP8 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:39572] ENSG00000224682 SOCS5P2 suppressor of cytokine signaling 5 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:44598] ENSG00000226471 ENSG00000228445 UGT1A2P UDP glucuronosyltransferase 1 family, polypeptide A2 pseudogene [Source:HGNC Symbol;Acc:HGNC:12534] ENSG00000228695 CES1P1 carboxylesterase 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:18546] ENSG00000229571 PRAMEF26 PRAME family member 26 [Source:HGNC Symbol;Acc:HGNC:49178] ENSG00000230205 ENSG00000250437 ENSG00000251634 ENSG00000255040 ENSG00000256660 CLEC12B C-type lectin domain family 12, member B [Source:HGNC Symbol;Acc:HGNC:31966] ENSG00000258590 NBEAP1 neurobeachin pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:1007] ENSG00000259431 THTPA thiamine triphosphatase [Source:HGNC Symbol;Acc:HGNC:18987] ENSG00000270423 ENSG00000272729

TABLE 5 Some biomarkers differentially expressed in urine samples Ensembl_ID HGNC_symbol Description ENSG00000068366 ACSL4 acyl-CoA synthetase long-chain family member 4 [Source:HGNC Symbol;Acc:HGNC:3571] ENSG00000175879 HOXD8 homeobox D8 [Source:HGNC Symbol;Acc:HGNC:5139] ENSG00000210194 MT-TE mitochondrially encoded tRNA glutamic acid [Source:HGNC Symbol;Acc:HGNC:7479] ENSG00000206652 RNU1-1 RNA, U1 small nuclear 1 [Source:HGNC Symbol;Acc:HGNC:10120] ENSG00000219074 SOD1P1 superoxide dismutase 1, soluble pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:45134] ENSG00000232833 NA NA ENSG00000270878 ENSG00000234629 WDR82P1 WD repeat domain 82 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:32447] ENSG00000236641 ENSG00000206172 HBA1 hemoglobin, alpha 1 [Source:HGNC Symbol;Acc:HGNC:4823] ENSG00000228857 ENSG00000257718 ENSG00000253759 IGHV3-57 immunoglobulin heavy variable 3-57 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:5612] ENSG00000259770 ENSG00000264280 NA NA ENSG00000200087 SNORA73B small nucleolar RNA, H/ACA box 73B [Source:HGNC Symbol;Acc:HGNC:10116] ENSG00000206634 SNORA22 small nucleolar RNA, H/ACA box 22 [Source:HGNC Symbol;Acc:HGNC:32612] ENSG00000239002 SCARNA10 small Cajal body-specific RNA 10 [Source:HGNC Symbol;Acc:HGNC:32567] ENSG00000196911 KPNA5 karyopherin alpha 5 (importin alpha 6) [Source:HGNC Symbol;Acc:HGNC:6398] ENSG00000171612 SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 [Source:HGNC Symbol;Acc:HGNC:29681] ENSG00000265933 LINC00668 long intergenic non-protein coding RNA 668 [Source:HGNC Symbol;Acc:HGNC:44328] ENSG00000154822 PLCL2 phospholipase C-like 2 [Source:HGNC Symbol;Acc:HGNC:9064] ENSG00000109536 FRG1 FSHD region gene 1 [Source:HGNC Symbol;Acc:HGNC:3954] ENSG00000047662 FAM184B family with sequence similarity 184, member B [Source:HGNC Symbol;Acc:HGNC:29235] ENSG00000062524 LTK leukocyte receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6721] ENSG00000109680 TBC1D19 TBC1 domain family, member 19 [Source:HGNC Symbol;Acc:HGNC:25624] ENSG00000112992 NNT nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863] ENSG00000119523 ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase [Source:HGNC Symbol;Acc:HGNC:23159] ENSG00000127990 SGCE sarcoglycan, epsilon [Source:HGNC Symbol;Acc:HGNC:10808] ENSG00000132825 PPP1R3D protein phosphatase 1, regulatory subunit 3D [Source:HGNC Symbol;Acc:HGNC:9294] ENSG00000135637 CCDC142 coiled-coil domain containing 142 [Source:HGNC Symbol;Acc:HGNC:25889] ENSG00000152465 NMT2 N-myristoyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:7858] ENSG00000160993 ALKBH4 alkB, alkylation repair homolog 4 (E. coli) [Source:HGNC Symbol;Acc:HGNC:21900] ENSG00000164078 MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [Source:HGNC Symbol;Acc:HGNC:7381] ENSG00000167524 uncharacterized serine/threonine-protein kinase SgK494 [Source:EntrezGene;Acc:124923] ENSG00000171243 SOSTDC1 sclerostin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21748] ENSG00000173212 MAB21L3 mab-21-like 3 (C. elegans) [Source:HGNC Symbol;Acc:HGNC:26787] ENSG00000177947 ODF3 outer dense fiber of sperm tails 3 [Source:HGNC Symbol;Acc:HGNC:19905] ENSG00000196123 KIAA0895L KIAA0895-like [Source:HGNC Symbol;Acc:HGNC:34408] ENSG00000223358 EHHADH-AS1 EHHADH antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44133] ENSG00000226742 HSBP1L1 heat shock factor binding protein 1-like 1 [Source:HGNC Symbol;Acc:HGNC:37243] ENSG00000233393 ENSG00000237037 NDUFA6-AS1 NDUFA6 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:45273] ENSG00000255537 ENSG00000157593 SLC35B2 ENSG00000258705 solute carrier family 35 (adenosine 3′-phospho 5′-phosphosulfate transporter), member B2 [Source:HGNC Symbol;Acc:HGNC:16872] ENSG00000160588 MPZL3 myelin protein zero-like 3 [Source:HGNC Symbol;Acc:HGNC:27279] ENSG00000170044 ZPLD1 zona pellucida-like domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27022] ENSG00000198382 UVRAG UV radiation resistance associated [Source:HGNC Symbol;Acc:HGNC:12640] ENSG00000131732 ZCCHC9 zinc finger, CCHC domain containing 9 [Source:HGNC Symbol;Acc:HGNC:25424] ENSG00000141582 CBX4 chromobox homolog 4 [Source:HGNC Symbol;Acc:HGNC:1554] ENSG00000162591 MEGF6 multiple EGF-like-domains 6 [Source:HGNC Symbol;Acc:HGNC:3232] ENSG00000206149 HERC2P9 hect domain and RLD 2 pseudogene 9 [Source:HGNC Symbol;Acc:HGNC:30495] ENSG00000070950 RAD18 RAD18 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:18278] ENSG00000100299 ARSA arylsulfatase A [Source:HGNC Symbol;Acc:HGNC:713] ENSG00000259959 ENSG00000075336 TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:25010] ENSG00000088833 NSFL1C NSFL1 (p97) cofactor (p47) [Source:HGNC Symbol;Acc:HGNC:15912] ENSG00000104756 KCTD9 potassium channel tetramerization domain containing 9 [Source:HGNC Symbol;Acc:HGNC:22401] ENSG00000152763 WDR78 WD repeat domain 78 [Source:HGNC Symbol;Acc:HGNC:26252] ENSG00000138346 DNA2 DNA replication helicase/nuclease 2 [Source:HGNC Symbol;Acc:HGNC:2939] ENSG00000144909 OSBPL11 oxysterol binding protein-like 11 [Source:HGNC Symbol;Acc:HGNC:16397] ENSG00000199237 RNU6-834P RNA, U6 small nuclear 834, pseudogene [Source:HGNC Symbol;Acc:HGNC:47797] ENSG00000254014 ENSG00000060762 MPC1 mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606] ENSG00000120306 CYSTM1 cysteine-rich transmembrane module containing 1 [Source:HGNC Symbol;Acc:HGNC:30239] ENSG00000164825 DEFB1 defensin, beta 1 [Source:HGNC Symbol;Acc:HGNC:2766] ENSG00000165685 TMEM52B transmembrane protein 52B [Source:HGNC Symbol;Acc:HGNC:26438] ENSG00000169344 UMOD uromodulin [Source:HGNC Symbol;Acc:HGNC:12559] ENSG00000184908 CLCNKB chloride channel, voltage-sensitive Kb [Source:HGNC Symbol;Acc:HGNC:2027] ENSG00000185275 CD24P4 CD24 molecule pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:1649] ENSG00000197061 HIST1H4C histone cluster 1, H4c [Source:HGNC Symbol;Acc:HGNC:4787] ENSG00000205795 CYS1 cystin 1 [Source:HGNC Symbol;Acc:HGNC:18525] ENSG00000210127 MT-TA mitochondrially encoded tRNA alanine [Source:HGNC Symbol;Acc:HGNC:7475] ENSG00000269900 RMRP RNA component of mitochondrial RNA processing endoribonuclease [Source:HGNC Symbol;Acc:HGNC:10031] ENSG00000270103 RNU11 RNA, U11 small nuclear [Source:HGNC Symbol;Acc:HGNC:10108] ENSG00000104327 CALB1 calbindin 1, 28 kDa [Source:HGNC Symbol;Acc:HGNC:1434] ENSG00000113889 KNG1 kininogen 1 [Source:HGNC Symbol;Acc:HGNC:6383] ENSG00000107485 GATA3 GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] ENSG00000008438 PGLYRP1 peptidoglycan recognition protein 1 [Source:HGNC Symbol;Acc:HGNC:8904] ENSG00000105647 PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Source:HGNC Symbol;Acc:HGNC:8980] ENSG00000116032 GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B [Source:HGNC Symbol;Acc:HGNC:16768] ENSG00000122862 SRGN serglycin [Source:HGNC Symbol;Acc:HGNC:9361] ENSG00000128645 HOXD1 homeobox D1 [Source:HGNC Symbol;Acc:HGNC:5132] ENSG00000134809 TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:11814] ENSG00000138207 RBP4 retinol binding protein 4, plasma [Source:HGNC Symbol;Acc:HGNC:9922] ENSG00000143546 S100A8 S100 calcium binding protein A8 [Source:HGNC Symbol;Acc:HGNC:10498] ENSG00000160181 TFF2 trefoil factor 2 [Source:HGNC Symbol;Acc:HGNC:11756] ENSG00000161992 PRR35 proline rich 35 [Source:HGNC Symbol;Acc:HGNC:14139] ENSG00000163209 SPRR3 small proline-rich protein 3 [Source:HGNC Symbol;Acc:HGNC:11268] ENSG00000164729 SLC35G3 solute carrier family 35, member G3 [Source:HGNC Symbol;Acc:HGNC:26848] ENSG00000165799 RNASE7 ribonuclease, RNase A family, 7 [Source:HGNC Symbol;Acc:HGNC:19278] ENSG00000168746 C20orf62 chromosome 20 open reading frame 62 [Source:HGNC Symbol;Acc:HGNC:16195] ENSG00000173915 USMG5 up-regulated during skeletal muscle growth 5 homolog (mouse) [Source:HGNC Symbol;Acc:HGNC:30889] ENSG00000175197 DDIT3 DNA-damage-inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] ENSG00000175283 DOLK dolichol kinase [Source:HGNC Symbol;Acc:HGNC:23406] ENSG00000176125 UFSP1 UFM1-specific peptidase 1 (non-functional) [Source:HGNC Symbol;Acc:HGNC:33821] ENSG00000179751 SYCN syncollin [Source:HGNC Symbol;Acc:HGNC:18442] ENSG00000181499 OR6T1 olfactory receptor, family 6, subfamily T, member 1 [Source:HGNC Symbol;Acc:HGNC:14848] ENSG00000187186 HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015 [Source:UniProtKB/TrEMBL;Acc:B7Z3J9] ENSG00000187808 SOWAHD sosondowah ankyrin repeat domain family member D [Source:HGNC Symbol;Acc:HGNC:32960] ENSG00000194297 RNU1-75P RNA, U1 small nuclear 75, pseudogene [Source:HGNC Symbol;Acc:HGNC:48417] ENSG00000197674 OR51C1P olfactory receptor, family 51, subfamily C, member 1 pseudogene [Source:HGNC Symbol;Acc:HGNC:15191] ENSG00000198518 NA NA ENSG00000199212 RNU105C RNA, U105C small nucleolar [Source:HGNC Symbol;Acc:HGNC:10104] ENSG00000199378 Y RNA [Source:RFAM;Acc:RF00019] ENSG00000199536 RNU6-315P RNA, U6 small nuclear 315, pseudogene [Source:HGNC Symbol;Acc:HGNC:47278] ENSG00000200131 RN7SKP77 RNA, 7SK small nuclear pseudogene 77 [Source:HGNC Symbol;Acc:HGNC:45801] ENSG00000200408 RNA5SP74 RNA, 5S ribosomal pseudogene 74 [Source:HGNC Symbol;Acc:HGNC:42851] ENSG00000201098 RNY1 RNA, Ro-associated Y1 [Source:HGNC Symbol;Acc:HGNC:10242] ENSG00000201640 RN7SKP28 RNA, 7SK small nuclear pseudogene 28 [Source:HGNC Symbol;Acc:HGNC:45752] ENSG00000201984 Y RNA [Source:RFAM;Acc:RF00019] ENSG00000203616 RHOT1P2 ras homolog family member T1 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:37838] ENSG00000204444 APOM apolipoprotein M [Source:HGNC Symbol;Acc:HGNC:13916] ENSG00000204544 MUC21 mucin 21, cell surface associated [Source:HGNC Symbol;Acc:HGNC:21661 ] ENSG00000205559 CHKB-AS1 CHKB antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:40146] ENSG00000207010 RNU6-1295P RNA, U6 small nuclear 1295, pseudogene [Source:HGNC Symbol;Acc:HGNC:48258] ENSG00000212497 RNA5SP465 RNA, 5S ribosomal pseudogene 465 [Source:HGNC Symbol;Acc:HGNC:43365] ENSG00000213343 RPL21P18 ribosomal protein L21 pseudogene 18 [Source:HGNC Symbol;Acc:HGNC:28362] ENSG00000213871 TAF9BP1 TAF9B RNA polymerase II, TATA box binding protein (TBP)- associated factor, 31 kDa pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:30687] ENSG00000213896 ENSG00000214070 ENSG00000214381 LINC00488 long intergenic non-protein coding RNA 488 [Source:HGNC Symbol;Acc:HGNC:32675] ENSG00000214759 ENSG00000215043 GLULP6 glutamate-ammonia ligase (glutamine synthetase) pseudogene 6 [Source:HGNC Symbol;Acc:HGNC:37990] ENSG00000215481 BCRP3 breakpoint cluster region pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:1016] ENSG00000216966 ENSG00000218180 SLC25A5P7 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 pseudogene 7 ENSG00000218803 GSTM2P1 [Source:HGNC Symbol;Acc:HGNC:513] glutathione S-transferase mu 2 (muscle) pseudogene 1 ENSG00000222281 RN7SKP111 [Source:HGNC Symbol;Acc:HGNC:38009] RNA, 7SK small nuclear pseudogene 111 [Source:HGNC Symbol;Acc:HGNC:45835] ENSG00000222460 RN7SKP271 RNA, 7SK small nuclear pseudogene 271 [Source:HGNC Symbol;Acc:HGNC:45995] ENSG00000222678 RN7SKP213 RNA, 7SK small nuclear pseudogene 213 [Source:HGNC Symbol;Acc:HGNC:45937] ENSG00000222985 RNU2-14P RNA, U2 small nuclear 14, pseudogene [Source:HGNC Symbol;Acc:HGNC:48507] ENSG00000223581 ENSG00000223916 ENSG00000225770 ENSG00000226403 ENSG00000226868 ENSG00000227401 RPL37P1 ribosomal protein L37 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:16337] ENSG00000227415 ENSG00000227646 STEAP2-AS1 STEAP2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40820] ENSG00000227704 ENSG00000227818 ENSG00000227864 ARL5AP1 ADP-ribosylation factor-like 5A pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43933] ENSG00000228366 ENSG00000228436 ENSG00000229242 ENSG00000229313 ENSG00000229376 CICP3 capicua transcriptional repressor pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:37742] ENSG00000229925 ENSG00000229932 YWHAZP3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:31101] ENSG00000230696 ENSG00000230706 ENSG00000230710 LINC00332 long intergenic non-protein coding RNA 332 [Source:HGNC Symbol;Acc:HGNC:42049] ENSG00000231937 ENSG00000232015 HSPE1P25 heat shock 10 kDa protein 1 pseudogene 25 [Source:HGNC Symbol;Acc:HGNC:49344] ENSG00000232464 ENSG00000232524 ENSG00000232658 ENSG00000233558 ENSG00000235573 ENSG00000235578 ENSG00000235942 LCE6A late cornified envelope 6A [Source:HGNC Symbol;Acc:HGNC:31824] ENSG00000236209 ENSG00000236751 LINC01186 long intergenic non-protein coding RNA 1186 [Source:HGNC Symbol;Acc:HGNC:49573] ENSG00000236824 BCYRN1 brain cytoplasmic RNA 1 [Source:HGNC Symbol;Acc:HGNC:1022] ENSG00000237213 RPL23AP22 ribosomal protein L23a pseudogene 22 [Source:HGNC Symbol;Acc:HGNC:35505] ENSG00000237979 ENSG00000237991 RPL35PI ribosomal protein L35 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:36695] ENSG00000238073 RBMY2HP RNA binding motif protein, Y-linked, family 2, member H pseudogene [Source:HGNC Symbol;Acc:HGNC:23893] ENSG00000238337 NA NA ENSG00000238609 RNU7-94P RNA, U7 small nuclear 94 pseudogene [Source:HGNC Symbol;Acc:HGNC:45628] ENSG00000239126 NA NA ENSG00000239183 SNORA84 small nucleolar RNA, H/ACA box 84 [Source:HGNC Symbol;Acc:HGNC:33615] ENSG00000239196 NA NA ENSG00000239272 RPL21P10 ribosomal protein L21 pseudogene 10 [Source:HGNC Symbol;Acc:HGNC:19795] ENSG00000239542 RN7SL399P RNA, 7SL, cytoplasmic 399, pseudogene [Source:HGNC Symbol;Acc:HGNC:46415] ENSG00000239857 GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:21690] ENSG00000240803 RN7SL231P RNA, 7SL, cytoplasmic 231, pseudogene [Source:HGNC Symbol;Acc:HGNC:46247] ENSG00000242229 RPS3AP14 ribosomal protein 53a pseudogene 14 [Source:HGNC Symbol;Acc:HGNC:35715] ENSG00000243004 ENSG00000243974 VTI1BP1 vesicle transport through interaction with t-SNAREs 1B pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43727] ENSG00000244063 ENSG00000244260 ENSG00000244582 RPL21P120 ribosomal protein L21 pseudogene 120 [Source:HGNC Symbol;Acc:HGNC:35743] ENSG00000248240 ENSG00000248370 ENSG00000248834 MARK2P5 MAP/microtubule affinity-regulating kinase 2 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:39796] ENSG00000248890 HHIP-AS1 HHIP antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44182] ENSG00000249014 HMGN2P4 high mobility group nucleosomal binding domain 2 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:33567] ENSG00000249256 ATP5LP3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit g, pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:13216] ENSG00000249942 ENSG00000250120 PCDHA10 protocadherin alpha 10 [Source:HGNC Symbol;Acc:HGNC:8664] ENSG00000250234 ENSG00000250411 ENSG00000251445 ENSG00000251583 ENSG00000252350 RPPH1-3P ribonuclease P RNA component HI, 3 pseudogene [Source:HGNC Symbol;Acc:HGNC:47030] ENSG00000252376 RNA5SP395 RNA, 5S ribosomal pseudogene 395 [Source:HGNC Symbol;Acc:HGNC:43295] ENSG00000252396 RN7SKP195 RNA, 7SK small nuclear pseudogene 195 [Source:HGNC Symbol;Acc:HGNC:45919] ENSG00000252731 ENSG00000253112 ENSG00000253292 MIOXP1 myo-inositol oxygenase pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:50748] ENSG00000253560 ENSG00000253597 NA NA ENSG00000253882 ENSG00000253892 ENSG00000253920 IGLV3-31 immunoglobulin lambda variable 3-31 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:5913] ENSG00000254057 ENSG00000254082 ENSG00000254086 ENSG00000254260 ENSG00000254389 RHPN1-AS1 RHPN1 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:28457] ENSG00000254509 ENSG00000254832 OR4A40P olfactory receptor, family 4, subfamily A, member 40 pseudogene [Source:HGNC Symbol;Acc:HGNC:31259] ENSG00000255038 ENSG00000255142 ENSG00000256037 MRPL40P1 mitochondrial ribosomal protein L40 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44532] ENSG00000257022 ENSG00000257241 ENSG00000257292 ENSG00000257476 ENSG00000257640 ENSG00000257803 ENSG00000258225 ENSG00000258379 ENSG00000258486 RN7SL1 RNA, 7SL, cytoplasmic 1 [Source:HGNC Symbol;Acc:HGNC:10038] ENSG00000259035 ENSG00000259211 ENSG00000259564 ENSG00000260077 ENSG00000260571 BNIP3P5 BCL2/adenovirus E1B 19 kDa interacting protein 3 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:39658] ENSG00000260601 ENSG00000261916 ENSG00000261996 ENSG00000262001 DLGAP1-AS2 DLGAP1 antisense RNA 2 [Source:HGNC Symbol;Acc:HGNC:28146] ENSG00000262313 ENSG00000265713 ENSG00000266021 NA NA ENSG00000267142 ENSG00000267363 ENSG00000267493 CIRBP-AS1 CIRBP antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:28588] ENSG00000267706 ENSG00000268582 ENSG00000268798 ENSG00000269364 LINC01233 long intergenic non-protein coding RNA 1233 [Source:HGNC Symbol;Acc:HGNC:49756] ENSG00000269815 ENSG00000270010 ENSG00000270188 MTRNR2L11 MT-RNR2-like 11 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:37168] ENSG00000270708 ENSG00000271225 ENSG00000271365 ENSG00000271581 ENSG00000271767 NA NA ENSG00000272870 ENSG00000273106 ENSG00000273327 OR6L2P olfactory receptor, family 6, subfamily L, member 2 pseudogene [Source:HGNC Symbol;Acc:HGNC:15125] ENSG00000125652 ALKBH7 alkB, alkylation repair homolog 7 (E. coli) [Source:HGNC Symbol;Acc:HGNC:21306] ENSG00000127528 KLF2 Kruppel-like factor 2 [Source:HGNC Symbol;Acc:HGNC:6347] ENSG00000170891 CYTL1 cytokine-like 1 [Source:HGNC Symbol;Acc:HGNC:24435] ENSG00000185130 HIST1H2BL histone cluster 1, H2b1[Source:HGNC Symbol;Acc:HGNC:4748] ENSG00000224172 ENSG00000227125 ENSG00000233115 FAM90A11P family with sequence similarity 90, member All, pseudogene [Source:HGNC Symbol;Acc:HGNC:32259] ENSG00000255079 ENSG00000267762 ENSG00000271029 ENSG00000150201 FXYD4 FXYD domain containing ion transport regulator 4 [Source:HGNC Symbol;Acc:HGNC:4028] ENSG00000211698 TRGV4 T cell receptor gamma variable 4 [Source:HGNC Symbol;Acc:HGNC:12289] ENSG00000217643 PTGES3P2 prostaglandin E synthase 3 (cytosolic) pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:43822] ENSG00000244734 HBB hemoglobin, beta [Source:HGNC Symbol;Acc:HGNC:4827] ENSG00000254325 ENSG00000163739 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [Source:HGNC Symbol;Acc:HGNC:4602] ENSG00000215004 MESTP4 mesoderm specific transcript pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:38554] ENSG00000230312 ENSG00000230799 ENSG00000242770 ENSG00000254638 ENSG00000258676 ENSG00000234519 ENSG00000236495 ENSG00000216629 OR2W4P olfactory receptor, family 2, subfamily W, member 4 pseudogene [Source:HGNC Symbol;Acc:HGNC:15071] ENSG00000259108 ENSG00000198868 MIR4461 microRNA 4461 [Source:HGNC Symbol;Acc:HGNC:41656] ENSG00000007306 CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 [Source:HGNC Symbol;Acc:HGNC:1819] ENSG00000043462 LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76 kDa) [Source:HGNC Symbol;Acc:HGNC:6529] ENSG00000057657 PRDM1 PR domain containing 1, with ZNF domain [Source:HGNC Symbol;Acc:HGNC:9346] ENSG00000059728 MXD1 MAX dimerization protein 1 [Source:HGNC Symbol;Acc:HGNC:6761] ENSG00000101336 HCK HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840] ENSG00000103569 AQP9 aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] ENSG00000120738 EGR1 early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] ENSG00000122861 PLAU plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] ENSG00000123395 ATG101 autophagy related 101 [Source:HGNC Symbol;Acc:HGNC:25679] ENSG00000140279 DUOX2 dual oxidase 2 [Source:HGNC Symbol;Acc:HGNC:13273] ENSG00000140678 ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) [Source:HGNC Symbol;Acc:HGNC:6152] ENSG00000140749 IGSF6 immunoglobulin superfamily, member 6 [Source:HGNC Symbol;Acc:HGNC:5953] ENSG00000145113 MUC4 mucin 4, cell surface associated [Source:HGNC Symbol;Acc:HGNC:7514] ENSG00000147180 ZNF711 zinc finger protein 711 [Source:HGNC Symbol;Acc:HGNC:13128] ENSG00000169429 CXCL8 chemokine (C-X-C motif) ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025] ENSG00000171223 JUNB jun B proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6205] ENSG00000188215 DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 [Source:HGNC Symbol;Acc:HGNC:28734] ENSG00000196352 CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) [Source:HGNC Symbol;Acc:HGNC:2665] ENSG00000212443 SNORA53 small nucleolar RNA, H/ACA box 53 [Source:HGNC Symbol;Acc:HGNC:32646] ENSG00000223880 LINC01078 long intergenic non-protein coding RNA 1078 [Source:HGNC Symbol;Acc:HGNC:49121] ENSG00000227056 RPL6P2 ribosomal protein L6 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:35964] ENSG00000231259 ENSG00000232990 MTATP6P7 mitochondrially encoded ATP synthase 6 pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:44581] ENSG00000241983 RN7SL566P RNA, 7SL, cytoplasmic 566, pseudogene [Source:HGNC Symbol;Acc:HGNC:46582] ENSG00000249588 ENSG00000254124 EEF1A1P37 eukaryotic translation elongation factor 1 alpha 1 pseudogene 37 [Source:HGNC Symbol;Acc:HGNC:37915] ENSG00000264462 MIR3648-1 microRNA 3648-1 [Source:HGNC Symbol;Acc:HGNC:38941] ENSG00000268543

TABLE 6 The sum of all impact sustained by the player, as measured by HITsp, regressed on RNA expression in plasma samples X0.5slope_ X0.8slope_ 0.1pvalue_0.1_ 0.1pvalue_0.1_ hgnc_ Cum_HITsp_ Cum_HITsp_ Ensembl_ID symbol description plasma plasma ENSG00000100181 TPTEP1 transmembrane phosphatase with 0.20378777 0.20378777 tensin homology pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43648] ENSG00000109272 PF4V1 platelet factor 4 variant 1 0.597728749 0.597728749 [Source:HGNC Symbol;Acc:HGNC:8862] ENSG00000113658 SMAD5 SMAD family member 5 0.114186069 0.114186069 [Source:HGNC Symbol;Acc:HGNC:6771] ENSG00000130600 H19 H19, imprinted maternally expressed 0.122017886 0.122017886 transcript (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:4713] ENSG00000188536 HBA2 hemoglobin, alpha 2 [Source:HGNC 0.233448354 0.233448354 Symbol;Acc:HGNC:4824] ENSG00000210195 MT-TT mitochondrially encoded tRNA 0.362408703 0.362408703 threonine [Source:HGNC Symbol;Acc:HGNC:7499] ENSG00000244734 HBB hemoglobin, beta [Source:HGNC 5.585155911 5.585155911 Symbol;Acc:HGNC:4827]

TABLE 7 The sum of all impact sustained by the player, as measured by linear acceleration regressed on RNA expression in plasma samples X0.5slope_ X0.8slope_ 0.1pvalue_0.1_ 0.1pvalue_0.1_ hgnc_ Cum_lin_ Cum_lin_ Ensembl_ID symbol description acc_plasma acc_plasma ENSG00000100181 TPTEP1 transmembrane phosphatase with 0.106289272 0.106289272 tensin homology pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43648] ENSG00000109272 PF4V1 platelet factor 4 variant 1 0.309869359 0.309869359 [Source:HGNC Symbol;Acc:HGNC:8862] ENSG00000188536 HBA2 hemoglobin, alpha 2 [Source:HGNC 0.117006674 0.117006674 Symbol;Acc:HGNC:4824] ENSG00000210196 MT-TP mitochondrially encoded tRNA proline 0.309422507 0.309422507 [Source:HGNC Symbol;Acc:HGNC:7494] EN5G00000244734 HBB hemoglobin, beta [Source:HGNC 2.913777061 2.913777061 Symbol;Acc:HGNC:4827]

TABLE 8 The highest impact sustained by the player in the game as measured by HITsp regressed on RNA expression in plasma samples X0.5slope_ X0.8slope_ 0.1pvalue_0.1_ 0.1pvalue_0.1_ hgnc_ Max_HITsp_ Max_HITsp_ Ensembl_ID symbol description plasma plasma ENSG00000007908 SELE selectin E [Source:HGNC 0.121635052 NA Symbol;Acc:HGNC:10718] ENSG00000010318 PHF7 PHD finger protein 7 [Source:HGNC 0.175646559 0.175646559 Symbol;Acc:HGNC:18458] ENSG00000021852 C8B complement component 8, beta 0.152730512 NA polypeptide [Source:HGNC Symbol;Acc:HGNC:1353] ENSG00000022556 NLRP2 NLR family, pyrin domain containing 2 −0.163995063 -0.163995063 [Source:HGNC Symbol;Acc:HGNC:22948] ENSG00000029725 RABEP rabaptin, RAB GTPase binding 0.216512318 0.216512318 1 effector protein 1 [Source:HGNC Symbol;Acc:HGNC:17677] ENSG00000048392 RRM2B ribonucleotide reductase M2 B (TP53 0.165078204 0.165078204 inducible) [Source:HGNC Symbol;Acc:HGNC:17296] ENSG00000055147 FAM114 family with sequence similarity 114, 0.161956419 0.161956419 A2 member A2 [Source:HGNC Symbol;Acc:HGNC:1333] ENSG00000074266 EED embryonic ectoderm development 0.149505509 0.149505509 [Source:HGNC Symbol;Acc:HGNC:3188] ENSG00000074755 ZZEF1 zinc finger, ZZ-type with EF-hand 0.381470401 0.381470401 domain 1 [Source:HGNC Symbol;Acc:HGNC:29027] ENSG00000075142 SRI sorcin [Source:HGNC 0.111723067 0.111723067 Symbol;Acc:HGNC:11292] ENSG00000075292 ZNF638 zinc finger protein 638 [Source:HGNC 0.305304639 0.305304639 Symbol;Acc:HGNC:17894] ENSG00000079393 DUSP1 dual specificity phosphatase 13 0.130119143 NA 3 [Source:HGNC Symbol;Acc:HGNC:19681] ENSG00000079459 FDFT1 farnesyl-diphosphate 0.134608276 0.134608276 farnesyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3629] ENSG00000081087 OSTM1 osteopetrosis associated 0.121396476 0.121396476 transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:21652] ENSG00000091490 SEL1L3 sel-1 suppressor of lin-12-like 3 (C. 0.302907764 0.302907764 elegans) [Source:HGNC Symbol;Acc:HGNC:29108] ENSG00000092931 MFSD1 major facilitator superfamily domain 0.123995301 0.123995301 1 containing 11 [Source:HGNC Symbol;Acc:HGNC:25458] ENSG00000099246 RAB18 RAB18, member RAS oncogene 0.165635406 −0.165635406 family [Source:HGNC Symbol;Acc:HGNC:14244] ENSG00000100023 PPIL2 peptidylprolyl isomerase (cyclophilin)- −0.161972775 −0.161972775 like 2 [Source:HGNC Symbol;Acc:HGNC:9261] ENSG00000100888 CHD8 chromodomain helicase DNA binding 0.229676288 0.229676288 protein 8 [Source:HGNC Symbol;Acc:HGNC:20153] ENSG00000101447 FAM83 family with sequence similarity 83, 0.1332232 0.1332232 D member D [Source:HGNC Symbol;Acc:HGNC:16122] ENSG00000102401 ARMCX armadillo repeat containing, X-linked 0.59294635 0.59294635 3 3 [Source:HGNC Symbol;Acc:HGNC:24065] ENSG00000104325 DECR1 2,4-dienoyl CoA reductase 1, −0.189408898 −0.189408898 mitochondrial [Source:HGNC Symbol;Acc:HGNC:2753] ENSG00000105609 LILRB5 leukocyte immunoglobulin-like −0.140206736 −0.140206736 receptor, subfamily B (with TM and ITIM domains), member 5 [Source:HGNC Symbol;Acc:HGNC:6609] ENSG00000107105 ELAVL2 ELAV like neuron-specific RNA 0.127378776 NA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:3313] ENSG00000109184 DCUN1 DCN1, defective in cullin neddylation 0.134859198 0.134859198 D4 1, domain containing 4 [Source:HGNC Symbol;Acc:HGNC:28998] ENSG00000109320 NFKB1 nuclear factor of kappa light 0.143532697 0.143532697 polypeptide gene enhancer in B-cells 1 [Source:HGNC Symbol;Acc:HGNC:7794] ENSG00000110002 VWA5A von Willebrand factor A domain −0.163688271 −0.163688271 containing 5A [Source:HGNC Symbol;Acc:HGNC:6658] ENSG00000111215 PRR4 proline rich 4 (lacrimal) 0.111251825 0.111251825 [Source:HGNC Symbol;Acc:HGNC:18020] ENSG00000111237 VPS29 vacuolar protein sorting 29 homolog −0.111163487 −0.111163487 (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:14340] ENSG00000115641 FHL2 four and a half LIM domains 2 −0.259669317 −0.259669317 [Source:HGNC Symbol;Acc:HGNC:3703] ENSG00000116984 MTR 5-methyltetrahydrofolate- 0.242310216 0.242310216 homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] ENSG00000117707 PROX1 prospero homeobox 1 [Source:HGNC 0.15802085 0.15802085 Symbol;Acc:HGNC:9459] ENSG00000118496 FBXO30 F-box protein 30 [Source:HGNC 0.122038094 0.122038094 Symbol;Acc:HGNC:15600] ENSG00000118503 TNFAIP tumor necrosis factor, alpha-induced −0.129476115 −0.129476115 3 protein 3 [Source:HGNC Symbol;Acc:HGNC:11896] ENSG00000119537 KDSR 3-ketodihydrosphingosine reductase 0.184864693 0.184864693 [Source:HGNC Symbol;Acc:HGNC:4021] ENSG00000119760 SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 0.112076344 0.112076344 [Source:HGNC Symbol;Acc:HGNC:30632] ENSG00000120158 RCL1 RNA terminal phosphate cyclase-like 0.11221667 0.11221667 1 [Source:HGNC Symbol;Acc:HGNC:17687] ENSG00000120903 CHRNA cholinergic receptor, nicotinic, alpha 2 0.160279926 0.160279926 2 (neuronal) [Source:HGNC Symbol;Acc:HGNC:1956] ENSG00000124256 ZBP1 Z-DNA binding protein 1 −0.177678732 −0.177678732 [Source:HGNC Symbol;Acc:HGNC:16176] ENSG00000127952 STYXL1 serine/threonine/tyrosine interacting- −0.143855782 −0.143855782 like 1 [Source:HGNC Symbol;Acc:HGNC:18165] ENSG00000128872 TMOD2 tropomodulin 2 (neuronal) 0.196045551 0.196045551 [Source:HGNC Symbol;Acc:HGNC:11872] ENSG00000129315 CCNT1 cyclin Ti [Source:HGNC 0.174120367 0.174120367 Symbol;Acc:HGNC:1599] ENSG00000131669 NINJ1 ninjurin 1 [Source:HGNC −0.117831337 −0.117831337 Symbol;Acc:HGNC:7824] ENSG00000135677 GNS glucosamine (N-acetyl)-6-sulfatase −0.166432372 −0.166432372 [Source:HGNC Symbol;Acc:HGNC:4422] ENSG00000135720 DYNC1 dynein, cytoplasmic 1, light 0.146577706 0.146577706 LI2 intermediate chain 2 [Source:HGNC Symbol;Acc:HGNC:2966] ENSG00000135828 RNASE ribonuclease L (2′,5′- 0.154329308 0.154329308 L oligoisoadenylate synthetase- dependent) [Source:HGNC Symbol;Acc:HGNC:10050] ENSG00000136193 SCRN1 secernin 1 [Source:HGNC 0.151707537 0.151707537 Symbol;Acc:HGNC:22192] ENSG00000136770 DNAJC DnaJ (Hsp40) homolog, subfamily C, 0.113451701 NA 1 member 1 [Source:HGNC Symbol;Acc:HGNC:20090] ENSG00000138160 KIF11 kinesin family member 11 0.115877374 0.115877374 [Source:HGNC Symbol;Acc:HGNC:6388] ENSG00000141076 CIRH1A cirrhosis, autosomal recessive 1A −0.166159403 −0.166159403 (cirhin) [Source:HGNC Symbol;Acc:HGNC:1983] ENSG00000141161 UNC45 unc-45 homolog B (C. elegans) −0.28423258 −0.28423258 B [Source:HGNC Symbol;Acc:HGNC:14304] ENSG00000142188 TMEM5 transmembrane protein 50B 0.12486265 0.12486265 0B [Source:HGNC Symbol;Acc:HGNC:1280] ENSG00000143520 FLG2 filaggrin family member 2 −0.303312359 −0.303312359 [Source:HGNC Symbol;Acc:HGNC:33276] ENSG00000143552 NUP210 nucleoporin 210 kDa-like 0.281078121 0.281078121 L [Source:HGNC Symbol;Acc:HGNC:29915] ENSG00000144741 SLC25A solute carrier family 25 (S- −0.128569249 -0.128569249 26 adenosylmethionine carrier), member 26 [Source:HGNC Symbol;Acc:HGNC:20661] ENSG00000146166 LGSN lengsin, lens protein with glutamine −0.12918315 NA synthetase domain [Source:HGNC Symbol;Acc:HGNC:21016] ENSG00000146373 RNF217 ring finger protein 217 [Source:HGNC −0.150117811 −0.150117811 Symbol;Acc:HGNC:21487] ENSG00000147164 SNX12 sorting nexin 12 [Source:HGNC 0.108423858 0.108423858 Symbol;Acc:HGNC:14976] ENSG00000147419 CCDC2 coiled-coil domain containing 25 0.11439188 0.11439188 5 [Source:HGNC Symbol;Acc:HGNC:25591] ENSG00000148123 Lipid phosphate phosphatase-related 0.106165133 NA protein type 1 [Source:UniProtKB/Swiss- Prot;Acc:Q8TBJ4] ENSG00000152404 CWF19 CWF19-like 2, cell cycle control (S. 0.106554189 0.106554189 L2 pombe) [Source:HGNC Symbol;Acc:HGNC:26508] ENSG00000152457 DCLRE DNA cross-link repair 1C 0.191026562 0.191026562 1C [Source:HGNC Symbol;Acc:HGNC:17642] ENSG00000155966 AFF2 AF4/FMR2 family, member 2 0.270635465 0.270635465 [Source:HGNC Symbol;Acc:HGNC:3776] ENSG00000156097 GPR61 G protein-coupled receptor 61 −0.148236127 NA [Source:HGNC Symbol;Acc:HGNC:13300] ENSG00000159128 IFNGR2 interferon gamma receptor 2 −0.129554016 −0.129554016 (interferon gamma transducer 1) [Source:HGNC Symbol;Acc:HGNC:5440] ENSG00000160094 ZNF362 zinc finger protein 362 [Source:HGNC −0.14269107 −0.14269107 Symbol;Acc:HGNC:18079] ENSG00000162236 STX5 syntaxin 5 [Source:HGNC −0.114569378 −0.114569378 Symbol;Acc:HGNC:11440] ENSG00000163029 SMC6 structural maintenance of 0.276954714 0.276954714 chromosomes 6 [Source:HGNC Symbol;Acc:HGNC:20466] ENSG00000164056 SPRY1 sprouty homolog 1, antagonist of FGF 0.147011146 0.147011146 signaling (Drosophila) [Source:HGNC Symbol;Acc:HGNC:11269] ENSG00000164167 LSM6 LSM6 homolog, U6 small nuclear 0.123620894 0.123620894 RNA associated (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:17017] ENSG00000164241 C5orf63 chromosome 5 open reading frame 0.185998415 0.185998415 63 [Source:HGNC Symbol;Acc:HGNC:40051] ENSG00000164342 TLR3 toll-like receptor 3 [Source:HGNC 0.118798462 NA Symbol;Acc:HGNC:11849] ENSG00000164691 TAGAP T-cell activation RhoGTPase −0.125513291 −0.125513291 activating protein [Source:HGNC Symbol;Acc:HGNC:15669] ENSG00000165819 METTL3 methyltransferase like 3 0.131405581 0.131405581 [Source:HGNC Symbol;Acc:HGNC:17563] ENSG00000167216 KATNA katanin p60 subunit A-like 2 0.219516484 NA L2 [Source:HGNC Symbol;Acc:HGNC:25387] ENSG00000167528 ZNF641 zinc finger protein 641 [Source:HGNC −0.123686678 −0.123686678 Symbol;Acc:HGNC:31834] ENSG00000167693 NXN nucleoredoxin [Source:HGNC −0.209096283 -0.209096283 Symbol;Acc:HGNC:18008] ENSG00000167740 CYB5D cytochrome b5 domain containing 2 −0.12047966 −0.12047966 2 [Source:HGNC Symbol;Acc:HGNC:28471] ENSG00000168234 TTC39C tetratricopeptide repeat domain 39C 0.100411688 0.100411688 [Source:HGNC Symbol;Acc:HGNC:26595] ENSG00000168394 TAP1 transporter 1, ATP-binding cassette, −0.164176847 -0.164176847 sub-family B (MDR/TAP) [Source:HGNC Symbol;Acc:HGNC:43] ENSG00000169330 KIAA10 KIAA1024 [Source:HGNC 0.140505947 NA 24 Symbol;Acc:HGNC:29172] ENSG00000169413 RNASE ribonuclease, RNase A family, k6 −0.132557953 −0.132557953 6 [Source:HGNC Symbol;Acc:HGNC:10048] ENSG00000169427 KCNK9 potassium channel, subfamily K, −0.121379856 NA member 9 [Source:HGNC Symbol;Acc:HGNC:6283] ENSG00000170049 KCNAB potassium voltage-gated channel, −0.185365138 −0.185365138 3 shaker-related subfamily, beta member 3 [Source:HGNC Symbol;Acc:HGNC:6230] ENSG00000170423 KRT78 keratin 78 [Source:HGNC 0.187955509 0.187955509 Symbol;Acc:HGNC:28926] ENSG00000170606 HSPA4 heat shock 70 kDa protein 4 0.20388256 0.20388256 [Source:HGNC Symbol;Acc:HGNC:5237] ENSG00000170832 U5P32 ubiquitin specific peptidase 32 0.188947651 0.188947651 [Source:HGNC Symbol;Acc:HGNC:19143] ENSG00000171401 KRT13 keratin 13 [Source:HGNC 0.25057251 NA Symbol;Acc:HGNC:6415] ENSG00000174437 ATP2A2 ATPase, Ca++ transporting, cardiac 0.400805765 0.400805765 muscle, slow twitch 2 [Source:HGNC Symbol;Acc:HGNC:812] ENSG00000174628 IQCK IQ motif containing K [Source:HGNC 0.136023094 NA Symbol;Acc:HGNC:28556] ENSG00000175224 ATG13 autophagy related 13 [Source:HGNC −0.139076734 −0.139076734 Symbol;Acc:HGNC:29091] ENSG00000176177 ENTHD ENTH domain containing 1 0.129447716 NA 1 [Source:HGNC Symbol;Acc:HGNC:26352] ENSG00000176274 NA NA 0.106120051 −0.106120051 ENSG00000176624 MEX3C mex-3 RNA binding family member C 0.180591536 0.180591536 [Source:HGNC Symbol;Acc:HGNC:28040] ENSG00000177628 GBA glucosidase, beta, acid −0.106595166 -0.106595166 [Source:HGNC Symbol;Acc:HGNC:4177] ENSG00000179603 GRM8 glutamate receptor, metabotropic 8 0.157319697 NA [Source:HGNC Symbol;Acc:HGNC:4600] ENSG00000179750 APOBE apolipoprotein B mRNA editing 0.100224101 NA C3B enzyme, catalytic polypeptide-like 3B [Source:HGNC Symbol;Acc:HGNC:17352] ENSG00000184083 FAM120 family with sequence similarity 120C 0.110074364 0.110074364 C [Source:HGNC Symbol;Acc:HGNC:16949] ENSG00000186529 CYP4F3 cytochrome P450, family 4, subfamily −0.163081719 -0.163081719 F, polypeptide 3 [Source:HGNC Symbol;Acc:HGNC:2646] ENSG00000186615 KTN1- KTN1 antisense RNA 1 0.142901608 NA AS1 [Source:HGNC Symbol;Acc:HGNC:19842] ENSG00000187600 TMEM2 transmembrane protein 247 0.108107182 NA 47 [Source:HGNC Symbol;Acc:HGNC:42967] ENSG00000187726 DNAJB1 DnaJ (Hsp40) homolog, subfamily B, 0.103453497 NA 3 member 13 [Source:HGNC Symbol;Acc:HGNC:30718] ENSG00000188467 SLC24A solute carrier family 24 0.103370533 NA (sodium/potassium/calcium 5 exchanger), member 5 [Source:HGNC Symbol;Acc:HGNC:20611] ENSG00000189292 FAM150 family with sequence similarity 150, 0.106279244 NA B member B [Source:HGNC Symbol;Acc:HGNC:27683] ENSG00000197170 PSMD1 proteasome (prosome, macropain) −0.182977534 -0.182977534 2 26S subunit, non-ATPase, 12 [Source:HGNC Symbol;Acc:HGNC:9557] ENSG00000198682 PAPSS 3′-phosphoadenosine 5′- 0.31037423 0.31037423 2 phosphosulfate synthase 2 [Source:HGNC Symbol;Acc:HGNC:8604] ENSG00000198818 SFT2D1 SFT2 domain containing 1 −0.154463245 −0.154463245 [Source:HGNC Symbol;Acc:HGNC:21102] ENSG00000204217 BMPR2 bone morphogenetic protein receptor, 0.187926619 0.187926619 type II (serine/threonine kinase) [Source:HGNC Symbol;Acc:HGNC:1078] ENSG00000204956 PCDHG protocadherin gamma subfamily A, 1 0.121529553 NA A1 [Source:HGNC Symbol;Acc:HGNC:8696] ENSG00000206053 HN1L hematological and neurological −0.116539758 -0.116539758 expressed 1-like [Source:HGNC Symbol;Acc:HGNC:14137] ENSG00000213023 SYT3 synaptotagmin III [Source:HGNC −0.142039238 −0.142039238 Symbol;Acc:HGNC:11511] ENSG00000214324 C3orf56 chromosome 3 open reading frame 0.101213919 NA 56 [Source:HGNC Symbol;Acc:HGNC:32481] ENSG00000223561 0.12794031 NA ENSG00000225492 GBP1P guanylate binding protein 1, 0.121917628 NA 1 interferon-inducible pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:39561] ENSG00000232712 KIZ-AS1 KIZ antisense RNA 1 [Source:HGNC 0.203847703 NA Symbol;Acc:HGNC:51231 ] ENSG00000233137 NA NA 0.145628143 0.145628143 ENSG00000234456 MAGI2- MAGI2 antisense RNA 3 1.165895131 1.165895131 AS3 [Source:HGNC Symbol;Acc:HGNC:40862] ENSG00000234722 LINC01 long intergenic non-protein coding 0.120258318 0.120258318 287 RNA 1287 [Source:HGNC Symbol;Acc:HGNC:50351] ENSG00000238083 LRRC37 leucine rich repeat containing 37, −0.122587313 −0.122587313 A2 member A2 [Source:HGNC Symbol;Acc:HGNC:32404] ENSG00000240057 0.134220987 NA ENSG00000241468 ATP5J2 ATP synthase, H+ transporting, −0.148342124 −0.148342124 mitochondrial Fo complex, subunit F2 [Source:HGNC Symbol;Acc:HGNC:848] ENSG00000248360 LINC00 long intergenic non-protein coding −0.127175488 −0.127175488 504 RNA 504 [Source:HGNC Symbol;Acc:HGNC:43555] ENSG00000249948 GBA3 glucosidase, beta, acid 3 −0.114794098 NA (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:19069] ENSG00000250519 -0.105296624 NA ENSG00000250722 SEPP1 selenoprotein P, plasma, 1 0.102671916 NA [Source:HGNC Symbol;Acc:HGNC:10751] ENSG00000255189 GLYATL glycine-N-acyltransferase-like 1 0.151317511 0.151317511 1P1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:37866] ENSG00000260231 JHDM1 JHDM1D antisense RNA 1 (head to 0.136907921 0.136907921 D-AS1 head) [Source:HGNC Symbol;Acc:HGNC:48959] ENSG00000265489 0.15073608 NA

TABLE 9 The highest impact sustained by the player in the game as measured by linear acceleration regressed on RNA expression in plasma samples X0.5slope_ X0.8slope_ 0.1pvalue_0.1_ 0.1pvalue_0.1_ hgnc_ Max_lin_acc_ Max_lin_acc_ Ensembl_ID symbol description plasma plasma ENSG00000010318 PHF7 PHD finger protein 7 [Source:HGNC 0.170229865 0.170229865 Symbol;Acc:HGNC:18458] ENSG00000025770 NCAPH non-SMC condensin II complex, 2 subunit H2 [Source:HGNC −0.112730034 −0.112730034 Symbol;Acc:HGNC:25071] ENSG00000029725 RABEP rabaptin, RAB GTPase binding 0.228780531 0.228780531 1 effector protein 1 [Source:HGNC Symbol;Acc:HGNC:17677] ENSG00000040531 CTNS cystinosin, lysosomal cystine −0.10929833 −0.10929833 transporter [Source:HGNC Symbol;Acc:HGNC:2518] ENSG00000047346 FAM214 family with sequence similarity 214, −0.109435184 −0.109435184 A member A [Source:HGNC Symbol;Acc:HGNC:25609] ENSG00000049167 ERCC8 excision repair cross- 0.109452269 NA complementation group 8 [Source:HGNC Symbol;Acc:HGNC:3439] ENSG00000064012 CASP8 caspase 8, apoptosis-related cysteine −0.187553974 −0.187553974 peptidase [Source:HGNC Symbol;Acc:HGNC:1509] ENSG00000071909 MYO3B myosin IIIB [Source:HGNC 0.251537467 0.251537467 Symbol;Acc:HGNC:15576] ENSG00000074755 ZZEF1 zinc finger, ZZ-type with EF-hand 0.318566019 0.318566019 domain 1 [Source:HGNC Symbol;Acc:HGNC:29027] ENSG00000079459 FDFT1 farnesyl-diphosphate 0.141827495 0.141827495 farnesyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3629] ENSG00000081087 OSTM1 osteopetrosis associated 0.121617273 0.121617273 transmembrane protein 1 [Source:HGNC ENSG00000081791 KIAA01 KIAA0141 [Source:HGNC −0.127139336 −0.127139336 41 Symbol;Acc:HGNC:21652] Symbol;Acc:HGNC:28969] ENSG00000084112 SSH1 slingshot protein phosphatase 1 0.303239347 0.303239347 [Source:HGNC Symbol;Acc:HGNC:30579] ENSG00000089597 GANAB glucosidase, alpha; neutral AB −0.225207094 −0.225207094 [Source:HGNC Symbol;Acc:HGNC:4138] ENSG00000100023 PPIL2 peptidylprolyl isomerase (cyclophilin)- −0.162688083 −0.162688083 like 2 [Source:HGNC Symbol;Acc:HGNC:9261] ENSG00000100412 ACO2 aconitase 2, mitochondrial 0.131888628 0.131888628 [Source:HGNC Symbol;Acc:HGNC:118] ENSG00000101464 PIGU phosphatidylinositol glycan anchor −0.135513742 -0.135513742 biosynthesis, class U [Source:HGNC Symbol;Acc:HGNC:15791] ENSG00000104859 CLASR CLK4-associating serine/arginine rich −0.20844473 −0.20844473 P protein [Source:HGNC Symbol;Acc:HGNC:17731] ENSG00000105197 TIMM50 translocase of inner mitochondrial −0.113849069 −0.113849069 membrane 50 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23656] ENSG00000105707 HPN hepsin [Source:HGNC −0.107147642 NA Symbol;Acc:HGNC:5155] ENSG00000107105 ELAVL2 ELAV like neuron-specific RNA 0.111552451 NA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:3313] ENSG00000107951 MTPAP mitochondrial poly(A) polymerase −0.117424914 -0.117424914 [Source:HGNC Symbol;Acc:HGNC:25532] ENSG00000108406 DHX40 DEAH (Asp-Glu-Ala-His) box 0.107679358 0.107679358 polypeptide 40 [Source:HGNC Symbol;Acc:HGNC:18018] ENSG00000109320 NFKB1 nuclear factor of kappa light 0.136994942 0.136994942 polypeptide gene enhancer in B-cells 1 [Source:HGNC Symbol;Acc:HGNC:7794] ENSG00000109790 KLHL5 kelch-like family member 5 0.507065945 0.507065945 [Source:HGNC Symbol;Acc:HGNC:6356] ENSG00000110002 VWA5A von Willebrand factor A domain −0.151667695 −0.151667695 containing 5A [Source:HGNC Symbol;Acc:HGNC:6658] ENSG00000111215 PRR4 proline rich 4 (lacrimal) 0.122484607 0.122484607 [Source:HGNC Symbol;Acc:HGNC:18020] ENSG00000111237 VPS29 vacuolar protein sorting 29 homolog −0.133121148 -0.133121148 (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:14340] ENSG00000111897 SERINC serine incorporator 1 [Source:HGNC −0.284161954 −0.284161954 1 Symbol;Acc:HGNC:13464] ENSG00000112561 TFEB transcription factor EB [Source:HGNC 0.129049727 0.129049727 Symbol;Acc:HGNC:11753] ENSG00000114013 CD86 CD86 molecule [Source:HGNC −0.102716542 −0.102716542 Symbol;Acc:HGNC:1705] ENSG00000114054 PCCB propionyl CoA carboxylase, beta −0.155835905 −0.155835905 polypeptide [Source:HGNC Symbol;Acc:HGNC:8654] ENSG00000115241 PPM1G protein phosphatase, Mg2+/Mn2+ 0.150004827 0.150004827 dependent, 1G [Source:HGNC Symbol;Acc:HGNC:9278] ENSG00000115641 FHL2 four and a half LIM domains 2 −0.233055563 −0.233055563 [Source:HGNC Symbol;Acc:HGNC:3703] ENSG00000116984 MTR 5-methyltetrahydrofolate- 0.247644585 0.247644585 homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] ENSG00000118307 CASC1 cancer susceptibility candidate 1 0.101482267 NA [Source:HGNC Symbol;Acc:HGNC:29599] ENSG00000119471 HSDL2 hydroxysteroid dehydrogenase like 2 0.134747511 0.134747511 [Source:HGNC Symbol;Acc:HGNC:18572] ENSG00000120685 PROSE proline and serine rich 1 −0.29165743 −0.29165743 R1 [Source:HGNC Symbol;Acc:HGNC:20291] ENSG00000120889 TNFRS tumor necrosis factor receptor −0.102924238 −0.102924238 F10B superfamily, member 10b [Source:HGNC Symbol;Acc:HGNC:11905] ENSG00000122497 NA NA −0.164022762 NA ENSG00000124191 TOX2 TOX high mobility group box family −0.140050174 −0.140050174 member 2 [Source:HGNC Symbol;Acc:HGNC:16095] ENSG00000127952 STYXL1 serine/threonine/tyrosine interacting- −0.193382641 −0.193382641 like 1 [Source:HGNC Symbol;Acc:HGNC:18165] ENSG00000128383 APOBE apolipoprotein B mRNA editing −0.108821233 −0.108821233 C3A enzyme, catalytic polypeptide-like 3A [Source:HGNC Symbol;Acc:HGNC:17343] ENSG00000129315 CCNT1 cyclin T1 [Source:HGNC 0.177435166 0.177435166 Symbol;Acc:HGNC:1599] ENSG00000130176 CNN1 calponin 1, basic, smooth muscle −0.133567285 −0.133567285 [Source:HGNC Symbol;Acc:HGNC:2155] ENSG00000130717 UCK1 uridine-cytidine kinase 1 0.115335421 NA [Source:HGNC Symbol;Acc:HGNC:14859] ENSG00000131351 HAUS8 HAUS augmin-like complex, subunit 8 −0.155439628 -0.155439628 [Source:HGNC Symbol;Acc:HGNC:30532] ENSG00000132530 XAF1 XIAP associated factor 1 −0.165628437 −0.165628437 [Source:HGNC Symbol;Acc:HGNC:30932] ENSG00000134825 TMEM2 transmembrane protein 258 −0.249985405 -0.249985405 58 [Source:HGNC Symbol;Acc:HGNC:1164] ENSG00000135677 GNS glucosamine (N-acetyl)-6-sulfatase −0.166966877 −0.166966877 [Source:HGNC Symbol;Acc:HGNC:4422] ENSG00000135838 NPL N-acetylneuraminate pyruvate lyase −0.162836999 −0.162836999 (dihydrodipicolinate synthase) [Source:HGNC Symbol;Acc:HGNC:16781] ENSG00000136193 SCRN1 secernin 1 [Source:HGNC 0.12810643 0.12810643 Symbol;Acc:HGNC:22192] ENSG00000136861 CDK5R CDK5 regulatory subunit associated 0.314399885 0.314399885 AP2 protein 2 [Source:HGNC Symbol;Acc:HGNC:18672] ENSG00000138035 PNPT1 polyribonucleotide 0.100640869 0.100640869 nucleotidyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23166] ENSG00000139192 TAPBPL TAP binding protein-like −0.111668814 −0.111668814 [Source:HGNC Symbol;Acc:HGNC:30683] ENSG00000139372 TDG thymine-DNA glycosylase −0.104151038 -0.104151038 [Source:HGNC Symbol;Acc:HGNC:11700] ENSG00000140497 SCAMP secretory carrier membrane protein 2 −0.170271333 −0.170271333 2 [Source:HGNC Symbol;Acc:HGNC:10564] ENSG00000140718 FTO fat mass and obesity associated 0.408281748 0.408281748 [Source:HGNC Symbol;Acc:HGNC:24678] ENSG00000140740 UQCRC ubiquinol-cytochrome c reductase 0.143643681 0.143643681 2 core protein 11 [Source:HGNC Symbol;Acc:HGNC:12586] ENSG00000140968 1RF8 interferon regulatory factor 8 0.166151883 0.166151883 [Source:HGNC Symbol;Acc:HGNC:5358] ENSG00000141076 CIRH1A cirrhosis, autosomal recessive 1A −0.19393658 −0.19393658 (cirhin) [Source:HGNC Symbol;Acc:HGNC:1983] ENSG00000141179 PCTP phosphatidylcholine transfer protein 0.769728362 0.769728362 [Source:HGNC Symbol;Acc:HGNC:8752] ENSG00000141720 NA NA 0.181018618 0.181018618 ENSG00000143149 ALDH9 aldehyde dehydrogenase 9 family, 0.160034228 0.160034228 A1 member A1 [Source:HGNC Symbol;Acc:HGNC:412] ENSG00000143595 AQP10 aquaporin 10 [Source:HGNC −0.19468292 −0.19468292 Symbol;Acc:HGNC:16029] ENSG00000143891 GALM galactose mutarotase (aldose 1- 0.108215249 0.108215249 epimerase) [Source:HGNC Symbol;Acc:HGNC:24063] ENSG00000145348 TBCK TBC1 domain containing kinase −0.189315008 −0.189315008 [Source:HGNC Symbol;Acc:HGNC:28261] ENSG00000145819 ARHGA Rho GTPase activating protein 26 −0.346909798 −0.346909798 P26 [Source:HGNC Symbol;Acc:HGNC:17073] ENSG00000146192 FGD2 FYVE, RhoGEF and PH domain −0.294768171 −0.294768171 containing 2 [Source:HGNC Symbol;Acc:HGNC:3664] ENSG00000146574 CCZ1B CCZ1 vacuolar protein trafficking and −0.115351222 −0.115351222 biogenesis associated homolog B (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:21717] ENSG00000152022 NA NA 0.107661715 0.107661715 ENSG00000156097 GPR61 G protein-coupled receptor 61 −0.163461044 NA [Source:HGNC Symbol;Acc:HGNC:13300] ENSG00000160094 ZNF362 zinc finger protein 362 [Source:HGNC −0.154109596 −0.154109596 Symbol;Acc:HGNC:18079] ENSG00000160172 FAM86 family with sequence similarity 86, −0.110118467 NA C2P member C2, pseudogene [Source:HGNC Symbol;Acc:HGNC:42392] ENSG00000160584 SIK3 SIK family kinase 3 [Source:HGNC −0.221008005 −0.221008005 Symbol;Acc:HGNC:29165] ENSG00000162236 STX5 syntaxin 5 [Source:HGNC −0.122245068 −0.122245068 Symbol;Acc:HGNC:11440] ENSG00000163162 RNF149 ring finger protein 149 [Source:HGNC −0.125223232 -0.125223232 Symbol;Acc:HGNC:23137] ENSG00000163431 LMOD1 leiomodin 1 (smooth muscle) −0.113030654 NA [Source:HGNC Symbol;Acc:HGNC:6647] ENSG00000164691 TAGAP T-cell activation RhoGTPase −0.138824035 −0.138824035 activating protein [Source:HGNC Symbol;Acc:HGNC:15669] ENSG00000164896 FASTK Fas-activated serine/threonine kinase −0.122541379 −0.122541379 [Source:HGNC Symbol;Acc:HGNC:24676] ENSG00000165424 ZCCHC zinc finger, CCHC domain containing −0.110472325 −0.110472325 24 24 [Source:HGNC Symbol;Acc:HGNC:26911] ENSG00000165487 MICU2 mitochondrial calcium uptake 2 0.118609041 0.118609041 [Source:HGNC Symbol;Acc:HGNC:31830] ENSG00000165819 METTL3 methyltransferase like 3 0.128671739 0.128671739 [Source:HGNC Symbol;Acc:HGNC:17563] ENSG00000166446 CDYL2 chromodomain protein, Y-like 2 0.202817183 0.202817183 [Source:HGNC Symbol;Acc:HGNC:23030] ENSG00000166579 NDEL1 nudE neurodevelopment protein 1-like −0.24862421 −0.24862421 1 [Source:HGNC Symbol;Acc:HGNC:17620] ENSG00000166963 MAP1A microtubule-associated protein 1A 2.01678209 2.01678209 [Source:HGNC Symbol;Acc:HGNC:6835] ENSG00000167216 KATNA katanin p60 subunit A-like 2 0.148293565 NA L2 [Source:HGNC Symbol;Acc:HGNC:25387] ENSG00000167491 GATAD GATA zinc finger domain containing 0.713949079 0.713949079 2A 2A [Source:HGNC Symbol;Acc:HGNC:29989] ENSG00000167693 NXN nucleoredoxin [Source:HGNC −0.215655184 −0.215655184 Symbol;Acc:HGNC:18008] ENSG00000167740 CYB5D cytochrome b5 domain containing 2 −0.154529266 −0.154529266 2 [Source:HGNC Symbol;Acc:HGNC:28471] ENSG00000168394 TAP1 transporter 1, ATP-binding cassette, −0.190104087 −0.190104087 sub-family B (MDR/TAP) [Source:HGNC Symbol;Acc:HGNC:43] ENSG00000169018 FEM1B fern-1 homolog b (C. elegans) 0.143878826 0.143878826 [Source:HGNC Symbol;Acc:HGNC:3649] ENSG00000169403 PTAFR platelet-activating factor receptor −0.197625182 −0.197625182 [Source:HGNC Symbol;Acc:HGNC:9582] ENSG00000170049 KCNAB potassium voltage-gated channel, −0.169352002 −0.169352002 3 shaker-related subfamily, beta member 3 [Source:HGNC Symbol;Acc:HGNC:6230] ENSG00000170365 SMAD1 SMAD family member 1 −0.274366666 −0.274366666 [Source:HGNC Symbol;Acc:HGNC:6767] ENSG00000170458 CD14 CD14 molecule [Source:HGNC 0.121428527 NA Symbol;Acc:HGNC:1628] ENSG00000170606 HSPA4 heat shock 70 kDa protein 4 0.162021198 0.162021198 [Source:HGNC Symbol;Acc:HGNC:5237] ENSG00000170876 TMEM4 transmembrane protein 43 −0.129208162 −0.129208162 3 [Source:HGNC Symbol;Acc:HGNC:28472] ENSG00000171466 ZNF562 zinc finger protein 562 [Source:HGNC 0.156962027 0.156962027 Symbol;Acc:HGNC:25950] ENSG00000171853 TRAPP trafficking protein particle complex 12 −0.191519409 −0.191519409 C12 [Source:HGNC Symbol;Acc:HGNC:24284] ENSG00000176177 ENTHD ENTH domain containing 1 0.151712936 NA 1 [Source:HGNC Symbol;Acc:HGNC:26352] ENSG00000177628 GBA glucosidase, beta, acid −0.110647138 −0.110647138 [Source:HGNC Symbol;Acc:HGNC:4177] ENSG00000178449 COX14 cytochrome c oxidase assembly −0.347340835 −0.347340835 homolog 14 (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:28216] ENSG00000181837 OR5D1 olfactory receptor, family 5, subfamily 0.120218825 NA 7P D, member 17 pseudogene [Source:HGNC Symbol;Acc:HGNC:15284] ENSG00000181929 PRKAG protein kinase, AMP-activated, −0.128936457 −0.128936457 1 gamma 1 non-catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9385] ENSG00000182022 CHST15 carbohydrate (N-acetylgalactosamine −0.132490353 −0.132490353 4-sulfate 6-0) sulfotransferase 15 [Source:HGNC Symbol;Acc:HGNC:18137] ENSG00000185052 SLC24A solute carrier family 24 0.500342517 0.500342517 3 (sodium/potassium/calcium exchanger), member 3 [Source:HGNC Symbol;Acc:HGNC:10977] ENSG00000188636 LDOC1 leucine zipper, down-regulated in 0.172136223 0.172136223 L cancer 1-like [Source:HGNC Symbol;Acc:HGNC:13343] ENSG00000189339 SLC35E solute carrier family 35, member E2B 0.128946098 0.128946098 2B [Source:HGNC Symbol;Acc:HGNC:33941] ENSG00000197006 METTL9 methyltransferase like 9 0.237131756 0.237131756 [Source:HGNC Symbol;Acc:HGNC:24586] ENSG00000197024 ZNF398 zinc finger protein 398 [Source:HGNC 0.152839795 0.152839795 Symbol;Acc:HGNC:18373] ENSG00000197170 PSMD1 proteasome (prosome, macropain) −0.18262561 −0.18262561 2 26S subunit, non-ATPase, 12 [Source:HGNC Symbol;Acc:HGNC:9557] ENSG00000197249 SERPIN serpin peptidase inhibitor, clade A −0.262362563 −0.262362563 A1 (alpha-1 antiproteinase, antitrypsin), member 1 [Source:HGNC Symbol;Acc:HGNC:8941] ENSG00000197989 SNHG1 small nucleolar RNA host gene 12 −0.281270998 −0.281270998 2 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:30062] ENSG00000198053 SIRPA signal-regulatory protein alpha −0.116808258 −0.116808258 [Source:HGNC Symbol;Acc:HGNC:9662] ENSG00000198682 PAPSS 3′-phosphoadenosine 5′- 0.277734156 0.277734156 2 phosphosulfate synthase 2 [Source:HGNC Symbol;Acc:HGNC:8604] ENSG00000198818 SFT2D1 SFT2 domain containing 1 −0.146314776 −0.146314776 [Source:HGNC Symbol;Acc:HGNC:21102] ENSG00000204427 ABHD1 abhydrolase domain containing 16A −0.123372105 −0.123372105 6A [Source:HGNC Symbol;Acc:HGNC:13921 ] ENSG00000206053 HN1L hematological and neurological −0.134975971 −0.134975971 expressed 1-like [Source:HGNC Symbol;Acc:HGNC:14137] ENSG00000206077 ZDHHC zinc finger, DHHC-type containing 0.13138876 NA 11B 11B [Source:HGNC Symbol;Acc:HGNC:32962] ENSG00000213023 SYT3 synaptotagmin III [Source:HGNC −0.135433001 −0.135433001 Symbol;Acc:HGNC:11511] ENSG00000213889 PPM1N protein phosphatase, Mg2+/Mn2+ −0.111596208 −0.111596208 dependent, 1N (putative) [Source:HGNC Symbol;Acc:HGNC:26845] ENSG00000215853 RPTN repetin [Source:HGNC −0.290132783 NA Symbol;Acc:HGNC:26809] ENSG00000230590 FTX FTX transcript, XIST regulator (non- −0.105300895 −0.105300895 protein coding) [Source:HGNC Symbol;Acc:HGNC:37190] ENSG00000232177 MTND4 MT-ND4 pseudogene 24 0.159020151 NA P24 [Source:HGNC Symbol;Acc:HGNC:42220] ENSG00000233614 DDX11L DEAD/H (Asp-Glu-Ala-Asp/His) box −1.173682324 NA 10 helicase 11 like 10 [Source:HGNC Symbol;Acc:HGNC:14125] ENSG00000234456 MAGI2- MAGI2 antisense RNA 3 0.90738652 0.90738652 AS3 [Source:HGNC Symbol;Acc:HGNC:40862] ENSG00000235568 NFAM1 NFAT activating protein with ITAM −0.188277675 −0.188277675 motif 1 [Source:HGNC Symbol;Acc:HGNC:29872] ENSG00000237973 MIR672 microRNA 6723 [Source:HGNC 14.86928693 14.86928693 3 Symbol;Acc:HGNC:50152] ENSG00000238083 LRRC37 leucine rich repeat containing 37, −0.161517096 −0.161517096 A2 member A2 [Source:HGNC Symbol;Acc:HGNC:32404] ENSG00000239437 RN7SL7 RNA, 75L, cytoplasmic 752, 0.20389067 NA 52P pseudogene [Source:HGNC Symbol;Acc:HGNC:46768] ENSG00000241468 ATP5J2 ATP synthase, H+ transporting, −0.159288511 −0.159288511 mitochondrial Fo complex, subunit F2 [Source:HGNC Symbol;Acc:HGNC:848] ENSG00000242588 0.162348015 0.162348015 ENSG00000245248 USP2- USP2 antisense RNA 1 (head to −0.161323318 −0.161323318 AS1 head) [Source:HGNC Symbol;Acc:HGNC:48673] ENSG00000245526 LINC00 long intergenic non-protein coding −0.1372132 −0.1372132 461 RNA 461 [Source:HGNC Symbol;Acc:HGNC:42810] ENSG00000248360 LINC00 long intergenic non-protein coding −0.127378703 −0.127378703 504 RNA 504 [Source:HGNC Symbol;Acc:HGNC:43555] ENSG00000248538 −0.182292708 NA ENSG00000250519 −0.124538483 NA ENSG00000251441 RTEL1P regulator of telomere elongation −0.111558201 NA 1 helicase 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44213] ENSG00000256050 0.201644537 NA ENSG00000262497 FAM187 family with sequence similarity 187, −0.112441006 NA B2P member B2, pseudogene [Source:HGNC Symbol;Acc:HGNC:49213]

TABLE 10 The highest impact sustained by the player in the game as measured by rotational acceleration regressed on RNA expression in plasma samples X0.5slope_ X0.8slope_ 0.1pvalue_0.1_ 0.1pvalue_0.1 hgnc_ Max_rot_acc_ Max_rot_acc_ Ensembl_ID symbol description plasma plasma ENSG00000198899 MT- mitochondrially encoded ATP −1.710072511 −1.710072511 ATP6 synthase 6 [Source:HGNC Symbol;Acc:HGNC:7414]

TABLE 11 The highest impact sustained by the player in the game as measured by the number of hits regressed on RNA expression in plasma samples X0.5slope_ X0.8slope_ 0.1pvalue_0.1_ 0.1pvalue_0.1_ hgnc_ Number_of_ Number_of_ Ensembl_ID symbol description hits_plasma hits_plasma ENSG00000002919 SNX11 sorting nexin 11 [Source:HGNC −0.18130183 −0.18130183 Symbol;Acc:HGNC:14975] ENSG00000006607 FARP2 FERM, RhoGEF and pleckstrin −0.413103168 −0.413103168 domain protein 2 [Source:HGNC Symbol;Acc:HGNC:16460] ENSG00000010219 DYRK4 dual-specificity tyrosine-(Y)- −0.268530317 −0.268530317 phosphorylation regulated kinase 4 [Source:HGNC Symbol;Acc:HGNC:3095] ENSG00000011021 CLCN6 chloride channel, voltage-sensitive −0.300156067 −0.300156067 6 [Source:HGNC Symbol;Acc:HGNC:2024] ENSG00000011132 APBA3 amyloid beta (A4) precursor protein- 0.16775879 0.16775879 binding, family A, member 3 [Source:HGNC Symbol;Acc:HGNC:580] ENSG00000011638 TMEM1 transmembrane protein 159 −0.228627306 −0.228627306 59 [Source:HGNC Symbol;Acc:HGNC:30136] ENSG00000012061 ERCC1 excision repair cross- −0.190496391 −0.190496391 complementation group 1 [Source:HGNC Symbol;Acc:HGNC:3433] ENSG00000013306 SLC25A solute carrier family 25, member 39 0.71738695 0.71738695 39 [Source:HGNC Symbol;Acc:HGNC:24279] ENSG00000029559 IBSP integrin-binding sialoprotein −0.273970392 NA [Source:HGNC Symbol;Acc:HGNC:5341] ENSG00000036530 CYP46A cytochrome P450, family 46, −0.341725844 −0.341725844 1 subfamily A, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:2641] ENSG00000047230 CTPS2 CTP synthase 2 [Source:HGNC 0.152436371 0.152436371 Symbol;Acc:HGNC:2520] ENSG00000047932 GOPC golgi-associated PDZ and coiled- 0.41112031 0.41112031 coil motif containing [Source:HGNC Symbol;Acc:HGNC:17643] ENSG00000050327 ARHGE Rho guanine nucleotide exchange −0.172498356 −0.172498356 F5 factor (GEF) 5 [Source:HGNC Symbol;Acc:HGNC:13209] ENSG00000052841 TTC17 tetratricopeptide repeat domain 17 −0.333510806 −0.333510806 [Source:HGNC Symbol;Acc:HGNC:25596] ENSG00000053372 MRT04 mRNA turnover 4 homolog (S. −0.282938139 −0.282938139 cerevisiae) [Source:HGNC Symbol;Acc:HGNC:18477] ENSG00000056277 ZNF280 zinc finger protein 280C −0.119273171 NA C [Source:HGNC Symbol;Acc:HGNC:25955] ENSG00000060558 GNA15 guanine nucleotide binding protein 0.383424973 0.383424973 (G protein), alpha 15 (Gq class) [Source:HGNC Symbol;Acc:HGNC:4383] ENSG00000061936 SFSWA splicing factor, suppressor of white- −0.328160243 −0.328160243 P apricot family [Source:HGNC Symbol;Acc:HGNC:10790] ENSG00000061987 MON2 MON2 homolog (S. cerevisiae) −0.247236391 −0.247236391 [Source:HGNC Symbol;Acc:HGNC:29177] ENSG00000063244 U2AF2 U2 small nuclear RNA auxiliary 0.384874145 0.384874145 factor 2 [Source:HGNC Symbol;Acc:HGNC:23156] ENSG00000064012 CASP8 caspase 8, apoptosis-related −0.301014707 −0.301014707 cysteine peptidase [Source:HGNC Symbol;Acc:HGNC:1509] ENSG00000065054 SLC9A3 solute carrier family 9, subfamily A 0.475185163 0.475185163 R2 (NHE3, cation proton antiporter 3), member 3 regulator 2 [Source:HGNC Symbol;Acc:HGNC:11076] ENSG00000065268 WDR18 WD repeat domain 18 0.140777372 NA [Source:HGNC Symbol;Acc:HGNC:17956] ENSG00000065883 CDK13 cyclin-dependent kinase 13 0.491099008 0.491099008 [Source:HGNC Symbol;Acc:HGNC:1733] ENSG00000066557 LRRC40 leucine rich repeat containing 40 0.154029534 NA [Source:HGNC Symbol;Acc:HGNC:26004] ENSG00000067369 TP53BP tumor protein p53 binding protein 1 −0.45179204 −0.45179204 1 [Source:HGNC Symbol;Acc:HGNC:11999] ENSG00000068745 IP6K2 inositol hexakisphosphate kinase 2 −0.340595998 −0.340595998 [Source:HGNC Symbol;Acc:HGNC:17313] ENSG00000072364 AFF4 AF4/FMR2 family, member 4 −0.377940237 −0.377940237 [Source:HGNC Symbol;Acc:HGNC:17869] ENSG00000074755 ZZEF1 zinc finger, ZZ-type with EF-hand −0.547759839 −0.547759839 domain 1 [Source:HGNC Symbol;Acc:HGNC:29027] ENSG00000075856 SART3 squamous cell carcinoma antigen −0.290538331 −0.290538331 recognized by T cells 3 [Source:HGNC Symbol;Acc:HGNC:16860] ENSG00000076382 SPAG5 sperm associated antigen 5 −0.294534162 −0.294534162 [Source:HGNC Symbol;Acc:HGNC:13452] ENSG00000077380 DYNC1I dynein, cytoplasmic 1, intermediate 0.316867603 0.316867603 2 chain 2 [Source:HGNC Symbol;Acc:HGNC:2964] ENSG00000077984 CST7 cystatin F (leukocystatin) 0.878464548 0.878464548 [Source:HGNC Symbol;Acc:HGNC:2479] ENSG00000078808 SDF4 stromal cell derived factor 4 0.767915274 0.767915274 [Source:HGNC Symbol;Acc:HGNC:24188] ENSG00000079313 REXO1 REX1, RNA exonuclease 1 0.251033654 0.251033654 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:24616] ENSG00000079332 SAR1A secretion associated, Ras related 0.385716192 0.385716192 GTPase 1A [Source:HGNC Symbol;Acc:HGNC:10534] ENSG00000081791 KIAA01 KIAA0141 [Source:HGNC −0.22694511 −0.22694511 41 Symbol;Acc:HGNC:28969] ENSG00000083099 LYRM2 LYR motif containing 2 −0.154230851 −0.154230851 [Source:HGNC Symbol;Acc:HGNC:25229] ENSG00000083635 NUFIP1 nuclear fragile X mental retardation −0.193120866 −0.193120866 protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8057] ENSG00000084234 APLP2 amyloid beta (A4) precursor-like −0.445100705 −0.445100705 protein 2 [Source:HGNC Symbol;Acc:HGNC:598] ENSG00000085719 CPNE3 copine III [Source:HGNC 0.337011459 0.337011459 Symbol;Acc:HGNC:2316] ENSG00000085978 ATG16L autophagy related 16-like 1 (S. −0.224370196 −0.224370196 1 cerevisiae) [Source:HGNC Symbol;Acc:HGNC:21498] ENSG00000086730 LAT2 linker for activation of T cells family, −0.15860923 −0.15860923 member 2 [Source:HGNC Symbol;Acc:HGNC:12749] ENSG00000087111 PIGS phosphatidylinositol glycan anchor −0.218275213 −0.218275213 biosynthesis, class S [Source:HGNC Symbol;Acc:HGNC:14937] ENSG00000087191 PSMC5 proteasome (prosome, macropain) −0.316917034 −0.316917034 26S subunit, ATPase, 5 [Source:HGNC Symbol;Acc:HGNC:9552] ENSG00000087589 CASS4 Cas scaffolding protein family −0.164417008 −0.164417008 member 4 [Source:HGNC Symbol;Acc:HGNC:15878] ENSG00000087884 AAMDC adipogenesis associated, Mth938 −0.146359987 NA domain containing [Source:HGNC Symbol;Acc:HGNC:30205] ENSG00000089177 K1F16B kinesin family member 16B −0.270083492 −0.270083492 [Source:HGNC Symbol;Acc:HGNC:15869] ENSG00000091164 TXNL1 thioredoxin-like 1 [Source:HGNC −0.271836525 −0.271836525 Symbol;Acc:HGNC:12436] ENSG00000092098 RNF31 ring finger protein 31 −0.234769781 −0.234769781 [Source:HGNC Symbol;Acc:HGNC:16031] ENSG00000099810 MTAP methylthioadenosine phosphorylase −0.177894282 −0.177894282 [Source: HGNC Symbol;Acc:HGNC:7413] ENSG00000100181 TPTEP1 transmembrane phosphatase with 4.020177071 4.020177071 tensin homology pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43648] ENSG00000100359 SGSM3 small G protein signaling modulator 0.279110078 0.279110078 3 [Source:HGNC Symbol;Acc:HGNC:25228] ENSG00000100811 YY1 YY1 transcription factor 0.639748136 0.639748136 [Source:HGNC Symbol;Acc:HGNC:12856] ENSG00000100836 PABPN poly(A) binding protein, nuclear 1 0.135052692 0.135052692 1 [Source:HGNC Symbol;Acc:HGNC:8565] ENSG00000100938 GMPR2 guanosine monophosphate −0.367031082 −0.367031082 reductase 2 [Source:HGNC Symbol;Acc:HGNC:4377] ENSG00000101266 CSNK2 casein kinase 2, alpha 1 0.215976365 0.215976365 A1 polypeptide [Source:HGNC Symbol;Acc:HGNC:2457] ENSG00000101337 TM9SF4 transmembrane 9 superfamily −0.327607154 −0.327607154 protein member 4 [Source:HGNC Symbol;Acc:HGNC:30797] ENSG00000101452 DHX35 DEAH (Asp-Glu-Ala-His) box −0.271561028 −0.271561028 polypeptide 35 [Source:HGNC Symbol;Acc:HGNC:15861] ENSG00000102003 SYP synaptophysin [Source:HGNC −0.232683457 NA Symbol;Acc:HGNC:11506] ENSG00000102024 PLS3 plastin 3 [Source:HGNC 0.134990538 NA Symbol;Acc:HGNC:9091] ENSG00000102053 ZC3H12 zinc finger CCCH-type containing B 12B [Source:HGNC −0.202615192 −0.202615192 Symbol;Acc:HGNC:17407] ENSG00000102174 PHEX phosphate regulating −0.122550026 NA endopeptidase homolog, X-linked [Source:HGNC Symbol;Acc:HGNC:8918] ENSG00000102743 SLC25A solute carrier family 25 −0.144896419 −0.144896419 15 (mitochondrial carrier; ornithine transporter) member 15 [Source:HGNC Symbol;Acc:HGNC:10985] ENSG00000102978 POLR2 polymerase (RNA) 11 (DNA directed) −0.200616615 −0.200616615 C polypeptide C, 33 kDa [Source:HGNC Symbol;Acc:HGNC:9189] ENSG00000103260 METRN meteorin, glial cell differentiation 0.119367309 NA regulator [Source:HGNC Symbol;Acc:HGNC:14151] ENSG00000103569 AQP9 aquaporin 9 [Source:HGNC −0.127208941 −0.127208941 Symbol;Acc:HGNC:643] ENSG00000104518 GSDMD gasdermin D [Source:HGNC 0.319544945 0.319544945 Symbol;Acc:HGNC:25697] ENSG00000104722 NEFM neurofilament, medium polypeptide −0.1251566 NA [Source:HGNC Symbol;Acc:HGNC:7734] ENSG00000104964 AES amino-terminal enhancer of split 0.932109933 0.932109933 [Source:HGNC Symbol;Acc:HGNC:307] ENSG00000105383 CD33 CD33 molecule [Source:HGNC −0.334137071 −0.334137071 Symbol;Acc:HGNC:1659] ENSG00000105619 TFPT TCF3 (E2A) fusion partner (in 0.229743673 NA childhood Leukemia) [Source:HGNC Symbol;Acc:HGNC:13630] ENSG00000105792 CFAP69 cilia and flagella associated protein −0.279866829 NA 69 [Source:HGNC Symbol;Acc:HGNC:26107] ENSG00000105821 DNAJC DnaJ (Hsp40) homolog, subfamily 0.279798004 0.279798004 2 C, member 2 [Source:HGNC Symbol;Acc:HGNC:13192] ENSG00000105879 CBLL1 Cbl proto-oncogene-like 1, E3 −0.297249955 −0.297249955 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:21225] ENSG00000105971 CAV2 caveolin 2 [Source:HGNC −0.389555214 −0.389555214 Symbol;Acc:HGNC:1528] ENSG00000106628 POLD2 polymerase (DNA directed), delta 2, 0.196918487 0.196918487 accessory subunit [Source:HGNC Symbol;Acc:HGNC:9176] ENSG00000106772 PRUNE prune homolog 2 (Drosophila) −0.769920327 −0.769920327 2 [Source:HGNC Symbol;Acc:HGNC:25209] ENSG00000106803 SEC61B 5ec61 beta subunit [Source:HGNC −0.115862109 −0.115862109 Symbol;Acc:HGNC:16993] ENSG00000107829 FBXW4 F-box and WD repeat domain −0.38916892 −0.38916892 containing 4 [Source:HGNC Symbol;Acc:HGNC:10847] ENSG00000108219 TSPAN tetraspanin 14 [Source:HGNC −0.593916068 −0.593916068 14 Symbol;Acc:HGNC:23303] ENSG00000108344 PSMD3 proteasome (prosome, macropain) −0.253290858 −0.253290858 26S subunit, non-ATPase, 3 [Source:HGNC Symbol;Acc:HGNC:9560] ENSG00000108439 PNPO pyridoxamine 5′-phosphate oxidase −0.105362262 −0.105362262 [Source:HGNC Symbol;Acc:HGNC:30260] ENSG00000108465 CDK5R CDK5 regulatory subunit associated −0.338333206 −0.338333206 AP3 protein 3 [Source:HGNC Symbol;Acc:HGNC:18673] ENSG00000109272 PF4V1 platelet factor 4 variant 1 11.0501801 11.0501801 [Source:HGNC Symbol;Acc:HGNC:8862] ENSG00000109758 HGFAC HGF activator [Source:HGNC 0.264047523 NA Symbol;Acc:HGNC:4894] ENSG00000110079 M54A4 membrane-spanning 4-domains, −0.24370514 NA A subfamily A, member 4A [Source:HGNC Symbol;Acc:HGNC:13371] ENSG00000110107 PRPF19 pre-mRNA processing factor 19 0.780895954 0.780895954 [Source:HGNC Symbol;Acc:HGNC:17896] ENSG00000110108 TMEM1 transmembrane protein 109 −0.168302183 −0.168302183 09 [Source:HGNC Symbol;Acc:HGNC:28771] ENSG00000110169 HPX hemopexin [Source:HGNC −0.257263857 NA Symbol;Acc:HGNC:5171 ] ENSG00000111237 VPS29 vacuolar protein sorting 29 homolog −0.228985346 −0.228985346 (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:14340] ENSG00000111729 CLEC4 C-type lectin domain family 4, −0.122305695 NA A member A [Source:HGNC Symbol;Acc:HGNC:13257] ENSG00000111860 CEP85L centrosomal protein 85 kDa-like −0.18194886 −0.18194886 [Source:HGNC Symbol;Acc:HGNC:21638] ENSG00000111880 RNGTT RNA guanylyltransferase and 5- −0.162725004 −0.162725004 phosphatase [Source:HGNC Symbol;Acc:HGNC:10073] ENSG00000112561 TFEB transcription factor EB 0.187014223 0.187014223 [Source:HGNC Symbol;Acc:HGNC:11753] ENSG00000112812 PRSS16 protease, serine, 16 (thymus) −0.513500979 −0.513500979 [Source:HGNC Symbol;Acc:HGNC:9480] ENSG00000113658 SMAD5 SMAD family member 5 2.438979927 2.438979927 [Source:HGNC Symbol;Acc:HGNC:6771] ENSG00000114021 NIT2 nitrilase family, member 2 −0.149608143 NA [Source:HGNC Symbol;Acc:HGNC:29878] ENSG00000115267 IFIH1 interferon induced with helicase C −0.103073933 −0.103073933 domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] ENSG00000115484 CCT4 chaperon in containing TCP1, 0.282495067 0.282495067 subunit 4 (delta) [Source:HGNC Symbol;Acc:HGNC:1617] ENSG00000115486 GGCX gamma-glutamyl carboxylase −0.282843188 −0.282843188 [Source:HGNC Symbol;Acc:HGNC:4247] ENSG00000115504 EHBP1 EH domain binding protein 1 0.342346276 0.342346276 [Source:HGNC Symbol;Acc:HGNC:29144] ENSG00000115896 PLCL1 phospholipase C-like 1 −0.238214243 −0.238214243 [Source:HGNC Symbol;Acc:HGNC:9063] ENSG00000116117 PARD3 par-3 family cell polarity regulator 0.776502959 0.776502959 B beta [Source:HGNC Symbol;Acc:HGNC:14446] ENSG00000117226 GBP3 guanylate binding protein 3 −0.224991748 −0.224991748 [Source:HGNC Symbol;Acc:HGNC:4184] ENSG00000117448 AKR1A1 aldo-keto reductase family 1, −0.165680072 −0.165680072 member A1 (aldehyde reductase) [Source:HGNC Symbol;Acc:HGNC:380] ENSG00000117481 NSUN4 NOP2/Sun domain family, member −0.470387718 −0.470387718 4 [Source:HGNC Symbol;Acc:HGNC:31802] ENSG00000117616 RSRP1 arginine/serine-rich protein 1 −0.379259917 −0.379259917 [Source:HGNC Symbol;Acc:HGNC:25234] ENSG00000117834 SLC5A9 solute carrier family 5 −0.324404916 −0.324404916 (sodium/sugar cotransporter), member 9 [Source:HGNC Symbol;Acc:HGNC:22146] ENSG00000119321 FKBP15 FK506 binding protein 15, 133 kDa −0.30904328 −0.30904328 [Source:HGNC Symbol;Acc:HGNC:23397] ENSG00000119725 ZNF410 zinc finger protein 410 −0.156064848 −0.156064848 [Source:HGNC Symbol;Acc:HGNC:20144] ENSG00000119943 PYROX pyridine nucleotide-disulphide −0.283809537 −0.283809537 D2 oxidoreductase domain 2 [Source:HGNC Symbol;Acc:HGNC:23517] ENSG00000120662 MTRF1 mitochondrial translational release 0.167354665 0.167354665 factor 1 [Source:HGNC Symbol;Acc:HGNC:7469] ENSG00000120708 TGFBI transforming growth factor, beta- −0.401291447 −0.401291447 induced, 68 kDa [Source:HGNC Symbol;Acc:HGNC:11771] ENSG00000120889 TNFRS tumor necrosis factor receptor −0.159792098 −0.159792098 superfamily, member 10b F10B [Source:HGNC Symbol;Acc:HGNC:11905] ENSG00000121481 RNF2 ring finger protein 2 [Source:HGNC −0.172574383 −0.172574383 Symbol;Acc:HGNC:10061 ] ENSG00000122484 RPAP2 RNA polymerase 11 associated −0.477597758 −0.477597758 protein 2 [Source:HGNC Symbol;Acc:HGNC:25791] ENSG00000124459 ZNF45 zinc finger protein 45 −0.157277664 −0.157277664 [Source:HGNC Symbol;Acc:HGNC:13111] ENSG00000124541 RRP36 ribosomal RNA processing 36 0.165299754 0.165299754 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:21374] ENSG00000124588 NQO2 NAD(P)H dehydrogenase, quinone −0.213251218 −0.213251218 2 [Source:HGNC Symbol;Acc:HGNC:7856] ENSG00000124602 UNC5C unc-5 homolog C (C. elegans)-like −0.181414722 NA L [Source:HGNC Symbol;Acc:HGNC:21203] ENSG00000125166 GOT2 glutamic-oxaloacetic transaminase 0.164458841 0.164458841 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:4433] ENSG00000125445 MRPS7 mitochondrial ribosomal protein S7 −0.185603919 −0.185603919 [Source:HGNC Symbol;Acc:HGNC:14499] ENSG00000125630 POLR1 polymerase (RNA) I polypeptide B, −0.265939431 −0.265939431 B 128 kDa [Source:HGNC Symbol;Acc:HGNC:20454] ENSG00000125633 CCDC9 coiled-coil domain containing 93 −0.316544829 −0.316544829 3 [Source:HGNC Symbol;Acc:HGNC:25611] ENSG00000125779 PANK2 pantothenate kinase 2 −0.21463338 −0.21463338 [Source:HGNC Symbol;Acc:HGNC:15894] ENSG00000125846 ZNF133 zinc finger protein 133 −0.303985979 −0.303985979 [Source:HGNC Symbol;Acc:HGNC:12917] ENSG00000125997 BPI fold containing family B, −0.115137701 NA P BPIFB9 member 9, pseudogene [Source:HGNC Symbol;Acc:HGNC:16109] ENSG00000126012 KDM5C lysine (K)-specific demethylase 5C −0.327948032 −0.327948032 [Source:HGNC Symbol;Acc:HGNC:11114] ENSG00000126216 TUBGC tubulin, gamma complex associated −0.276604625 −0.276604625 P3 protein 3 [Source:HGNC Symbol;Acc:HGNC:18598] ENSG00000126461 SCAF1 SR-related CTD-associated factor 1 0.228635347 0.228635347 [Source:HGNC Symbol;Acc:HGNC:30403] ENSG00000126653 NSRP1 nuclear speckle splicing regulatory −0.308333688 −0.308333688 protein 1 [Source:HGNC Symbol;Acc:HGNC:25305] ENSG00000128383 APOBE apolipoprotein B mRNA editing −0.167275864 −0.167275864 C3A enzyme, catalytic polypeptide-like 3A [Source:HGNC Symbol;Acc:HGNC:17343] ENSG00000128881 TTBK2 tau tubulin kinase 2 [Source:HGNC −0.288481704 −0.288481704 Symbol;Acc:HGNC:19141] ENSG00000130589 HELZ2 helicase with zinc finger 2, 0.458283236 0.458283236 transcriptional coactivator [Source:HGNC Symbol;Acc:HGNC:30021] ENSG00000130600 H19 H19, imprinted maternally 2.354612983 2.354612983 expressed transcript (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:4713] ENSG00000130703 OSBPL oxysterol binding protein-like 2 0.364186697 0.364186697 2 [Source:HGNC Symbol;Acc:HGNC:15761] ENSG00000130935 NOL11 nucleolar protein 11 [Source:HGNC −0.143170588 −0.143170588 Symbol;Acc:HGNC:24557] ENSG00000131016 AKAP12 A kinase (PRKA) anchor protein 12 −0.284729614 −0.284729614 [Source:HGNC Symbol;Acc:HGNC:370] ENSG00000131068 DEFB11 defensin, beta 118 [Source:HGNC −0.103207397 NA 8 Symbol;Acc:HGNC:16196] ENSG00000131469 RPL27 ribosomal protein L27 1.593865307 1.593865307 [Source:HGNC Symbol;Acc:HGNC:10328] ENSG00000131508 UBE2D ubiquitin-conjugating enzyme E2D 2 0.917517388 0.917517388 2 [Source:HGNC Symbol;Acc:HGNC:12475] ENSG00000132530 XAF1 XIAP associated factor 1 −0.317553234 −0.317553234 [Source:HGNC Symbol;Acc:HGNC:30932] ENSG00000133106 EPSTI1 epithelial stromal interaction 1 0.368204938 0.368204938 (breast) [Source:HGNC Symbol;Acc:HGNC:16465] ENSG00000133460 SLC2A1 solute carrier family 2 (facilitated −0.796053407 −0.796053407 1 glucose transporter), member 11 [Source:HGNC Symbol;Acc:HGNC:14239] ENSG00000133704 1PO8 importin 8 [Source:HGNC −0.196186167 −0.196186167 Symbol;Acc:HGNC:9853] ENSG00000133835 HSD17 hydroxysteroid (17-beta) −0.264490829 −0.264490829 B4 dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] ENSG00000134184 GSTM1 glutathione 5-transferase mu 1 0.190616913 NA [Source:HGNC Symbol;Acc:HGNC:4632] ENSG00000134330 IAH1 isoamyl acetate-hydrolyzing −0.186984626 −0.186984626 esterase 1 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:27696] ENSG00000134853 PDGFR platelet-derived growth factor −0.258883375 −0.258883375 A receptor, alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:8803] ENSG00000134899 ERCC5 excision repair cross- 0.188493076 0.188493076 complementation group 5 [Source:HGNC Symbol;Acc:HGNC:3437] ENSG00000134954 ETS1 v-ets avian erythroblastosis virus 1.367586635 1.367586635 E26 oncogene homolog 1 [Source:HGNC Symbol;Acc:HGNC:3488] ENSG00000135074 ADAM1 ADAM metallopeptidase domain 19 −0.285510493 −0.285510493 9 [Source:HGNC Symbol;Acc:HGNC:197] ENSG00000135249 RINT1 RAD50 interactor 1 [Source:HGNC −0.172799072 −0.172799072 Symbol;Acc:HGNC:21876] ENSG00000135776 ABCB10 ATP-binding cassette, sub-family B 0.138199013 0.138199013 (MDR/TAP), member 10 [Source:HGNC Symbol;Acc:HGNC:41] ENSG00000135828 RNASE ribonuclease L (2′,5′- −0.233082 −0.233082 L oligoisoadenylate synthetase- dependent) [Source:HGNC Symbol;Acc:HGNC:10050] ENSG00000135925 WNT10 wingless-type MMTV integration 0.132456504 NA A site family, member 10A [Source:HGNC Symbol;Acc:HGNC:13829] ENSG00000136048 DRAM1 DNA-damage regulated autophagy −0.158362576 −0.158362576 modulator 1 [Source:HGNC Symbol;Acc:HGNC:25645] ENSG00000136869 TLR4 toll-like receptor 4 [Source:HGNC −0.187905349 −0.187905349 Symbol;Acc:HGNC:11850] ENSG00000136881 BAAT bile acid CoA:amino acid N- −0.179763218 NA acyltransferase [Source:HGNC Symbol;Acc:HGNC:932] ENSG00000137101 CD72 CD72 molecule [Source:HGNC −0.250696821 −0.250696821 Symbol;Acc:HGNC:1696] ENSG00000137337 MDC1 mediator of DNA-damage −0.435575453 −0.435575453 checkpoint 1 [Source:HGNC Symbol;Acc:HGNC:21163] ENSG00000137513 NARS2 asparaginyl-tRNA synthetase 2, −0.157310972 −0.157310972 mitochondrial (putative) [Source:HGNC Symbol;Acc:HGNC:26274] ENSG00000137713 PPP2R1 protein phosphatase 2, regulatory −0.393093416 −0.393093416 B subunit A, beta [Source:HGNC Symbol;Acc:HGNC:9303] ENSG00000137819 PAQR5 progestin and adipoQ receptor −0.269509334 NA family member V [Source:HGNC Symbol;Acc:HGNC:29645] ENSG00000137955 RABGG Rab geranylgeranyltransferase, −0.154111805 −0.154111805 TB beta subunit [Source:HGNC Symbol;Acc:HGNC:9796] ENSG00000137965 IFI44 interferon-induced protein 44 −0.122874288 −0.122874288 [Source:HGNC Symbol;Acc:HGNC:16938] ENSG00000138152 BTBD16 BTB (POZ) domain containing 16 0.34233563 NA [Source:HGNC Symbol;Acc:HGNC:26340] ENSG00000138297 NA NA −0.142481452 NA ENSG00000138459 SLC35A solute carrier family 35, member A5 −0.155735853 −0.155735853 5 [Source:HGNC Symbol;Acc:HGNC:20792] ENSG00000138796 HADH hydroxyacyl-CoA dehydrogenase 0.197773445 0.197773445 [Source:HGNC Symbol;Acc:HGNC:4799] ENSG00000139192 TAPBPL TAP binding protein-like −0.154699461 −0.154699461 [Source:HGNC Symbol;Acc:HGNC:30683] ENSG00000139436 GIT2 G protein-coupled receptor kinase −0.356554053 −0.356554053 interacting ArfGAP 2 [Source:HGNC Symbol;Acc:HGNC:4273] ENSG00000139515 PDX1 pancreatic and duodenal homeobox −0.163009091 NA 1 [Source:HGNC Symbol;Acc:HGNC:6107] ENSG00000139874 SSTR1 somatostatin receptor 1 −0.173526356 NA [Source:HGNC Symbol;Acc:HGNC:11330] ENSG00000140015 KCNH5 potassium voltage-gated channel, −0.291948339 NA subfamily H (eag-related), member 5 [Source:HGNC Symbol;Acc:HGNC:6254] ENSG00000140379 BCL2A1 BCL2-related protein A1 −0.189089134 NA [Source:HGNC Symbol;Acc:HGNC:991] ENSG00000140740 UQCRC ubiquinol-cytochrome c reductase 0.202041894 0.202041894 2 core protein 11 [Source:HGNC Symbol;Acc:HGNC:12586] ENSG00000141101 NOB1 NIN1/RPN12 binding protein 1 −0.14120592 −0.14120592 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:29540] ENSG00000141179 PCTP phosphatidylcholine transfer protein 0.946862159 0.946862159 [Source:HGNC Symbol;Acc:HGNC:8752] ENSG00000141391 SLMO1 slowmo homolog 1 (Drosophila) −0.121053874 NA [Source:HGNC Symbol;Acc:HGNC:24639] ENSG00000141582 CBX4 chromobox homolog 4 0.126638185 NA [Source:HGNC Symbol;Acc:HGNC:1554] ENSG00000141665 FBX015 F-box protein 15 [Source:HGNC −0.351552536 −0.351552536 Symbol;Acc:HGNC:13617] ENSG00000141858 SAMD1 sterile alpha motif domain 0.103377803 NA containing 1 [Source:HGNC Symbol;Acc:HGNC:17958] ENSG00000141946 ZIM3 zinc finger, imprinted 3 −0.129758699 NA [Source:HGNC Symbol;Acc:HGNC:16366] ENSG00000142856 ITGB3B integrin beta 3 binding protein 0.352560138 0.352560138 P (beta3-endonexin) [Source:HGNC Symbol;Acc:HGNC:6157] ENSG00000143226 FCGR2 Fc fragment of IgG, low affinity IIa, −0.339026469 −0.339026469 A receptor (CD32) [Source:HGNC Symbol;Acc:HGNC:3616] ENSG00000143314 MRPL2 mitochondrial ribosomal protein L24 0.167078328 0.167078328 4 [Source:HGNC Symbol;Acc:HGNC:14037] ENSG00000143390 RFX5 regulatory factor X, 5 (influences −0.273652914 −0.273652914 HLA class 11 expression) [Source:HGNC Symbol;Acc:HGNC:9986] ENSG00000143536 CRNN cornulin [Source:HGNC −0.504517688 −0.504517688 Symbol;Acc:HGNC:1230] ENSG00000143633 C1orf13 chromosome 1 open reading frame −0.296642104 −0.296642104 1 131 [Source:HGNC Symbol;Acc:HGNC:25332] ENSG00000143774 GUK1 guanylate kinase 1 [Source:HGNC 0.375454312 0.375454312 Symbol;Acc:HGNC:4693] ENSG00000144026 ZNF514 zinc finger protein 514 −0.159206514 −0.159206514 [Source:HGNC Symbol;Acc:HGNC:25894] ENSG00000144559 TAMM4 TAM41, mitochondrial translocator −0.202585771 −0.202585771 1 assembly and maintenance protein, homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:25187] ENSG00000144802 NFKBIZ nuclear factor of kappa light −0.30522935 −0.30522935 polypeptide gene enhancer in B- cells inhibitor, zeta [Source:HGNC Symbol;Acc:HGNC:29805] ENSG00000145214 DGKQ diacylglycerol kinase, theta 110 kDa 0.338305913 0.338305913 [Source:HGNC Symbol;Acc:HGNC:2856] ENSG00000145439 CBR4 carbonyl reductase 4 0.268785989 0.268785989 [Source:HGNC Symbol;Acc:HGNC:25891] ENSG00000145476 CYP4V2 cytochrome P450, family 4, −0.304900483 −0.304900483 subfamily V, polypeptide 2 [Source:HGNC Symbol;Acc:HGNC:23198] gamma-aminobutyric acid (GABA) ENSG00000145863 GABRA A receptor, alpha 6 [Source:HGNC −0.122296325 NA 6 Symbol;Acc:HGNC:4080] ENSG00000146192 FGD2 FYVE, RhoGEF and PH domain −0.433566775 −0.433566775 containing 2 [Source:HGNC Symbol;Acc:HGNC:3664] ENSG00000146535 GNA12 guanine nucleotide binding protein 0.559219799 0.559219799 (G protein) alpha 12 [Source:HGNC Symbol;Acc:HGNC:4380] ENSG00000147124 ZNF41 zinc finger protein 41 −0.16831668 −0.16831668 [Source:HGNC Symbol;Acc:HGNC:13107] ENSG00000147402 NA NA −0.17974862 NA ENSG00000147454 SLC25A solute carrier family 25 2.024656588 2.024656588 37 (mitochondrial iron transporter), member 37 [Source:HGNC Symbol;Acc:HGNC:29786] ENSG00000147471 PROSC proline synthetase co-transcribed 0.34892489 0.34892489 homolog (bacterial) [Source:HGNC Symbol;Acc:HGNC:9457] ENSG00000148219 ASTN2 astrotactin 2 [Source:HGNC −0.42723069 −0.42723069 Symbol;Acc:HGNC:17021] peptidase domain containing ENSG00000149090 PAMR1 associated with muscle −0.19414373 −0.19414373 regeneration 1 [Source:HGNC Symbol;Acc:HGNC:24554] ENSG00000149474 CSRP2 CSRP2 binding protein −0.17555367 −0.17555367 BP [Source:HGNC Symbol;Acc:HGNC:15904] ENSG00000149499 EML3 echinoderm microtubule associated −0.276933033 −0.276933033 protein like 3 [Source:HGNC Symbol;Acc:HGNC:26666] ENSG00000150457 LATS2 large tumor suppressor kinase 2 −0.152222375 −0.152222375 [Source:HGNC Symbol;Acc:HGNC:6515] ENSG00000151239 TWF1 twinfilin actin-binding protein 1 −0.132016998 NA [Source:HGNC Symbol;Acc:HGNC:9620] ENSG00000151572 ANO4 anoctamin 4 [Source:HGNC −0.332189885 −0.332189885 Symbol;Acc:HGNC:23837] ENSG00000151577 DRD3 dopamine receptor D3 −0.152498795 NA [Source:HGNC Symbol;Acc:HGNC:3024] ENSG00000151726 ACSL1 acyl-CoA synthetase long-chain −0.305164415 −0.305164415 family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] ENSG00000152049 KCNE4 potassium voltage-gated channel, −0.164073615 NA Isk-related family, member 4 [Source:HGNC Symbol;Acc:HGNC:6244] ENSG00000152219 ARL14E ADP-ribosylation factor-like 14 −0.165131265 −0.165131265 P effector protein [Source:HGNC Symbol;Acc:HGNC:26798] ENSG00000152348 ATG10 autophagy related 10 −0.189974522 −0.189974522 [Source:HGNC Symbol;Acc:HGNC:20315] ENSG00000152457 DCLRE DNA cross-link repair 1C −0.309025285 −0.309025285 1C [Source:HGNC Symbol;Acc:HGNC:17642] ENSG00000152591 DSPP dentin sialophosphoprotein −1.107310915 −1.107310915 [Source:HGNC Symbol;Acc:HGNC:3054] ENSG00000153560 UBP1 upstream binding protein 1 (LBP- 0.487512878 0.487512878 1a) [Source:HGNC Symbol;Acc:HGNC:12507] ENSG00000154065 ANKRD ankyrin repeat domain 29 −0.270364727 NA 29 [Source:HGNC Symbol;Acc:HGNC:27110] ENSG00000154217 PITPNC phosphatidylinositol transfer protein, 0.184098148 0.184098148 1 cytoplasmic 1 [Source:HGNC Symbol;Acc:HGNC:21045] ENSG00000154920 EME1 essential meiotic structure-specific −0.175166827 NA endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:24965] ENSG00000155307 SAMSN SAM domain, SH3 domain and −0.334492222 −0.334492222 1 nuclear localization signals 1 [Source:HGNC Symbol;Acc:HGNC:10528] ENSG00000155330 C16orf8 chromosome 16 open reading −0.196420793 −0.196420793 7 frame 87 [Source:HGNC Symbol;Acc:HGNC:33754] ENSG00000155749 ALS2C amyotrophic lateral sclerosis 2 0.17679216 0.17679216 R12 (juvenile) chromosome region, candidate 12 [Source:HGNC Symbol;Acc:HGNC:14439] ENSG00000155827 RNF20 ring finger protein 20, E3 ubiquitin −0.35020149 −0.35020149 protein ligase [Source:HGNC Symbol;Acc:HGNC:10062] ENSG00000156398 SFXN2 sideroflexin 2 [Source:HGNC −0.279110846 −0.279110846 Symbol;Acc:HGNC:16086] ENSG00000156650 KAT6B K(lysine) acetyltransferase 6B −0.343476766 −0.343476766 [Source:HGNC Symbol;Acc:HGNC:17582] ENSG00000157036 EXOG endo/exonuclease (5′-3′), −0.195141631 −0.195141631 endonuclease G-like [Source:HGNC Symbol;Acc:HGNC:3347] ENSG00000157542 KCNJ6 potassium inwardly-rectifying −0.52400914 −0.52400914 channel, subfamily J, member 6 [Source:HGNC Symbol;Acc:HGNC:6267] ENSG00000157827 FMNL2 formin-like 2 [Source:HGNC −0.296967858 −0.296967858 Symbol;Acc:HGNC:18267] ENSG00000158106 RHPN1 rhophilin, Rho GTPase binding 0.226466468 NA protein 1 [Source:HGNC Symbol;Acc:HGNC:19973] ENSG00000158352 SHROO shroom family member 4 −0.297192674 −0.297192674 M4 [Source:HGNC Symbol;Acc:HGNC:29215] ENSG00000158578 ALAS2 aminolevulinate, delta-, synthase 2 0.431841882 0.431841882 [Source:HGNC Symbol;Acc:HGNC:397] ENSG00000158987 RAPGE Rap guanine nucleotide exchange −0.166980492 −0.166980492 F6 factor (GEF) 6 [Source:HGNC Symbol;Acc:HGNC:20655] ENSG00000159339 PAD 14 peptidyl arginine deiminase, type IV −0.507543043 −0.507543043 [Source:HGNC Symbol;Acc:HGNC:18368] ENSG00000159398 CES5A carboxylesterase 5A [Source:HGNC −0.327309834 −0.327309834 Symbol;Acc:HGNC:26459] ENSG00000159674 SPON2 spondin 2, extracellular matrix 0.335120133 0.335120133 protein [Source:HGNC Symbol;Acc:HGNC:11253] ENSG00000160172 FAM86 family with sequence similarity 86, −0.159269559 NA C2P member C2, pseudogene [Source:HGNC Symbol;Acc:HGNC:42392] ENSG00000160233 LRRC3 leucine rich repeat containing 3 0.170594569 NA [Source:HGNC Symbol;Acc:HGNC:14965] ENSG00000160336 ZNF761 zinc finger protein 761 −0.162895236 −0.162895236 [Source:HGNC Symbol;Acc:HGNC:23179] ENSG00000160584 SIK3 SIK family kinase 3 [Source:HGNC −0.421688526 −0.421688526 Symbol;Acc:HGNC:29165] ENSG00000160818 GPATC G patch domain containing 4 −0.245177172 −0.245177172 H4 [Source:HGNC Symbol;Acc:HGNC:25982] ENSG00000161551 ZNF577 zinc finger protein 577 −0.18526194 −0.18526194 [Source:HGNC Symbol;Acc:HGNC:28673] ENSG00000162006 MSLNL mesothelin-like [Source:HGNC 0.184037758 NA Symbol;Acc:HGNC:14170] ENSG00000162086 ZNF75A zinc finger protein 75a −0.169535209 NA [Source:HGNC Symbol;Acc:HGNC:13146] ENSG00000162174 ASRGL asparaginase like 1 [Source:HGNC −0.239517911 −0.239517911 1 Symbol;Acc:HGNC:16448] ENSG00000162645 GBP2 guanylate binding protein 2, −0.538214742 −0.538214742 interferon-inducible [Source:HGNC Symbol;Acc:HGNC:4183] ENSG00000162695 SLC30A solute carrier family 30 (zinc −0.165053222 −0.165053222 7 transporter), member 7 [Source:HGNC Symbol;Acc:HGNC:19306] ENSG00000162733 DDR2 discoidin domain receptor tyrosine −0.37037397 −0.37037397 kinase 2 [Source:HGNC Symbol;Acc:HGNC:2731] ENSG00000162736 NCSTN nicastrin [Source:HGNC −0.299631159 −0.299631159 Symbol;Acc:HGNC:17091] ENSG00000163380 LMOD3 leiomodin 3 (fetal) [Source:HGNC −0.212595649 NA Symbol;Acc:HGNC:6649] ENSG00000163431 LMOD1 leiomodin 1 (smooth muscle) −0.170738272 NA [Source:HGNC Symbol;Acc:HGNC:6647] ENSG00000163463 KRTCA keratinocyte associated protein 2 −0.156575708 −0.156575708 P2 [Source:HGNC Symbol;Acc:HGNC:28942] ENSG00000163611 SPICE1 spindle and centriole associated −0.254944321 −0.254944321 protein 1 [Source:HGNC Symbol;Acc:HGNC:25083] ENSG00000163823 CCR1 chemokine (C-C motif) receptor 1 −0.146844607 −0.146844607 [Source:HGNC Symbol;Acc:HGNC:1602] ENSG00000164022 AIMP1 aminoacyl tRNA synthetase −0.135480176 NA complex-interacting multifunctional protein 1 [Source:HGNC Symbol;Acc:HGNC:10648] ENSG00000164056 SPRY1 sprouty homolog 1, antagonist of −0.223768011 −0.223768011 FGF signaling (Drosophila) [Source:HGNC Symbol;Acc:HGNC:11269] ENSG00000164134 NAA15 N(alpha)-acetyltransferase 15, NatA −0.283214671 −0.283214671 auxiliary subunit [Source:HGNC Symbol;Acc:HGNC:30782] ENSG00000164451 FAM26 family with sequence similarity 26, −0.134450736 NA D member D [Source:HGNC Symbol;Acc:HGNC:21094] ENSG00000164902 PHAX phosphorylated adaptor for RNA −0.195139648 −0.195139648 export [Source:HGNC Symbol;Acc:HGNC:10241] ENSG00000165028 NIPSNA nipsnap homolog 3B (C. elegans) 0.146588799 NA P3B [Source:HGNC Symbol;Acc:HGNC:23641] ENSG00000165091 TMC1 transmembrane channel-like 1 −0.232626923 NA [Source:HGNC Symbol;Acc:HGNC:16513] ENSG00000165120 SSMEM serine-rich single-pass membrane −0.126816678 NA 1 protein 1 [Source:HGNC Symbol;Acc:HGNC:29580] ENSG00000166164 BRD7 bromodomain containing 7 0.403386129 0.403386129 [Source:HGNC Symbol;Acc:HGNC:14310] ENSG00000166428 PLD4 phospholipase D family, member 4 0.217585702 0.217585702 [Source:HGNC Symbol;Acc:HGNC:23792] ENSG00000166432 ZMAT1 zinc finger, matrin-type 1 −0.114299765 NA [Source:HGNC Symbol;Acc:HGNC:29377] ENSG00000166579 NDEL1 nudE neurodevelopment protein 1- −0.576552434 −0.576552434 like 1 [Source:HGNC Symbol;Acc:HGNC:17620] ENSG00000166743 ACSM1 acyl-CoA synthetase medium-chain −0.215717692 −0.215717692 family member 1 [Source:HGNC Symbol;Acc:HGNC:18049] ENSG00000166825 ANPEP alanyl (membrane) aminopeptidase −0.503749533 −0.503749533 [Source:HGNC Symbol;Acc:HGNC:500] ENSG00000166928 MS4A14 membrane-spanning 4-domains, −0.204502412 −0.204502412 subfamily A, member 14 [Source:HGNC Symbol;Acc:HGNC:30706] ENSG00000167264 DUS2 dihydrouridine synthase 2 −0.218993775 −0.218993775 [Source:HGNC Symbol;Acc:HGNC:26014] ENSG00000167562 ZNF701 zinc finger protein 701 −0.206263045 −0.206263045 [Source:HGNC Symbol;Acc:HGNC:25597] ENSG00000167671 UBXN6 UBX domain protein 6 0.455725512 0.455725512 [Source:HGNC Symbol;Acc:HGNC:14928] ENSG00000167986 DDB1 damage-specific DNA binding −0.269982898 −0.269982898 protein 1, 127 kDa [Source:HGNC Symbol;Acc:HGNC:2717] ENSG00000168237 GLYCT glycerate kinase [Source:HGNC −0.228938069 −0.228938069 K Symbol;Acc:HGNC:24247] ENSG00000168405 CMAHP cytidine monophospho-N- 0.417242996 0.417242996 acetylneuraminic acid hydroxylase, pseudogene [Source:HGNC Symbol;Acc:HGNC:2098] ENSG00000168496 FEN1 flap structure-specific endonuclease −0.153126534 −0.153126534 1 [Source:HGNC Symbol;Acc:HGNC:3650] ENSG00000168899 VAMP5 vesicle-associated membrane 0.11902243 NA protein 5 [Source:HGNC Symbol;Acc:HGNC:12646] ENSG00000169410 PTPN9 protein tyrosine phosphatase, non- −0.162806486 −0.162806486 receptor type 9 [Source:HGNC Symbol;Acc:HGNC:9661] ENSG00000169583 CLIC3 chloride intracellular channel 3 0.420172779 NA [Source:HGNC Symbol;Acc:HGNC:2064] ENSG00000169814 BTD biotinidase [Source:HGNC −0.153315448 NA Symbol;Acc:HGNC:1122] ENSG00000170807 LMOD2 leiomodin 2 (cardiac) −0.12798119 NA [Source:HGNC Symbol;Acc:HGNC:6648] ENSG00000170954 ZNF415 zinc finger protein 415 −0.16348594 NA [Source:HGNC Symbol;Acc:HGNC:20636] ENSG00000171227 TMEM3 transmembrane protein 37 −0.137482976 NA 7 [Source:HGNC Symbol;Acc:HGNC:18216] ENSG00000171604 CXXC5 CXXC finger protein 5 0.297490763 0.297490763 [Source:HGNC Symbol;Acc:HGNC:26943] ENSG00000171649 ZIK1 zinc finger protein interacting with K −0.141838729 −0.141838729 protein 1 [Source:HGNC Symbol;Acc:HGNC:33104] ENSG00000171804 WDR87 WD repeat domain 87 −0.518560175 −0.518560175 [Source:HGNC Symbol;Acc:HGNC:29934] ENSG00000171860 C3AR1 complement component 3a receptor −0.193301684 NA 1 [Source:HGNC Symbol;Acc:HGNC:1319] ENSG00000172059 KLF11 Kruppel-like factor 11 0.341315009 0.341315009 [Source:HGNC Symbol;Acc:HGNC:11811] ENSG00000172367 PDZD3 PDZ domain containing 3 −0.177350325 NA [Source:HGNC Symbol;Acc:HGNC:19891] ENSG00000172653 NA NA −0.172022851 NA ENSG00000173334 TRIB1 tribbles pseudokinase 1 −0.196550302 −0.196550302 [Source:HGNC Symbol;Acc:HGNC:16891] ENSG00000173369 C1QB complement component 1, q −0.124839375 NA subcomponent, B chain [Source:HGNC Symbol;Acc:HGNC:1242] ENSG00000173391 OLR1 oxidized low density lipoprotein −0.159206313 NA (lectin-like) receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] ENSG00000173597 SULT1B sulfotransferase family, cytosolic, −0.235586513 −0.235586513 1 1B, member 1 [Source:HGNC Symbol;Acc:HGNC:17845] ENSG00000173933 RBM4 RNA binding motif protein 4 −0.135920039 −0.135920039 [Source:HGNC Symbol;Acc:HGNC:9901] ENSG00000174417 TRHR thyrotropin-releasing hormone −0.1942987 NA receptor [Source:HGNC Symbol;Acc:HGNC:12299] ENSG00000175029 CTBP2 C-terminal binding protein 2 0.368157478 0.368157478 [Source:HGNC Symbol;Acc:HGNC:2495] ENSG00000175040 CHST2 carbohydrate (N- 0.163933576 NA a cetylglucosamine-6-O) sulfotransferase 2 [Source:HGNC Symbol;Acc:HGNC:1970] ENSG00000175155 YPEL2 yippee-like 2 (Drosophila) 0.912413876 0.912413876 [Source:HGNC Symbol;Acc:HGNC:18326] ENSG00000175224 ATG13 autophagy related 13 −0.296603347 −0.296603347 [Source:HGNC Symbol;Acc:HGNC:29091] ENSG00000175691 ZNF77 zinc finger protein 77 −0.116937542 NA [Source:HGNC Symbol;Acc:HGNC:13150] ENSG00000176485 PLA2G1 phospholipase A2, group XVI −0.154817362 −0.154817362 6 [Source:HGNC Symbol;Acc:HGNC:17825] ENSG00000176845 METRN meteorin, glial cell differentiation 0.187720515 0.187720515 L regulator-like [Source:HGNC Symbol;Acc:HGNC:27584] ENSG00000177000 MTHFR methylenetetrahydrofolate −0.287460753 −0.287460753 reductase (NAD(P)H) [Source:HGNC Symbol;Acc:HGNC:7436] ENSG00000177337 DLGAP DLGAP1 antisense RNA 1 −0.124554317 −0.124554317 1-AS1 [Source:HGNC Symbol;Acc:HGNC:31676] ENSG00000177359 −0.475105891 −0.475105891 ENSG00000177370 T1MM22 translocase of inner mitochondrial −0.119372538 −0.119372538 membrane 22 homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:17317] ENSG00000177479 ARIH2 ariadne RBR E3 ubiquitin protein −0.372741031 −0.372741031 ligase 2 [Source:HGNC Symbol;Acc:HGNC:690] ENSG00000177575 CD163 CD163 molecule [Source:HGNC −0.315699194 −0.315699194 Symbol;Acc:HGNC:1631] ENSG00000177646 ACAD9 acyl-CoA dehydrogenase family, −0.202601143 −0.202601143 member 9 [Source:HGNC Symbol;Acc:HGNC:21497] ENSG00000177674 AGTRA angiotensin 11 receptor-associated −0.132216496 −0.132216496 P protein [Source:HGNC Symbol;Acc:HGNC:13539] ENSG00000177683 THAP5 THAP domain containing 5 −0.129846416 −0.129846416 [Source:HGNC Symbol;Acc:HGNC:23188] ENSG00000177868 CCDC2 coiled-coil domain containing 23 −0.108167815 −0.108167815 3 [Source:HGNC Symbol;Acc:HGNC:29204] ENSG00000178386 ZNF223 zinc finger protein 223 −0.146368231 NA [Source:HGNC Symbol;Acc:HGNC:13016] ENSG00000178462 TUBAL3 tubulin, alpha-like 3 [Source:HGNC −0.161937894 NA Symbol;Acc:HGNC:23534] ENSG00000178567 EPM2A1 EPM2A (laforin) interacting protein −0.15061393 −0.15061393 P1 1 [Source:HGNC Symbol;Acc:HGNC:19735] ENSG00000178623 GPR35 G protein-coupled receptor 35 0.129576478 NA [Source:HGNC Symbol;Acc:HGNC:4492] ENSG00000178917 ZNF852 zinc finger protein 852 −0.19624491 −0.19624491 [Source:HGNC Symbol;Acc:HGNC:27713] ENSG00000178965 ERICH3 glutamate-rich 3 [Source:HGNC −0.334601985 −0.334601985 Symbol;Acc:HGNC:25346] ENSG00000178974 FBX034 F-box protein 34 [Source:HGNC −0.189250392 −0.189250392 Symbol;Acc:HGNC:20201] ENSG00000178997 EXD1 exonuclease 3′-5 domain −0.170508154 NA containing 1 [Source:HGNC Symbol;Acc:HGNC:28507] ENSG00000180008 50054 suppressor of cytokine signaling 4 −0.149357471 −0.149357471 [Source:HGNC Symbol;Acc:HGNC:19392] ENSG00000180667 YOD1 YOD1 deubiquitinase 1.460095794 1.460095794 [Source:HGNC Symbol;Acc:HGNC:25035] ENSG00000180771 NA NA −0.111139539 NA ENSG00000181458 TMEM4 transmembrane protein 45A −0.20960528 −0.20960528 5A [Source:HGNC Symbol;Acc:HGNC:25480] ENSG00000182054 IDH2 isocitrate dehydrogenase 2 0.442800518 0.442800518 (NADP+), mitochondrial [Source:HGNC Symbol;Acc:HGNC:5383] ENSG00000182885 GPR97 G protein-coupled receptor 97 −0.210363075 −0.210363075 [Source:HGNC Symbol;Acc:HGNC:13728] ENSG00000182898 TCHHL trichohyalin-like 1 [Source:HGNC −0.229019793 NA 1 Symbol;Acc:HGNC:31796] ENSG00000183145 RIPPLY ripply transcriptional repressor 3 −0.126308067 NA 3 [Source:HGNC Symbol;Acc:HGNC:3047] ENSG00000183722 LHFP lipoma HMGIC fusion partner −0.111798531 −0.111798531 [Source:HGNC Symbol;Acc:HGNC:6586] ENSG00000183921 SDR42 short chain −0.165479768 NA E2 dehydrogenase/reductase family 42E, member 2 [Source:HGNC Symbol;Acc:HGNC:35414] ENSG00000184319 RPL23A ribosomal protein L23a pseudogene 0.392529136 NA P82 82 [Source:HGNC Symbol;Acc:HGNC:33730] ENSG00000184601 C14orf1 chromosome 14 open reading 0.101784654 NA 80 frame 180 [Source:HGNC Symbol;Acc:HGNC:33795] ENSG00000185164 NOMO2 NODAL modulator 2 [Source:HGNC −0.102084963 NA Symbol;Acc:HGNC:22652] ENSG00000185187 SIGIRR single immunoglobulin and toll- 0.140935062 NA interleukin 1 receptor (TIR) domain [Source:HGNC Symbol;Acc:HGNC:30575] ENSG00000185298 CCDC1 coiled-coil domain containing 137 0.26108327 NA 37 [Source:HGNC Symbol;Acc:HGNC:33451] ENSG00000185860 C1orf11 chromosome 1 open reading frame −0.230196066 NA 0 110 [Source:HGNC Symbol;Acc:HGNC:28736] ENSG00000186163 trypsinogen-like pseudogene −0.177096942 NA [Source:EntrezGene;Acc:207147] ENSG00000186335 SLC36A solute carrier family 36 −0.246423368 NA 2 (proton/amino acid symporter), member 2 [Source:HGNC Symbol;Acc:HGNC:18762] ENSG00000186407 CD300E CD300e molecule [Source:HGNC −0.401181378 −0.401181378 Symbol;Acc:HGNC:28874] ENSG00000187116 LILRA5 leukocyte immunoglobulin-like −0.135587282 −0.135587282 receptor, subfamily A (with TM domain), member 5 [Source:HGNC Symbol;Acc:HGNC:16309] ENSG00000187979 −0.197353089 NA ENSG00000187990 NA NA 1.230076089 1.230076089 ENSG00000188322 SBK1 SH3 domain binding kinase 1 0.283124513 0.283124513 [Source:HGNC Symbol;Acc:HGNC:17699] ENSG00000188536 HBA2 hemoglobin, alpha 2 [Source:HGNC 4.258424612 4.258424612 Symbol;Acc:HGNC:4824] ENSG00000188761 BCL2L1 BCL2-like 15 [Source:HGNC −0.135276205 NA 5 Symbol;Acc:HGNC:33624] ENSG00000188785 ZNF548 zinc finger protein 548 −0.180896338 −0.180896338 [Source:HGNC Symbol;Acc:HGNC:26561] ENSG00000188933 USP32P ubiquitin specific peptidase 32 −0.170492461 NA 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43570] ENSG00000189046 ALKBH2 alkB, alkylation repair homolog 2 (E. −0.127674621 NA coli) [Source:HGNC Symbol;Acc:HGNC:32487] ENSG00000189339 SLC35E solute carrier family 35, member 0.235773815 0.235773815 2B E2B [Source:HGNC Symbol;Acc:HGNC:33941] ENSG00000189343 RPS2P4 ribosomal protein S2 pseudogene 0.529956999 0.529956999 6 46 [Source:HGNC Symbol;Acc:HGNC:35839] ENSG00000196189 SEMA4 sema domain, immunoglobulin −0.295647233 −0.295647233 A domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A [Source:HGNC Symbol;Acc:HGNC:10729] ENSG00000196453 ZNF777 zinc finger protein 777 0.199366514 0.199366514 [Source:HGNC Symbol;Acc:HGNC:22213] ENSG00000196502 SULT1A sulfotransferase family, cytosolic, −0.243654476 −0.243654476 1 1A, phenol-preferring, member 1 [Source:HGNC Symbol;Acc:HGNC:11453] ENSG00000196652 ZKSCA zinc finger with KRAB and SCAN −0.187422891 −0.187422891 N5 domains 5 [Source:HGNC Symbol;Acc:HGNC:12867] ENSG00000196693 ZNF33B zinc finger protein 33B −0.157550964 −0.157550964 [Source:HGNC Symbol;Acc:HGNC:13097] ENSG00000196735 HLA- major histocompatibility complex, 0.375325641 0.375325641 DQA1 class II, DQ alpha 1 [Source:HGNC Symbol;Acc:HGNC:4942] ENSG00000196743 GM2A GM2 ganglioside activator −0.184789361 −0.184789361 [Source:HGNC Symbol;Acc:HGNC:4367] ENSG00000196981 WDR5B WD repeat domain 5B −0.233300195 NA [Source:HGNC Symbol;Acc:HGNC:17826] ENSG00000197013 ZNF429 zinc finger protein 429 −0.228412404 −0.228412404 [Source:HGNC Symbol;Acc:HGNC:20817] ENSG00000197083 ZNF300 zinc finger protein 300 pseudogene −0.146514604 NA P1 1 (functional) [Source:HGNC Symbol;Acc:HGNC:27032] ENSG00000197302 ZNF720 zinc finger protein 720 −0.18798112 −0.18798112 [Source:HGNC Symbol;Acc:HGNC:26987] ENSG00000197343 ZNF655 zinc finger protein 655 −0.212949896 −0.212949896 [Source:HGNC Symbol;Acc:HGNC:30899] ENSG00000197414 NA NA −0.141068539 NA ENSG00000197548 ATG7 autophagy related 7 [Source:HGNC −0.379355148 −0.379355148 Symbol;Acc:HGNC:16935] ENSG00000197599 CCDC1 coiled-coil domain containing 154 0.184705043 NA 54 [Source:HGNC Symbol;Acc:HGNC:34454] ENSG00000197646 PDCD1 programmed cell death 1 ligand 2 −0.110184048 NA LG2 [Source:HGNC Symbol;Acc:HGNC:18731] ENSG00000197779 ZNF81 zinc finger protein 81 −0.142247292 −0.142247292 [Source:HGNC Symbol;Acc:HGNC:13156] ENSG00000197857 ZNF44 zinc finger protein 44 −0.286352369 −0.286352369 [Source:HGNC Symbol;Acc:HGNC:13110] ENSG00000198131 ZNF544 zinc finger protein 544 −0.206585267 −0.206585267 [Source:HGNC Symbol;Acc:HGNC:16759] ENSG00000198223 CSF2R colony stimulating factor 2 receptor, −0.234620375 −0.234620375 A alpha, low-affinity (granulocyte- macrophage) [Source:HGNC Symbol;Acc:HGNC:2435] ENSG00000198563 DDX39 DEAD (Asp-Glu-Ala-Asp) box −0.220385678 −0.220385678 B polypeptide 39B [Source:HGNC Symbol;Acc:HGNC:13917] ENSG00000198657 OR8B4 olfactory receptor, family 8, −0.161081721 NA subfamily B, member 4 [Source:HGNC Symbol;Acc:HGNC:8473] ENSG00000198723 C19orf4 chromosome 19 open reading −0.198512226 −0.198512226 5 frame 45 [Source:HGNC Symbol;Acc:HGNC:24745] ENSG00000198740 ZNF652 zinc finger protein 652 0.709702366 0.709702366 [Source:HGNC Symbol;Acc:HGNC:29147] ENSG00000198755 RPL10A ribosomal protein L10a 0.406926049 0.406926049 [Source:HGNC Symbol;Acc:HGNC:10299] ENSG00000198912 C1orf17 chromosome 1 open reading frame 4 174 [Source:HGNC −0.181616083 −0.181616083 Symbol;Acc:HGNC:27915] ENSG00000203805 PPAPD phosphatidic acid phosphatase type −0.201347805 NA C1A 2 domain containing 1A [Source:HGNC Symbol;Acc:HGNC:23531] ENSG00000203825 −0.193698104 NA ENSG00000203849 NA NA −0.376035075 −0.376035075 ENSG00000204103 MAFB v-maf avian musculoaponeurotic 0.124948255 0.124948255 fibrosarcoma oncogene homolog B [Source:HGNC Symbol;Acc:HGNC:6408] ENSG00000204362 −0.314891592 −0.314891592 ENSG00000204463 BAG6 BCL2-associated athanogene 6 0.943103177 0.943103177 [Source:HGNC Symbol;Acc:HGNC:13919] ENSG00000204713 TR1M27 tripartite motif containing 27 −0.257524614 −0.257524614 [Source:HGNC Symbol;Acc:HGNC:9975] ENSG00000205628 LINC01 long intergenic non-protein coding −0.120082591 NA 446 RNA 1446 [Source:HGNC Symbol;Acc:HGNC:50773] ENSG00000205976 −0.262326119 −0.262326119 ENSG00000206172 HBA1 hemoglobin, alpha 1 [Source:HGNC 0.902138597 0.902138597 Symbol;Acc:HGNC:4823] ENSG00000210195 MT-TT mitochondrially encoded tRNA 6.848136516 6.848136516 threonine [Source:HGNC Symbol;Acc:HGNC:7499] ENSG00000211445 GPX3 glutathione peroxidase 3 (plasma) −0.178654533 −0.178654533 [Source:HGNC Symbol;Acc:HGNC:4555] ENSG00000211940 NA NA −0.143844223 NA ENSG00000213020 ZNF611 zinc finger protein 611 −0.259329982 −0.259329982 [Source:HGNC Symbol;Acc:HGNC:28766] ENSG00000213088 ACKR1 atypical chemokine receptor 1 −0.128327477 NA (Duffy blood group) [Source:HGNC Symbol;Acc:HGNC:4035] ENSG00000213533 TMEM1 transmembrane protein 110 −0.107013536 NA 10 [Source:HGNC Symbol;Acc:HGNC:30526] ENSG00000213626 LBH limb bud and heart development 0.623364127 0.623364127 [Source:HGNC Symbol;Acc:HGNC:29532] ENSG00000214212 C19orf3 chromosome 19 open reading −0.135417642 −0.135417642 8 frame 38 [Source:HGNC Symbol;Acc:HGNC:34073] ENSG00000214782 M54A18 membrane-spanning 4-domains, −0.156586447 NA subfamily A, member 18 [Source:HGNC Symbol;Acc:HGNC:37636] ENSG00000215256 DHRS4- DHRS4 antisense RNA 1 −0.186141459 −0.186141459 AS1 [Source:HGNC Symbol;Acc:HGNC:23175] ENSG00000215386 MIR99A mir-99a-let-7c cluster host gene −0.250013734 NA HG (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:1274] ENSG00000215764 NA NA 0.262621436 NA ENSG00000215853 RPTN repetin [Source:HGNC −0.464578408 NA Symbol;Acc:HGNC:26809] ENSG00000215864 NBPF7 neuroblastoma breakpoint family, −0.143526164 NA member 7 [Source:HGNC Symbol;Acc:HGNC:31989] ENSG00000215887 ZNF859 zinc finger protein 859, pseudogene −0.273183578 NA P [Source:HGNC Symbol;Acc:HGNC:34507] ENSG00000219448 −0.236180736 NA ENSG00000223528 −0.258929764 NA ENSG00000223843 EFCAB EFCAB6 antisense RNA 1 −0.124469557 NA 6-AS1 [Source:HGNC Symbol;Acc:HGNC:39999] ENSG00000224051 CPTP ceramide-1-phosphate transfer 0.209225527 NA protein [Source:HGNC Symbol;Acc:HGNC:28116] ENSG00000224082 UBTFL8 upstream binding transcription −0.220169926 NA factor, RNA polymerase l-like 8 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:44476] ENSG00000224442 −0.189075329 NA ENSG00000224896 SIGLEC sialic acid binding Ig-like lectin 30, −0.114996185 NA pseudogene [Source:HGNC 30P Symbol;Acc:HGNC:15623] ENSG00000225901 MTND2 MT-ND2 pseudogene 9 −0.127889211 NA P9 [Source:HGNC Symbol;Acc:HGNC:42110] ENSG00000225972 MTND1 MT-ND1 pseudogene 23 42.13892989 42.13892989 P23 [Source:HGNC Symbol;Acc:HGNC:42092] ENSG00000226686 −0.113280249 NA ENSG00000226995 LINC00 long intergenic non-protein coding −0.161639525 NA 658 RNA 658 [Source:HGNC Symbol;Acc:HGNC:44315] ENSG00000227339 THRAP thyroid hormone receptor −0.245411465 NA 3P1 associated protein 3 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:32386] ENSG00000227372 TP73- TP73 antisense RNA 1 0.31982772 0.31982772 AS1 [Source:HGNC Symbol;Acc:HGNC:29052] ENSG00000227500 SCAMP secretory carrier membrane protein 0.229215804 0.229215804 4 4 [Source:HGNC Symbol;Acc:HGNC:30385] ENSG00000227972 PRKRIR protein-kinase, interferon-inducible −0.113340677 NA P3 double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:39567] ENSG00000228215 −0.126130156 NA ENSG00000228753 ElF4BP eukaryotic translation initiation −0.199072583 NA 2 factor 4B pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:37935] ENSG00000228828 −0.141012861 NA ENSG00000229344 1.731408495 1.731408495 ENSG00000229696 KARSP lysyl-tRNA synthetase pseudogene −0.125478733 NA 1 1 [Source:HGNC Symbol;Acc:HGNC:39207] ENSG00000230448 LINC00 long intergenic non-protein coding −0.171384523 NA 276 RNA 276 [Source:HGNC Symbol;Acc:HGNC:38663] ENSG00000230880 NA NA −0.260494382 −0.260494382 ENSG00000231043 −0.168594923 NA ENSG00000231276 E2F4P1 E2F transcription factor 4, −0.132551729 NA p107/p130-binding pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:38684] ENSG00000231721 LINC- long intergenic non-protein coding −0.171442837 −0.171442837 PINT RNA, p53 induced transcript [Source:HGNC Symbol;Acc:HGNC:26885] ENSG00000232327 0.13135561 NA ENSG00000232722 MR0H4 maestro heat-like repeat family 0.104588946 NA P member 4, pseudogene [Source:HGNC Symbol;Acc:HGNC:44902] ENSG00000233755 −0.140940391 NA ENSG00000233922 −0.130672957 NA ENSG00000234420 ZNF37B zinc finger protein 37B, pseudogene −0.347517612 −0.347517612 P [Source:HGNC Symbol;Acc:HGNC:13103] ENSG00000234444 ZNF736 zinc finger protein 736 −0.382466167 −0.382466167 [Source:HGNC Symbol;Acc:HGNC:32467] ENSG00000234709 UPF3A UPF3A pseudogene 3 −0.13929854 NA P3 [Source:HGNC Symbol;Acc:HGNC:38395] ENSG00000235106 LINC00 long intergenic non-protein coding 0.165641267 0.165641267 094 RNA 94 [Source:HGNC Symbol;Acc:HGNC:24742] ENSG00000236990 −0.116330885 NA ENSG00000237290 LINC01 long intergenic non-protein coding −0.179447695 NA 343 RNA 1343 [Source:HGNC Symbol;Acc:HGNC:50553] ENSG00000238083 LRRC37 leucine rich repeat containing 37, −0.158451543 −0.158451543 A2 member A2 [Source:HGNC Symbol;Acc:HGNC:32404] ENSG00000238208 −0.217256857 NA ENSG00000238243 OR2W3 olfactory receptor, family 2, −0.185364224 −0.185364224 subfamily W, member 3 [Source:HGNC Symbol;Acc:HGNC:15021] ENSG00000238278 ALG1L6 asparagine-linked glycosylation 1- 0.107200388 NA P like 6, pseudogene [Source:HGNC Symbol;Acc:HGNC:44375] ENSG00000239789 MRPS1 mitochondrial ribosomal protein S17 −0.104360759 NA 7 [Source:HGNC Symbol;Acc:HGNC:14047] ENSG00000240954 RPL4P1 ribosomal protein L4 pseudogene 1 −0.171298291 NA [Source:HGNC Symbol;Acc:HGNC:23551] ENSG00000242732 RGAG4 retrotransposon gag domain −0.1237928 NA containing 4 [Source:HGNC Symbol;Acc:HGNC:29430] ENSG00000242759 LINC00 long intergenic non-protein coding −0.173358615 NA 882 RNA 882 [Source:HGNC Symbol;Acc:HGNC:48568] ENSG00000244306 LINC01 long intergenic non-protein coding −0.168835608 NA 296 RNA 1296 [Source:HGNC Symbol;Acc:HGNC:48904] ENSG00000244480 −0.100412433 NA ENSG00000244625 MIATNB MIAT neighbor (non-protein coding) −0.318979642 −0.318979642 [Source:HGNC Symbol;Acc:HGNC:50731] ENSG00000244734 HBB hemoglobin, beta [Source:HGNC 109.5087838 109.5087838 Symbol;Acc:HGNC:4827] ENSG00000245281 −0.113045576 NA ENSG00000246250 −0.212714334 NA ENSG00000246339 EXTL3- EXTL3 antisense RNA 1 −0.113036851 NA AS1 [Source:HGNC Symbol;Acc:HGNC:27985] ENSG00000248724 NPHP3- NPHP3 antisense RNA 1 −0.182694059 NA AS1 [Source:HGNC Symbol;Acc:HGNC:24129] ENSG00000250067 YJEFN3 YjeF N-terminal domain containing −0.482058637 −0.482058637 3 [Source:HGNC Symbol;Acc:HGNC:24785] ENSG00000250303 −0.213124179 −0.213124179 ENSG00000250565 ATP6V1 ATPase, H+ transporting, lysosomal −0.248463482 −0.248463482 E2 31 kDa, V1 subunit E2 [Source:HGNC Symbol;Acc:HGNC:18125] ENSG00000253665 −0.106655671 NA ENSG00000254290 −0.124740686 NA ENSG00000254718 −0.15305955 NA ENSG00000255507 −0.124782855 NA ENSG00000255836 −0.125463823 NA ENSG00000256596 −0.129305477 NA ENSG00000256612 CYP2B7 cytochrome P450, family 2, −0.27215482 −0.27215482 P subfamily B, polypeptide 7, pseudogene [Source:HGNC Symbol;Acc:HGNC:2616] ENSG00000257335 MGAM maltase-glucoamylase (alpha- −0.604937865 −0.604937865 glucosidase) [Source:HGNC Symbol;Acc:HGNC:7043] ENSG00000258616 −0.264079574 NA ENSG00000258634 −0.135548354 NA ENSG00000258783 KRT18P keratin 18 pseudogene 6 −0.116670007 NA 6 [Source:HGNC Symbol;Acc:HGNC:20280] ENSG00000259029 DUX4L1 double homeobox 4 like 18 0.155741858 NA 8 [Source:HGNC Symbol;Acc:HGNC:37716] ENSG00000259345 −0.225236375 −0.225236375 ENSG00000259417 LINC01 long intergenic non-protein coding −0.232468575 NA 314 RNA 1314 [Source:HGNC Symbol;Acc:HGNC:50507] ENSG00000259703 LINC00 long intergenic non-protein coding −0.139199501 NA 593 RNA 593 [Source:HGNC Symbol;Acc:HGNC:32382] ENSG00000259845 HERC2 hect domain and RLD 2 −0.183062825 NA P10 pseudogene 10 [Source:HGNC Symbol;Acc:HGNC:39056] ENSG00000260303 −0.214352381 NA ENSG00000260392 −0.164078762 NA ENSG00000260776 −0.222848391 −0.222848391 ENSG00000260840 −0.171448953 NA ENSG00000261226 0.213547775 NA ENSG00000261360 −0.144182385 NA ENSG00000261649 GOLGA golgin A6 family-like 7, pseudogene −0.184249007 NA 6L7P [Source:HGNC Symbol;Acc:HGNC:37442] ENSG00000261824 LINC00 long intergenic non-protein coding −0.288689728 −0.288689728 662 RNA 662 [Source:HGNC Symbol;Acc:HGNC:27122] ENSG00000261934 PCDHG protocadherin gamma subfamily A, −0.133685949 NA A9 9 [Source:HGNC Symbol;Acc:HGNC:8707] ENSG00000262561 −0.115702096 NA ENSG00000263914 −0.213490416 NA ENSG00000266173 STRAD STE20-related kinase adaptor alpha −0.166186341 −0.166186341 A [Source:HGNC Symbol;Acc:HGNC:30172] ENSG00000266537 −0.128245629 NA ENSG00000266904 LINC00 long intergenic non-protein coding −0.232081247 −0.232081247 663 RNA 663 [Source:HGNC Symbol;Acc:HGNC:28609] ENSG00000266913 −0.141142048 NA ENSG00000266947 −0.109348188 NA ENSG00000267106 ZNF561- ZNF561 antisense RNA 1 (head to −0.187392298 −0.187392298 AS1 head) [Source:HGNC Symbol;Acc:HGNC:27613] ENSG00000267372 −0.213066741 NA ENSG00000267575 −0.228500466 −0.228500466 ENSG00000267650 −0.208510187 NA ENSG00000269837 IPO5P1 importin 5 pseudogene 1 −0.139039195 NA [Source:HGNC Symbol;Acc:HGNC:49687] ENSG00000270442 −0.167429075 NA ENSG00000271220 0.136971852 NA ENSG00000272005 NA NA −0.156552099 NA ENSG00000272054 −0.146334126 NA ENSG00000272374 −0.23487933 NA ENSG00000273374 −0.131128191 NA

TABLE 12 The sum of all impact sustained by the player, as measured by HITsp, regressed on RNA expression in urine samples X0.5slope_0.1pvalue_ X0.8slope_0.1pvalue_ Ensembl_ID hgnc_symbol description 0.1_Cum_HITsp_urine 0.1_Cum_HITsp_urine ENSG00000209082 MT-TL1 mitochondrially encoded 0.184735959 0.184735959 tRNA leucine 1 (UUA/G) [Source: HGNC Symbol; Acc: HGNC: 7490] ENSG00000210156 MT-TK mitochondrially encoded 0.123469871 0.123469871 tRNA lysine [Source: HGNC Symbol; Acc: HGNC: 7489] ENSG00000210196 MT-TP mitochondrially encoded 0.102709777 0.102709777 tRNA proline [Source: HGNC Symbol; Acc: HGNC: 7494]

TABLE 13 The sum of all impact sustained by the player, as measured by linear rotation, regressed on RNA expression in urine samples X0.5slope_0.1pvalue_ X0.8slope_0.1pvalue_ Ensembl_ID hgnc_symbol description 0.1_Cum_lin_acc_urine 0.1_Cum_lin_acc_urine ENSG00000198712 MT-CO2 mitochondrially encoded cytochrome 1.060970772 1.060970772 c oxidase II [Source: HGNC Symbol; Acc: HGNC: 7421] ENSG00000198840 MT-ND3 mitochondrially encoded NADH 0.423175824 0.423175824 dehydrogenase 3 [Source: HGNC Symbol; Acc: HGNC: 7458] ENSG00000198938 MT-CO3 mitochondrially encoded cytochrome 1.826905522 1.826905522 c oxidase III [Source: HGNC Symbol; Acc: HGNC: 7422] ENSG00000209082 MT-TL1 mitochondrially encoded tRNA 0.106648801 0.106648801 leucine 1 (UUA/G) [Source: HGNC Symbol; Acc: HGNC: 7490] ENSG00000228253 MT-ATP8 mitochondrially encoded ATP 0.324958434 0.324958434 synthase 8 [Source: HGNC Symbol; Acc: HGNC: 7415]

TABLE 14 The highest impact sustained by the player in the game as measured by HITsp regressed on RNA expression in urine samples X0.5slope_0.1pvalue_ X0.8slope_0.1pvalue_ Ensembl_ID hgnc_symbol description Max_HITsp_urine Max_HITsp_urine ENSG00000002586 CD99 CD99 molecule [Source: HGNC 0.126839875 0.126839875 Symbol; Acc: HGNC: 7082] ENSG00000003987 MTMR7 myotubularin related protein 7 −0.104493328 −0.104493328 [Source: HGNC Symbol; Acc: HGNC: 7454] ENSG00000004864 SLC25A13 solute carrier family 25 −0.122839256 −0.122839256 (aspartate/glutamate carrier), member 13 [Source: HGNC Symbol; Acc: HGNC: 10983] ENSG00000005175 RPAP3 RNA polymerase 11 associated 0.165078296 0.165078296 protein 3 [Source: HGNC Symbol; Acc: HGNC: 26151] ENSG00000005249 PRKAR2B protein kinase, cAMP-dependent, 0.581721586 0.581721586 regulatory, type II, beta [Source: HGNC Symbol; Acc: HGNC: 9392] ENSG00000005801 ZNF195 zinc finger protein 195 0.112661978 0.112661978 [Source: HGNC Symbol; Acc: HGNC: 12986] ENSG00000005810 MYCBP2 MYC binding protein 2, E3 ubiquitin 0.334133677 0.334133677 protein ligase [Source: HGNC Symbol; Acc: HGNC: 23386] ENSG00000005961 ITGA2B integrin, alpha 2b (platelet 0.257722578 0.257722578 glycoprotein IIb of IIb/IIIa complex, antigen CD41) [Source: HGNC Symbol; Acc: HGNC: 6138] ENSG00000006432 MAP3K9 mitogen-activated protein kinase 0.207240949 0.207240949 kinase kinase 9 [Source: HGNC Symbol; Acc: HGNC: 6861] ENSG00000006715 VPS41 vacuolar protein sorting 41 homolog 0.32418401 0.32418401 (S. cerevisiae) [Source: HGNC Symbol; Acc: HGNC: 12713] ENSG00000007047 MARK4 MAP/microtubule affinity-regulating 0.149286836 0.149286836 kinase 4 [Source: HGNC Symbol; Acc: HGNC: 13538] ENSG00000008323 PLEKHG6 pleckstrin homology domain 0.188514525 0.188514525 containing, family G (with RhoGef domain) member 6 [Source: HGNC Symbol; Acc: HGNC: 25562] ENSG00000011275 RNF216 ring finger protein 216 0.200742457 0.200742457 [Source: HGNC Symbol; Acc: HGNC: 21698] ENSG00000011376 LARS2 leucyl-tRNA synthetase 2, 0.158614373 0.158614373 mitochondrial [Source: HGNC Symbol; Acc: HGNC: 17095] ENSG00000011638 TMEM159 transmembrane protein 159 0.18025885 0.18025885 [Source: HGNC Symbol; Acc: HGNC: 30136] ENSG00000012779 ALOX5 arachidonate 5-lipoxygenase 0.365154546 0.365154546 [Source: HGNC Symbol; Acc: HGNC: 435] ENSG00000013016 EHD3 EH-domain containing 3 0.105112549 0.105112549 [Source: HGNC Symbol; Acc: HGNC: 3244] ENSG00000021574 SPAST spastin [Source: HGNC 0.101822754 0.101822754 Symbol; Acc: HGNC: 11233] ENSG00000025293 PHF20 PHD finger protein 20 0.308279226 0.308279226 [Source: HGNC Symbol; Acc: HGNC: 16098] ENSG00000031003 FAM13B family with sequence similarity 13, 0.280432554 0.280432554 member B [Source: HGNC Symbol; Acc: HGNC: 1335] ENSG00000033170 FUT8 fucosyltransferase 8 (alpha (1,6) 0.140437657 0.140437657 fucosyltransferase) [Source: HGNC Symbol; Acc: HGNC: 4019] ENSG00000034677 RNF19A ring finger protein 19A, RBR E3 0.380697512 0.380697512 ubiquitin protein ligase [Source: HGNC Symbol; Acc: HGNC: 13432] ENSG00000035403 VCL vinculin [Source: HGNC 0.800493703 0.800493703 Symbol; Acc: HGNC: 12665] ENSG00000041353 RAB27B RAB27B, member RAS oncogene 1.154708123 1.154708123 family [Source: HGNC Symbol; Acc: HGNC: 9767] ENSG00000044090 CUL7 cullin 7 [Source: HGNC 0.138205514 0.138205514 Symbol; Acc: HGNC: 21024] ENSG00000048405 ZNF800 zinc finger protein 800 0.131989059 0.131989059 [Source: HGNC Symbol; Acc: HGNC: 27267] ENSG00000048740 CELF2 CUGBP, Elav-like family member 2 0.179995745 0.179995745 [Source: HGNC Symbol; Acc: HGNC: 2550] ENSG00000048991 R3HDM1 R3H domain containing 1 0.156568778 0.156568778 [Source: HGNC Symbol; Acc: HGNC: 9757] ENSG00000049323 LTBP1 latent transforming growth factor 0.407651458 0.407651458 beta binding protein 1 [Source: HGNC Symbol; Acc: HGNC: 6714] ENSG00000049656 CLPTM1L CLPTM1-like [Source: HGNC −0.117394386 −0.117394386 Symbol; Acc: HGNC: 24308] ENSG00000058063 ATP11B ATPase, class VI, type 11B 0.329116611 0.329116611 [Source: HGNC Symbol; Acc: HGNC: 13553] ENSG00000061918 GUCY1B3 guanylate cyclase 1, soluble, beta 3 0.143191421 0.143191421 [Source: HGNC Symbol; Acc: HGNC: 4687] ENSG00000062598 ELMO2 engulfment and cell motility 2 0.328452394 0.328452394 [Source: HGNC Symbol; Acc: HGNC: 17233] ENSG00000064102 ASUN asunder spermatogenesis regulator 0.160003638 0.160003638 [Source: HGNC Symbol; Acc: HGNC: 20174] ENSG00000064313 TAF2 TAF2 RNA polymerase II, TATA box 0.18412105 0.18412105 binding protein (TBP)-associated factor, 150 kDa [Source: HGNC Symbol; Acc: HGNC: 11536] ENSG00000064545 TMEM161A transmembrane protein 161A −0.101928753 −0.101928753 [Source: HGNC Symbol; Acc: HGNC: 26020] ENSG00000066322 ELOVL1 ELOVL fatty acid elongase 1 0.37012654 0.37012654 [Source: HGNC Symbol; Acc: HGNC: 14418] ENSG00000066629 EML1 echinoderm microtubule associated 0.168702634 0.168702634 protein like 1 [Source: HGNC Symbol; Acc: HGNC: 3330] ENSG00000067167 TRAM1 translocation associated membrane 0.176334589 0.176334589 protein 1 [Source: HGNC Symbol; Acc: HGNC: 20568] ENSG00000067369 TP53BP1 tumor protein p53 binding protein 1 0.316851129 0.316851129 [Source: HGNC Symbol; Acc: HGNC: 11999] ENSG00000068796 KIF2A kinesin heavy chain member 2A 0.443154366 0.443154366 [Source: HGNC Symbol; Acc: HGNC: 6318] ENSG00000069869 NEDD4 neural precursor cell expressed, 0.13353304 0.13353304 developmentally down-regulated 4, E3 ubiquitin protein ligase [Source: HGNC Symbol; Acc: HGNC: 7727] ENSG00000070190 DAPP1 dual adaptor of phosphotyrosine and 0.334739101 0.334739101 3-phosphoinositides [Source: HGNC Symbol; Acc: HGNC: 16500] ENSG00000072135 PTPN18 protein tyrosine phosphatase, non- 0.6446986 0.6446986 receptor type 18 (brain-derived) [Source: HGNC Symbol; Acc: HGNC: 9649] ENSG00000072657 TRHDE thyrotropin-releasing hormone −0.121750066 −0.121750066 degrading enzyme [Source: HGNC Symbol; Acc: HGNC: 30748] ENSG00000075151 EIF4G3 eukaryotic translation initiation factor 0.79102486 0.79102486 4 gamma, 3 [Source: HGNC Symbol; Acc: HGNC: 3298] ENSG00000075624 ACTB actin, beta [Source: HGNC 13.16966173 13.16966173 Symbol; Acc: HGNC: 132] ENSG00000078124 ACER3 alkaline ceramidase 3 −0.116568958 −0.116568958 [Source: HGNC Symbol; Acc: HGNC: 16066] ENSG00000078142 PIK3C3 phosphatidylinositol 3-kinase, 0.210110272 0.210110272 catalytic subunit type 3 [Source: HGNC Symbol; Acc: HGNC: 8974] ENSG00000080608 KIAA0020 KIAA0020 [Source: HGNC 0.266493195 0.266493195 Symbol; Acc: HGNC: 29676] ENSG00000081320 STK17B serine/threonine kinase 17b 0.168493738 0.168493738 [Source: HGNC Symbol; Acc: HGNC: 11396] ENSG00000082397 EPB41L3 erythrocyte membrane protein band 0.267548883 0.267548883 4.1-like 3 [Source: HGNC Symbol; Acc: HGNC: 3380] ENSG00000083544 TDRD3 tudor domain containing 3 0.120739157 0.120739157 [Source: HGNC Symbol; Acc: HGNC: 20612] ENSG00000086189 DIMT1 DIM1 dimethyladenosine transferase 0.106525588 0.106525588 1 homolog (S. cerevisiae) [Source: HGNC Symbol; Acc: HGNC: 30217] ENSG00000086232 EIF2AK1 eukaryotic translation initiation factor 0.602897763 0.602897763 2-alpha kinase 1 [Source: HGNC Symbol; Acc: HGNC: 24921] ENSG00000086619 ERO1LB ERO1-like beta (S. cerevisiae) −0.126810199 −0.126810199 [Source: HGNC Symbol; Acc: HGNC: 14355] ENSG00000087095 NLK nemo-like kinase [Source: HGNC 0.223717032 0.223717032 Symbol; Acc: HGNC: 29858] ENSG00000088053 GP6 glycoprotein VI (platelet) 0.112208462 0.112208462 [Source: HGNC Symbol; Acc: HGNC: 14388] ENSG00000089327 FXYD5 FXYD domain containing ion 0.200859973 0.200859973 transport regulator 5 [Source: HGNC Symbol; Acc: HGNC: 4029] ENSG00000095303 PTGS1 prostaglandin-endoperoxide 0.733879376 0.733879376 synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [Source: HGNC Symbol; Acc: HGNC: 9604] ENSG00000099834 CDHR5 cad herin-related family member 5 −0.179748368 −0.179748368 [Source: HGNC Symbol; Acc: HGNC: 7521] ENSG00000100077 ADRBK2 adrenergic, beta, receptor kinase 2 [Source: HGNC 0.579989071 0.579989071 Symbol; Acc: HGNC: 290] ENSG00000100351 GRAP2 GRB2-related adaptor protein 2 0.372875678 0.372875678 [Source: HGNC Symbol; Acc: HGNC: 4563] ENSG00000100422 CERK ceramide kinase [Source: HGNC −0.117307396 −0.117307396 Symbol; Acc: HGNC: 19256] ENSG00000100580 TMED8 transmembrane emp24 protein 0.203951184 0.203951184 transport domain containing 8 [Source: HGNC Symbol; Acc: HGNC: 18633] ENSG00000100592 DAAM1 dishevelled associated activator of 0.296800198 0.296800198 morphogenesis 1 [Source: HGNC Symbol; Acc: HGNC: 18142] ENSG00000101162 TUBB1 tubulin, beta 1 class VI 0.93464511 0.93464511 [Source: HGNC Symbol; Acc: HGNC: 16257] ENSG00000101210 EEF1A2 eukaryotic translation elongation 0.269827941 0.269827941 factor 1 alpha 2 [Source: HGNC Symbol; Acc: HGNC: 3192] ENSG00000101544 ADNP2 ADNP homeobox 2 [Source: HGNC 0.108650713 0.108650713 Symbol; Acc: HGNC: 23803] ENSG00000101608 MYL12A myosin, light chain 12A, regulatory, 0.726900736 0.726900736 non-sarcomeric [Source: HGNC Symbol; Acc: HGNC: 16701] ENSG00000101782 R1OK3 RIO kinase 3 [Source: HGNC 0.23805903 0.23805903 Symbol; Acc: HGNC: 11451] ENSG00000101856 PGRMC1 progesterone receptor membrane 0.361020607 NA component 1 [Source: HGNC Symbol; Acc: HGNC: 16090] ENSG00000101871 MID1 midline 1 [Source: HGNC 0.102338145 0.102338145 Symbol; Acc: HGNC: 7095] ENSG00000102243 VGLL1 vestigial-like family member 1 0.513257603 0.513257603 [Source: HGNC Symbol; Acc: HGNC: 20985] ENSG00000102572 STK24 serine/threonine kinase 24 0.291512329 0.291512329 [Source: HGNC Symbol; Acc: HGNC: 11403] ENSG00000102804 TSC22D1 TSC22 domain family, member 1 0.62464408 0.62464408 [Source: HGNC Symbol; Acc: HGNC: 16826] ENSG00000103194 USP10 ubiquitin specific peptidase 10 0.260120846 0.260120846 [Source: HGNC Symbol; Acc: HGNC: 12608] ENSG00000103876 FAH fumarylacetoacetate hydrolase 0.143367228 0.143367228 (fumarylacetoacetase) [Source: HGNC Symbol; Acc: HGNC: 3579] ENSG00000104447 TRPS1 trichorhinophalangeal syndrome I 0.201685685 0.201685685 [Source: HGNC Symbol; Acc: HGNC: 12340] ENSG00000104763 ASAH1 N-acylsphingosine amidohydrolase 0.229623019 0.229623019 (acid ceramidase) 1 [Source: HGNC Symbol; Acc: HGNC: 735] ENSG00000105186 ANKRD27 ankyrin repeat domain 27 (VPS9 0.155274119 0.155274119 domain) [Source: HGNC Symbol; Acc: HGNC: 25310] ENSG00000105329 TGFB1 transforming growth factor, beta 1 0.174204583 0.174204583 [Source: HGNC Symbol; Acc: HGNC: 11766] ENSG00000105778 AVL9 AVL9 homolog (S. cerevisiase) 0.280409696 0.280409696 [Source: HGNC Symbol; Acc: HGNC: 28994] ENSG00000105887 MTPN myotrophin [Source: HGNC 0.370822464 0.370822464 Symbol; Acc: HGNC: 15667] ENSG00000106615 RHEB Ras homolog enriched in brain 0.149766607 0.149766607 [Source: HGNC Symbol; Acc: HGNC: 10011] ENSG00000107077 KDM4C lysine (K)-specific demethylase 4C 0.109162843 0.109162843 [Source: HGNC Symbol; Acc: HGNC: 17071] ENSG00000107099 DOCK8 dedicator of cytokinesis 8 0.347940675 0.347940675 [Source: HGNC Symbol; Acc: HGNC: 19191] ENSG00000107438 PDLIM1 PDZ and LIM domain 1 0.330990056 0.330990056 [Source: HGNC Symbol; Acc: HGNC: 2067] ENSG00000107669 ATE1 arginyltransferase 1 [Source: HGNC 0.372522035 0.372522035 Symbol; Acc: HGNC: 782] ENSG00000107863 ARHGAP21 Rho GTPase activating protein 21 0.303455407 0.303455407 [Source: HGNC Symbol; Acc: HGNC: 23725] ENSG00000108094 CUL2 cullin 2 [Source: HGNC 0.186832148 0.186832148 Symbol; Acc: HGNC: 2552] ENSG00000108389 MTMR4 myotubularin related protein 4 [Source: HGNC 0.379527121 0.379527121 Symbol; Acc: HGNC: 7452] ENSG00000108883 EFTUD2 elongation factor Tu GTP binding 0.3006319 0.3006319 domain containing 2 [Source: HGNC Symbol; Acc: HGNC: 30858] ENSG00000108960 MMD monocyte to macrophage 0.165657861 0.165657861 differentiation-associated [Source: HGNC Symbol; Acc: HGNC: 7153] ENSG00000109084 TMEM97 transmembrane protein 97 0.79542134 0.79542134 [Source: HGNC Symbol; Acc: HGNC: 28106] ENSG00000110060 PUS3 pseudouridylate synthase 3 0.154578345 0.154578345 [Source: HGNC Symbol; Acc: HGNC: 25461] ENSG00000110514 MADD MAP-kinase activating death domain 0.503549474 0.503549474 [Source: HGNC Symbol; Acc: HGNC: 6766] ENSG00000110906 KCTD10 potassium channel tetramerization 0.161059712 0.161059712 domain containing 10 [Source: HGNC Symbol; Acc: HGNC: 23236] ENSG00000110934 BIN2 bridging integrator 2 [Source: HGNC 0.248982133 0.248982133 Symbol; Acc: HGNC: 1053] ENSG00000111348 ARHGDIB Rho GDP dissociation inhibitor (GDI) 1.141723559 1.141723559 beta [Source: HGNC Symbol; Acc: HGNC: 679] ENSG00000112118 MCM3 minichromosome maintenance 0.227295728 0.227295728 complex component 3 [Source: HGNC Symbol; Acc: HGNC: 6945] ENSG00000112499 SLC22A2 solute carrier family 22 (organic −0.133185802 −0.133185802 cation transporter), member 2 [Source: HGNC Symbol; Acc: HGNC: 10966] ENSG00000112541 PDE10A phosphodiesterase 10A 0.828007185 0.828007185 [Source: HGNC Symbol; Acc: HGNC: 8772] ENSG00000112796 ENPP5 ectonucleotide 0.10593299 0.10593299 pyrophosphatase/phosphodiesterase 5 (putative) [Source: HGNC Symbol; Acc: HGNC: 13717] ENSG00000112893 MAN2A1 mannosidase, alpha, class 2A, 0.217921951 0.217921951 member 1 [Source: HGNC Symbol; Acc: HGNC: 6824] ENSG00000113140 SPARC secreted protein, acidic, cysteine-rich 0.511013974 0.511013974 (osteonectin) [Source: HGNC Symbol; Acc: HGNC: 11219] ENSG00000113494 PRLR prolactin receptor [Source: HGNC −0.201971842 −0.201971842 Symbol; Acc: HGNC: 9446] ENSG00000113580 NR3C1 nuclear receptor subfamily 3, group −0.140459284 −0.140459284 C, member 1 (glucocorticoid receptor) [Source: HGNC Symbol; Acc: HGNC: 7978] ENSG00000113649 TCERG1 transcription elongation regulator 1 0.401292787 0.401292787 [Source: HGNC Symbol; Acc: HGNC: 15630] ENSG00000114098 ARMC8 armadillo repeat containing 8 0.430175492 0.430175492 [Source: HGNC Symbol; Acc: HGNC: 24999] ENSG00000114166 KAT2B K(lysine) acetyltransferase 2B 0.133553074 0.133553074 [Source: HGNC Symbol; Acc: HGNC: 8638] ENSG00000114541 FRMD4B FERM domain containing 4B 0.183283074 0.183283074 [Source: HGNC Symbol; Acc: HGNC: 24886] ENSG00000114638 UPK1B uroplakin 1B [Source: HGNC 0.303753692 0.303753692 Symbol; Acc: HGNC: 12578] ENSG00000114805 PLCH1 phospholipase C, eta 1 0.158661406 0.158661406 [Source: HGNC Symbol; Acc: HGNC: 29185] ENSG00000115159 GPD2 glycerol-3-phosphate 0.171842902 0.171842902 dehydrogenase 2 (mitochondrial) [Source: HGNC Symbol; Acc: HGNC: 4456] ENSG00000115464 USP34 ubiquitin specific peptidase 34 0.481266265 0.481266265 [Source: HGNC Symbol; Acc: HGNC: 20066] ENSG00000115525 ST3GAL5 ST3 beta-galactoside alpha-2,3- 0.16022356 0.16022356 sialyltransferase 5 [Source: HGNC Symbol; Acc: HGNC: 10872] ENSG00000115641 FHL2 four and a half LIM domains 2 0.146032055 0.146032055 [Source: HGNC Symbol; Acc: HGNC: 3703] ENSG00000115935 WIPF1 WAS/WASL interacting protein 0.286397025 0.286397025 family, member 1 [Source: HGNC Symbol; Acc: HGNC: 12736] ENSG00000116191 RALGPS2 Ral GEF with PH domain and SH3 0.135643961 0.135643961 binding motif 2 [Source: HGNC Symbol; Acc: HGNC: 30279] ENSG00000116237 ICMT isoprenylcysteine carboxyl −0.110133125 −0.110133125 methyltransferase [Source: HGNC Symbol; Acc: HGNC: 5350] ENSG00000116580 GON4L gon-4-like (C. elegans) 0.335638953 0.335638953 [Source: HGNC Symbol; Acc: HGNC: 25973] ENSG00000117139 KDM5B lysine (K)-specific demethylase 5B 0.481213482 0.481213482 [Source: HGNC Symbol; Acc: HGNC: 18039] ENSG00000117335 CD46 CD46 molecule, complement 0.208538675 0.208538675 regulatory protein [Source: HGNC Symbol; Acc: HGNC: 6953] ENSG00000117400 MPL MPL proto-oncogene, 0.189039952 0.189039952 thrombopoietin receptor [Source: HGNC Symbol; Acc: HGNC: 7217] ENSG00000117461 PIK3R3 phosphoinositide-3-kinase, 0.390225521 0.390225521 regulatory subunit 3 (gamma) [Source: HGNC Symbol; Acc: HGNC: 8981] ENSG00000118855 MFSD1 major facilitator superfamily domain 0.161327765 0.161327765 containing 1 [Source: HGNC Symbol; Acc: HGNC: 25874] ENSG00000119242 CCDC92 coiled-coil domain containing 92 0.174015024 0.174015024 [Source: HGNC Symbol; Acc: HGNC: 29563] ENSG00000119684 MLH3 mutL homolog 3 [Source: HGNC 0.339439682 0.339439682 Symbol; Acc: HGNC: 7128] ENSG00000119938 PPP1R3C protein phosphatase 1, regulatory 0.195538023 0.195538023 subunit 3C [Source: HGNC Symbol; Acc: HGNC: 9293] ENSG00000120162 MOB3B MOB kinase activator 3B −0.128479144 −0.128479144 [Source: HGNC Symbol; Acc: HGNC: 23825] ENSG00000120690 ELF1 E74-like factor 1 (ets domain 0.405314708 0.405314708 transcription factor) [Source: HGNC Symbol; Acc: HGNC: 3316] ENSG00000120885 CLU clusterin [Source: HGNC 0.46226576 0.46226576 Symbol; Acc: HGNC: 2095] ENSG00000121989 ACVR2A activin A receptor, type IIA 0.148006169 0.148006169 [Source: HGNC Symbol; Acc: HGNC: 173] ENSG00000122176 FMOD fibromodulin [Source: HGNC 0.118763672 0.118763672 Symbol; Acc: HGNC: 3774] ENSG00000122545 7-Sep septin 7 [Source: HGNC 0.232295239 0.232295239 Symbol; Acc: HGNC: 1717] ENSG00000122550 KLHL7 kelch-like family member 7 0.101786764 0.101786764 [Source: HGNC Symbol; Acc: HGNC: 15646] ENSG00000122557 HERPUD2 HERPUD family member 2 0.183005889 0.183005889 [Source: HGNC Symbol; Acc: HGNC: 21915] ENSG00000122779 TRIM24 tripartite motif containing 24 0.488522926 0.488522926 [Source: HGNC Symbol; Acc: HGNC: 11812] ENSG00000123091 RNF11 ring finger protein 11 [Source: HGNC 0.880092531 0.880092531 Symbol; Acc: HGNC: 10056] ENSG00000123095 BHLHE41 basic helix-loop-helix family, member 0.290146569 0.290146569 e41 [Source: HGNC Symbol; Acc: HGNC: 16617] ENSG00000124228 DDX27 DEAD (Asp-Glu-Ala-Asp) box 0.155817465 0.155817465 polypeptide 27 [Source: HGNC Symbol; Acc: HGNC: 15837] ENSG00000124333 VAMP7 vesicle-associated membrane 0.12828441 0.12828441 protein 7 [Source: HGNC Symbol; Acc: HGNC: 11486] ENSG00000124491 F13A1 coagulation factor XIII, A1 0.546443396 0.546443396 polypeptide [Source: HGNC Symbol; Acc: HGNC: 3531] ENSG00000124635 HIST1H2BJ histone cluster 1, H2bj 0.156372055 0.156372055 [Source: HGNC Symbol; Acc: HGNC: 4761] ENSG00000124813 RUNX2 runt-related transcription factor 2 0.120780718 0.120780718 [Source: HGNC Symbol; Acc: HGNC: 10472] ENSG00000125246 CLYBL citrate lyase beta like [Source: HGNC −0.107136431 −0.107136431 Symbol; Acc: HGNC: 18355] ENSG00000125676 THOC2 THO complex 2 [Source: HGNC 0.616135842 0.616135842 Symbol; Acc: HGNC: 19073] ENSG00000125734 GPR108 G protein-coupled receptor 108 −0.105816696 −0.105816696 [Source: HGNC Symbol; Acc: HGNC: 17829] ENSG00000125945 ZNF436 zinc finger protein 436 0.165003054 0.165003054 [Source: HGNC Symbol; Acc: HGNC: 20814] ENSG00000125952 MAX MYC associated factor X 0.415943432 0.415943432 [Source: HGNC Symbol; Acc: HGNC: 6913] ENSG00000126351 THRA thyroid hormone receptor, alpha −0.123070122 −0.123070122 [Source: HGNC Symbol; Acc: HGNC: 11796] ENSG00000127314 RAP1B RAP1B, member of RAS oncogene 0.515735425 0.515735425 family [Source: HGNC Symbol; Acc: HGNC: 9857] ENSG00000127920 GNG11 guanine nucleotide binding protein 0.150922583 0.150922583 (G protein), gamma 11 [Source: HGNC Symbol; Acc: HGNC: 4403] ENSG00000127947 PTPN12 protein tyrosine phosphatase, non- 0.324687197 0.324687197 receptor type 12 [Source: HGNC Symbol; Acc: HGNC: 9645] ENSG00000127980 PEX1 peroxisomal biogenesis factor 1 −0.113166927 −0.113166927 [Source: HGNC Symbol; Acc: HGNC: 8850] ENSG00000128045 RASL11B RAS-like, family 11, member B 0.101121756 0.101121756 [Source: HGNC Symbol; Acc: HGNC: 23804] ENSG00000128245 YWHAH tyrosine 3- 0.154477464 0.154477464 monooxygenase/tryptophan 5- monooxygenase activation protein, eta [Source: HGNC Symbol; Acc: HGNC: 12853] ENSG00000128266 GNAZ guanine nucleotide binding protein 0.117449745 0.117449745 (G protein), alpha z polypeptide [Source: HGNC Symbol; Acc: HGNC: 4395] ENSG00000129353 SLC44A2 solute carrier family 44 (choline 0.718830106 0.718830106 transporter), member 2 [Source: HGNC Symbol; Acc: HGNC: 17292] ENSG00000129422 MTUS1 microtubule associated tumor 0.693637092 0.693637092 suppressor 1 [Source: HGNC Symbol; Acc: HGNC: 29789] ENSG00000130830 MPP1 membrane protein, palmitoylated 1, 0.226645535 0.226645535 55 kDa [Source: HGNC Symbol; Acc: HGNC: 7219] ENSG00000131171 SH3BGRL SH3 domain binding glutamate-rich 0.719515363 0.719515363 protein like [Source: HGNC Symbol; Acc: HGNC: 10823] ENSG00000131725 WDR44 WD repeat domain 44 0.434981931 0.434981931 [Source: HGNC Symbol; Acc: HGNC: 30512] ENSG00000131781 FMO5 flavin containing monooxygenase 5 −0.128089256 −0.128089256 [Source: HGNC Symbol; Acc: HGNC: 3773] ENSG00000132170 PPARG peroxisome proliferator-activated 1.953750607 1.953750607 receptor gamma [Source: HGNC Symbol; Acc: HGNC: 9236] ENSG00000132357 CARD6 caspase recruitment domain family, 0.137262799 0.137262799 member 6 [Source: HGNC Symbol; Acc: HGNC: 16394] ENSG00000132824 SERINC3 serine incorporator 3 [Source: HGNC 0.107902612 0.107902612 Symbol; Acc: HGNC: 11699] ENSG00000133606 MKRN1 makorin ring finger protein 1 0.490172081 0.490172081 [Source: HGNC Symbol; Acc: HGNC: 7112] ENSG00000134240 HMGCS2 3-hydroxy-3-methylglutaryl-CoA 1.398835274 1.398835274 synthase 2 (mitochondrial) [Source: HGNC Symbol; Acc: HGNC: 5008] ENSG00000134265 NAPG N-ethylmaleimide-sensitive factor 0.210671394 0.210671394 attachment protein, gamma [Source: HGNC Symbol; Acc: HGNC: 7642] ENSG00000135365 PHF21A PHD finger protein 21A 0.298980862 0.298980862 [Source: HGNC Symbol; Acc: HGNC: 24156] ENSG00000135521 LTV1 LTV1 ribosome biogenesis factor 0.158856248 0.158856248 [Source: HGNC Symbol; Acc: HGNC: 21173] ENSG00000135540 NHSL1 NHS-like 1 [Source: HGNC 0.46724515 0.46724515 Symbol; Acc: HGNC: 21021] ENSG00000135597 REPS1 RALBP1 associated Eps domain 0.114862103 0.114862103 containing 1 [Source: HGNC Symbol; Acc: HGNC: 15578] ENSG00000135966 TGFBRAP1 transforming growth factor, beta 0.124184608 0.124184608 receptor associated protein 1 [Source: HGNC Symbol; Acc: HGNC: 16836] ENSG00000135976 ANKRD36 ankyrin repeat domain 36 −0.109182456 −0.109182456 [Source: HGNC Symbol; Acc: HGNC: 24079] ENSG00000136231 IGF2BP3 insulin-like growth factor 2 mRNA 0.276307789 0.276307789 binding protein 3 [Source: HGNC Symbol; Acc: HGNC: 28868] ENSG00000136689 IL1RN interleukin 1 receptor antagonist 2.077635851 2.077635851 [Source: HGNC Symbol; Acc: HGNC: 6000] ENSG00000136715 SAP130 Sin3A-associated protein, 130 kDa 0.439952614 0.439952614 [Source: HGNC Symbol; Acc: HGNC: 29813] ENSG00000136717 BIN1 bridging integrator 1 [Source: HGNC −0.143377353 −0.143377353 Symbol; Acc: HGNC: 1052] ENSG00000136738 STAM signal transducing adaptor molecule 0.353135957 0.353135957 (SH3 domain and ITAM motif) 1 [Source: HGNC Symbol; Acc: HGNC: 11357] ENSG00000136868 SLC31A1 solute carrier family 31 (copper 0.110813662 0.110813662 transporter), member 1 [Source: HGNC Symbol; Acc: HGNC: 11016] ENSG00000136925 TSTD2 thiosulfate sulfurtransferase 0.128876718 0.128876718 (rhodanese)-like domain containing 2 [Source: HGNC Symbol; Acc: HGNC: 30087] ENSG00000137073 UBAP2 ubiquitin associated protein 2 0.418369571 0.418369571 [Source: HGNC Symbol; Acc: HGNC: 14185] ENSG00000137076 TLN1 talin 1 [Source: HGNC 1.597978957 1.597978957 Symbol; Acc: HGNC: 11845] ENSG00000138293 NA NA 2.156656327 2.156656327 ENSG00000138735 PDE5A phosphodiesterase 5A, cGMP- 0.282062238 0.282062238 specific [Source: HGNC Symbol; Acc: HGNC: 8784] ENSG00000139055 ERP27 endoplasmic reticulum protein 27 0.357585235 0.357585235 [Source: HGNC Symbol; Acc: HGNC: 26495] ENSG00000139323 POC1B POC1 centriolar protein B 0.17988861 0.17988861 [Source: HGNC Symbol; Acc: HGNC: 30836] ENSG00000139998 RAB15 RAB15, member RAS oncogene 0.138583198 0.138583198 family [Source: HGNC Symbol; Acc: HGNC: 20150] ENSG00000140022 STON2 stonin 2 [Source: HGNC 0.324331784 0.324331784 Symbol; Acc: HGNC: 30652] ENSG00000140299 BNIP2 BCL2/adenovirus E1B 19 kDa 0.206087205 0.206087205 interacting protein 2 [Source: HGNC Symbol; Acc: HGNC: 1083] ENSG00000140374 ETFA electron-transfer-flavoprotein, alpha 0.778717155 0.778717155 polypeptide [Source: HGNC Symbol; Acc: HGNC: 3481] ENSG00000140750 ARHGAP17 Rho GTPase activating protein 17 0.151421455 0.151421455 [Source: HGNC Symbol; Acc: HGNC: 18239] ENSG00000141298 SSH2 slingshot protein phosphatase 2 0.414272422 0.414272422 [Source: HGNC Symbol; Acc: HGNC: 30580] ENSG00000141556 TBCD tubulin folding cofactor D 0.171961864 0.171961864 [Source: HGNC Symbol; Acc: HGNC: 11581] ENSG00000141664 ZCCHC2 zinc finger, CCHC domain containing 0.376619618 0.376619618 2 [Source: HGNC Symbol; Acc: HGNC: 22916] ENSG00000142669 SH3BGRL3 SH3 domain binding glutamate-rich 1.622707315 1.622707315 protein like 3 [Source: HGNC Symbol; Acc: HGNC: 15568] ENSG00000143179 UCK2 uridine-cytidine kinase 2 0.117654114 0.117654114 [Source: HGNC Symbol; Acc: HGNC: 12562] ENSG00000143207 RFWD2 ring finger and WD repeat domain 2, 0.100026363 0.100026363 E3 ubiquitin protein ligase [Source: HGNC Symbol; Acc: HGNC: 17440] ENSG00000143379 SETDB1 SET domain, bifurcated 1 0.141059768 0.141059768 [Source: HGNC Symbol; Acc: HGNC: 10761] ENSG00000143409 FAM63A family with sequence similarity 63, 0.254846943 0.254846943 member A [Source: HGNC Symbol; Acc: HGNC: 25648] ENSG00000143494 VASH2 vasohibin 2 [Source: HGNC −0.100842302 −0.100842302 Symbol; Acc: HGNC: 25723] ENSG00000143624 INTS3 integrator complex subunit 3 0.145035158 0.145035158 [Source: HGNC Symbol; Acc: HGNC: 26153] ENSG00000144120 TMEM177 transmembrane protein 177 0.103732969 0.103732969 [Source: HGNC Symbol; Acc: HGNC: 28143] ENSG00000144468 RHBDD1 rhomboid domain containing 1 0.568537348 0.568537348 [Source: HGNC Symbol; Acc: HGNC: 23081] ENSG00000146006 LRRTM2 leucine rich repeat transmembrane −0.1015115 −0.1015115 neuronal 2 [Source: HGNC Symbol; Acc: HGNC: 19409] ENSG00000146859 TMEM140 transmembrane protein 140 0.1056982 0.1056982 [Source: HGNC Symbol; Acc: HGNC: 21870] ENSG00000146904 EPHA1 EPH receptor A1 [Source: HGNC 0.113076631 0.113076631 Symbol; Acc: HGNC: 3385] ENSG00000147394 ZNF185 zinc finger protein 185 (LIM domain) 0.305348237 0.305348237 [Source: HGNC Symbol; Acc: HGNC: 12976] ENSG00000147606 SLC26A7 solute carrier family 26 (anion −0.135780362 −0.135780362 exchanger), member 7 [Source: HGNC Symbol; Acc: HGNC: 14467] ENSG00000147649 MTDH metadherin [Source: HGNC 0.152534374 0.152534374 Symbol; Acc: HGNC: 29608] ENSG00000148175 STOM stomatin [Source: HGNC 0.102889947 0.102889947 Symbol; Acc: HGNC: 3383] ENSG00000148396 SEC16A SEC16 homolog A (S. cerevisiae) 0.45980412 0.45980412 [Source: HGNC Symbol; Acc: HGNC: 29006] ENSG00000148484 RSU1 Ras suppressor protein 1 0.315640995 0.315640995 [Source: HGNC Symbol; Acc: HGNC: 10464] ENSG00000148498 PARD3 par-3 family cell polarity regulator 0.165264157 0.165264157 [Source: HGNC Symbol; Acc: HGNC: 16051] ENSG00000148660 CAMK2G calcium/calmodulin-dependent 0.206367559 0.206367559 protein kinase 11 gamma [Source: HGNC Symbol; Acc: HGNC: 1463] ENSG00000148840 PPRC1 peroxisome proliferator-activated 0.538595703 0.538595703 receptor gamma, coactivator-related 1 [Source: HGNC Symbol; Acc: HGNC: 30025] ENSG00000148843 PDCD11 programmed cell death 11 0.174944261 0.174944261 [Source: HGNC Symbol; Acc: HGNC: 13408] ENSG00000148908 RGS10 regulator of G-protein signaling 10 0.292282672 0.292282672 [Source: HGNC Symbol; Acc: HGNC: 9992] ENSG00000149177 PTPRJ protein tyrosine phosphatase, 0.200352211 0.200352211 receptor type, J [Source: HGNC Symbol; Acc: HGNC: 9673] ENSG00000150054 MPP7 membrane protein, palmitoylated 7 0.455594167 0.455594167 (MAGUK p55 subfamily member 7) [Source: HGNC Symbol; Acc: HGNC: 26542] ENSG00000150093 ITGB1 integrin, beta 1 (fibronectin receptor, 0.42848484 0.42848484 beta polypeptide, antigen CD29 includes MDF2, MSK12) [Source: HGNC Symbol; Acc: HGNC: 6153] ENSG00000150637 CD226 CD226 molecule [Source: HGNC 0.145668728 0.145668728 Symbol; Acc: HGNC: 16961] ENSG00000150867 PIP4K2A phosphatidylinositol-5-phosphate 4- 0.159042165 0.159042165 kinase, type II, alpha [Source: HGNC Symbol; Acc: HGNC: 8997] ENSG00000151414 NEK7 NIMA-related kinase 7 0.161350347 0.161350347 [Source: HGNC Symbol; Acc: HGNC: 13386] ENSG00000151576 QTRTD1 queuine tRNA-ribosyltransferase 0.144212504 0.144212504 domain containing 1 [Source: HGNC Symbol; Acc: HGNC: 25771] ENSG00000151702 FLI1 Fli-1 proto-oncogene, ETS 0.180062833 0.180062833 transcription factor [Source: HGNC Symbol; Acc: HGNC: 3749] ENSG00000152061 RABGAP1L RAB GTPase activating protein 1- 1.171136762 1.171136762 like [Source: HGNC Symbol; Acc: HGNC: 24663] ENSG00000152127 MGAT5 mannosyl (alpha-1,6-)-glycoprotein 0.148717437 0.148717437 beta-1,6-N-acetyl- glucosaminyltransferase [Source: HGNC Symbol; Acc: HGNC: 7049] ENSG00000152601 MBNL1 muscleblind-like splicing regulator 1 2.124148939 2.124148939 [Source: HGNC Symbol; Acc: HGNC: 6923] ENSG00000152926 ZNF117 zinc finger protein 117 0.288912125 0.288912125 [Source: HGNC Symbol; Acc: HGNC: 12897] ENSG00000153071 DAB2 Dab, mitogen-responsive 1.970334898 1.970334898 phosphoprotein, homolog 2 (Drosophila) [Source: HGNC Symbol; Acc: HGNC: 2662] ENSG00000153310 FAM49B family with sequence similarity 49, 0.225356306 0.225356306 member B [Source: HGNC Symbol; Acc: HGNC: 25216] ENSG00000153317 ASAP1 ArfGAP with SH3 domain, ankyrin 0.261303062 0.261303062 repeat and PH domain 1 [Source: HGNC Symbol; Acc: HGNC: 2720] ENSG00000154229 PRKCA protein kinase C, alpha 0.171395515 0.171395515 [Source: HGNC Symbol; Acc: HGNC: 9393] ENSG00000155530 LRGUK leucine-rich repeats and guanylate −0.117734369 −0.117734369 kinase domain containing [Source: HGNC Symbol; Acc: HGNC: 21964] ENSG00000155903 RASA2 RAS p21 protein activator 2 0.153128973 0.153128973 [Source: HGNC Symbol; Acc: HGNC: 9872] ENSG00000156026 MCU mitochondrial calcium uniporter 0.137850826 0.137850826 [Source: HGNC Symbol; Acc: HGNC: 23526] ENSG00000156265 MAP3K7CL MAP3K7 C-terminal like 0.478343633 0.478343633 [Source: HGNC Symbol; Acc: HGNC: 16457] ENSG00000156642 NPTN neuroplastin [Source: HGNC 0.116218446 0.116218446 Symbol; Acc: HGNC: 17867] ENSG00000156958 GALK2 galactokinase 2 [Source: HGNC 0.165082885 0.165082885 Symbol; Acc: HGNC: 4119] ENSG00000157191 NECAP2 NECAP endocytosis associated 2 0.13810038 0.13810038 [Source: HGNC Symbol; Acc: HGNC: 25528] ENSG00000157895 C12orf43 chromosome 12 open reading frame −0.112628987 −0.112628987 43 [Source: HGNC Symbol; Acc: HGNC: 25719] ENSG00000158710 TAGLN2 transgelin 2 [Source: HGNC 0.614972326 0.614972326 Symbol; Acc: HGNC: 11554] ENSG00000159023 EPB41 erythrocyte membrane protein band 0.539881931 0.539881931 4.1 [Source: HGNC Symbol; Acc: HGNC: 3377] ENSG00000159256 MORC3 MORC family CW-type zinc finger 3 0.758914986 0.758914986 [Source: HGNC Symbol; Acc: HGNC: 23572] ENSG00000159267 HLCS holocarboxylase synthetase (biotin- 0.174980594 0.174980594 (proprionyl-CoA-carboxylase (ATP- hydrolysing)) ligase) [Source: HGNC Symbol; Acc: HGNC: 4976] ENSG00000159346 ADIPOR1 adiponectin receptor 1 0.727523194 0.727523194 [Source: HGNC Symbol; Acc: HGNC: 24040] ENSG00000159840 ZYX zyxin [Source: HGNC 0.144777358 0.144777358 Symbol; Acc: HGNC: 13200] ENSG00000161533 ACOX1 acyl-CoA oxidase 1, palmitoyl 0.809566065 0.809566065 [Source: HGNC Symbol; Acc: HGNC: 119] ENSG00000161570 NA NA 1.032379771 1.032379771 ENSG00000161911 TREML1 triggering receptor expressed on 0.123634521 NA myeloid cells-like 1 [Source: HGNC Symbol; Acc: HGNC: 20434] ENSG00000162105 SHANK2 SH3 and multiple ankyrin repeat 0.246685655 0.246685655 domains 2 [Source: HGNC Symbol; Acc: HGNC: 14295] ENSG00000162434 JAK1 Janus kinase 1 [Source: HGNC 0.482198988 0.482198988 Symbol; Acc: HGNC: 6190] ENSG00000162722 TRIM58 tripartite motif containing 58 0.101513502 0.101513502 [Source: HGNC Symbol; Acc: HGNC: 24150] ENSG00000162852 CNST consortin, connexin sorting protein 0.138455689 0.138455689 [Source: HGNC Symbol; Acc: HGNC: 26486] ENSG00000163346 PBXIP1 pre-B-cell leukemia homeobox 0.106013633 0.106013633 interacting protein 1 [Source: HGNC Symbol; Acc: HGNC: 21199] ENSG00000163590 PPM1L protein phosphatase, Mg2+/Mn2+ 0.146308014 0.146308014 dependent, 1L [Source: HGNC Symbol; Acc: HGNC: 16381] ENSG00000163602 RYBP RING1 and YY1 binding protein 0.207794377 0.207794377 [Source: HGNC Symbol; Acc: HGNC: 10480] ENSG00000163735 CXCL5 chemokine (C-X-C motif) ligand 5 0.436775595 NA [Source: HGNC Symbol; Acc: HGNC: 10642] ENSG00000164134 NAA15 N(alpha)-acetyltransferase 15, NatA 0.166966709 0.166966709 auxiliary subunit [Source: HGNC Symbol; Acc: HGNC: 30782] ENSG00000164181 ELOVL7 ELOVL fatty acid elongase 7 0.343620943 0.343620943 [Source: HGNC Symbol; Acc: HGNC: 26292] ENSG00000164266 SPINK1 serine peptidase inhibitor, Kazal type 0.229695948 0.229695948 1 [Source: HGNC Symbol; Acc: HGNC: 11244] ENSG00000164305 CASP3 caspase 3, apoptosis-related 0.161082798 0.161082798 cysteine peptidase [Source: HGNC Symbol; Acc: HGNC: 1504] ENSG00000164402 8-Sep septin 8 [Source: HGNC 0.438118618 0.438118618 Symbol; Acc: HGNC: 16511] ENSG00000164808 SPIDR scaffolding protein involved in DNA 0.216089141 0.216089141 repair [Source: HGNC Symbol; Acc: HGNC: 28971] ENSG00000164924 YWHAZ tyrosine 3- 2.8151181 2.8151181 monooxygenase/tryptophan 5- monooxygenase activation protein, zeta [Source: HGNC Symbol; Acc: HGNC: 12855] ENSG00000165097 KDM1B lysine (K)-specific demethylase 1B 0.129948737 0.129948737 [Source: HGNC Symbol; Acc: HGNC: 21577] ENSG00000165702 GFI1B growth factor independent 1B 0.183122257 0.183122257 transcription repressor [Source: HGNC Symbol; Acc: HGNC: 4238] ENSG00000165929 TC2N tandem C2 domains, nuclear 0.659066708 0.659066708 [Source: HGNC Symbol; Acc: HGNC: 19859] ENSG00000166004 KIAA1731 KIAA1731 [Source: HGNC 0.225572018 0.225572018 Symbol; Acc: HGNC: 29366] ENSG00000166086 JAM3 junctional adhesion molecule 3 0.289140461 0.289140461 [Source: HGNC Symbol; Acc: HGNC: 15532] ENSG00000166224 SGPL1 sphingosine-1-phosphate lyase 1 0.137913948 0.137913948 [Source: HGNC Symbol; Acc: HGNC: 10817] ENSG00000166387 PPFIBP2 PTPRF interacting protein, binding 1.655069459 1.655069459 protein 2 (liprin beta 2) [Source: HGNC Symbol; Acc: HGNC: 9250] ENSG00000166478 ZNF143 zinc finger protein 143 0.179673424 0.179673424 [Source: HGNC Symbol; Acc: HGNC: 12928] ENSG00000166501 PRKCB protein kinase C, beta 0.295744677 0.295744677 [Source: HGNC Symbol; Acc: HGNC: 9395] ENSG00000166710 B2M beta-2-microglobulin [Source: HGNC 4.496484843 4.496484843 Symbol; Acc: HGNC: 914] ENSG00000166750 SLFN5 schlafen family member 5 0.325737786 0.325737786 [Source: HGNC Symbol; Acc: HGNC: 28286] ENSG00000166938 DIS3L DIS3 like exosome 3′-5′ 0.119131994 0.119131994 exoribonuclease [Source: HGNC Symbol; Acc: HGNC: 28698] ENSG00000167257 RNF214 ring finger protein 214 0.127744953 0.127744953 [Source: HGNC Symbol; Acc: HGNC: 25335] ENSG00000167258 CDK12 cyclin-dependent kinase 12 0.153129356 0.153129356 [Source: HGNC Symbol; Acc: HGNC: 24224] ENSG00000168300 PCMTD1 protein-L-isoaspartate (D-aspartate) 1.065572832 1.065572832 O-methyltransferase domain containing 1 [Source: HGNC Symbol; Acc: HGNC: 30483] ENSG00000168310 IRF2 interferon regulatory factor 2 0.185064835 0.185064835 [Source: HGNC Symbol; Acc: HGNC: 6117] ENSG00000168497 SDPR serum deprivation response 0.46748538 0.46748538 [Source: HGNC Symbol; Acc: HGNC: 10690] ENSG00000168769 TET2 tet methylcytosine dioxygenase 2 0.29323869 0.29323869 [Source: HGNC Symbol; Acc: HGNC: 25941] ENSG00000169247 SH3TC2 SH3 domain and tetratricopeptide 0.247290195 0.247290195 repeats 2 [Source: HGNC Symbol; Acc: HGNC: 29427] ENSG00000169313 P2RY12 purinergic receptor P2Y, G-protein 0.135294865 NA coupled, 12 [Source: HGNC Symbol; Acc: HGNC: 18124] ENSG00000169474 SPRR1A small proline-rich protein 1A 0.168877928 NA [Source: HGNC Symbol; Acc: HGNC: 11259] ENSG00000169621 APLF aprataxin and PNKP like factor 0.125437738 0.125437738 [Source: HGNC Symbol; Acc: HGNC: 28724] ENSG00000169756 LIMS1 LIM and senescent cell antigen-like 0.258104105 0.258104105 domains 1 [Source: HGNC Symbol; Acc: HGNC: 6616] ENSG00000170043 TRAPPC1 trafficking protein particle complex 1 0.341070426 0.341070426 [Source: HGNC Symbol; Acc: HGNC: 19894] ENSG00000170325 PRDM10 PR domain containing 10 0.142571737 0.142571737 [Source: HGNC Symbol; Acc: HGNC: 13995] ENSG00000170485 NPAS2 neuronal PAS domain protein 2 0.266419951 0.266419951 [Source: HGNC Symbol; Acc: HGNC: 7895] ENSG00000170500 LONRF2 LON peptidase N-terminal domain −0.140749468 −0.140749468 and ring finger 2 [Source: HGNC Symbol; Acc: HGNC: 24788] ENSG00000170802 FOXN2 forkhead box N2 [Source: HGNC 0.215981377 0.215981377 Symbol; Acc: HGNC: 5281] ENSG00000171311 EXOSC1 exosome component 1 0.144462988 0.144462988 [Source: HGNC Symbol; Acc: HGNC: 17286] ENSG00000171467 ZNF318 zinc finger protein 318 0.133403376 0.133403376 [Source: HGNC Symbol; Acc: HGNC: 13578] ENSG00000172183 ISG20 interferon stimulated exonuclease −0.132523483 −0.132523483 gene 20 kDa [Source: HGNC Symbol; Acc: HGNC: 6130] ENSG00000173210 ABLIM3 actin binding LIM protein family, 0.946294206 0.946294206 member 3 [Source: HGNC Symbol; Acc: HGNC: 29132] ENSG00000174233 ADCY6 adenylate cyclase 6 [Source: HGNC 0.172218544 0.172218544 Symbol; Acc: HGNC: 237] ENSG00000175567 UCP2 uncoupling protein 2 (mitochondrial, 0.637523997 0.637523997 proton carrier) [Source: HGNC Symbol; Acc: HGNC: 12518] ENSG00000176928 GCNT4 glucosaminyl (N-acetyl) transferase 0.164625593 0.164625593 4, core 2 [Source: HGNC Symbol; Acc: HGNC: 17973] ENSG00000177119 ANO6 anoctamin 6 [Source: HGNC 0.421488814 0.421488814 Symbol; Acc: HGNC: 25240] ENSG00000177125 ZBTB34 zinc finger and BTB domain 0.186014362 0.186014362 containing 34 [Source: HGNC Symbol; Acc: HGNC: 31446] ENSG00000177200 CHD9 chromodomain helicase DNA binding 0.84980392 0.84980392 protein 9 [Source: HGNC Symbol; Acc: HGNC: 25701] ENSG00000177324 BEND2 BEN domain containing 2 0.214957462 0.214957462 [Source: HGNC Symbol; Acc: HGNC: 28509] ENSG00000177853 ZNF518A zinc finger protein 518A 0.210018134 0.210018134 [Source: HGNC Symbol; Acc: HGNC: 29009] ENSG00000178222 RNF212 ring finger protein 212 −0.110184033 −0.110184033 [Source: HGNC Symbol; Acc: HGNC: 27729] ENSG00000180182 MED14 mediator complex subunit 14 0.179758964 0.179758964 [Source: HGNC Symbol; Acc: HGNC: 2370] ENSG00000180488 FAM73A family with sequence similarity 73, 0.161075392 0.161075392 member A [Source: HGNC Symbol; Acc: HGNC: 24741] ENSG00000180573 HIST1H2AC histone cluster 1, H2ac 0.673344658 0.673344658 [Source: HGNC Symbol; Acc: HGNC: 4733] ENSG00000180694 TMEM64 transmembrane protein 64 0.166737406 0.166737406 [Source: HGNC Symbol; Acc: HGNC: 25441] ENSG00000181104 F2R coagulation factor II (thrombin) 0.121614855 0.121614855 receptor [Source: HGNC Symbol; Acc: HGNC: 3537] ENSG00000182446 NPLOC4 nuclear protein localization 4 0.170807299 0.170807299 homolog (S. cerevisiae) [Source: HGNC Symbol; Acc: HGNC: 18261] ENSG00000182481 KPNA2 karyopherin alpha 2 (RAG cohort 1, 0.151727599 0.151727599 importin alpha 1) [Source: HGNC Symbol; Acc: HGNC: 6395] ENSG00000182606 TRAK1 trafficking protein, kinesin binding 1 0.700261402 0.700261402 [Source: HGNC Symbol; Acc: HGNC: 29947] ENSG00000183726 TMEM50A transmembrane protein 50A 0.121322558 0.121322558 [Source: HGNC Symbol; Acc: HGNC: 30590] ENSG00000184178 SCFD2 sec1 family domain containing 2 0.112150892 0.112150892 [Source: HGNC Symbol; Acc: HGNC: 30676] ENSG00000184602 SNN stannin [Source: HGNC 0.123344813 0.123344813 Symbol; Acc: HGNC: 11149] ENSG00000185008 ROBO2 roundabout, axon guidance receptor, −0.176023148 −0.176023148 homolog 2 (Drosophila) [Source: HGNC Symbol; Acc: HGNC: 10250] ENSG00000185245 GP1BA glycoprotein lb (platelet), alpha 0.156428222 0.156428222 polypeptide [Source: HGNC Symbol; Acc: HGNC: 4439] ENSG00000186298 PPP1CC protein phosphatase 1, catalytic 0.281181523 0.281181523 subunit, gamma isozyme [Source: HGNC Symbol; Acc: HGNC: 9283] ENSG00000187109 NAP1L1 nucleosome assembly protein 1-like 0.630375971 0.630375971 1 [Source: HGNC Symbol; Acc: HGNC: 7637] ENSG00000187554 TLR5 toll-like receptor 5 [Source: HGNC 0.209734995 0.209734995 Symbol; Acc: HGNC: 11851] ENSG00000187699 C2orf88 chromosome 2 open reading frame 0.253185892 0.253185892 88 [Source: HGNC Symbol; Acc: HGNC: 28191] ENSG00000189308 LIN54 lin-54 DREAM MuvB core complex 0.137504827 0.137504827 component [Source: HGNC Symbol; Acc: HGNC: 25397] ENSG00000189403 HMGB1 high mobility group box 1 0.325629479 0.325629479 [Source: HGNC Symbol; Acc: HGNC: 4983] ENSG00000196116 TDRD7 tudor domain containing 7 0.129014991 0.129014991 [Source: HGNC Symbol; Acc: HGNC: 30831] ENSG00000196678 ERI2 ERI1 exoribonuclease family 0.105444259 0.105444259 member 2[Source: HGNC Symbol; Acc: HGNC: 30541] ENSG00000196782 MAML3 mastermind-like 3 (Drosophila) 0.285976894 0.285976894 [Source: HGNC Symbol; Acc: HGNC: 16272] ENSG00000197147 LRRC8B leucine rich repeat containing 8 0.125211782 0.125211782 family, member B [Source: HGNC Symbol; Acc: HGNC: 30692] ENSG00000197566 ZNF624 zinc finger protein 624 0.111470664 0.111470664 [Source: HGNC Symbol; Acc: HGNC: 29254] ENSG00000198286 CARD11 caspase recruitment domain family, 0.141821377 0.141821377 member 11 [Source: HGNC Symbol; Acc: HGNC: 16393] ENSG00000198466 ZNF587 zinc finger protein 587 0.515936917 0.515936917 [Source: HGNC Symbol; Acc: HGNC: 30955] ENSG00000198478 SH3BGRL2 SH3 domain binding glutamate-rich 2.135999854 2.135999854 protein like 2 [Source: HGNC Symbol; Acc: HGNC: 15567] ENSG00000198513 ATL1 atlastin GTPase 1 [Source: HGNC 0.11638794 0.11638794 Symbol; Acc: HGNC: 11231] ENSG00000198948 MFAP3L microfibrillar-associated protein 3- 0.297833822 0.297833822 like [Source: HGNC Symbol; Acc: HGNC: 29083] ENSG00000204310 AGPAT1 1-acylglycerol-3-phosphate 0- 0.10136124 0.10136124 acyltransferase 1 [Source: HGNC Symbol; Acc: HGNC: 324] ENSG00000204420 C6orf25 chromosome 6 open reading frame 0.42024942 0.42024942 25 [Source: HGNC Symbol; Acc: HGNC: 13937] ENSG00000204842 ATXN2 ataxin 2 [Source: HGNC 0.372568288 0.372568288 Symbol; Acc: HGNC: 10555] ENSG00000205542 TMSB4X thymosin beta 4, X-linked 6.744611196 6.744611196 [Source: HGNC Symbol; Acc: HGNC: 11881] ENSG00000206560 ANKRD28 ankyrin repeat domain 28 0.187959185 0.187959185 [Source: HGNC Symbol; Acc: HGNC: 29024] ENSG00000209082 MT-TL1 mitochondrially encoded tRNA 3.117140247 3.117140247 leucine 1 (UUA/G) [Source: HGNC Symbol; Acc: HGNC: 7490] ENSG00000213516 RBMXL1 RNA binding motif protein, X-linked- 0.131637518 0.131637518 like 1 [Source: HGNC Symbol; Acc: HGNC: 25073] ENSG00000214049 UCA1 urothelial cancer associated 1 (non- 0.426710459 0.426710459 protein coding) [Source: HGNC Symbol; Acc: HGNC: 37126] ENSG00000215271 HOMEZ homeobox and leucine zipper 0.118937964 0.118937964 encoding [Source: HGNC Symbol; Acc: HGNC: 20164] ENSG00000215421 ZNF407 zinc finger protein 407 0.151443222 0.151443222 [Source: HGNC Symbol; Acc: HGNC: 19904] ENSG00000215834 FMO9P flavin containing monooxygenase 9 0.205901188 0.205901188 pseudogene [Source: HGNC Symbol; Acc: HGNC: 32210] ENSG00000221823 PPP3R1 protein phosphatase 3, regulatory 0.216269193 0.216269193 subunit B, alpha [Source: HGNC Symbol; Acc: HGNC: 9317] ENSG00000226759 DAB1-AS1 DAB1 antisense RNA 1 −0.114905454 −0.114905454 [Source: HGNC Symbol; Acc: HGNC: 49443] ENSG00000227165 WDR11-AS1 WDR11 antisense RNA 1 0.10770574 0.10770574 [Source: HGNC Symbol; Acc: HGNC: 27437] ENSG00000228474 OST4 oligosaccharyltransferase 4 homolog 1.417131385 1.417131385 (S. cerevisiae) [Source: HGNC Symbol; Acc: HGNC: 32483] ENSG00000228794 LINC01128 long intergenic non-protein coding 0.101019848 0.101019848 RNA 1128 [Source: HGNC Symbol; Acc: HGNC: 49377] ENSG00000229124 VIM-AS1 VIM antisense RNA 1 0.159633467 NA [Source: HGNC Symbol; Acc: HGNC: 44879] ENSG00000229754 CXCR2P1 chemokine (C-X-C motif) receptor 2 0.332552072 0.332552072 pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 6028] ENSG00000241945 PWP2 PWP2 periodic tryptophan protein 0.131951558 0.131951558 homolog (yeast) [Source: HGNC Symbol; Acc: HGNC: 9711] ENSG00000244734 HBB hemoglobin, beta [Source: HGNC 0.439040702 0.439040702 Symbol; Acc: HGNC: 4827] ENSG00000249307 LINC01088 long intergenic non-protein coding RNA 1088 [Source: HGNC 0.150687296 0.150687296 Symbol; Acc: HGNC: 49148] ENSG00000250508 0.104851059 0.104851059 ENSG00000253729 PRKDC protein kinase, DNA-activated, 0.37333201 0.37333201 catalytic polypeptide [Source: HGNC Symbol; Acc: HGNC: 9413] ENSG00000255240 0.119700484 0.119700484 ENSG00000259207 ITGB3 integrin, beta 3 (platelet glycoprotein 0.277129861 NA IIla, antigen CD61) [Source: HGNC Symbol; Acc: HGNC: 6156] ENSG00000259673 IQCH-AS1 IQCH antisense RNA 1 −0.123239864 −0.123239864 [Source: HGNC Symbol; Acc: HGNC: 44104] ENSG00000272631 0.113665967 0.113665967

TABLE 15 The highest impact sustained by the player in the game as measured by the number of hits regressed on RNA expression in urine samples hgnc_sym- X0.5slope_0.1pvalue_0.1_Num- X0.8slope_0.1pvalue_0.1_Num- Ensembl_ID bol description ber_of_hits_urine ber_of_ hits urine ENSG00000004864 SLC25A13 solute carrier family 25 −0.110127348 −0.110127348 (aspartate/glutamate carrier), member 13 [Source:HGNC Symbol; Acc:HGNC:10983] ENSG00000005189 Putative RNA exonuclease NEF-sp −0.111815797 −0.111815797 [Source:UniProtKB/Swiss- Prot; Acc:Q96IC2] ENSG00000011451 WIZ widely interspaced zinc finger motifs 0.122786525 0.122786525 [Source:HGNC Symbol; Acc:HGNC:30917] ENSG00000016602 CLCA4 chloride channel accessory 4 0.227126793 0.227126793 [Source:HGNC Symbol; Acc:HGNC:2018] ENSG00000057294 PKP2 plakophilin 2 [Source:HGNC 0.11972821 0.11972821 Symbol; Acc:HGNC:9024] ENSG00000059588 TARBP1 TAR (HIV-1) RNA binding protein 1 0.163273139 0.163273139 [Source:HGNC Symbol; Acc:HGNC:11568] ENSG00000064270 ATP2C2 ATPase, Ca++ transporting, type 2C, 0.161536114 0.161536114 member 2 [Source:HGNC Symbol; Acc:HGNC:29103] ENSG00000066027 PPP2R5A protein phosphatase 2, regulatory −0.118772549 −0.118772549 subunit B′, alpha [Source:HGNC Symbol; Acc:HGNC:9309] ENSG00000070915 SLC12A3 solute carrier family 12 0.191921278 0.191921278 (sodium/chloride transporter), member 3 [Source:HGNC Symbol; Acc:HGNC:10912] ENSG00000075043 KCNQ2 potassium voltage-gated channel, 0.208091842 0.208091842 KQT-like subfamily, member 2 [Source:HGNC Symbol; Acc:HGNC:6296] ENSG00000075218 GTSE1 G-2 and S-phase expressed 1 0.147670253 0.147670253 [Source:HGNC Symbol; Acc:HGNC:13698] ENSG00000076984 MAP2K7 mitogen-activated protein kinase 0.114517641 0.114517641 kinase 7 [Source:HGNC Symbol; Acc:HGNC:6847] ENSG00000077044 DGKD diacylglycerol kinase, delta 130 kDa 0.314768539 0.314768539 [Source:HGNC Symbol; Acc:HGNC:2851] ENSG00000078124 ACER3 alkaline ceramidase 3 −0.154178092 −0.154178092 [Source:HGNC Symbol; Acc:HGNC:16066] ENSG00000080189 SLC35C2 solute carrier family 35 (GDP-fucose 0.110284769 0.110284769 transporter), member C2 [Source:HGNC Symbol; Acc:HGNC:17117] ENSG00000081803 CADPS2 Ca++ dependent secretion activator 0.232518544 0.232518544 2 [Source:HGNC Symbol; Acc:HGNC:16018] ENSG00000082929 C4orf6 chromosome 4 open reading frame 6 0.126772668 NA [Source:HGNC Symbol; Acc:HGNC:13716] ENSG00000086015 MAST2 microtubule associated 0.216637512 0.216637512 serine/threonine kinase 2 [Source:HGNC Symbol; Acc:HGNC:19035] ENSG00000086967 MYBPC2 myosin binding protein C, fast type 0.203070289 0.203070289 [Source:HGNC Symbol; Acc:HGNC:7550] ENSG00000090530 LEPREL1 leprecan-like 1 [Source:HGNC 0.12250088 0.12250088 Symbol; Acc:HGNC:19317] ENSG00000100478 AP4S1 adaptor-related protein complex 4, −0.102729491 −0.102729491 sigma 1 subunit [Source:HGNC Symbol; Acc:HGNC:575] ENSG00000102606 ARHGEF7 Rho guanine nucleotide exchange 0.167882897 0.167882897 factor (GEF) 7 [Source:HGNC Symbol; Acc:HGNC:15607] ENSG00000102882 MAPK3 mitogen-activated protein kinase 3 0.185955908 0.185955908 [Source:HGNC Symbol; Acc:HGNC:6877] ENSG00000103540 CCP110 centriolar coiled coil protein 110 kDa 0.159911215 0.159911215 [Source:HGNC Symbol; Acc:HGNC:24342] ENSG00000104081 BMF Bcl2 modifying factor [Source:HGNC 0.128283042 0.128283042 Symbol; Acc:HGNC:24132] ENSG00000104522 TSTA3 tissue specific transplantation 0.115170328 0.115170328 antigen P35B [Source:HGNC Symbol; Acc:HGNC:12390] ENSG00000104866 PPP1R37 protein phosphatase 1, regulatory 0.141274881 0.141274881 subunit 37 [Source:HGNC Symbol; Acc:HGNC:27607] ENSG00000105778 AVL9 AVL9 homolog (S. cerevisiase) 0.259806443 0.259806443 [Source:HGNC Symbol; Acc:HGNC:28994] ENSG00000106078 COBL cordon-bleu WH2 repeat protein 0.268699256 0.268699256 [Source:HGNC Symbol; Acc:HGNC:22199] ENSG00000106799 TGFBR1 transforming growth factor, beta −0.14151085 −0.14151085 receptor 1 [Source:HGNC Symbol; Acc:HGNC:11772] ENSG00000107164 FUBP3 far upstream element (FUSE) 0.13205712 0.13205712 binding protein 3 [Source:HGNC Symbol; Acc:HGNC:4005] ENSG00000108262 GIT1 G protein-coupled receptor kinase 0.121783678 0.121783678 interacting ArfGAP 1 [Source:HGNC Symbol; Acc:HGNC:4272] ENSG00000108509 CAMTA2 calmodulin binding transcription 0.145777329 0.145777329 activator 2 [Source:HGNC Symbol; Acc:HGNC:18807] ENSG00000109101 FOXN1 forkhead box N1 [Source:HGNC 0.102486654 0.102486654 Symbol; Acc:HGNC:12765] ENSG00000110906 KCTD10 potassium channel tetramerization 0.206396894 0.206396894 domain containing 10 [Source:HGNC Symbol; Acc:HGNC:23236] ENSG00000111581 NUP107 nucleoporin 107 kDa [Source:HGNC −0.130990824 −0.130990824 Symbol; Acc:HGNC:29914] ENSG00000111752 PHC1 polyhomeotic homolog 1 0.12426254 0.12426254 (Drosophila) [Source:HGNC Symbol; Acc:HGNC:3182] ENSG00000111788 0.115531105 0.115531105 ENSG00000111846 GCNT2 glucosaminyl (N-acetyl) transferase 0.175996115 0.175996115 2, I-branching enzyme (I blood group) [Source:HGNC Symbol; Acc:HGNC:4204] ENSG00000112679 DUSP22 dual specificity phosphatase 22 0.366644466 0.366644466 [Source:HGNC Symbol; Acc:HGNC:16077] ENSG00000113494 PRLR prolactin receptor [Source:HGNC −0.170802527 −0.170802527 Symbol; Acc:HGNC:9446] ENSG00000115159 GPD2 glycerol-3-phosphate 0.164714658 0.164714658 dehydrogenase 2 (mitochondrial) [Source:HGNC Symbol; Acc:HGNC:4456] ENSG00000115339 GALNT3 polypeptide N- 0.15392124 0.15392124 acetylgalactosaminyltransferase 3 [Source:HGNC Symbol; Acc:HGNC:4125] ENSG00000116005 PCYOX1 prenylcysteine oxidase 1 0.130228451 0.130228451 [Source:HGNC Symbol; Acc:HGNC:20588] ENSG00000116138 DNAJC16 DnaJ (Hsp40) homolog, subfamily C, −0.163592011 −0.163592011 member 16 [Source:HGNC Symbol; Acc:HGNC:29157] ENSG00000117569 PTBP2 polypyrimidine tract binding protein 2 −0.129890437 −0.129890437 [Source:HGNC Symbol; Acc:HGNC:17662] ENSG00000118194 TNNT2 troponin T type 2 (cardiac) 0.219544874 0.219544874 [Source:HGNC Symbol; Acc:HGNC:11949] ENSG00000119242 CCDC92 coiled-coil domain containing 92 0.184147564 0.184147564 [Source:HGNC Symbol; Acc:HGNC:29563] ENSG00000119943 PYROXD2 pyridine nucleotide-disulphide 0.168384424 0.168384424 oxidoreductase domain 2 [Source:HGNC Symbol; Acc:HGNC:23517] ENSG00000120088 CRHR1 corticotropin releasing hormone 0.116938068 0.116938068 receptor 1 [Source:HGNC Symbol; Acc:HGNC:2357] ENSG00000121957 GPSM2 G-protein signaling modulator 2 −0.109771975 −0.109771975 [Source:HGNC Symbol; Acc:HGNC:29501] ENSG00000124302 CHST8 carbohydrate (N- 0.118261551 0.118261551 acetylgalactosamine 4-0) sulfotransferase 8 [Source:HGNC Symbol; Acc:HGNC:15993] ENSG00000124466 LYPD3 LY6/PLAUR domain containing 3 0.123140736 0.123140736 [Source:HGNC Symbol; Acc:HGNC:24880] ENSG00000125746 EML2 echinoderm microtubule associated 0.207340861 0.207340861 protein like 2 [Source:HGNC Symbol; Acc:HGNC:18035] ENSG00000127124 HIVEP3 human immunodeficiency virus type I 0.285164542 0.285164542 enhancer binding protein 3 [Source:HGNC Symbol; Acc:HGNC:13561] ENSG00000128284 APOL3 apolipoprotein L, 3 [Source:HGNC 0.148601853 0.148601853 Symbol; Acc:HGNC:14868] ENSG00000128309 MPST mercaptopyruvate sulfurtransferase 0.246697583 0.246697583 [Source: HGNC Symbol; Acc:HGNC:7223] ENSG00000129946 SHC2 SHC (Src homology 2 domain 0.111409901 0.111409901 containing) transforming protein 2 [Source:HGNC Symbol; Acc:HGNC:29869] ENSG00000131398 KCNC3 potassium voltage-gated channel, 0.102329443 0.102329443 Shaw-related subfamily, member 3 [Source:HGNC Symbol; Acc:HGNC:6235] ENSG00000131771 PPP1R1B protein phosphatase 1, regulatory 0.21384967 0.21384967 (inhibitor) subunit 1B [Source:HGNC Symbol; Acc:HGNC:9287] ENSG00000132518 GUCY2D guanylate cyclase 2D, membrane 0.177486345 0.177486345 (retina-specific) [Source:HGNC Symbol; Acc:HGNC:4689] ENSG00000132570 PCBD2 pterin-4 alpha-carbinolamine 0.13642788 0.13642788 dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 [Source:HGNC Symbol; Acc:HGNC:24474] ENSG00000134531 EMP1 epithelial membrane protein 1 0.20283912 0.20283912 [Source:HGNC Symbol; Acc:HGNC:3333] ENSG00000136367 ZFHX2 zinc finger homeobox 2 0.234495015 0.234495015 [Source:HGNC Symbol; Acc:HGNC:20152] ENSG00000136861 CDK5RAP2 CDK5 regulatory subunit associated 0.334534954 0.334534954 protein 2 [Source:HGNC Symbol; Acc:HGNC:18672] ENSG00000137504 CREBZF CREB/ATF bZIP transcription factor 0.111526524 0.111526524 [Source:HGNC Symbol; Acc:HGNC:24905] ENSG00000138101 DTNB dystrobrevin, beta [Source:HGNC −0.122242688 −0.122242688 Symbol; Acc:HGNC:3058] ENSG00000140274 DUOXA2 dual oxidase maturation factor 2 0.1254845 NA [Source:HGNC Symbol; Acc:HGNC:32698] ENSG00000140750 ARHGAP17 Rho GTPase activating protein 17 0.193254366 0.193254366 [Source:HGNC Symbol; Acc:HGNC:18239] ENSG00000143013 LMO4 LIM domain only 4 [Source:HGNC 0.106151504 0.106151504 Symbol; Acc:HGNC:6644] ENSG00000143179 UCK2 uridine-cytidine kinase 2 0.164205324 0.164205324 [Source:HGNC Symbol; Acc:HGNC:12562] ENSG00000143322 ABL2 ABL proto-oncogene 2, non-receptor −0.217758256 −0.217758256 tyrosine kinase [Source:HGNC Symbol; Acc:HGNC:77] ENSG00000144130 NT5DC4 5′-nucleotidase domain containing 4 0.103745073 0.103745073 [Source:HGNC Symbol; Acc:HGNC:27678] ENSG00000144339 TMEFF2 transmembrane protein with EGF- 0.120238816 0.120238816 like and two follistatin-like domains 2 [Source:HGNC Symbol; Acc:HGNC:11867] ENSG00000145016 KIAA0226 KIAA0226 [Source:HGNC −0.298082516 −0.298082516 Symbol; Acc:HGNC:28991] EN5G00000148204 CRB2 crumbs family member 2 0.119128829 0.119128829 [Source:HGNC Symbol; Acc:HGNC:18688] ENSG00000150093 ITGB1 integrin, beta 1 (fibronectin receptor, 0.271478366 0.271478366 beta polypeptide, antigen CD29 includes MDF2, MSK12) [Source:HGNC Symbol; Acc:HGNC:6153] ENSG00000151176 PLBD2 phospholipase B domain containing 0.11988385 0.11988385 2 [Source:HGNC Symbol; Acc:HGNC:27283] ENSG00000151418 ATP6V1G3 ATPase, H transporting, lysosomal −0.275920997 NA 13k Da, V1 subunit G3 [Source:HGNC Symbol; Acc:HGNC:18265] ENSG00000151650 VENTX VENT homeobox [Source:HGNC 0.106920255 0.106920255 Symbol; Acc:HGNC:13639] ENSG00000154040 CABYR calcium binding tyrosine-(Y)- −0.10106877 −0.10106877 phosphorylation regulated [Source:HGNC Symbol; Acc:HGNC:15569] ENSG00000157978 LDLRAP1 low density lipoprotein receptor 0.12547496 0.12547496 adaptor protein 1 [Source:HGNC Symbol; Acc:HGNC:18640] ENSG00000158747 NBL1 neuroblastoma 1, DAN family BMP 0.102166884 0.102166884 antagonist [Source:HGNC Symbol; Acc:HGNC:7650] ENSG00000159267 HLCS holocarboxylase synthetase (biotin- 0.231199561 0.231199561 (proprionyl-CoA-carboxylase (ATP- hydrolysing)) ligase) [Source:HGNC Symbol; Acc:HGNC:4976] ENSG00000160917 CPSF4 cleavage and polyadenylation 0.110691457 0.110691457 specific factor 4, 30 kDa [Source:HGNC Symbol; Acc:HGNC:2327] ENSG00000161103 −0.235903358 −0.235903358 ENSG00000161649 CD300LG CD300 molecule-like family member 0.14510522 0.14510522 g [Source:HGNC Symbol; Acc:HGNC:30455] ENSG00000161654 LSM12 LSM12 homolog (S. cerevisiae) 0.10849167 0.10849167 [Source:HGNC Symbol; Acc:HGNC:26407] ENSG00000162458 FBLIM1 filamin binding LIM protein 1 0.150448664 0.150448664 [Source:HGNC Symbol; Acc:HGNC:24686] ENSG00000163029 SMC6 structural maintenance of −0.217725066 −0.217725066 chromosomes 6 [Source:HGNC Symbol; Acc:HGNC:20466] ENSG00000164011 ZNF691 zinc finger protein 691 0.103609573 0.103609573 [Source:HGNC Symbol; Acc:HGNC:28028] ENSG00000164076 CAMKV CaM kinase-like vesicle-associated 0.116482874 0.116482874 [Source:HGNC Symbol; Acc:HGNC:28788] ENSG00000164078 MST1R macrophage stimulating 1 receptor 0.173140081 0.173140081 (c-met-related tyrosine kinase) [Source:HGNC Symbol; Acc:HGNC:7381] ENSG00000164080 RAD54L2 RAD54-like 2 (S. cerevisiae) 0.276992712 0.276992712 [Source:HGNC Symbol; Acc:HGNC:29123] ENSG00000165238 WNK2 WNK lysine deficient protein kinase 0.313527705 0.313527705 2 [Source:HGNC Symbol; Acc:HGNC:14542] ENSG00000165406 8-Mar membrane-associated ring finger 0.196983114 0.196983114 (C3HC4) 8, E3 ubiquitin protein ligase [Source:HGNC Symbol; Acc:HGNC:23356] ENSG00000166897 ELFN2 extracellular leucine-rich repeat and 0.149450538 0.149450538 fibronectin type III domain containing 2 [Source:HGNC Symbol; Acc:HGNC:29396] ENSG00000167333 TR1M68 tripartite motif containing 68 0.191617012 0.191617012 [Source:HGNC Symbol; Acc:HGNC:21161] ENSG00000170113 NIPA1 non imprinted in Prader- 0.184095954 0.184095954 Willi/Angelman syndrome 1 [Source:HGNC Symbol; Acc:HGNC:17043] ENSG00000170382 LRRN2 leucine rich repeat neuronal 2 0.129756093 0.129756093 [Source:HGNC Symbol; Acc:HGNC:16914] ENSG00000170485 NPAS2 neuronal PAS domain protein 2 0.314985749 0.314985749 [Source:HGNC Symbol; Acc:HGNC:7895] ENSG00000171124 FUT3 fucosyltransferase 3 (galactoside 0.114542381 0.114542381 3(4)-L-fucosyltransferase, Lewis blood group) [Source:HGNC Symbol; Acc:HGNC:4014] ENSG00000171282 NA NA 0.204037734 0.204037734 ENSG00000172350 ABCG4 ATP-binding cassette, sub-family G 0.165612528 0.165612528 (WHITE), member 4 [Source:HGNC Symbol; Acc:HGNC:13884] ENSG00000172732 MUS81 MUS81 structure-specific 0.107666424 0.107666424 endonuclease subunit [Source:HGNC Symbol; Acc:HGNC:29814] ENSG00000174403 C200rf1 C20orf166 antisense RNA 1 0.101093828 0.101093828 66-AS1 [Source:HGNC Symbol; Acc:HGNC:26393] ENSG00000176490 DIRAS1 DIRAS family, GTP-binding RAS-like 0.109381543 0.109381543 1 [Source:HGNC Symbol; Acc:HGNC:19127] ENSG00000176619 LMNB2 lamin B2 [Source:HGNC 0.113686714 0.113686714 Symbol; Acc:HGNC:6638] ENSG00000177409 SAMD9L sterile alpha motif domain containing −0.100124985 −0.100124985 9-like [Source:HGNC Symbol; Acc:HGNC:1349] ENSG00000177463 NR2C2 nuclear receptor subfamily 2, group 0.145768463 0.145768463 C, member 2 [Source:HGNC Symbol; Acc:HGNC:7972] ENSG00000177732 SOX12 SRY (sex determining region Y)-box 0.107453892 0.107453892 12 [Source:HGNC Symbol; Acc:HGNC:11198] ENSG00000178222 RNF212 ring finger protein 212 −0.129043541 −0.129043541 [Source:HGNC Symbol; Acc:HGNC:27729] ENSG00000178381 ZFAND2A zinc finger, AN1-type domain 2A 0.114942582 0.114942582 [Source:HGNC Symbol; Acc:HGNC:28073] ENSG00000179344 HLA- major histocompatibility complex, 0.110543773 0.110543773 DQB1 class II, DQ beta 1 [Source:HGNC Symbol; Acc:HGNC:4944] ENSG00000179364 PACS2 phosphofurin acidic cluster sorting 0.23829197 0.23829197 protein 2 [Source:HGNC Symbol; Acc:HGNC:23794] ENSG00000179954 SSC5D scavenger receptor cysteine rich 0.229332392 0.229332392 family, 5 domains [Source:HGNC Symbol; Acc:HGNC:26641] ENSG00000181830 SLC35C1 solute carrier family 35 (GDP-fucose 0.109327452 0.109327452 transporter), member C1 [Source:HGNC Symbol; Acc:HGNC:20197] 0.101454141 0.101454141 ENSG00000182173 TSEN54 TSEN54 tRNA splicing endonuclease subunit [Source:HGNC Symbol; Acc:HGNC:27561] ENSG00000182872 RBM10 RNA binding motif protein 10 0.137603426 0.137603426 [Source:HGNC Symbol; Acc:HGNC:9896] ENSG00000182979 MTA1 metastasis associated 1 0.170722298 0.170722298 [Source:HGNC Symbol; Acc:HGNC:7410] ENSG00000184428 TOP1MT topoisomerase (DNA) I, 0.156880641 0.156880641 mitochondria [Source:HGNC Symbol; Acc:HGNC:29787] ENSG00000185681 MORN5 MORN repeat containing 5 0.110300187 0.110300187 [Source:HGNC Symbol; Acc:HGNC:17841] ENSG00000186716 BCR breakpoint cluster region 0.22887557 0.22887557 [Source:HGNC Symbol; Acc:HGNC:1014] ENSG00000187091 PLCD1 phospholipase C, delta 1 0.149312832 0.149312832 [Source:HGNC Symbol; Acc:HGNC:9060] EN5G00000187726 DNAJB13 DnaJ (Hsp40) homolog, subfamily B, 0.109771337 0.109771337 member 13 [Source:HGNC Symbol; Acc:HGNC:30718] ENSG00000188295 ZNF669 zinc finger protein 669 −0.114965733 −0.114965733 [Source:HGNC Symbol; Acc:HGNC:25736] ENSG00000188305 C19orf35 chromosome 19 open reading frame 0.109109673 0.109109673 35 [Source:HGNC Symbol; Acc:HGNC:24793] ENSG00000188342 GTF2F2 general transcription factor IIF, −0.111631344 −0.111631344 polypeptide 2, 30 kDa [Source:HGNC Symbol; Acc:HGNC:4653] ENSG00000188522 FAM83G family with sequence similarity 83, 0.132724731 0.132724731 member G [Source:HGNC Symbol; Acc:HGNC:32554] ENSG00000196912 ANKRD36B ankyrin repeat domain 36B 0.156343623 0.156343623 [Source:HGNC Symbol; Acc:HGNC:29333] ENSG00000196979 0.119560483 0.119560483 ENSG00000197588 KLKP1 kallikrein pseudogene 1 0.102829337 0.102829337 [Source:HGNC Symbol; Acc:HGNC:21260] ENSG00000198712 MT-CO2 mitochondrially encoded cytochrome 39.44977646 39.44977646 c oxidase II [Source:HGNC Symbol; Acc:HGNC:7421] ENSG00000198763 MT-ND2 mitochondrially encoded NADH 58.26926395 58.26926395 dehydrogenase 2 [Source:HGNC Symbol; Acc:HGNC:7456] ENSG00000198840 MT-ND3 mitochondrially encoded NADH 15.75329743 15.75329743 dehydrogenase 3 [Source:HGNC Symbol; Acc:HGNC:7458] ENSG00000198938 MT-CO3 mitochondrially encoded cytochrome 69.19449684 69.19449684 c oxidase III [Source:HGNC Symbol; Acc:HGNC:7422] ENSG00000200786 RNA5S RNA, 5S ribosomal pseudogene 234 0.132518474 0.132518474 P234 [Source:HGNC Symbol; Acc:HGNC:43134] ENSG00000204227 RING1 ring finger protein 1 [Source:HGNC 0.100397335 0.100397335 Symbol; Acc:HGNC:10018] ENSG00000204394 VARS valyl-tRNA synthetase 0.137036746 0.137036746 [Source:HGNC Symbol; Acc:HGNC:12651] ENSG00000204544 MUC21 mucin 21, cell surface associated 0.436615679 0.436615679 [Source:HGNC Symbol; Acc:HGNC:21661] ENSG00000205913 SRRM2- SRRM2 antisense RNA 1 0.179522346 0.179522346 AS1 [Source:HGNC Symbol; Acc:HGNC:44162] ENSG00000206072 SERPIN serpin peptidase inhibitor, clade B 0.174187171 0.174187171 B11 (ovalbumin), member 11 (gene/pseudogene) [Source:HGNC Symbol; Acc:HGNC:14221] ENSG00000209082 MT-TL1 mitochondrially encoded tRNA 3.752960902 3.752960902 leucine 1 (UUA/G) [Source:HGNC Symbol; Acc:HGNC:7490] ENSG00000210049 MT-TF mitochondrially encoded tRNA 1.326454211 1.326454211 phenylalanine [Source:HGNC Symbol; Acc:HGNC:7481] ENSG00000210077 MT-TV mitochondrially encoded tRNA valine 1.931189951 1.931189951 [Source:HGNC Symbol; Acc:HGNC:7500] ENSG00000210100 MT-TI mitochondrially encoded tRNA 0.748172138 NA isoleucine [Source:HGNC Symbol; Acc:HGNC:7488] ENSG00000210107 MT-TQ mitochondrially encoded tRNA 0.827008658 0.827008658 glutamine [Source:HGNC Symbol; Acc:HGNC:7495] ENSG00000210117 MT-TW mitochondrially encoded tRNA 0.954577644 0.954577644 tryptophan [Source:HGNC Symbol; Acc:HGNC:7501] ENSG00000210140 MT-TC mitochondrially encoded tRNA 1.479211632 1.479211632 cysteine [Source:HGNC Symbol; Acc:HGNC:7477] ENSG00000210156 MT-TK mitochondrially encoded tRNA lysine 2.666703242 2.666703242 [Source:HGNC Symbol; Acc:HGNC:7489] ENSG00000210176 MT-TH mitochondrially encoded tRNA 0.682012426 0.682012426 histidine [Source:HGNC Symbol; Acc:HGNC:7487] ENSG00000210191 MT-TL2 mitochondrially encoded tRNA 0.922588714 0.922588714 leucine 2 (CUN) [Source:HGNC Symbol; Acc:HGNC:7491] ENSG00000210194 MT-TE mitochondrially encoded tRNA 1.836315218 1.836315218 glutamic acid [Source:HGNC Symbol; Acc:HGNC:7479] ENSG00000210195 MT-TT mitochondrially encoded tRNA 1.382306537 1.382306537 threonine [Source:HGNC Symbol; Acc:HGNC:7499] ENSG00000210196 MT-TP mitochondrially encoded tRNA 2.287555836 2.287555836 proline [Source:HGNC Symbol; Acc:HGNC:7494] ENSG00000214717 ZBED1 zinc finger, BED-type containing 1 0.117523428 0.117523428 [Source:HGNC Symbol; Acc:HGNC:447] ENSG00000215764 NA NA 0.147764961 NA ENSG00000224546 EIF4BP3 eukaryotic translation initiation factor 0.106753603 0.106753603 4B pseudogene 3 [Source:HGNC Symbol; Acc:HGNC:37936] ENSG00000225630 MTND2 MT-ND2 pseudogene 28 2.381423925 2.381423925 P28 [Source:HGNC Symbol; Acc:HGNC:42129] ENSG00000228253 MT- mitochondrially encoded ATP 11.70455103 11.70455103 ATP8 synthase 8 [Source:HGNC Symbol; Acc:HGNC:7415] ENSG00000229344 0.876864647 NA ENSG00000232040 ZBED9 zinc finger, BED-type containing 9 0.105378625 0.105378625 [Source:HGNC Symbol; Acc:HGNC:13851] ENSG00000232111 0.420895402 0.420895402 ENSG00000234690 0.105457816 0.105457816 ENSG00000236279 CLEC2L C-type lectin domain family 2, 0.114925734 0.114925734 member L [Source:HGNC Symbol; Acc:HGNC:21969] ENSG00000240707 LINC01 long intergenic non-protein coding 0.16582864 0.16582864 168 RNA 1168 [Source:HGNC Symbol; Acc:HGNC:49537] ENSG00000241945 PWP2 PWP2 periodic tryptophan protein 0.15435837 0.15435837 homolog (yeast) [Source:HGNC Symbol; Acc:HGNC:9711] ENSG00000247498 0.117411337 0.117411337 ENSG00000249307 LINC01 long intergenic non-protein coding 0.129530264 0.129530264 088 RNA 1088 [Source:HGNC Symbol; Acc:HGNC:49148] ENSG00000249476 0.142630541 0.142630541 ENSG00000249713 0.11885548 NA ENSG00000250198 0.108768085 0.108768085 ENSG00000250508 0.113241056 0.113241056 ENSG00000250519 0.196753321 0.196753321 ENSG00000253641 0.108338901 0.108338901 ENSG00000258628 −0.167706429 −0.167706429 ENSG00000259176 −0.14367802 −0.14367802 ENSG00000259479 SORD2P sorbitol dehydrogenase 2, 0.273747163 0.273747163 pseudogene [Source:HGNC Symbol; Acc:HGNC:49919] ENSG00000260139 CSPG4 chondroitin sulfate proteoglycan 4 0.12083532 0.12083532 P13 pseudogene 13 [Source:HGNC Symbol; Acc:HGNC:49195] ENSG00000269190 FBXO17 F-box protein 17 [Source:HGNC 0.106896024 0.106896024 Symbol; Acc:HGNC:18754] ENSG00000271178 IGHV30 immunoglobulin heavy variable 0.103406674 NA R16-13 3/OR16-13 (non-functional) [Source:HGNC Symbol; Acc:HGNC:5637]

TABLE 16 Biomarkers differentially expressed in the blood samples of subjects who experienced most forceful head impact (Max_HITsp) when compared with the subjects' baseline, subjects who experienced least forceful head impact (Min_HITsp), or subjects who are not contact sports athletes (Track_field_control) Max_HITsp_ Max_HITsp_ Max_HITsp_ Max_HITsp_ blood_vs_ blood_vs_ blood_vs_ blood_vs_Min_ Track_field_ Track_field_ baseline_blood_ HITsp_blood_ control_blood_ Ensembl_ID HGNC_symbol Description control_blood previous_day previous_day previous_day ENSG00000015413 DPEP1 dipeptidase 1 (renal) NA NA NA −2.07 [Source: HGNC Symbol; Acc: HGNC: 3002] ENSG00000099998 GGT5 gamma-glutamyltransferase 5 NA NA NA −2.27 [Source: HGNC Symbol; Acc: HGNC: 4260] ENSG00000102098 SCML2 sex comb on midleg-like 2 NA NA 4.04 NA (Drosophila) [Source: HGNC Symbol; Acc: HGNC: 10581] ENSG00000135587 SMPD2 sphingomyelin phosphodiesterase 2, NA NA NA −2.51 neutral membrane (neutral sphingomyelinase) [Source: HGNC Symbol; Acc: HGNC: 11121] ENSG00000138433 CIR1 corepressor interacting with RBPJ, 1 NA −2.25 NA NA [Source: HGNC Symbol; Acc: HGNC: 24217] ENSG00000163029 SMC6 structural maintenance of NA NA NA 2.01 chromosomes 6 [Source: HGNC Symbol; Acc: HGNC: 20466] ENSG00000177045 S1X5 SIX homeobox 5 NA −2.69 −3.62 −3.80 [Source: HGNC Symbol; Acc: HGNC: 10891] ENSG00000181885 CLDN7 claudin 7 NA −2.93 NA NA [Source: HGNC Symbol; Acc: HGNC: 2049] ENSG00000185252 ZNF74 zinc finger protein 74 NA NA NA −2.34 [Source: HGNC Symbol; Acc: HGNC: 13144] ENSG00000185338 SOCS1 suppressor of cytokine signaling 1 NA −3.19 −4.52 −3.90 [Source: HGNC Symbol; Acc: HGNC: 19383] ENSG00000188365 NA −3.80 NA −4.57 ENSG00000212857 NA NA NA NA NA −4.47 ENSG00000213443 C-type lectin domain family 2, NA −4.55 NA NA member D [Source: EntrezGene; Acc: 29121] ENSG00000214708 NA −3.99 NA NA ENSG00000219926 NA −2.49 NA NA ENSG00000227603 NA −3.43 NA NA ENSG00000230843 NA −3.90 NA NA ENSG00000231232 NA −3.78 NA NA ENSG00000231435 NA −2.55 NA −3.26 ENSG00000234009 RPL5P34 ribosomal protein L5 pseudogene 34 NA −4.22 NA NA [Source: HGNC Symbol; Acc: HGNC: 36463] ENSG00000236559 4.58 NA NA 4.31 ENSG00000237027 NA NA NA 3.75 ENSG00000240752 NA NA NA −4.02 ENSG00000241552 RN7SL58P RNA, 7SL, cytoplasmic 58, NA −3.71 NA NA pseudogene [Source: HGNC Symbol; Acc: HGNC: 46074] ENSG00000243075 RN7SL519P RNA, 7SL, cytoplasmic 519, NA NA NA 4.84 pseudogene [Source: HGNC Symbol; Acc: HGNC: 46535] ENSG00000248498 ASNSP1 asparagine synthetase pseudogene 1 NA NA NA 5.34 [Source: HGNC Symbol; Acc: HGNC: 754] ENSG00000249734 NA NA NA 3.90 ENSG00000254681 PKD1P5 polycystic kidney disease 1 (autosomal NA −3.37 NA −4.62 dominant) pseudogene 5 [Source: HGNC Symbol; Acc: HGNC: 30069] ENSG00000256915 4.47 NA NA 4.47 ENSG00000258406 4.97 NA NA 4.62 ENSG00000259842 IGHV3OR16- immunoglobulin heavy variable NA −3.74 NA NA 16 3/OR16-16 (pseudogene) [Source: HGNC Symbol; Acc: HGNC: 5640] ENSG00000262539 NA −3.71 NA NA ENSG00000269316 NA −3.46 −4.27 −3.99 ENSG00000269753 NA NA NA −3.73 NA NA ENSG00000270170 NCBP2-AS2 NCBP2 antisense RNA 2 (head to head) NA −4.00 NA NA [Source: HGNC Symbol; Acc: HGNC: 25121] ENSG00000271945 NA −4.75 NA NA ENSG00000272183 NA −4.19 NA NA ENSG00000273185 NA NA NA 4.15

TABLE 17 Biomarkers differentially expressed in the urine or saliva samples of subjects who experienced most forceful head impact (Max_HITsp) as compared to the subjects' baseline or subjects who are not contact sports athletes (Track_field_contro1). Max_HITsp_ Max_HITsp_ saliva_vs_ urine_vs_ Track_field_ Max_HITsp_ Track_ control_ urine_vs_ field_ saliva_ HGNC_ baseline_ control_ previous_ Ensembl_ID symbol Descriptiom urine urine day ENSG00000104327 CALB1 calbindin 1, 28 kDa [Source:HGNC −2.36 NA NA Symbol; Acc:HGNC:1434] ENSG00000113889 KNG1 kininogen 1 [Source:HGNC Symbol; Acc:HGNC:6383 −2.55 NA NA ENSG00000125652 ALKBH7 alkB, alkylation repair homolog 7 (E. coli) [Source:HGNC NA 2.38 NA Symbol; Acc:HGNC:21306] ENSG00000125780 TGM3 transglutaminase 3 [Source:HGNC NA NA 2.43 Symbol; Acc:HGNC:11779] ENSG00000127528 KLF2 Kruppel-like factor 2 [Source:HGNC NA 3.21 NA Symbol; Acc:HGNC:6347] ENSG00000150201 FXYD4 FXYD domain containing ion transport regulator 4 NA −2.48 NA [Source:HGNC Symbol; Acc:HGNC:4028] ENSG00000170891 CYTL1 cytokine-like 1 [Source:HGNC Symbol; Acc:HGNC:24435] NA 4.25 NA ENSG00000185130 HIST1H2BL histone cluster 1, H2bl [Source:HGNC NA 4.01 NA Symbol; Acc:HGNC:4748] ENSG00000206172 HBA1 hemoglobin, alpha 1 [Source:HGNC NA 4.22 NA Symbol; Acc:HGNC:4823] ENSG00000211698 TRGV4 T cell receptor gamma variable 4 [Source:HGNC NA 3.92 NA Symbol; Acc:HGNC:12289] ENSG00000217643 PTGES3P2 prostaglandin E synthase 3 (cytosolic) pseudogene 2 NA 3.24 NA [Source:HGNC Symbol; Acc:HGNC:43822] ENSG00000224172 NA 4.55 ENSG00000227125 NA 3.35 NA ENSG00000228857 NA 4.04 NA ENSG00000233115 FAM90A11P family with sequence similarity 90, member A11, NA 4.44 NA pseudogene [Source:HGNC Symbol; Acc:HGNC:32259] ENSG00000234519 NA −3.85 NA ENSG00000234629 WDR82P1 WD repeat domain 82 pseudogene 1 [Source:HGNC NA 3.74 NA Symbol; Acc:HGNC:32447] ENSG00000236495 NA −4.14 NA ENSG00000236641 NA 3.98 NA ENSG00000253759 IGHV3-57 immunoglobulin heavy variable 3-57 (pseudogene) NA 4.17 NA [Source:HGNC Symbol; Acc:HGNC:5612] ENSG00000255079 NA 3.81 NA ENSG00000257718 NA 3.90 NA ENSG00000259770 NA 3.65 NA ENSG00000264280 NA NA NA 4.35 NA ENSG00000267762 NA 3.63 NA ENSG00000271029 NA 3.98 NA

TABLE 18 Biomarkers differentially expressed when the blood samples of subjects who experienced most frequent head impact (Max_freq_hits) are compared to the subject's baseline or subjects who are not contact sports athletes (Track_field_control) Max_feq_ hits_blood_vs_ Max_freq_ Track_field_ Max_freq_ hits_blood_vs_ control_ hits_blood_ Track_field_ blood_ HGNC_ vs_baseline_ control_ previous_ Ensembl_ID symbol Descriptiom blood blood day ENSG00000172201 ID4 inhibitor of DNA binding 4, dominant negative −3.88 NA NA helix-loop-helix protein [Source:HGNC Symbol; Acc:HGNC:5363] ENSG00000210196 MT-TP mitochondrially encoded tRNA proline [Source:HGNC NA NA 3.89 Symbol; Acc:HGNC:7494] ENSG00000214772 −3.94 NA NA ENSG00000235858 NA 4.24 NA ENSG00000244060 RPS2P41 ribosomal protein S2 pseudogene 41 [Source:HGNC NA 3.74 NA Symbol; Acc:HGNC:36357] ENSG00000250535 STK19B serine/threonine kinase 19B, pseudogene NA −4.06 NA [Source:HGNC Symbol; Acc:HGNC:21668] ENSG00000253469 −4.43 NA NA ENSG00000256915 NA 4.19 NA ENSG00000260265 −4.56 NA NA

TABLE 19 Biomarkers differentially expressed when the urine samples of subjects who experienced most frequent head impacts (Max_freq_hits) are compared to the subjects 'baseline, subjects who experienced least forceful head impact (Min_freq_hits), or subjects who are not contact sports athletes (Track_field_control) Max_freq_ Ma′_freq_ Max_freq_ Max_freq_ Max_freq_ hits_urine_ hits_urine_ hits_urine_ hits_urine_ hits_urine_vs_ vs_ vs_Min_ vs_Track_ vs_baseline_ Track_field_ baseline_ freq_hits_ field_control_ urine_ control_urine_ Ensembl_ID HGNC_symbol Description urine urine urine previous_day previous_day ENSG00000008438 PGLYRP1 peptidoglycan recognition NA NA 3.29 NA NA protein 1 [Source: HGNC Symbol; Acc: HGNC: 8904] ENSG00000060762 MPC1 mitochondrial pyruvate −2.26 NA NA NA NA carrier 1 [Source: HGNC Symbol; Acc: HGNC: 21606] ENSG00000104327 CALB1 calbindin 1, 28 kDa −2.57 NA NA −2.44 NA [Source: HGNC Symbol; Acc: HGNC: 1434] ENSG00000105518 TMEM205 transmembrane protein 205 NA NA NA NA −2.05   [Source: HGNC Symbol; Acc: HGNC: 29631] ENSG00000105647 PIK3R2 phosphoinositide-3-kinase, NA NA 2.65 NA NA regulatory subunit 2 (beta) [Source: HGNC Symbol; Acc: HGNC: 8980] ENSG00000107485 GATA3 GATA binding protein 3 NA −2.33 NA NA NA [Source: HGNC Symbol; Acc: HGNC: 4172] ENSG00000113889 KNG1 kininogen 1 −2.63 NA NA −2.58 NA [Source: HGNC Symbol; Acc: HGNC: 6383] ENSG00000116032 GRIN3B glutamate receptor, ionotropic, NA NA 2.41 NA NA N-methyl-D-aspartate 3B [Source: HGNC Symbol; Acc: HGNC: 16768] ENSG00000120306 CYSTM1 cysteine-rich transmembrane −2.02 NA NA NA NA module containing 1 [Source: HGNC Symbol; Acc: HGNC: 30239] ENSG00000120699 EXOSC8 exosome component 8 NA NA NA NA NA [Source: HGNC Symbol; Acc: HGNC: 17035] ENSG00000122862 SRGN serglycin NA NA 3.03 NA NA [Source: HGNC Symbol; Acc: HGNC: 9361] ENSG00000125652 ALKBH7 alkB, alkylation repair NA NA 2.39 NA 2.49 homolog 7 (E. coli) [Source: HGNC Symbol; Acc: HGNC: 21306] ENSG00000127528 KLF2 Kruppel-like factor 2 NA NA 3.28 NA NA [Source: HGNC Symbol; Acc: HGNC: 6347] ENSG00000128645 HOXD1 homeobox D1 NA NA 2.26 NA NA [Source: HGNC Symbol; Acc: HGNC: 5132] ENSG00000134809 TIMM10 translocase of inner NA NA −2.21   NA NA mitochondrial membrane 10 homolog (yeast) [Source: HGNC Symbol; Acc: HGNC: 11814] ENSG00000137731 FXYD2 FXYD domain containing ion NA NA NA −2.14 NA transport regulator 2 [Source: HGNC Symbol; Acc: HGNC: 4026] ENSG00000138207 RBP4 retinol binding protein 4, NA NA −2.23   NA NA plasma [Source: HGNC Symbol; Acc: HGNC: 9922] ENSG00000143546 S100A8 S100 calcium binding NA NA 2.65 NA NA protein A8 [Source: HGNC Symbol; Acc: HGNC: 10498] ENSG00000150201 FXYD4 FXYD domain containing ion NA NA −2.58   NA −2.57   transport regulator 4 [Source: HGNC Symbol; Acc: HGNC: 4028] ENSG00000160181 TFF2 trefoil factor 2 NA NA 2.78 NA NA [Source: HGNC Symbol; Acc: HGNC: 11756] ENSG00000161992 PRR35 proline rich 35 NA NA 3.16 NA NA [Source: HGNC Symbol; Acc: HGNC: 14139] ENSG00000163209 SPRR3 small proline-rich protein 3 NA NA 2.86 NA NA [Source: HGNC Symbol; Acc: HGNC: 11268] ENSG00000163577 EIF5A2 eukaryotic translation initiation NA NA NA NA NA factor 5A2 [Source: HGNC Symbol; Acc: HGNC: 3301] ENSG00000163739 CXCL1 chemokine (C-X-C motif) NA NA 2.66 NA NA ligand 1(melanoma growth stimulating activity, alpha) [Source: HGNC Symbol; Acc: HGNC: 4602] ENSG00000164114 MAP9 microtubule-associated NA NA NA NA NA protein 9 [Source: HGNC Symbol; Acc: HGNC: 26118] ENSG00000164729 SLC35G3 solute carrier family 35, NA NA 2.38 NA NA member G3 [Source: HGNC Symbol; Acc: HGNC: 26848] ENSG00000164825 DEFB1 defensin, beta 1 −3.23 NA NA NA NA [Source: HGNC Symbol; Acc: HGNC: 2766] ENSG00000165685 TMEM52B transmembrane protein 52B −2.27 NA NA −3.00 NA [Source: HGNC Symbol; Acc: HGNC: 26438] ENSG00000165799 RNASE7 ribonuclease, RNase A family, NA NA 2.63 NA NA 7 [Source: HGNC Symbol; Acc: HGNC: 19278] ENSG00000168746 C20orf62 chromosome 20 open reading NA NA 3.41 NA NA frame 62 [Source: HGNC Symbol; Acc: HGNC: 16195] ENSG00000169344 UMOD uromodulin −2.08 NA NA NA NA [Source: HGNC Symbol; Acc: HGNC: 12559] ENSG00000170891 CYTL1 cytokine-like 1 NA NA 3.24 NA NA [Source: HGNC Symbol; Acc: HGNC: 24435] ENSG00000173915 USMG5 up-regulated during skeletal NA NA −2.09   NA NA muscle growth 5 homolog (mouse) [Source: HGNC Symbol; Acc: HGNC: 30889] ENSG00000175197 DDIT3 DNA-damage-inducible NA NA 2.25 NA NA transcript 3 [Source: HGNC Symbol; Acc: HGNC: 2726] ENSG00000175283 DOLK dolichol kinase NA NA 2.17 NA NA [Source: HGNC Symbol; Acc: HGNC: 23406] ENSG00000176125 UFSP1 UFM1-specific peptidase 1 NA NA 3.85 NA NA (non-functional) [Source: HGNC Symbol; Acc: HGNC: 33821] ENSG00000179751 SYCN syncollin NA NA 2.85 NA NA [Source: HGNC Symbol; Acc: HGNC: 18442] ENSG00000181499 OR6T1 olfactory receptor, family 6, NA NA 3.35 NA NA subfamily T, member 1 [Source: HGNC Symbol; Acc: HGNC: 14848] ENSG00000184908 CLCNKB chloride channel, voltage- −2.34 NA NA −2.40 NA sensitive Kb [Source: HGNC Symbol; Acc: HGNC: 2027] ENSG00000185130 HIST1H2BL histone cluster 1, H2bl NA 3.91 NA NA NA [Source: HGNC Symbol; Acc: HGNC: 4748] ENSG00000185275 CD24P4 CD24 molecule pseudogene 4 −2.13 NA NA NA NA [Source: HGNC Symbol; Acc: HGNC: 1649] ENSG00000187186 HCG2040265, isoform NA NA 2.85 NA NA CRA_a; Uncharacterized protein; cDNA FLJ50015 [Source: UniProtKB/TrEMBL; Acc: B7Z3J9] ENSG00000187808 SOWAHD sosondowah ankyrin repeat NA NA 3.42 NA NA domain family member D [Source: HGNC Symbol; Acc: HGNC: 32960] ENSG00000194297 RNU1-75P RNA, U1 small nuclear 75, NA NA 3.18 NA NA pseudogene [Source: HGNC Symbol; Acc: HGNC: 48417] ENSG00000197061 HIST1H4C histone cluster 1, H4c −2.05 NA NA NA NA [Source: HGNC Symbol; Acc: HGNC: 4787] ENSG00000197674 OR51C1P olfactory receptor, family 51, NA NA 2.60 NA NA subfamily C, member 1 pseudogene [Source: HGNC Symbol; Acc: HGNC: 15191] ENSG00000198518 NA NA NA NA −2.01   NA NA ENSG00000198888 MT-ND1 mitochondrially encoded NA NA −2.13 NA NADH dehydrogenase 1 [Source: HGNC Symbol; Acc: HGNC: 7455] ENSG00000199212 RNU105C RNA, U105C small nucleolar NA NA 3.03 NA NA [Source: HGNC Symbol; Acc: HGNC: 10104] ENSG00000199378 Y RNA NA NA 3.56 NA NA [Source: RFAM; Acc: RF00019] ENSG00000199536 RNU6-315P RNA, U6 small nuclear 315, NA NA 2.83 NA NA pseudogene [Source: HGNC Symbol; Acc: HGNC: 47278] ENSG00000200087 SNORA73B small nucleolar RNA, NA NA 3.84 NA 3.44 H/ACA box 73B [Source: HGNC Symbol; Acc: HGNC: 10116] ENSG00000200131 RN7SKP77 RNA, 7SK small nuclear NA NA 4.78 NA 4.33 pseudogene 77 [Source: HGNC Symbol; Acc: HGNC: 45801] ENSG00000200408 RNA5SP74 RNA, 5S ribosomal NA NA 3.83 NA NA pseudogene 74 [Source: HGNC Symbol; Acc: HGNC: 42851] ENSG00000201098 RNY1 RNA, Ro-associated Y1 NA NA −2.69   NA −2.68   [Source: HGNC Symbol; Acc: HGNC: 10242] ENSG00000201640 RN7SKP28 RNA, 7SK small nuclear NA NA 3.29 NA NA pseudogene 28 [Source: HGNC Symbol; Acc: HGNC: 45752] ENSG00000201984 Y RNA NA NA 3.57 NA NA [Source: RFAM; Acc: RF00019] ENSG00000203616 RHOT1P2 ras homolog family member NA NA 3.37 NA NA Ti pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 37838] ENSG00000204444 APOM apolipoprotein M NA NA −2.73   NA −2.78 [Source: HGNC Symbol; Acc: HGNC: 13916] ENSG00000204544 MUC21 mucin 21, cell surface NA NA 2.75 NA NA associated [Source: HGNC Symbol; Acc: HGNC: 21661] ENSG00000205559 CHKB-AS1 CHKB antisense RNA 1 (head NA NA 3.27 NA NA to head) [Source: HGNC Symbol; Acc: HGNC: 40146] ENSG00000205795 CYS1 cystin 1 −2.38 NA NA NA NA [Source: HGNC Symbol; Acc: HGNC: 18525] ENSG00000206172 HBA1 hemoglobin, alpha 1 NA NA 3.27 NA 3.65 [Source: HGNC Symbol; Acc: HGNC: 4823] ENSG00000206634 SNORA22 small nucleolar RNA, NA NA 3.37 NA NA H/ACA box 22 [Source: HGNC Symbol; Acc: HGNC: 32612] ENSG00000206652 RNU1-1 RNA, U1 small nuclear 1 [Source: HGNC Symbol; NA NA 2.13 NA NA Acc: HGNC: 10120] ENSG00000207010 RNU6-1295P RNA, U6 small nuclear 1295, NA NA 3.60 NA NA pseudogene [Source: HGNC Symbol; Acc: HGNC: 48258] ENSG00000210127 MT-TA mitochondrially encoded −2.25 NA NA −2.60 NA tRNA alanine [Source: HGNC Symbol; Acc: HGNC: 7475] ENSG00000210140 MT-TC mitochondrially encoded NA NA NA −2.23 NA tRNA cysteine [Source: HGNC Symbol; Acc: HGNC: 7477] ENSG00000210196 MT-TP mitochondrially encoded NA NA NA NA NA tRNA proline [Source: HGNC Symbol; Acc: HGNC: 7494] ENSG00000211698 TRGV4 T cell receptor gamma NA NA 4.35 NA 4.22 variable 4 [Source: HGNC Symbol; Acc: HGNC: 12289] ENSG00000212497 RNA5SP465 RNA, 5S ribosomal NA NA 3.53 NA NA pseudogene 465 [Source: HGNC Symbol; Acc: HGNC: 43365] ENSG00000213343 RPL21P18 ribosomal protein L21 NA NA 3.50 NA NA pseudogene 18 [Source: HGNC Symbol; Acc: HGNC: 28362] ENSG00000213871 TAF9BP1 TAF9B RNA polymerase II, NA NA 3.06 NA NA TATA box binding protein (TBP)-associated factor, 31 kDa pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 30687] ENSG00000213896 NA NA 4.31 NA NA ENSG00000214070 NA NA 3.27 NA NA ENSG00000214381 LINC00488 long intergenic non-protein NA NA 2.61 NA NA coding RNA 488 [Source: HGNC Symbol; Acc: HGNC: 32675] ENSG00000214759 NA NA 3.22 NA NA ENSG00000215004 MESTP4 mesoderm specific transcript NA NA 3.14 NA NA pseudogene 4 [Source: HGNC Symbol; Acc: HGNC: 38554] ENSG00000215043 GLULP6 glutamate-ammonia ligase NA NA 3.79 NA NA (glutamine synthetase) pseudogene 6 [Source: HGNC Symbol; Acc: HGNC: 37990] ENSG00000215481 BCRP3 breakpoint cluster region NA NA 3.07 NA NA pseudogene 3 [Source: HGNC Symbol; Acc: HGNC: 1016] ENSG00000216966 NA NA 3.41 NA NA ENSG00000217643 PTGES3P2 prostaglandin E synthase 3 NA NA 3.33 NA 3.27 (cytosolic) pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 43822] ENSG00000218180 SLC25A5P7 solute carrier family 25 NA NA 2.85 NA NA (mitochondrial carrier; adenine nucleotide translocator), member 5 pseudogene 7 [Source: HGNC Symbol; Acc: HGNC: 513] ENSG00000218803 GSTM2P1 glutathione S-transferase mu 2 NA NA 2.75 NA 2.84 (muscle) pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 38009] ENSG00000219074 SOD1P1 superoxide dismutase 1, NA NA 3.03 NA NA soluble pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 45134] ENSG00000221571 RNU6ATAC35P RNA, U6atac small nuclear NA NA NA NA 35, pseudogene [Source: HGNC Symbol; Acc: HGNC: 46934] ENSG00000222281 RN7SKP111 RNA, 7SK small nuclear NA NA 3.68 NA NA pseudogene 111 [Source: HGNC Symbol; Acc: HGNC: 45835] ENSG00000222460 RN7SKP271 RNA, 7SK small nuclear NA NA 4.25 NA NA pseudogene 271 [Source: HGNC Symbol; Acc: HGNC: 45995] ENSG00000222678 RN7SKP213 RNA, 7SK small nuclear NA NA 2.85 NA NA pseudogene 213 [Source: HGNC Symbol; Acc: HGNC: 45937] ENSG00000222985 RNU2-14P RNA, U2 small nuclear 14, NA NA 3.72 NA NA pseudogene [Source: HGNC Symbol; Acc: HGNC: 48507] ENSG00000223581 NA NA 3.84 NA NA ENSG00000223916 NA NA 3.64 NA NA ENSG00000223963 PRKRIRP8 protein-kinase, interferon- NA NA NA NA inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 8 [Source: HGNC Symbol; Acc: HGNC: 39572] ENSG00000224172 NA NA 4.79 NA 4.28 ENSG00000224682 SOCS5P2 suppressor of cytokine NA NA NA NA signaling 5 pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 44598] ENSG00000225255 NA NA NA NA ENSG00000225770 NA NA 3.53 NA 3.45 ENSG00000226403 NA NA 3.50 NA NA ENSG00000226471 NA NA NA NA ENSG00000226868 NA NA 3.29 NA NA ENSG00000227056 RPL6P2 ribosomal protein L6 NA NA NA NA pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 35964] ENSG00000227125 NA NA 2.60 NA NA ENSG00000227401 RPL37P1 ribosomal protein L37 NA NA 3.30 NA NA pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 16337] ENSG00000227415 NA NA 3.39 NA NA ENSG00000227603 NA NA NA NA NA ENSG00000227646 STEAP2-AS1 STEAP2 antisense RNA 1 NA NA 3.16 NA NA [Source: HGNC Symbol; Acc: HGNC: 40820] ENSG00000227675 NA NA NA NA NA NA NA ENSG00000227704 NA NA 3.83 NA NA ENSG00000227818 NA NA 3.57 NA NA ENSG00000227864 ARL5AP1 ADP-ribosylation factor-like NA NA 3.57 NA NA 5A pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 43933] ENSG00000228366 NA NA 3.28 NA NA ENSG00000228436 NA NA 2.51 NA NA ENSG00000228857 NA NA 4.14 NA NA ENSG00000229242 NA NA 3.04 NA NA ENSG00000229313 NA NA 3.05 NA NA ENSG00000229376 CICP3 capicua transcriptional NA NA 2.92 NA NA repressor pseudogene 3 [Source: HGNC Symbol; Acc: HGNC: 37742] ENSG00000229925 NA NA 2.91 NA NA ENSG00000229932 YWHAZP3 tyrosine 3- NA NA 3.50 NA NA monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 3 [Source: HGNC Symbol; Acc: HGNC: 31101] ENSG00000230185 C9orf147 chromosome 9 open reading NA NA NA NA NA frame 147 [Source: HGNC Symbol; Acc: HGNC: 31438] ENSG00000230312 NA NA 3.42 NA NA ENSG00000230696 NA NA 3.16 NA NA ENSG00000230706 NA NA 3.14 NA NA ENSG00000230710 LINC00332 long intergenic non-protein NA NA 3.35 NA NA coding RNA 332 [Source: HGNC Symbol; Acc: HGNC: 42049] ENSG00000230799 NA NA 3.10 NA NA ENSG00000231937 NA NA 3.43 NA NA ENSG00000232015 HSPE1P25 heat shock 10 kDa protein 1 NA NA 3.87 NA NA pseudogene 25 [Source: HGNC Symbol; Acc: HGNC: 49344] ENSG00000232464 NA NA 3.46 NA NA ENSG00000232524 NA NA 2.80 NA NA ENSG00000232591 NA NA NA NA NA ENSG00000232658 NA NA 2.99 NA NA ENSG00000232833 NA NA NA NA 3.78 NA NA ENSG00000233115 FAM90A11P family with sequence NA NA 3.66 NA NA similarity 90, member A11, pseudogene Source: HGNC Symbol; Acc: HGNC: 32259] ENSG00000233558 NA NA 2.88 NA NA ENSG00000234629 WDR82P1 WD repeat domain 82 NA NA 3.54 NA NA pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 32447] ENSG00000235573 NA NA 3.51 NA NA ENSG00000235578 NA NA 4.25 NA 4.06 ENSG00000235942 LCE6A late cornified envelope 6A NA NA 2.91 NA NA [Source: HGNC Symbol; Acc: HGNC: 31824] ENSG00000236209 NA NA 2.79 NA NA ENSG00000236641 NA NA 3.67 NA NA ENSG00000236751 LINC01186 long intergenic non-protein NA NA 3.06 NA NA coding RNA 1186 [Source: HGNC Symbol; Acc: HGNC: 49573] ENSG00000236824 BCYRN1 brain cytoplasmic RNA 1 NA NA −2.33   NA NA [Source: HGNC Symbol; Acc: HGNC: 1022] ENSG00000237213 RPL23AP22 ribosomal protein L23a NA NA 3.15 NA NA pseudogene 22 [Source: HGNC Symbol; Acc: HGNC: 35505] ENSG00000237979 NA NA 3.42 NA 3.43 ENSG00000237991 RPL35P1 ribosomal protein L35 NA NA 3.72 NA 3.99 pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 36695] ENSG00000238073 RBMY2HP RNA binding motif protein, NA NA 3.34 NA NA Y-linked, family 2, member H pseudogene [Source: HGNC Symbol; Acc: HGNC: 23893] ENSG00000238337 NA NA NA NA 3.37 NA NA ENSG00000238609 RNU7-94P RNA, U7 small nuclear 94 NA NA 3.30 NA NA pseudogene [Source: HGNC Symbol; Acc: HGNC: 45628] ENSG00000239126 NA NA NA NA 3.29 NA NA ENSG00000239183 SNORA84 small nucleolar RNA, NA NA 3.73 NA NA H/ACA box 84 [Source: HGNC Symbol; Acc: HGNC: 33615] ENSG00000239196 NA NA NA NA 3.81 NA NA ENSG00000239272 RPL21P10 ribosomal protein L21 NA NA 3.82 NA NA pseudogene 10 [Source: HGNC Symbol; Acc: HGNC: 19795] ENSG00000239542 RN7SL399P RNA, 7SL, cytoplasmic NA NA 3.58 NA NA 399, pseudogene [Source: HGNC Symbol; Acc: HGNC: 46415] ENSG00000239857 GET4 golgi to ER traffic protein NA NA 2.59 NA NA 4 homolog (S. cerevisiae) [Source: HGNC Symbol; Acc: HGNC: 21690] ENSG00000240005 NA NA NA −3.53   ENSG00000240803 RN7SL231P RNA, 7SL, cytoplasmic NA NA 3.42 NA NA 231, pseudogene [Source: HGNC Symbol; Acc: HGNC: 46247] ENSG00000242229 RPS3AP14 ribosomal protein S3a NA NA 3.44 NA NA pseudogene 14 [Source: HGNC Symbol; Acc: HGNC: 35715] ENSG00000242770 NA NA 4.06 NA NA ENSG00000243004 NA NA 2.02 NA NA ENSG00000243974 VTI1BP1 vesicle transport through NA NA 3.37 NA NA interaction with t-SNAREs 1B pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 43727] ENSG00000244060 RPS2P41 ribosomal protein S2 NA NA NA NA pseudogene 41 [Source: HGNC Symbol; Acc: HGNC: 36357] ENSG00000244063 NA NA 3.33 NA NA ENSG00000244260 NA NA 2.21 NA NA ENSG00000244582 RPL21P120 ribosomal protein L21 NA NA 3.58 NA NA pseudogene 120 [Source: HGNC Symbol; Acc: HGNC: 35743] ENSG00000244734 HBB hemoglobin, beta NA NA 3.07 NA 3.80 [Source: HGNC Symbol; Acc: HGNC: 4827] ENSG00000248240 NA NA 2.79 NA NA ENSG00000248370 NA NA 3.64 NA NA ENSG00000248834 MARK2P5 MAP/microtubule affinity- NA NA 4.17 NA NA regulating kinase 2 pseudogene 5 [Source: HGNC Symbol; Acc: HGNC: 39796] ENSG00000248890 HHIP-AS1 HHIP antisense RNA 1 NA NA 2.96 NA NA [Source: HGNC Symbol; Acc: HGNC: 44182] ENSG00000249014 HMGN2P4 high mobility group NA NA 3.11 NA NA nucleosomal binding domain 2 pseudogene 4 [Source: HGNC Symbol; Acc: HGNC: 33567] ENSG00000249256 ATP5LP3 ATP synthase, H+ NA NA 3.15 NA NA transporting, mitochondrial Fo complex, subunit g, pseudogene 3 [Source: HGNC Symbol; Acc: HGNC: 13216] ENSG00000249942 NA NA 3.44 NA NA ENSG00000250120 PCDHA10 protocadherin alpha 10 NA NA 2.81 NA NA [Source: HGNC Symbol; Acc: HGNC: 8664] ENSG00000250234 NA NA 3.96 NA NA ENSG00000250411 NA NA 3.28 NA NA ENSG00000251048 NA NA NA −4.21   ENSG00000251445 NA NA 3.49 NA 3.87 ENSG00000251583 NA NA 3.14 NA NA ENSG00000252350 RPPH1-3P ribonuclease P RNA NA NA 3.56 NA NA component H1, 3 pseudogene [Source: HGNC Symbol; Acc: HGNC: 47030] ENSG00000252376 RNA5SP395 RNA, 5S ribosomal NA NA 3.59 NA NA pseudogene 395 [Source: HGNC Symbol; Acc: HGNC: 43295] ENSG00000252396 RN7SKP195 RNA, 7SK small nuclear NA NA 3.58 NA NA pseudogene 195 [Source: HGNC Symbol; Acc: HGNC: 45919] ENSG00000252731 NA NA 4.20 NA NA ENSG00000253112 NA NA 3.09 NA NA ENSG00000253292 MIOXP1 myo-inositol oxygenase NA NA 3.21 NA NA pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 50748] ENSG00000253469 NA NA NA NA NA ENSG00000253560 NA NA 3.30 NA NA ENSG00000253597 NA NA NA NA 3.64 NA NA ENSG00000253759 IGHV3-57 immunoglobulin heavy NA NA 4.36 NA 4.47 variable 3-57 (pseudogene) [Source: HGNC Symbol; Acc: HGNC: 5612] ENSG00000253882 NA NA 3.06 NA NA ENSG00000253892 NA NA 3.08 NA NA ENSG00000253920 IGLV3-31 immunoglobulin lambda NA NA 3.38 NA NA variable 3-31 (pseudogene) [Source: HGNC Symbol; Acc: HGNC: 5913] ENSG00000254057 NA NA 3.36 NA NA ENSG00000254082 NA NA 3.72 NA NA ENSG00000254086 NA NA 3.78 NA NA ENSG00000254124 EEF1A1P37 eukaryotic translation NA NA NA NA NA elongation factor 1 alpha 1 pseudogene 37 [Source: HGNC Symbol; Acc: HGNC: 37915] ENSG00000254260 NA NA 3.08 NA NA ENSG00000254325 NA NA 2.96 NA NA ENSG00000254389 RHPN1-AS1 RHPN1 antisense RNA 1 (head to head) NA NA 2.95 NA NA [Source: HGNC Symbol; Acc: HGNC: 28457] ENSG00000254509 NA NA 3.07 NA NA ENSG00000254624 OR4R3P olfactory receptor, family 4, NA NA NA NA NA subfamily R, member 3 pseudogene [Source: HGNC Symbol; Acc: HGNC: 15182] ENSG00000254638 NA NA 3.94 NA NA ENSG00000254832 OR4A40P olfactory receptor, family 4, NA NA 3.41 NA NA subfamily A, member 40 pseudogene [Source: HGNC Symbol; Acc: HGNC: 31259] ENSG00000255038 NA NA 3.09 NA NA ENSG00000255040 NA NA NA NA ENSG00000255079 NA NA 3.07 NA NA ENSG00000255142 NA NA 3.13 NA NA ENSG00000256037 MRPL40P1 mitochondrial ribosomal NA NA 4.02 NA NA protein L40 pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 44532] ENSG00000256660 CLEC12B C-type lectin domain family NA NA NA NA NA 12, member B [Source: HGNC Symbol; Acc: HGNC: 31966] ENSG00000256915 NA NA NA NA NA ENSG00000257022 NA NA 3.42 NA NA ENSG00000257241 NA NA 3.78 NA NA ENSG00000257292 NA NA 3.88 NA NA ENSG00000257476 NA NA 2.88 NA NA ENSG00000257640 NA NA 2.96 NA NA ENSG00000257718 NA NA 4.18 NA 3.76 ENSG00000257803 NA NA 4.21 NA NA ENSG00000258225 NA NA 3.53 NA NA ENSG00000258379 NA NA 3.11 NA NA ENSG00000258486 RN7SL1 RNA, 7SL, cytoplasmic 1 NA NA −2.17   NA NA [Source: HGNC Symbol; Acc: HGNC: 10038] ENSG00000258590 NBEAP1 neurobeachin pseudogene 1 NA NA NA NA NA [Source: HGNC Symbol; Acc: HGNC: 1007] ENSG00000258676 NA NA 3.04 NA 3.13 ENSG00000259035 NA NA 2.32 NA NA ENSG00000259211 NA NA 3.70 NA NA ENSG00000259431 THTPA thiamine triphosphatase NA NA NA NA NA [Source: HGNC Symbol; Acc: HGNC: 18987] ENSG00000259564 NA NA 3.34 NA NA ENSG00000259770 NA NA 3.97 NA 3.53 ENSG00000260077 NA NA 2.61 NA NA ENSG00000260571 BNIP3P5 BCL2/adenovirus E1B 19kDa NA NA 3.48 NA NA interacting protein 3 pseudogene 5 [Source: HGNC Symbol; Acc: HGNC: 39658] ENSG00000260601 NA NA 3.59 NA NA ENSG00000261916 NA NA 2.88 NA NA ENSG00000261996 NA NA 3.15 NA NA ENSG00000262001 DLGAP1-AS2 DLGAP1 antisense RNA 2 NA NA 2.15 NA NA [Source: HGNC Symbol; Acc: HGNC: 28146] ENSG00000262313 NA NA 2.82 NA NA ENSG00000264280 NA NA NA NA 3.54 NA NA ENSG00000265713 NA NA 2.62 NA NA ENSG00000266021 NA NA NA NA 3.32 NA NA ENSG00000267142 NA NA 3.35 NA 3.49 ENSG00000267363 NA NA 3.48 NA NA ENSG00000267493 CIRBP-AS1 CIRBP antisense RNA 1 NA NA 2.98 NA NA [Source: HGNC Symbol; Acc: HGNC: 28588] ENSG00000267500 NA NA NA NA ENSG00000267706 NA NA 3.50 NA NA ENSG00000267762 NA NA 3.34 NA NA ENSG00000268582 NA NA 3.87 NA NA ENSG00000268798 NA NA 3.10 NA NA ENSG00000269364 LINC01233 long intergenic non-protein NA NA 3.94 NA NA coding RNA 1233 [Source: HGNC Symbol; Acc: HGNC: 49756] ENSG00000269815 NA NA 3.60 NA NA ENSG00000269900 RMRP RNA component of −2.01 NA NA NA NA mitochondrial RNA processing endoribonuclease [Source: HGNC Symbol; Acc: HGNC: 10031] ENSG00000270010 NA NA 3.57 NA NA ENSG00000270103 RNU11 RNA, U11 small nuclear −3.06 −2.54 NA −2.77 NA [Source: HGNC Symbol; Acc: HGNC: 10108] ENSG00000270188 MTRNR2L11 MT-RNR2-like 11 NA NA 2.63 NA NA (pseudogene) [Source: HGNC Symbol; Acc: HGNC: 37168] ENSG00000270708 NA NA 3.60 NA 4.10 ENSG00000270878 NA NA 3.74 NA 3.58 ENSG00000271029 NA NA 3.62 NA NA ENSG00000271225 NA NA 2.89 NA NA ENSG00000271365 NA NA 3.66 NA NA ENSG00000271581 NA NA 2.50 NA NA ENSG00000271767 NA NA NA NA 3.13 NA NA ENSG00000272870 NA NA 2.43 NA NA ENSG00000273106 NA NA 3.33 NA NA ENSG00000273327 OR6L2P olfactory receptor, family 6, NA NA 2.90 NA NA subfamily L, member 2 pseudogene [Source: HGNC Symbol; Acc: HGNC: 15125]

TABLE 20 Biomarkers differentially expressed when the saliva samples of subjects who experienced most frequent head impact (Max_freq_hits) are compared to the subjects' baseline or subjects who experienced least frequent head impact (Min_freq_hits) Max_freq_hits_ Max_freq_hits_ saliva_vs_ saliva_vs_Min_ Ensembl_ID HGNC_symbol Description baseline_saliva freq_hits_saliva ENSG00000120699 EXOSC8 exosome component 8 [Source:HGNC −3.24 NA Symbol; Acc:HGNC:17035] ENSG00000163577 EIF5A2 eukaryotic translation initiation factor 5A2 −3.28 NA [Source:HGNC Symbol; Acc:HGNC:3301] ENSG00000164114 MAP9 microtubule-associated protein 9 [Source:HGNC −2.96 NA Symbol; Acc:HGNC:26118] ENSG00000180708 OR10K2 olfactory receptor, family 10, subfamily K, member 2 −4.16 NA [Source:HGNC Symbol; Acc:HGNC:14826] ENSG00000221571 RNU6ATAC35P RNA, U6atac small nuclear 35, pseudogene 4.58 NA [Source:HGNC Symbol; Acc:HGNC:46934] ENSG00000223963 PRKRIRP8 protein-kinase, interferon-inducible double stranded −3.94 −4.59 RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 8 [Source:HGNC Symbol; Acc:HGNC:39572] ENSG00000224682 SOCS5P2 suppressor of cytokine signaling 5 pseudogene 2 NA −3.98 [Source:HGNC Symbol; Acc:HGNC:44598] ENSG00000226471 3.44 NA ENSG00000228445 UGT1A2P UDP glucuronosyltransferase 1 family, polypeptide A2 −4.43 NA pseudogene [Source:HGNC Symbol; Acc:HGNC:12534] ENSG00000228695 CES1P1 carboxylesterase 1 pseudogene 1 [Source:HGNC 2.37 NA Symbol; Acc:HGNC:18546] ENSG00000229571 PRAMEF26 PRAME family member 26 [Source:HGNC −4.02 NA Symbol; Acc:HGNC:49178] ENSG00000230205 3.98 NA ENSG00000250437 NA 3.98 ENSG00000251634 4.09 NA ENSG00000255040 −3.84 NA ENSG00000256660 CLEC12B C-type lectin domain family 12, member B −3.31 NA [Source:HGNC Symbol; Acc:HGNC:31966] ENSG00000258590 NBEAP1 neurobeachin pseudogene 1 [Source:HGNC NA −4.25 Symbol; Acc:HGNC:1007] ENSG00000259431 THTPA thiamine triphosphatase [Source:HGNC −4.58 −4.57 Symbol; Acc:HGNC:18987] ENSG00000270423 4.32 NA ENSG00000272729 −4.11 NA

TABLE 21 Biomarkers differentially expressed when the blood samples of subjects who experienced least forceful head impact (Min_HITsp) are compared to the subjects' baseline or subjects who are not contact sports athletes (Track_field_control) Min_ Min_HITsp_ Min_HITsp_ HITsp_ Min_HITsp_ blood_vs_ blood_vs_ blood_vs_ blood_vs_ baseline_ Track_field_ baseline_ Track_field_ blood_ control_blood_ Ensembl_ID HGNC_symbol Description blood control_blood previous_day previous_day ENSG00000096006 CRISP3 cysteine-rich secretory protein 3 NA NA −3.65 NA [Source:HGNC Symbol;Acc:HGNC:16904] ENSG00000165480 SKA3 spindle and kinetochore associated 2.29 NA 2.49 NA complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:20262] ENSG00000210196 MT-TP mitochondrially encoded tRNA proline NA 3.21 NA 3.03 [Source:HGNC Symbol;Acc:HGNC:7494] ENSG00000212297 RNU6 RNA, U6 small nuclear 821, NA 4.09 NA 4.58 821P pseudogene [Source:HGNC Symbol;Acc:HGNC:47784] ENSG00000214114 MYCBP MYC binding protein [Source:HGNC NA 2.58 NA Symbol;Acc:HGNC:7554] ENSG00000230140 NA 2.93 NA 3.11 ENSG00000233690 EBAG9 estrogen receptor binding site NA NA −4.02 NA P1 associated, antigen, 9 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:45233] ENSG00000235688 NA NA NA −4.52 ENSG00000254624 OR4R3 olfactory receptor, family 4, subfamily NA NA −4.30 NA P R, member 3 pseudogene [Source: HGNC Symbol;Acc:HGNC:15182] ENSG00000259834 potassium voltage-gated channel, NA 4.21 NA 4.53 shaker-related subfamily, member 3 [Source:EntrezGene;Acc:3738] ENSG00000271533 NA NA −4.09 NA ENSG00000271945 NA NA −4.87 NA

TABLE 22 Biomarkers differentially expressed when the urine sample of subjects who experienced least forceful head impact (Min_HITsp) are compared to subjects who are not contact sports athletes (Track_field_control) Min_HITsp_ urine_vs_ Min_HITsp_ Track_field_ urine_vs_ control_ Track_field_ urine_ HGNC_ control_ previous_ Ensembl_ID symbol Description urine day ENSG00000007306 CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 2.71 2.68 7 [Source:HGNC Symbol; Acc:HGNC:1819] ENSG00000043462 LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing 2.25 2.13 leukocyte protein of 76 kDa) [Source:HGNC Symbol; Acc:HGNC:6529] ENSG00000057657 PRDM1 PR domain containing 1, with ZNF domain 2.30 2.19 [Source:HGNC Symbol; Acc:HGNC:9346] ENSG00000059728 MXD1 MAX dimerization protein 1 [Source:HGNC 2.45 2.33 Symbol; Acc:HGNC:6761] ENSG00000099985 OSM oncostatin M [Source:HGNC Symbol; Acc:HGNC:8506] NA 2.89 ENSG00000101336 HCK HCK proto-oncogene, Src family tyrosine kinase 2.39 2.27 [Source:HGNC Symbol; Acc:HGNC:4840] ENSG00000103569 AQP9 aquaporin 9 [Source:HGNC Symbol; Acc:HGNC:643] 3.21 3.09 ENSG00000116741 RGS2 regulator of G-protein signaling 2 [Source:HGNC NA 2.27 Symbol; Acc:HGNC:9998] ENSG00000120738 EGR1 early growth response 1 [Source:HGNC 2.42 NA Symbol; Acc:HGNC:3238] ENSG00000122861 PLAU plasminogen activator, urokinase [Source:HGNC 2.70 2.56 Symbol; Acc:HGNC:9052] ENSG00000122862 SRGN serglycin [Source:HGNC Symbol; Acc:HGNC:9361] NA 3.83 ENSG00000123395 ATG101 autophagy related 101 [Source:HGNC 2.09 NA Symbol; Acc:HGNC:25679] ENSG00000140279 DUOX2 dual oxidase 2 [Source:HGNC Symbol; 2.50 2.39 Acc:HGNC:13273] ENSG00000140678 ITGAX integrin, alpha X (complement component 3 receptor 4 2.24 NA subunit) [Source:HGNC Symbol; Acc:HGNC:6152] ENSG00000140749 IGSF6 immunoglobulin superfamily, member 6 [Source:HGNC 2.93 2.75 Symbol; Acc:HGNC:5953] ENSG00000145113 MUC4 mucin 4, cell surface associated [Source:HGNC 2.48 2.38 Symbol; Acc:HGNC:7514] ENSG00000147180 ZNF711 zinc finger protein 711 [Source:HGNC 2.77 2.71 Symbol; Acc:HGNC:13128] ENSG00000150201 FXYD4 FXYD domain containing ion transport regulator 4 −2.95   NA [Source:HGNC Symbol; Acc:HGNC:4028] ENSG00000153802 TMPRSS11D transmembrane protease, serine 11D [Source:HGNC NA 2.10 Symbol; Acc:HGNC:24059] ENSG00000163739 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth 3.37 3.25 stimulating activity, alpha) [Source:HGNC Symbol; Acc:HGNC:4602] ENSG00000169429 CXCL8 chemokine (C-X-C motif) ligand 8 [Source:HGNC 3.66 3.71 Symbol; Acc:HGNC:6025] ENSG00000171223 JUNB jun B proto-oncogene [Source:HGNC 2.55 2.40 Symbol; Acc:HGNC:6205] ENSG00000186831 KRT17P2 keratin 17 pseudogene 2 [Source:HGNC NA 3.57 Symbol; Acc:HGNC:6429] ENSG00000188215 DCUN1D3 DCN1, defective in cullin neddylation 1, domain 2.06 NA containing 3 [Source:HGNC Symbol; Acc:HGNC:28734] ENSG00000196352 CD55 CD55 molecule, decay accelerating factor for complement 2.02 NA (Cromer blood group) [Source:HGNC Symbol; Acc:HGNC:2665] ENSG00000198868 MIR4461 microRNA 4461 [Source:HGNC 4.30 4.68 Symbol; Acc:HGNC:41656] ENSG00000200087 SNORA73B small nucleolar RNA, H/ACA box 73B [Source:HGNC 3.83 4.08 Symbol; Acc:HGNC:10116] ENSG00000200408 RNA5SP74 RNA, 5S ribosomal pseudogene 74 [Source:HGNC NA 3.84 Symbol; Acc:HGNC:42851] ENSG00000200785 SNORD8 small nucleolar RNA, C/D box 8 [Source:HGNC NA 4.11 Symbol; Acc:HGNC:20159] ENSG00000204293 OR8B2 olfactory receptor, family 8, subfamily B, member 2 NA 3.47 [Source:HGNC Symbol; Acc:HGNC:8471] ENSG00000206172 HBA1 hemoglobin, alpha 1 [Source:HGNC 4.09 4.19 Symbol; Acc:HGNC:4823] ENSG00000206634 SNORA22 small nucleolar RNA, H/ACA box 22 [Source:HGNC 4.08 4.24 Symbol; Acc:HGNC:32612] ENSG00000211698 TRGV4 T cell receptor gamma variable 4 [Source:HGNC 3.45 3.83 Symbol; Acc:HGNC:12289] ENSG00000212443 SNORA53 small nucleolar RNA, H/ACA box 53 [Source:HGNC 3.89 4.04 Symbol; Acc:HGNC:32646] ENSG00000213370 RANP6 RAN, member RAS oncogene family pseudogene 6 NA 3.95 [Source:HGNC Symbol; Acc:HGNC:39861] ENSG00000215004 MESTP4 mesoderm specific transcript pseudogene 4 3.31 3.30 [Source:HGNC Symbol; Acc:HGNC:38554] ENSG00000215043 GLULP6 glutamate-ammonia ligase (glutamine synthetase) NA 4.31 pseudogene 6 [Source:HGNC Symbol; Acc:HGNC:37990] ENSG00000216966 NA 4.04 ENSG00000217643 PTGES3P2 prostaglandin E synthase 3 (cytosolic) pseudogene 2 3.50 3.43 [Source:HGNC Symbol; Acc:HGNC:43822] ENSG00000223581 NA 4.24 ENSG00000223880 LINC01078 long intergenic non-protein coding RNA 1078 3.97 4.25 [Source:HGNC Symbol; Acc:HGNC:49121] ENSG00000225255 NA 2.73 ENSG00000227056 RPL6P2 ribosomal protein L6 pseudogene 2 [Source:HGNC −3.64   NA Symbol; Acc:HGNC:35964] ENSG00000227401 RPL37P1 ribosomal protein L37 pseudogene 1 [Source:HGNC NA 3.94 Symbol; Acc:HGNC:16337] ENSG00000228857 4.35 4.93 ENSG00000230185 C9orf147 chromosome 9 open reading frame 147 [Source:HGNC NA 3.02 Symbol; Acc:HGNC:31438] ENSG00000230312 4.17 4.85 ENSG00000230799 3.64 3.69 ENSG00000231259 4.28 4.64 ENSG00000232658 NA 3.68 ENSG00000232833 NA 4.19 ENSG00000232990 MTATP6P7 mitochondrially encoded ATP synthase 6 pseudogene 7 3.91 4.69 [Source:HGNC Symbol; Acc:HGNC:44581] ENSG00000234629 WDR82P1 WD repeat domain 82 pseudogene 1 [Source:HGNC NA 3.68 Symbol; Acc:HGNC:32447] ENSG00000235101 SETP9 SET pseudogene 9 [Source:HGNC NA 3.81 Symbol; Acc:HGNC:42928] ENSG00000238073 RBMY2HP RNA binding motif protein, Y-linked, family 2, NA 4.21 member H pseudogene [Source:HGNC Symbol; Acc:HGNC:23893] ENSG00000239002 SCARNA10 small Cajal body-specific RNA 10 [Source:HGNC 4.64 4.53 Symbol; Acc:HGNC:32567] ENSG00000239272 RPL21P10 ribosomal protein L21 pseudogene 10 [Source:HGNC NA 3.95 Symbol; Acc:HGNC:19795] ENSG00000240131 NA 4.11 ENSG00000241397 LINC00903 long intergenic non-protein coding RNA 903 NA 4.09 [Source:HGNC Symbol; Acc:HGNC:40351] ENSG00000241983 RN7SL566P RNA, 7SL, cytoplasmic 566, pseudogene [Source:HGNC 3.89 NA Symbol; Acc:HGNC:46582] ENSG00000242770 3.67 4.30 ENSG00000244063 NA 4.03 ENSG00000244361 RPL30P7 ribosomal protein L30 pseudogene 7 [Source:HGNC NA 4.26 Symbol; Acc:HGNC:36402] ENSG00000249019 NA 3.86 ENSG00000249588 4.12 4.12 ENSG00000253759 IGHV3-57 immunoglobulin heavy variable 3-57 (pseudogene) 4.13 4.52 [Source:HGNC Symbol; Acc:HGNC:5612] ENSG00000253882 NA 3.10 ENSG00000254124 EEF1A1P37 eukaryotic translation elongation factor 1 alpha 1 4.19 NA pseudogene 37 [Source:HGNC Symbol; Acc:HGNC:37915] ENSG00000254325 3.80 3.67 ENSG00000254638 3.77 4.46 ENSG00000257241 NA 4.32 ENSG00000257718 3.66 3.83 ENSG00000257803 NA 3.91 ENSG00000258676 3.48 3.38 ENSG00000259770 3.79 3.92 ENSG00000261596 NA 3.50 ENSG00000264280 3.31 3.47 ENSG00000264462 MIR3648-1 microRNA 3648-1 [Source:HGNC 3.20 NA Symbol; Acc:HGNC:38941] ENSG00000267500 4.06 ENSG00000268543 3.80 3.92 ENSG00000270810 NA 4.33 ENSG00000272870 NA 2.67

TABLE 23 Biomakers differentially expressed when the blood samples of subjects who experienced frequent head impact (Min_freq_hits) are compared to the subjects' baseline or subjects who are not contact sports athletes (Track_field_control). Min freq_ hits_blood_ Min freq_ vs_Track_ hits_blood_ field_ vs_baseline_ control_ blood_ blood_ HGNC_ previous_ previous_ Ensembl_ID symbol Description day day ENSG00000040341 STAU2 staufen double-stranded RNA binding protein 2 NA 2.21 [Source:HGNC Symbol; Acc:HGNC:11371] ENSG00000086666 ZFAND6 zinc finger, AN1-type domain 6 [Source:HGNC 2.58 2.71 Symbol; Acc:HGNC:30164] ENSG00000110013 SIAE sialic acid acetylesterase [Source:HGNC NA 2.48 Symbol; Acc:HGNC:18187] ENSG00000119778 ATAD2 ATPase family, AAA domain containing 2B [Source:HGNC NA 2.11 B Symbol; Acc:HGNC:29230] ENSG00000165480 SKA3 spindle and kinetochore associated complex subunit 3 2.42 NA [Source:HGNC Symbol; Acc:HGNC:20262] ENSG00000168461 RAB31 RAB31, member RAS oncogene family [Source:HGNC 2.34 NA Symbol; Acc:HGNC:9771] ENSG00000198168 SVIP small VCP/p97-interacting protein [Source:HGNC 2.26 NA Symbol; Acc:HGNC:25238] ENSG00000198886 MT-ND4 mitochondrially encoded NADH dehydrogenase 4 NA 3.28 [Source:HGNC Symbol; Acc:HGNC:7459] ENSG00000202354 RNY3 RNA, Ro-associated Y3 [Source:HGNC 3.35 NA Symbol; Acc:HGNC:10243] ENSG00000210196 MT-TP mitochondrially encoded tRNA proline [Source:HGNC NA 3.15 Symbol; Acc:HGNC:7494] ENSG00000271043 MTRNR2L2 MT-RNR2-like 2 [Source:HGNC 2.75 3.84 Symbol; Acc:HGNC:37156]

TABLE 24 Biomarkers differentially expressed when the urine sample of subjects who experienced frequent head impact (Min_freq_hits) are compared to subjects who are not contact sports athletes (Track_field_control) Mins_freq_ Mins_feq_ hits_urine_ hits_urine_ vs_Track_ vs_Track_ field_control_ HGNC_ field_control_ urine_previous_ Ensembl_ID symbol Description urine day ENSG00000125652 ALKBH7 alkB, alkylation repair homolog 7 (E. coli) NA 2.29 [Source:HGNC Symbol; Acc:HGNC:21306] ENSG00000198868 MIR4461 microRNA 4461 [Source:HGNC 4.15 NA Symbol; Acc:HGNC:41656] ENSG00000206172 HBA1 hemoglobin, alpha 1 [Source:HGNC 3.81 3.84 Symbol; Acc:HGNC:4823] ENSG00000216629 OR2W4P olfactory receptor, family 2, subfamily W, member 4 −2.91   NA pseudogene [Source:HGNC Symbol; Acc:HGNC:15071] ENSG00000228857 4.34 4.47 ENSG00000236641 3.77 NA ENSG00000244734 HBB hemoglobin, beta [Source:HGNC 3.59 3.77 Symbol; Acc:HGNC:4827] ENSG00000254325 3.26 NA ENSG00000257718 3.60 3.55 ENSG00000259108 −3.16   −3.20  

TABLE 25 Biomarkers differentially expressed when the baseline blood sample of subjects who are contact sport athletes (baseline) are compared to the subjects who are not contact sports athletes (Track_field_control) baseline_ blood_ baseline_ vs_Track_ blood_ field_ vs_Track_ control_ field_ blood_ control_ previous_ Ensembl_ID HGNC_symbol Description blood day ENSG00000178172 SPINK6 serine peptidase inhibitor, Kazal type 6 [Source:HGNC 4.24 4.78 Symbol; Acc:HGNC:29486] ENSG00000198022 NA 2.75 ENSG00000200225 RNA5SP382 RNA, 5S ribosomal pseudogene 382 [Source:HGNC NA 4.26 Symbol; Acc:HGNC:43282] ENSG00000201704 RNA5SP396 RNA, 5S ribosomal pseudogene 396 [Source:HGNC NA 3.68 Symbol; Acc:HGNC:43296] ENSG00000204566 C10orf115 chromosome 10 open reading frame 115 [Source:HGNC 3.82 NA Symbol; Acc:HGNC:31449] ENSG00000212297 RNU6-821P RNA, U6 small nuclear 821, pseudogene [Source:HGNC 3.78 4.18 Symbol; Acc:HGNC:47784] ENSG00000223881 4.42 NA ENSG00000227675 NA 3.88 ENSG00000230140 2.67 2.71 ENSG00000230604 TSEN15P2 TSEN15 tRNA splicing endonuclease subunit pseudogene NA 4.27 2 [Source:HGNC Symbol; Acc:HGNC:43963] ENSG00000232591 NA 3.65 ENSG00000236559 4.52 4.65 ENSG00000237027 3.51 3.51 ENSG00000238215 NA 3.89 ENSG00000238283 TBC1D3P1 TBC1 domain family, member 3 pseudogene 1 NA 4.01 [Source:HGNC Symbol; Acc:HGNC:27445] ENSG00000242120 NA 2.89 ENSG00000243075 RN7SL519P RNA, 7SL, cytoplasmic 519, pseudogene [Source:HGNC 4.14 4.30 Symbol; Acc:HGNC:46535] ENSG00000248242 NA 3.71 ENSG00000248498 ASNSP1 asparagine synthetase pseudogene 1 [Source:HGNC NA 3.57 Symbol; Acc:HGNC:754] ENSG00000249734 NA 3.41 ENSG00000256721 CACNA1C-IT3 CACNA1C intronic transcript 3 (non-protein coding) 3.40 NA [Source:HGNC Symbol; Acc:HGNC:41314] ENSG00000256915 3.73 3.94 ENSG00000258406 3.99 4.33 ENSG00000259513 CYCSP38 cytochrome c, somatic pseudogene 38 [Source:HGNC NA 4.26 Symbol; Acc:HGNC:24411] ENSG00000259790 ANP32BP1 acidic (leucine-rich) nuclear phosphoprotein 32 family, NA 3.85 member B pseudogene 1 [Source:HGNC Symbol; Acc:HGNC:24267] ENSG00000259834 potassium voltage-gated channel, shaker-related NA 4.12 subfamily, member 3 [Source:EntrezGene;Acc:3738] ENSG00000260265 4.41 4.08 ENSG00000267167 NA 3.89 ENSG00000268055 NA 3.49 ENSG00000268280 3.82 3.91 ENSG00000271945 NA 4.93 ENSG00000273185 4.77 4.91

TABLE 26 Biomarkers differentially expressed when the baseline urine sample of subjects who are contact sport athletes (baseline) are compared to the subjects who are not contact sports athletes (Track_field_control baseline_ urine_ baseline_ vs_Track_ urine_ field_ vs_Track_ control_ field_ urine_ HGNC_ control_ previous_ Ensembl_ID symbol Description urine day ENSG00000068366 ACSL4 acyl-CoA synthetase long-chain family member 4 2.01 NA [Source:HGNC Symbol; Acc:HGNC:3571] ENSG00000175879 HOXD8 homeobox D8 [Source:HGNC Symbol; Acc:HGNC:5139] 2.50 2.48 ENSG00000188536 HBA2 hemoglobin, alpha 2 [Source:HGNC NA 3.44 Symbol; Acc:HGNC:4824] ENSG00000200087 SNORA73B small nucleolar RNA, H/ACA box 73B [Source:HGNC 4.20 4.17 Symbol; Acc:HGNC:10116] ENSG00000200131 RN7SKP77 RNA, 7SK small nuclear pseudogene 77 [Source:HGNC NA 3.96 Symbol; Acc:HGNC:45801] ENSG00000200785 SNORD8 small nucleolar RNA, CID box 8 [Source:HGNC NA 5.28 Symbol; Acc:HGNC:20159] ENSG00000206172 HBA1 hemoglobin, alpha 1 [Source:HGNC 3.56 3.68 Symbol; Acc:HGNC:4823] ENSG00000206634 SNORA22 small nucleolar RNA, H/ACA box 22 [Source:HGNC 4.23 3.97 Symbol; Acc:HGNC:32612] ENSG00000206652 RNU1-1 RNA, U1 small nuclear 1 [Source:HGNC 2.82 2.80 Symbol; Acc:HGNC:10120] ENSG00000210194 MT-TE mitochondrially encoded tRNA glutamic acid 2.74 2.73 [Source:HGNC Symbol; Acc:HGNC:7479] ENSG00000211698 TRGV4 T cell receptor gamma variable 4 [Source:HGNC NA 3.31 Symbol; Acc:HGNC:12289] ENSG00000219074 SOD1P1 superoxide dismutase 1, soluble pseudogene 1 3.86 3.79 [Source:HGNC Symbol; Acc:HGNC:45134] ENSG00000228857 4.05 4.07 ENSG00000232015 HSPE1P25 heat shock 10 kDa protein 1 pseudogene 25 NA 3.76 [Source:HGNC Symbol; Acc:HGNC:49344] ENSG00000232833 NA NA 3.72 3.61 ENSG00000234629 WDR82P1 WD repeat domain 82 pseudogene 1 [Source:HGNC 3.51 NA Symbol; Acc:HGNC:32447] ENSG00000236559 NA NA ENSG00000236641 3.46 3.43 ENSG00000239002 SCARNA10 small Cajal body-specific RNA 10 [Source:HGNC 3.37 3.31 Symbol; Acc:HGNC:32567] ENSG00000244734 HBB hemoglobin, beta [Source:HGNC NA 4.18 Symbol; Acc:HGNC:4827] ENSG00000251445 NA 3.76 ENSG00000253759 IGHV3-57 immunoglobulin heavy variable 3-57 (pseudogene) 3.88 3.62 [Source:HGNC Symbol; Acc:HGNC:5612] ENSG00000257718 3.82 3.80 ENSG00000259770 3.22 NA ENSG00000264280 NA NA 3.33 3.30 ENSG00000270878 3.07 3.07 ENSG00000271043 MTRNR2L2 MT-RNR2-like 2 [Source:HGNC NA 3.06 Symbol; Acc:HGNC:37156]

TABLE 27 Some biomarkers that are differentially expressed in plasma based on the number of head impact incidents high_freq_ high_freq_ hits_vs_ low_freq_ hits_vs_ Low_freq_ hits_vs_ Ensembl_ID hgnc_symbol description Baseline.x hits.x Baseline.x ENSG00000229344 1.94 1.85 NA ENSG00000212338 Small nucleolar RNA SNORA67 −1.37 NA −1.29 [Source:RFAM;Acc:RF00272] ENSG00000186453 FAM228A family with sequence similarity 228, member −1.12 NA −1.41 A [Source:HGNC Symbol; Acc:HGNC:34418] ENSG00000234723 −1.08 NA NA ENSG00000249072 1.81 1.76 NA ENSG00000270683 FAM71BP1 family with sequence similarity 71, member −1.10 −1.27 NA B pseudogene 1 [Source:HGNC Symbol; Acc:HGNC:49805] ENSG00000227593 −1.39 NA −1.33 ENSG00000252596 NA NA −1.41 NA −1.36 ENSG00000239011 NA NA −1.12 NA −1.37 ENSG00000163993 S100P S100 calcium binding protein P −1.60 NA −1.53 [Source:HGNC Symbol; Acc:HGNC:10504] ENSG00000237731 RNGTTP1 RNA guanylyltransferase and 5- −1.10 NA −1.64 phosphatase pseudogene 1 [Source:HGNC Symbol; Acc:HGNC:39652] ENSG00000229775 −1.69 NA −1.65 ENSG00000237256 PGAM3P phosphoglycerate mutase 3, pseudogene −1.49 NA −1.67 [Source:HGNC Symbol; Acc:HGNC:16557] ENSG00000225181 −1.22 NA −1.84 ENSG00000200510 NA NA 1.10 NA NA ENSG00000264469 −1.07 NA NA ENSG00000203691 NA NA −1.13 NA NA ENSG00000201271 RNU1-112P RNA, U1 small nuclear 112, pseudogene −1.21 NA NA [Source:HGNC Symbol; Acc:HGNC:48454] ENSG00000242716 NA NA 1.73 1.76 NA ENSG00000215030 RPL13P12 ribosomal protein L13 pseudogene 12 1.06 1.24 NA [Source:HGNC Symbol; Acc:HGNC:35701] ENSG00000158856 DMTN dematin actin binding protein 1.81 1.20 NA [Source:HGNC Symbol; Acc:HGNC:3382] ENSG00000100345 MYH9 myosin, heavy chain 9, non-muscle 1.61 1.17 NA [Source:HGNC Symbol; Acc:HGNC:7579] ENSG00000175602 CCDC85B coiled-coil domain containing 85B 1.54 1.16 NA [Source:HGNC Symbol; Acc:HGNC:24926] ENSG00000219188 CACYBPP3 calcyclin binding protein pseudogene 3 −1.19 −1.08 NA [Source:HGNC Symbol; Acc:HGNC:45124] ENSG00000199287 NA NA −1.28 −2.02 NA ENSG00000176043 NA −1.32 1.69 ENSG00000227159 DDX11L16 DEAD/H (Asp-Glu-Ala-Asp/His) box 1.06 NA 1.32 helicase 11 like 16 [Source:HGNC Symbol; Acc:HGNC:37115] ENSG00000264386 M1R4513 microRNA 4513 [Source:HGNC 1.10 NA 1.23 Symbol; Acc:HGNC:41855] ENSG00000252670 NA NA NA −1.36 1.22 ENSG00000231680 −1.12 NA −1.01 ENSG00000253780 IGHVIII-2-1 immunoglobulin heavy variable (III)-2-1 −1.36 NA −1.07 (pseudogene) [Source:HGNC Symbol; Acc:HGNC:5695] ENSG00000220505 EIF4EBP2P3 eukaryotic translation initiation factor 4E −1.48 NA −1.09 binding protein 2 pseudogene 3 [Source:HGNC Symbol; Acc:HGNC:49318] ENSG00000249941 −1.33 NA −1.10 ENSG00000225906 −1.29 NA −1.11 ENSG00000232578 −1.17 NA −1.13 ENSG00000211967 IGHV3-53 immunoglobulin heavy variable 3-53 −1.05 NA −1.15 [Source:HGNC Symbol; Acc:HGNC:5610] ENSG00000235186 NA NA −1.15 ENSG00000258088 −1.46 NA −1.16 ENSG00000186038 HTR3E 5-hydroxytryptamine (serotonin) receptor −1.14 NA −1.17 3E, ionotropic [Source:HGNC Symbol; Acc:HGNC:24005] ENSG00000206848 RNU6-890P RNA, U6 small nuclear 890, pseudogene −1.47 NA −1.21 [Source:HGNC Symbol; Acc:HGNC:47853] ENSG00000270680 NA 1.35 −1.23 ENSG00000226272 ARHGAP26- ARHGAP26 antisense RNA 1 −1.34 NA −1.24 AS1 [Source:HGNC Symbol; Acc:HGNC:40792] ENSG00000197568 HHLA3 HERV-H LTR-associating 3 [Source:HGNC −1.43 NA −1.24 Symbol; Acc:HGNC:4906] ENSG00000256972 −1.15 NA −1.25 ENSG00000250392 NA NA −1.25 ENSG00000260198 −1.17 NA −1.26 ENSG00000249465 RBMXP4 RNA binding motif protein, X-linked −1.54 NA −1.27 pseudogene 4 [Source:HGNC Symbol; Acc:HGNC:34028] ENSG00000187689 AMTN amelotin [Source:HGNC −1.43 NA −1.30 Symbol; Acc:HGNC:33188] ENSG00000199470 Small nucleolar RNA SNORA64/SNORA10 −1.10 NA −1.31 family [Source:RFAM;Acc:RF00264] ENSG00000238763 NA NA −1.25 NA −1.33 ENSG00000226939 −1.18 NA −1.34 ENSG00000232650 −1.17 NA −1.35 ENSG00000217557 −1.11 NA −1.36 ENSG00000185296 −1.15 NA −1.36 ENSG00000221291 −1.23 NA −1.37 ENSG00000265408 −1.21 NA −1.43 ENSG00000212564 RNU6-1326P RNA, U6 small nuclear 1326, pseudogene NA NA −1.45 [Source:HGNC Symbol; Acc:HGNC:48289] ENSG00000259418 −1.27 NA −1.45 ENSG00000261665 TUBA8P2 tubulin, alpha 8 pseudogene 2 NA 1.10 −1.49 [Source:HGNC Symbol; Acc:HGNC:44569] ENSG00000250256 −1.20 NA −1.51 ENSG00000235902 −1.36 NA −1.54 ENSG00000255408 PCDHA3 protocadherin alpha 3 [Source:HGNC −1.37 NA −1.58 Symbol; Acc:HGNC:8669] ENSG00000252672 NA NA NA NA −1.60 ENSG00000230645 −1.27 NA −1.61 ENSG00000229031 −1.52 NA −1.62 ENSG00000267670 NA NA −1.64 ENSG00000240286 MEAF6P1 MYST/Esa1-associated factor 6 −1.07 NA −1.69 pseudogene 1 [Source:HGNC Symbol; Acc:HGNC:42660] ENSG00000168992 OR7E102P olfactory receptor, family 7, subfamily E, −1.26 NA −1.84 member 102 pseudogene [Source:HGNC Symbol; Acc:HGNC:15043] ENSG00000182393 IFNL1 interferon, lambda 1 [Source:HGNC NA 2.15 −1.91 Symbol; Acc:HGNC:18363] ENSG00000168067 MAP4K2 mitogen-activated protein kinase kinase 1.59 NA NA kinase kinase 2 [Source:HGNC Symbol; Acc:HGNC:6864] ENSG00000272468 1.58 NA NA ENSG00000166086 JAM3 junctional adhesion molecule 3 1.26 NA NA [Source:HGNC Symbol; Acc:HGNC:15532] ENSG00000260229 −1.02 NA NA ENSG00000222524 RN7SKP109 RNA, 7SK small nuclear pseudogene 109 −1.05 NA NA [Source:HGNC Symbol; Acc:HGNC:45833] ENSG00000225785 −1.07 NA NA ENSG00000252863 RNU6-1183P RNA, U6 small nuclear 1183, pseudogene −1.11 NA NA [Source:HGNC Symbol; Acc:HGNC:48146] ENSG00000230589 IMP3P1 IMP3 pseudogene 1 [Source:HGNC −1.12 NA NA Symbol; Acc:HGNC:49385] ENSG00000253849 −1.12 NA NA ENSG00000224924 LINC00320 long intergenic non-protein coding RNA 320 −1.15 NA NA [Source:HGNC Symbol; Acc:HGNC:19690] ENSG00000233545 CYCSP33 cytochrome c, somatic pseudogene 33 −1.15 NA NA [Source:HGNC Symbol; Acc:HGNC:24407] ENSG00000224288 −1.18 NA NA ENSG00000239791 −1.20 NA NA ENSG00000231957 GNAI2P2 guanine nucleotide binding protein (G −1.21 NA NA protein), alpha inhibiting activity polypeptide 2 pseudogene 2 [Source:HGNC Symbol; Acc:HGNC:45110] ENSG00000136872 ALDOB aldolase B, fructose-bisphosphate −1.22 NA NA [Source:HGNC Symbol; Acc:HGNC:417] ENSG00000254845 NA NA −1.29 NA NA ENSG00000226104 NA NA −1.32 NA NA ENSG00000241757 RN7SL714P RNA, 7SL, cytoplasmic 714, pseudogene −1.33 NA NA [Source:HGNC Symbol; Acc:HGNC:46730] ENSG00000261340 −1.35 NA NA ENSG00000213144 −1.39 NA NA ENSG00000219368 ZNF299P zinc finger protein 299, pseudogene −1.57 NA NA [Source:HGNC Symbol; Acc:HGNC:13088] ENSG00000244414 CFHR1 complement factor H-related 1 −1.73 NA NA [Source:HGNC Symbol; Acc:HGNC:4888] ENSG00000237973 MIR6723 microRNA 6723 [Source:HGNC 1.18 1.89 NA Symbol; Acc:HGNC:50152] ENSG00000223554 1.37 1.53 NA ENSG00000244921 1.04 1.51 NA ENSG00000259045 1.14 1.42 NA ENSG00000133136 GNG5P2 guanine nucleotide binding protein (G 1.32 1.23 NA protein), gammas pseudogene 2 [Source:HGNC Symbol; Acc:HGNC:24826] ENSG00000227468 1.43 1.20 NA ENSG00000141179 PCTP phosphatidylcholine transfer protein 1.46 1.13 NA [Source:HGNC Symbol; Acc:HGNC:8752] ENSG00000148848 ADAM12 ADAM metallopeptidase domain 12 1.13 1.09 NA [Source:HGNC Symbol; Acc:HGNC:190] ENSG00000234975 FTH1P2 ferritin, heavy polypeptide 1 pseudogene 2 1.01 1.07 NA [Source:HGNC Symbol; Acc:HGNC:3989] ENSG00000265565 M1R3143 microRNA 3143 [Source:HGNC 1.27 1.01 NA Symbol; Acc:HGNC:38284] ENSG00000172476 RAB40A RAB40A, member RAS oncogene family −1.10 −1.09 NA [Source:HGNC Symbol; Acc:HGNC:18283] ENSG00000120586 NA NA −1.38 −1.16 NA ENSG00000230019 YWHAQP9 YWHAQ pseudogene 9 [Source:HGNC −1.19 −1.18 NA Symbol; Acc:HGNC:37688] ENSG00000253377 −1.65 −1.18 NA ENSG00000243824 −1.32 −1.22 NA ENSG00000184674 NA NA −1.15 −1.22 NA ENSG00000250461 −1.96 −1.28 NA ENSG00000266603 NA NA −1.11 −1.31 NA ENSG00000263929 NA NA −1.29 −1.33 NA ENSG00000250612 −2.06 −1.43 NA ENSG00000259411 HNRNPA1P45 heterogeneous nuclear ribonucleoprotein −1.33 −1.52 NA A1 pseudogene 45 [Source:HGNC Symbol; Acc:HGNC:48775] ENSG00000238754 Small nucleolar RNA U109 NA −1.55 NA [Source:RFAM;Acc:RF01233] ENSG00000252497 RPPH1-2P ribonuclease P RNA component H1, 2 −1.54 −1.56 NA pseudogene [Source:HGNC Symbol; Acc:HGNC:47029] ENSG00000268995 VN1R82P vomeronasal 1 receptor 82 pseudogene −1.12 −1.58 NA [Source:HGNC Symbol; Acc:HGNC:37402] ENSG00000235938 NA NA NA −2.41 1.78 ENSG00000268230 NA −1.39 1.52 ENSG00000270457 NA −1.94 1.40 ENSG00000203426 NA NA NA −1.52 1.30 ENSG00000236876 TMSB4XP1 thymosin beta 4, X-linked pseudogene 1 NA NA 1.24 [Source:HGNC Symbol; Acc:HGNC:11883] ENSG00000109854 HTATIP2 HIV-1 Tat interactive protein 2, 30 kDa 1.04 NA 1.22 [Source:HGNC Symbol; Acc:HGNC:16637] ENSG00000239617 NA NA 1.22 ENSG00000200702 Y RNA [Source:RFAM;Acc:RF00019] NA −1.27 1.22 ENSG00000221096 NA NA NA −1.71 1.14 ENSG00000271361 HTATSF1P2 HIV-1 Tat specific factor 1 pseudogene 2 1.01 NA 1.11 [Source:HGNC Symbol; Acc:HGNC:38586] ENSG00000263740 RN7SL4P RNA, 7SL, cytoplasmic 4, pseudogene NA NA 1.10 [Source:HGNC Symbol; Acc:HGNC:10039] ENSG00000198829 SUCNR1 succinate receptor 1 [Source:HGNC NA NA 1.09 Symbol; Acc:HGNC:4542] ENSG00000248898 NA −1.34 1.08 ENSG00000236090 LDHAP3 lactate dehydrogenase A pseudogene 3 −1.35 NA −1.02 [Source:HGNC Symbol; Acc:HGNC:6538] ENSG00000164237 CMBL carboxymethylenebutenolidase homolog −1.17 NA −1.02 (Pseudomonas) [Source:HGNC Symbol; Acc:HGNC:25090] ENSG00000159231 CBR3 carbonyl reductase 3 [Source:HGNC NA 1.16 −1.06 Symbol; Acc:HGNC:1549] ENSG00000162817 C1orf115 chromosome 1 open reading frame 115 −1.02 NA −1.07 [Source:HGNC Symbol; Acc:HGNC:25873] ENSG00000213401 MAGEA12 melanoma antigen family A, 12 −1.18 NA −1.07 [Source:HGNC Symbol; Acc:HGNC:6799] ENSG00000266596 NA NA NA NA −1.07 ENSG00000263542 −1.13 NA −1.08 ENSG00000165841 CYP2C19 cytochrome P450, family 2, subfamily C, −1.13 NA −1.09 polypeptide 19 [Source:HGNC Symbol; Acc:HGNC:2621] ENSG00000164124 TMEM144 transmembrane protein 144 [Source:HGNC −1.36 NA −1.10 Symbol; Acc:HGNC:25633] ENSG00000230528 NOS2P3 nitric oxide synthase 2 pseudogene 3 −1.51 NA −1.10 [Source:HGNC Symbol; Acc:HGNC:35124] ENSG00000252164 RNA5SP282 RNA, 5S ribosomal pseudogene 282 −1.38 NA −1.10 [Source:HGNC Symbol; Acc:HGNC:43182] ENSG00000227274 −1.10 NA −1.10 ENSG00000225216 −1.25 NA −1.11 ENSG00000257519 −1.09 NA −1.11 ENSG00000253008 M1R2355 microRNA 2355 [Source:HGNC −1.15 NA −1.12 Symbol; Acc:HGNC:38328] ENSG00000136457 CHAD chondroadherin [Source:HGNC NA NA −1.12 Symbol; Acc:HGNC:1909] ENSG00000227438 −1.13 NA −1.13 ENSG00000200492 Small nucleolar RNA U3 −1.17 NA −1.13 [Source:RFAM;Acc:RF00012] ENSG00000239072 NA NA −1.19 NA −1.14 ENSG00000222036 POTEG POTE ankyrin domain family, member G −1.22 NA −1.14 [Source:HGNC Symbol; Acc:HGNC:33896] ENSG00000254683 SNRPCP6 small nuclear ribonucleoprotein polypeptide −1.06 NA −1.15 C pseudogene 6 [Source:HGNC Symbol; Acc:HGNC:49821] ENSG00000266667 −1.47 NA −1.15 ENSG00000119888 EPCAM epithelial cell adhesion molecule −1.01 NA −1.15 [Source:HGNC Symbol; Acc:HGNC:11529] ENSG00000251983 RN7SKP157 RNA, 7SK small nuclear pseudogene 157 −1.27 NA −1.16 [Source:HGNC Symbol; Acc:HGNC:45881] ENSG00000179914 ITLN1 intelectin 1 (galactofuranose binding) −1.01 NA −1.16 [Source:HGNC Symbol; Acc:HGNC:18259] ENSG00000197753 LHFPL5 lipoma HMGIC fusion partner-like 5 −1.30 NA −1.16 [Source:HGNC Symbol; Acc:HGNC:21253] ENSG00000259588 NA NA −1.16 ENSG00000181227 −1.37 NA −1.16 ENSG00000141194 OR4D1 olfactory receptor, family 4, subfamily D, −1.52 NA −1.17 member 1 [Source:HGNC Symbol; Acc:HGNC:8293] ENSG00000251354 −1.40 NA −1.17 ENSG00000267513 −1.38 NA −1.17 ENSG00000227790 −1.22 NA −1.17 ENSG00000232491 NA NA −1.18 ENSG00000171794 UTF1 undifferentiated embryonic cell transcription −1.28 NA −1.18 factor 1 [Source:HGNC Symbol; Acc:HGNC:12634] ENSG00000263774 NA NA −1.18 ENSG00000177602 GSG2 germ cell associated 2 (haspin) −1.04 NA −1.19 [Source:HGNC Symbol; Acc:HGNC:19682] ENSG00000232120 NA NA −1.19 ENSG00000264235 NA 1.26 −1.19 ENSG00000183346 C100rf107 chromosome 10 open reading frame 107 −1.24 NA −1.19 [Source:HGNC Symbol; Acc:HGNC:28678] ENSG00000265946 −1.27 NA −1.20 ENSG00000133116 KL klotho [Source:HGNC −1.25 NA −1.20 Symbol; Acc:HGNC:6344] ENSG00000200783 RN7SKP180 RNA, 7SK small nuclear pseudogene 180 −1.01 NA −1.20 [Source:HGNC Symbol; Acc:HGNC:45904] ENSG00000227011 C17orf112 chromosome 17 open reading frame 112 −1.54 NA −1.21 [Source:HGNC Symbol; Acc:HGNC:42963] ENSG00000237621 OR9A1P olfactory receptor, family 9, subfamily A, −1.05 NA −1.21 member 1 pseudogene [Source:HGNC Symbol; Acc:HGNC:8486] ENSG00000259761 −1.23 NA −1.21 ENSG00000196565 HBG2 hemoglobin, gamma G [Source:HGNC −1.40 NA −1.21 Symbol; Acc:HGNC:4832] ENSG00000236852 NA NA −1.21 ENSG00000173728 C1orf100 chromosome 1 open reading frame 100 NA NA −1.21 [Source:HGNC Symbol; Acc:HGNC:30435] ENSG00000238617 NA NA −1.07 NA −1.22 ENSG00000255031 −1.23 NA −1.22 ENSG00000204250 LINC00587 long intergenic non-protein coding RNA 587 −1.69 NA −1.22 [Source:HGNC Symbol; Acc:HGNC:31372] ENSG00000259047 −1.27 NA −1.22 ENSG00000266941 NA NA −1.22 ENSG00000258273 −1.17 NA −1.23 ENSG00000087494 PTHLH parathyroid hormone-like hormone −1.30 NA −1.23 [Source:HGNC Symbol; Acc:HGNC:9607] ENSG00000252343 RNU2-34P RNA, U2 small nuclear 34, pseudogene −1.16 NA −1.23 [Source:HGNC Symbol; Acc:HGNC:48527] ENSG00000272626 −1.14 NA −1.24 ENSG00000258828 KRT8P2 keratin 8 pseudogene 2 [Source:HGNC −1.38 NA −1.24 Symbol; Acc:HGNC:20282] ENSG00000224618 −1.54 NA −1.24 ENSG00000234713 −1.39 NA −1.24 ENSG00000237356 −1.09 NA −1.24 ENSG00000250770 −1.07 NA −1.25 ENSG00000238858 NA NA NA NA −1.25 ENSG00000234683 −1.39 NA −1.25 ENSG00000271415 −1.19 NA −1.25 ENSG00000239073 NA NA −1.43 NA −1.25 ENSG00000248891 NA NA −1.26 ENSG00000251062 −1.33 NA −1.26 ENSG00000223783 −1.33 NA −1.27 ENSG00000259604 NA NA −1.27 ENSG00000226659 −1.43 NA −1.27 ENSG00000235147 NA 1.12 −1.28 ENSG00000264296 NA NA −1.29 ENSG00000223026 RN7SKP247 RNA, 7SK small nuclear pseudogene 247 −1.22 NA −1.29 [Source:HGNC Symbol; Acc:HGNC:45971] ENSG00000241656 UBA52P7 ubiquitin A-52 residue ribosomal protein −1.12 NA −1.29 fusion product 1 pseudogene 7 [Source:HGNC Symbol; Acc:HGNC:36615] ENSG00000257777 NA NA −1.30 ENSG00000221083 Small nucleolar RNA SNORA77 −2.14 NA −1.30 [Source:RFAM;Acc:RF00599] ENSG00000269069 −1.21 NA −1.30 ENSG00000241954 NA NA −1.30 ENSG00000163793 DNAJC5G DnaJ (Hsp40) homolog, subfamily C, −1.39 NA −1.32 member 5 gamma [Source:HGNC Symbol; Acc:HGNC:24844] ENSG00000264910 RN7SL525P RNA, 7SL, cytoplasmic 525, pseudogene −1.21 NA −1.32 [Source:HGNC Symbol; Acc:HGNC:46541] ENSG00000211538 MIR501 microRNA 501 [Source:HGNC NA NA −1.32 Symbol; Acc:HGNC:32135] ENSG00000256257 CACNA1C-1T2 CACNA1C intronic transcript 2 (non-protein NA NA −1.32 coding) [Source:HGNC Symbol; Acc:HGNC:41313] ENSG00000253784 −1.33 NA −1.32 ENSG00000226981 ABHD17AP6 abhydrolase domain containing 17A NA NA −1.32 pseudogene 6 [Source:HGNC Symbol; Acc:HGNC:34044] ENSG00000134627 PIWIL4 piwi-like RNA-mediated gene silencing 4 −1.10 NA −1.33 [Source:HGNC Symbol; Acc:HGNC:18444] ENSG00000197417 SHPK sedoheptulokinase [Source:HGNC −1.10 NA −1.33 Symbol; Acc:HGNC:1492] ENSG00000257004 −1.15 NA −1.34 ENSG00000215089 KRT18P11 keratin 18 pseudogene 11 [Source:HGNC NA 1.24 −1.34 Symbol; Acc:HGNC:6431] ENSG00000255003 CYCSP28 cytochrome c, somatic pseudogene 28 −1.25 NA −1.34 [Source:HGNC Symbol; Acc:HGNC:24402] ENSG00000167230 NA NA −1.07 NA −1.35 ENSG00000234113 −1.39 NA −1.35 ENSG00000121594 CD80 CD80 molecule [Source:HGNC −1.29 NA −1.35 Symbol; Acc:HGNC:1700] ENSG00000228648 −1.25 NA −1.36 ENSG00000229338 −1.73 NA −1.36 ENSG00000226801 OSTCP8 oligosaccharyltransferase complex subunit NA 1.40 −1.36 pseudogene 8 [Source:HGNC Symbol; Acc:HGNC:42869] ENSG00000213014 VN2R17P vomeronasal 2 receptor 17 pseudogene −1.31 NA −1.36 [Source:HGNC Symbol; Acc:HGNC:33223] ENSG00000227970 NR1H5P nuclear receptor subfamily 1, group H, −1.21 NA −1.37 member 5, pseudogene [Source:HGNC Symbol; Acc:HGNC:32673] ENSG00000230495 −1.40 NA −1.37 ENSG00000235154 −1.36 NA −1.37 ENSG00000253603 −1.68 NA −1.37 ENSG00000177685 CRACR2B calcium release activated channel regulator NA 1.24 −1.38 2B [Source:HGNC Symbol; Acc:HGNC:28703] ENSG00000243136 RN7SL22P RNA, 7SL, cytoplasmic 22, pseudogene −1.62 NA −1.39 [Source:HGNC Symbol; Acc:HGNC:46038] ENSG00000264439 −1.17 NA −1.39 ENSG00000240808 −1.59 NA −1.39 ENSG00000263435 −1.35 NA −1.39 ENSG00000243290 IGKV1-12 immunoglobulin kappa variable 1-12 −1.03 NA −1.39 [Source:HGNC Symbol; Acc:HGNC:5730] ENSG00000258845 −1.26 NA −1.41 ENSG00000260282 EIF4EBP2P2 eukaryotic translation initiation factor 4E −1.22 NA −1.42 binding protein 2 pseudogene 2 [Source:HGNC Symbol; Acc:HGNC:49317] ENSG00000252904 Small nucleolar RNA SNORA76 −1.48 NA −1.42 [Source:RFAM;Acc:RF00598] ENSG00000266187 RN7SL480P RNA, 7SL, cytoplasmic 480, pseudogene NA NA −1.42 [Source:HGNC Symbol; Acc:HGNC:46496] ENSG00000258790 KIAA0391 KIAA0391 [Source:HGNC −1.27 NA −1.44 Symbol; Acc:HGNC:19958] ENSG00000258642 NA NA −1.45 ENSG00000127588 GNG13 guanine nucleotide binding protein (G NA 1.36 −1.45 protein), gamma 13 [Source:HGNC Symbol; Acc:HGNC:14131] ENSG00000213048 OR5S1P olfactory receptor, family 5, subfamily S, −1.12 NA −1.46 member 1 pseudogene [Source:HGNC Symbol; Acc:HGNC:15040] ENSG00000225112 NA 1.14 −1.47 ENSG00000266399 −1.13 NA −1.48 ENSG00000184108 TRIML1 tripartite motif family-like 1 [Source:HGNC −1.24 NA −1.49 Symbol; Acc:HGNC:26698] ENSG00000254070 −1.40 NA −1.50 ENSG00000250360 −1.09 NA −1.50 ENSG00000147183 CPXCR1 CPX chromosome region, candidate 1 −1.37 NA −1.51 [Source:HGNC Symbol; Acc:HGNC:2332] ENSG00000234724 HDAC1P1 histone deacetylase 1 pseudogene 1 −1.29 NA −1.52 [Source:HGNC Symbol; Acc:HGNC:45190] ENSG00000257915 GLULP5 glutamate-ammonia ligase (glutamine −1.12 NA −1.52 synthetase) pseudogene 5 [Source:HGNC Symbol; Acc:HGNC:37989] ENSG00000254273 −1.11 NA −1.55 ENSG00000230867 −1.31 NA −1.55 ENSG00000188060 RAB42 RAB42, member RAS oncogene family −1.31 NA −1.56 [Source:HGNC Symbol; Acc:HGNC:28702] ENSG00000200753 Small nucleolar RNA SNORD56 −1.16 NA −1.57 [Source:RFAM;Acc:RF00275] ENSG00000230022 FNTAP2 famesyltransferase, CAAX box, alpha −1.29 NA −1.57 pseudogene 2 [Source:HGNC Symbol; Acc:HGNC:3784] ENSG00000259802 NA 1.12 −1.57 ENSG00000227676 LINC01068 long intergenic non-protein coding RNA −1.33 NA −1.59 1068 [Source:HGNC Symbol; Acc:HGNC:49106] ENSG00000252180 NA NA −1.43 NA −1.59 ENSG00000229485 KSR1P1 kinase suppressor of ras 1 pseudogene 1 NA 1.16 −1.61 [Source:HGNC Symbol; Acc:HGNC:44977] ENSG00000233643 −1.06 NA −1.61 ENSG00000268357 VN1R81P vomeronasal 1 receptor 81 pseudogene −1.44 NA −1.61 [Source:HGNC Symbol; Acc:HGNC:37401] ENSG00000270496 BNIP3P7 BCL2/adenovirus E1B 19 kDa interacting −1.68 NA −1.63 protein 3 pseudogene 7 [Source:HGNC Symbol; Acc:HGNC:49101] ENSG00000206637 Small nucleolar RNA SNORA70 −1.26 NA −1.64 [Source:RFAM;Acc:RF00156] ENSG00000198787 OR4D12P olfactory receptor, family 4, subfamily D, −1.48 NA −1.66 member 12 pseudogene [Source:HGNC Symbol; Acc:HGNC:19587] ENSG00000234619 RPL7P11 ribosomal protein L7 pseudogene 11 −1.09 NA −1.70 [Source:HGNC Symbol; Acc:HGNC:35667] ENSG00000230515 −1.29 NA −1.71 ENSG00000250347 −1.20 NA −1.71 ENSG00000228513 −1.34 NA −1.72 ENSG00000207712 MIR627 microRNA 627 [Source:HGNC −1.10 NA −1.74 Symbol; Acc:HGNC:32883] ENSG00000270377 −1.20 NA −1.85 ENSG00000249429 −1.79 NA −1.96

TABLE 28 Some biomarkers that are differentially expressed in plasma based on the level of head impact. Max_hitsp_vs_ Max_hitsp_vs_ Min_hitsp_vs_ Ensembl_ID hgnc_symbol description Baseline.x Min_hitsp.x Baseline.x ENSG00000225181 NA NA −1.88 ENSG00000264386 MIR4513 microRNA 4513 [Source: HGNC NA −1.47 1.49 Symbol; Acc: HGNC: 41855] ENSG00000252670 NA NA NA NA 1.34 ENSG00000235186 NA NA −1.33 ENSG00000270680 NA NA −1.37 ENSG00000201271 RNU1−112P RNA, U1 small nuclear 112, pseudogene NA NA −1.39 [Source: HGNC Symbol; Acc: HGNC: 48454] ENSG00000238763 NA NA NA NA −1.41 ENSG00000230645 NA NA −1.50 ENSG00000261665 TUBA8P2 tubulin, alpha 8 pseudogene 2 [Source: HGNC NA NA −1.62 Symbol; Acc: HGNC: 44569] ENSG00000265408 NA NA −1.64 ENSG00000182393 IFNL1 interferon, lambda 1 [Source: HGNC NA 1.85 −1.87 Symbol; Acc: HGNC: 18363] ENSG00000237973 MIR6723 microRNA 6723 [Source: HGNC NA 1.49 NA Symbol; Acc: HGNC: 50152] ENSG00000221096 NA NA NA −1.48 NA ENSG00000259145 NA NA NA −1.62 NA ENSG00000268995 VN1R82P vomeronasal 1 receptor 82 pseudogene NA −1.80 NA [Source: HGNC Symbol; Acc: HGNC: 37402] ENSG00000238754 Small nucleolar RNA U109NA NA −1.88 NA [Source: RFAM; Acc: RF01233] ENSG00000203426 NA NA NA −1.70 1.64 ENSG00000239617 NA −1.76 1.57 ENSG00000200702 Y RNA [Source: RFAM; Acc: RF00019] NA −1.42 1.54 ENSG00000109854 HTATIP2 HIV-1 Tat interactive protein 2, 30 kDa NA NA 1.45 [Source: HGNC Symbol; Acc: HGNC: 16637] ENSG00000248898 NA −1.80 1.34 ENSG00000198829 SUCNR1 succinate receptor 1 [Source: HGNC NA NA 1.25 Symbol; Acc: HGNC: 4542] ENSG00000269028 MTRNR2L12 MT-RNR2-like 12 [Source: HGNC NA −1.83 1.12 Symbol; Acc: HGNC: 37169] ENSG00000259588 NA NA −1.28 ENSG00000196565 HBG2 hemoglobin, gamma G [Source: HGNC NA NA −1.30 Symbol; Acc: HGNC: 4832] ENSG00000127588 GNG13 guanine nucleotide binding protein (G protein), NA 2.00 −1.33 gamma 13 [Source: HGNC Symbol; Acc: HGNC: 14131] ENSG00000215089 KRT18P11 keratin 18 pseudogene 11 [Source: HGNC NA NA −1.33 Symbol; Acc: HGNC: 6431] ENSG00000177685 CRACR2B calcium release activated channel regulator 2B NA 1.94 −1.36 [Source: HGNC Symbol; Acc: HGNC: 28703] ENSG00000159231 CBR3 carbonyl reductase 3 [Source: HGNC NA 1.38 −1.38 Symbol; Acc: HGNC: 1549] ENSG00000181227 NA NA −1.42 ENSG00000204389 HSPA1A heat shock 70 kDa protein 1A [Source: HGNC NA 1.35 −1.43 Symbol; Acc: HGNC: 5232] ENSG00000147183 CPXCR1 CPXchromosome region, candidate 1 NA NA −1.44 [Source: HGNC Symbol; Acc: HGNC: 2332] ENSG00000233265 MICF MHC class I polypeptide-related sequence F NA 1.95 −1.44 (pseudogene) [Source: HGNC Symbol; Acc: HGNC: 16801] ENSG00000236852 NA NA −1.45 ENSG00000252343 RNU2-34P RNA, U2 small nuclear 34, pseudogene NA NA −1.47 [Source: HGNC Symbol; Acc: HGNC: 48527] ENSG00000229485 KSR1P1 kinase suppressor of ras 1 pseudogene 1 NA 2.02 −1.52 [Source: HGNC Symbol; Acc: HGNC: 44977] ENSG00000259802 NA NA −1.59 ENSG00000264235 NA NA −1.74 ENSG00000158856 DMTN dematin actin binding protein [Source: HGNC 1.99 1.31 NA Symbol; Acc: HGNC: 3382] ENSG00000265565 MIR3143 microRNA 3143 [Source: HGNC 1.94 1.47 NA Symbol; Acc: HGNC: 38284] ENSG00000272468 1.89 1.23 NA ENSG00000100345 MYH9 myosin, heavy chain 9, non-muscle [Source: HGNC 1.85 1.41 NA Symbol; Acc: HGNC: 7579] ENSG00000268230 1.82 1.24 NA ENSG00000242716 NA NA 1.82 2.01 NA ENSG00000175602 CCDC85B coiled-coil domain containing 85B [Source: HGNC 1.81 1.30 NA Symbol; Acc: HGNC: 24926] ENSG00000223554 1.78 2.21 NA ENSG00000235938 NA NA 1.66 NA 1.47 ENSG00000133136 GNG5P2 guanine nucleotide binding protein (G protein), 1.63 1.64 NA gamma 5 pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 24826] ENSG00000227159 DDX11L16 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 1.62 NA 1.20 16 [Source: HGNC Symbol; Acc: HGNC: 37115] ENSG00000168067 MAP4K2 mitogen-activated protein kinase kinase kinase 1.62 1.03 NA kinase 2 [Source: HGNC Symbol; Acc: HGNC: 6864] ENSG00000270457 1.40 NA NA ENSG00000215030 RPL13P12 ribosomal protein L13 pseudogene 12 1.39 2.18 NA [Source: HGNC Symbol; Acc: HGNC: 35701] ENSG00000176043 1.38 NA 1.44 ENSG00000141179 PCTP phosphatidylcholine transfer protein [Source: HGNC 1.36 1.22 NA Symbol; Acc: HGNC: 8752] ENSG00000263740 RN7SL4P RNA, 7SL, cytoplasmic 4, pseudogene 1.34 NA 1.12 [Source: HGNC Symbol; Acc: HGNC: 10039] ENSG00000148848 ADAM12 ADAM metallopeptidase domain 12 [Source: HGNC 1.30 1.17 NA Symbol; Acc: HGNC: 190] ENSG00000271361 HTATSF1P2 HIV-1 Tat specific factor 1 pseudogene 2 1.24 NA 1.42 [Source: HGNC Symbol; Acc: HGNC: 38586] ENSG00000229344 1.23 1.27 NA ENSG00000234975 FTH1P2 ferritin, heavy polypeptide 1 pseudogene 2 1.16 1.28 NA [Source: HGNC Symbol; Acc: HGNC: 3989] ENSG00000236876 TMSB4XP1 thymosin beta 4, X-linked pseudogene 1 1.16 NA NA [Source: HGNC Symbol; Acc: HGNC: 11883] ENSG00000166086 JAM3 junctional adhesion molecule 3 [Source: HGNC 1.07 NA NA Symbol; Acc: HGNC: 15532] ENSG00000162817 C1orf115 chromosome 1 open reading frame 115 −1.04 NA −1.13 [Source: HGNC Symbol; Acc: HGNC: 25873] ENSG00000164237 CMBL carboxymethylenebutenolidase homolog −1.06 NA NA (Pseudomonas) [Source: HGNC Symbol; Acc: HGNC: 25090] ENSG00000172476 RAB40A RAB40A, member RAS oncogene family −1.10 −1.23 NA [Source: HGNC Symbol; Acc: HGNC: 18283] ENSG00000260198 −1.22 NA −1.18 ENSG00000237256 PGAM3P phosphoglycerate mutase 3, pseudogene −1.23 NA −1.87 [Source: HGNC Symbol; Acc: HGNC: 16557] ENSG00000119888 EPCAM epithelial cell adhesion molecule [Source: HGNC −1.26 NA NA Symbol; Acc: HGNC: 11529] ENSG00000230589 IMP3P1 IMP3 pseudogene 1 [Source: HGNC −1.26 NA NA Symbol; Acc: HGNC: 49385] ENSG00000230022 FNTAP2 farnesyltransferase, CAAX box, alpha pseudogene 1.27 NA −1.70 2 [Source: HGNC Symbol; Acc: HGNC: 3784] ENSG00000227438 −1.28 NA −1.25 ENSG00000227790 −1.29 NA −1.31 ENSG00000237356 −1.29 NA −1.23 ENSG00000204250 LINC00587 long intergenic non-protein coding RNA 587 −1.29 NA −1.39 [Source: HGNC Symbol; Acc: HGNC: 31372] ENSG00000270683 FAM71BP1 family with sequence similarity 71, member B −1.29 −1.66 NA pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 49805] ENSG00000200783 RN7SKP180 RNA, 7SK small nuclear pseudogene 180 −1.30 NA −1.28 [Source: HGNC Symbol; Acc: HGNC: 45904] ENSG00000165841 CYP2C19 cytochrome P450, family 2, subfamily C, −1.33 NA −1.28 polypeptide 19 [Source: HGNC Symbol; Acc: HGNC: 2621] ENSG00000263542 −1.34 NA −1.30 ENSG00000256972 −1.34 NA NA ENSG00000250347 −1.34 NA −1.83 ENSG00000263929 NA NA −1.35 −1.65 NA ENSG00000269069 −1.35 NA −1.40 ENSG00000261340 −1.35 NA NA ENSG00000197568 HHLA3 HERV-H LTR-associating 3 [Source: HGNC −1.36 NA −1.23 Symbol; Acc: HGNC: 4906] ENSG00000227011 C17orf112 chromosome 17 open reading frame 112 −1.36 NA −1.33 [Source: HGNC Symbol; Acc: HGNC: 42963] ENSG00000198787 OR4D12P olfactory receptor, family 4, subfamily D, member 12 −1.36 NA −1.69 pseudogene [Source: HGNC Symbol; Acc: HGNC: 19587] ENSG00000258088 −1.36 NA −1.22 ENSG00000229775 −1.36 NA −1.59 ENSG00000258790 KIAA0391 KIAA0391[Source: HGNC −1.36 NA −1.36 Symbol; Acc: HGNC: 19958] ENSG00000223783 −1.36 NA −1.18 ENSG00000224924 LINC00320 long intergenic non-protein coding RNA 320 −1.36 NA NA [Source: HGNC Symbol; Acc: HGNC: 19690] ENSG00000159186 −1.37 NA NA ENSG00000188060 RAB42 RAB42, member RAS oncogene family −1.37 NA −1.49 [Source: HGNC Symbol; Acc: HGNC: 28702] ENSG00000257723 CHCHD3P2 coiled-coil-helix-coiled-coil-helix domain containing −1.38 −1.42 NA 3 pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 44698] ENSG00000241656 UBA52P7 ubiquitin A-52 residue ribosomal protein fusion −1.39 NA −1.35 product 1 pseudogene 7 [Source: HGNC Symbol; Acc: HGNC: 36615] ENSG00000253008 MIR2355 microRNA 2355 [Source: HGNC −1.39 NA −1.36 Symbol; Acc: HGNC: 38328] ENSG00000224618 −1.40 NA NA ENSG00000266399 −1.40 NA −1.75 ENSG00000167230 NA NA −1.40 NA −1.31 ENSG00000200492 Small nucleolar RNA U3 −1.40 NA −1.37 [Source: RFAM; Acc: RF00012] ENSG00000239072 NA NA −1.41 NA −1.37 ENSG00000222524 RN7SKP109 RNA, 7SK small nuclear pseudogene 109 −1.41 NA NA [Source: HGNC Symbol; Acc: HGNC: 45833] ENSG00000226659 −1.41 NA NA ENSG00000249465 RBMXP4 RNA binding motif protein, X-linked pseudogene 4 −1.41 NA NA [Source: HGNC Symbol; Acc: HGNC: 34028] ENSG00000238460 −1.42 −1.67 NA ENSG00000255003 CYCSP28 cytochrome c, somatic pseudogene 28 −1.42 NA −1.65 [Source: HGNC Symbol; Acc: HGNC: 24402] ENSG00000255031 −1.42 NA −1.45 ENSG00000264439 −1.43 NA −1.63 ENSG00000213014 VN2R17P vomeronasal 2 receptor 17 pseudogene −1.44 NA −1.34 [Source: HGNC Symbol; Acc: HGNC: 33223] ENSG00000172769 OR5B3 olfactory receptor, family 5, subfamily B, member 3 −1.44 NA NA [Source: HGNC Symbol; Acc: HGNC: 8324] ENSG00000225216 −1.44 NA NA ENSG00000235147 −1.44 NA −1.90 ENSG00000270798 −1.45 −1.43 NA ENSG00000233545 CYCSP33 cytochrome c, somatic pseudogene 33 −1.45 NA NA [Source: HGNC Symbol; Acc: HGNC: 24407] ENSG00000248891 −1.45 NA −1.70 ENSG00000203691 NA NA −1.45 NA NA ENSG00000225906 −1.45 NA NA ENSG00000184674 NA NA −1.47 −1.79 NA ENSG00000168992 OR7E102P olfactory receptor, family 7, subfamily E, member −1.47 NA −2.00 102 pseudogene [Source: HGNC Symbol; Acc: HGNC: 15043] ENSG00000186453 FAM228A family with sequence similarity 228, member A −1.47 NA −1.29 [Source: HGNC Symbol; Acc: HGNC: 34418] ENSG00000226981 ABHD17AP6 abhydrolase domain containing 17A pseudogene 6 −1.47 NA −1.45 [Source: HGNC Symbol; Acc: HGNC: 34044] ENSG00000183346 C10orf107 chromosome 10 open reading frame 107 −1.47 NA NA [Source: HGNC Symbol; Acc: HGNC: 28678] ENSG00000227274 −1.47 NA NA ENSG00000212338 Small nucleolar RNA SNORA67 −1.47 NA −1.42 [Source: RFAM; Acc: RF00272] ENSG00000255408 PCDHA3 protocadherin alpha 3 [Source: HGNC −1.48 NA −1.44 Symbol; Acc: HGNC: 8669] ENSG00000219368 ZNF299P zinc finger protein 299, pseudogene [Source: HGNC −1.48 NA NA Symbol; Acc: HGNC: 13088] ENSG00000253849 −1.48 NA NA ENSG00000234713 −1.48 NA −1.41 ENSG00000263253 −1.48 NA NA ENSG00000213401 MAGEA12 melanoma antigen family A, 12 [Source: HGNC −1.48 NA NA Symbol; Acc: HGNC: 6799] ENSG00000266603 NA NA −1.48 −1.95 NA ENSG00000223026 RN7SKP247 RNA, 7SK small nuclear pseudogene 247 −1.49 NA −1.39 [Source: HGNC Symbol; Acc: HGNC: 45971] ENSG00000251062 −1.49 NA −1.75 ENSG00000163993 S100P S100 calcium binding protein P [Source: HGNC −1.49 NA −1.45 Symbol; Acc: HGNC: 10504] ENSG00000224418 STK24-AS1 STK24 antisense RNA 1 [Source: HGNC −1.49 −1.34 NA Symbol; Acc: HGNC: 39935] ENSG00000213144 −1.50 NA NA ENSG00000179914 ITLN1 intelectin 1 (galactofuranose binding) −1.50 NA −1.26 [Source: HGNC Symbol; Acc: HGNC: 18259] ENSG00000259047 −1.50 NA −1.46 ENSG00000237621 OR9A1P olfactory receptor, family 9, subfamily A, member 1 −1.50 NA −1.25 pseudogene[Source: HGNC Symbol; Acc: HGNC: 8486] ENSG00000241954 −1.51 NA −1.68 ENSG00000231682 −1.51 −1.32 NA ENSG00000254070 −1.52 NA −1.72 ENSG00000258273 −1.52 NA −1.49 ENSG00000251751 RN7SKP46 RNA, 7SK small nuclear pseudogene 46 −1.52 NA −1.41 [Source: HGNC Symbol; Acc: HGNC: 45770] ENSG00000228513 −1.52 NA −1.96 ENSG00000226272 ARHGAP26- ARHGAP26antisense RNA 1 [Source: HGNC −1.52 NA −1.22 AS1 Symbol; Acc: HGNC: 40792] ENSG00000233643 −1.52 NA −1.64 ENSG00000258828 KRT8P2 keratin 8 pseudogene 2 [Source: HGNC −1.53 NA −1.35 Symbol; Acc: HGNC: 20282] ENSG00000234619 RPL7P11 ribosomal protein L7 pseudogene 11 [Source: HGNC −1.53 NA −1.78 Symbol; Acc: HGNC: 35667] ENSG00000234683 −1.53 NA NA ENSG00000164124 TMEM144 transmembrane protein 144 [Source: HGNC −1.53 NA −1.05 Symbol; Acc: HGNC: 25633] ENSG00000258642 −1.54 NA −1.63 ENSG00000197753 LHFPL5 lipoma HMGIC fusion partner-like 5 [Source: HGNC −1.55 NA NA Symbol; Acc: HGNC: 21253] ENSG00000252672 NA NA −1.55 NA −1.94 ENSG00000271415 −1.55 NA −1.52 ENSG00000239791 −1.56 NA NA ENSG00000227970 NR1H5P nuclear receptor subfamily 1, group H, member 5, −1.56 NA −1.33 pseudogene [Source: HGNC Symbol; Acc: HGNC: 32673] ENSG00000206848 RNU6-890P RNA, U6 small nuclear 890, pseudogene −1.56 NA NA [Source: HGNC Symbol; Acc: HGNC: 47853] ENSG00000177602 GSG2 germ cell associated 2 (haspin) [Source: HGNC −1.57 NA −1.23 Symbol; Acc: HGNC: 19682] ENSG00000171794 UTF1 undifferentiated embryonic cell transcription factor 1 −1.58 NA NA [Source: HGNC Symbol; Acc: HGNC: 12634] ENSG00000226801 OSTCP8 oligosaccharyltransferase complex subunit −1.58 NA −1.87 pseudogene 8 [Source: HGNC Symbol; Acc: HGNC: 42869] ENSG00000172594 SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A −1.58 −1.31 NA [Source: HGNC Symbol; Acc: HGNC: 17389] ENSG00000254845 NA NA −1.58 NA NA ENSG00000263493 NA NA −1.59 NA NA ENSG00000243824 −1.59 −1.64 NA ENSG00000120586 NA NA −1.60 −1.55 NA ENSG00000226104 NA NA −1.60 NA NA ENSG00000256257 CACNA1C-IT2 CACNA1C intronic transcript 2 (non-protein coding) −1.60 NA −1.46 [Source: HGNC Symbol; Acc: HGNC: 41313] ENSG00000237731 RNGTTP1 RNA guanylyltransferase and 5′-phosphatase −1.60 NA −1.69 pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 39652] ENSG00000225785 −1.60 −1.33 NA ENSG00000173728 C1orf100 chromosome 1 open reading frame 100 −1.61 NA −1.32 [Source: HGNC Symbol; Acc: HGNC: 30435] ENSG00000232650 −1.61 NA −1.48 ENSG00000133116 KL klotho [Source: HGNC Symbol; Acc: HGNC: 6344] −1.61 NA −1.14 ENSG00000134627 PIWIL4 piwi-like RNA-mediated gene silencing 4 −1.61 NA −1.27 [Source: HGNC Symbol; Acc: HGNC: 18444] ENSG00000257777 −1.62 NA −1.32 ENSG00000263774 −1.62 NA −1.58 ENSG00000234723 −1.63 −1.65 NA ENSG00000232491 −1.63 NA −1.59 ENSG00000235902 −1.64 NA −1.73 ENSG00000232120 −1.64 NA −1.37 ENSG00000186038 HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, −1.64 NA −1.21 ionotropic [Source: HGNC Symbol; Acc: HGNC: 24005] ENSG00000228648 −1.65 NA −1.39 ENSG00000260282 EIF4EBP2P2 eukaryotic translation initiation factor 4E binding −1.65 NA −1.52 protein 2 pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 49317] ENSG00000252596 NA NA −1.66 NA −1.62 ENSG00000270496 BNIP3P7 BCL2/adenovirus E1B 19 kDa interacting protein 3 −1.66 NA −1.85 pseudogene 7 [Source: HGNC Symbol; Acc: HGNC: 49101] ENSG00000187689 AMTN amelotin [Source: HGNC Symbol; Acc: HGNC: 33188] −1.67 NA −1.26 ENSG00000225112 −1.68 NA −1.76 ENSG00000254273 −1.68 NA −1.76 ENSG00000266596 NA NA −1.69 NA NA ENSG00000232578 −1.69 NA NA ENSG00000200753 Small nucleolar RNA SNORD56 −1.69 NA −1.74 [Source: RFAM;Acc: RF00275] ENSG00000239011 NA NA −1.69 NA −1.64 ENSG00000258845 −1.70 NA −1.64 ENSG00000238858 NA NA −1.70 NA −1.67 ENSG00000252180 NA NA −1.70 NA −1.86 ENSG00000267670 −1.71 NA −1.80 ENSG00000212564 RNU6−1326P RNA, U6 small nuclear 1326, pseudogene −1.71 NA −1.88 [Source: HGNC Symbol; Acc: HGNC: 48289] ENSG00000211967 IGHV3-53 immunoglobulin heavy variable 3-53 [Source: HGNC −1.71 NA −1.15 Symbol; Acc: HGNC: 5610] ENSG00000249429 −1.71 NA −2.03 ENSG00000266187 RN7SL480P RNA, 7SL, cytoplasmic 480, pseudogene −1.72 NA −2.01 [Source: HGNC Symbol; Acc: HGNC: 46496] ENSG00000265946 −1.72 NA NA ENSG00000252904 Small nucleolar RNA SNORA76 −1.72 NA −1.68 [Source: RFAM;Acc: RF00598] ENSG00000241757 RN7SL714P RNA, 7SL, cytoplasmic 714, pseudogene −1.73 NA NA [Source: HGNC Symbol; Acc: HGNC: 46730] ENSG00000222036 POTEG POTE ankyrin domain family, member G −1.73 NA −1.08 [Source: HGNC Symbol; Acc: HGNC: 33896] ENSG00000230495 −1.73 NA −1.32 ENSG00000257519 −1.73 NA NA ENSG00000221291 −1.74 NA −1.70 ENSG00000223881 −1.74 −1.53 NA ENSG00000251983 RN7SKP157 RNA, 7SK small nuclear pseudogene 157 −1.74 NA NA [Source: HGNC Symbol; Acc: HGNC: 45881] ENSG00000240545 RN75L492P RNA, 7SL, cytoplasmic 492, pseudogene −1.74 −1.56 NA [Source: HGNC Symbol; Acc: HGNC: 46508] ENSG00000230867 −1.75 NA −1.61 ENSG00000235154 −1.75 NA −1.28 ENSG00000197417 SHPK sedoheptulokinase [Source: HGNC −1.76 NA −1.33 Symbol; Acc: HGNC: 1492] ENSG00000266941 −1.77 NA −1.57 ENSG00000234113 −1.77 NA −1.37 ENSG00000163793 DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 −1.79 NA −1.26 gamma [Source: HGNC Symbol; Acc: HGNC: 24844] ENSG00000240286 MEAF6P1 MYST/Esa1-associated factor 6 pseudogene 1 −1.79 NA −2.10 [Source: HGNC Symbol; Acc: HGNC: 42660] ENSG00000207712 MIR627 microRNA 627 [Source: HGNC −1.80 NA −2.13 Symbol; Acc: HGNC: 32883] ENSG00000121594 CD80 CD80 molecule [Source: HGNC −1.80 NA −1.34 Symbol; Acc: HGNC: 1700] ENSG00000199470 Small nucleolar RNASNORA64/SNORA10 family −1.81 NA −1.40 [Source: RFAM;Acc: RF00264] ENSG00000240808 −1.82 NA −1.43 ENSG00000264469 −1.82 NA NA ENSG00000257915 GLULP5 glutamate-ammonia ligase (glutamine synthetase) −1.82 NA −1.65 pseudogene 5 [Source: HGNC Symbol; Acc: HGNC: 37989] ENSG00000270377 −1.83 NA −2.22 ENSG00000227593 −1.84 NA −1.31 ENSG00000220505 EIF4EBP2P3 eukaryotic translation initiation factor 4E binding −1.85 NA NA protein 2 pseudogene 3 [Source: HGNC Symbol; Acc: HGNC: 49318] ENSG00000230515 −1.85 NA −1.78 ENSG00000250770 −1.86 NA −1.25 ENSG00000226939 −1.86 NA −1.33 ENSG00000239073 NA NA −1.87 NA −1.40 ENSG00000251354 −1.87 NA NA ENSG00000231957 GNAI2P2 guanine nucleotide binding protein (G protein), −1.89 −1.43 NA alpha inhibiting activity polypeptide 2 pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 45110] ENSG00000141194 OR4D1 olfactory receptor, family 4, subfamily D, member 1 −1.90 NA NA [Source: HGNC Symbol; Acc: HGNC: 8293] ENSG00000250256 −1.90 NA −1.60 ENSG00000259761 −1.91 NA −1.28 ENSG00000257004 −1.93 NA −1.65 ENSG00000259418 −1.94 NA −1.44 ENSG00000266667 −1.95 NA ENSG00000264910 RN7SL525P RNA, 7SL, cytoplasmic 525, pseudogene −1.95 NA −1.62 [Source: HGNC Symbol; Acc: HGNC: 46541] ENSG00000252164 RNA5SP282 RNA, 5S ribosomal pseudogene 282 [Source: HGNC −1.96 NA NA Symbol; Acc: HGNC: 43182] ENSG00000239547 RN7SL843P RNA, 7SL, cytoplasmic 843, pseudogene −1.96 NA NA [Source: HGNC Symbol; Acc: HGNC: 46859] ENSG00000211538 MIR501 microRNA 501 [Source: HGNC −1.99 NA −1.58 Symbol; Acc: HGNC: 32135] ENSG00000231680 −1.99 NA NA ENSG00000250392 −2.00 NA −1.35 ENSG00000087494 PTHLH parathyroid hormone-like hormone [Source: HGNC −2.00 NA −1.18 Symbol; Acc: HGNC: 9607] ENSG00000217557 −2.02 NA −1.59 ENSG00000267513 −2.03 NA NA ENSG00000263435 −2.04 NA −1.43 ENSG00000184108 TRIML1 tripartite motif family-like 1 [Source: HGNC −2.05 NA −1.50 Symbol; Acc: HGNC: 26698] ENSG00000229338 −2.06 NA −1.36 ENSG00000243290 IGKV1−12 immunoglobulin kappa variable 1−12 [Source: HGNC −2.07 NA −1.37 Symbol; Acc: HGNC: 5730] ENSG00000272626 −2.07 NA −1.36 ENSG00000253603 −2.08 NA −1.40 ENSG00000249941 −2.11 NA NA ENSG00000260229 −2.13 −1.41 NA ENSG00000243136 RN7SL22P RNA, 7SL, cytoplasmic 22, pseudogene −2.17 NA −1.47 [Source: HGNC Symbol; Acc: HGNC: 46038] ENSG00000206637 Small nucleolar RNA SNORA70 −2.17 NA −2.13 [Source: RFAM;Acc: RF00156] ENSG00000229031 −2.19 NA −1.59 ENSG00000268357 VN1R81P vomeronasal 1 receptor 81 pseudogene −2.20 NA −1.89 [Source: HGNC Symbol; Acc: HGNC: 37401] ENSG00000227676 LINC01068 long intergenic non-protein coding RNA 1068 −2.20 NA −1.76 [Source: HGNC Symbol; Acc: HGNC: 49106] ENSG00000234724 HDAC1P1 histone deacetylase 1 pseudogene 1 −2.22 NA −1.51 [Source: HGNC Symbol; Acc: HGNC: 45190] ENSG00000264296 −2.23 NA −1.58 ENSG00000185296 −2.24 NA −1.45 ENSG00000250612 −2.25 −1.79 NA ENSG00000253784 −2.27 NA −1.59 ENSG00000236090 LDHAP3 lactate dehydrogenase A pseudogene 3 −2.29 −1.32 NA [Source: HGNC Symbol; Acc: HGNC: 6538] ENSG00000244414 CFHR1 complement factor H-related 1 [Source: HGNC −2.50 −1.41 NA Symbol; Acc: HGNC: 4888] ENSG00000253780 IGHVIII-2-1 immunoglobulin heavy variable (III)-2-1 −2.57 −1.47 NA (pseudogene) [Source: HGNC Symbol; Acc: HGNC: 5695] ENSG00000238617 NA NA −2.65 NA −1.30 ENSG00000250360 −2.66 NA −1.62 ENSG00000213048 OR5S1P olfactory receptor, family 5, subfamily S, member 1 −2.81 NA −1.70 pseudogene [Source: HGNC Symbol; Acc: HGNC: 15040]

TABLE 29 Biomarkers that are differentially expressed in urine based on the number of head impact incidents High_freq_hits_ High_freq_hits_ vs_Low_freq_ Low_freq_hits_ Ensembl_ID hgnc_symbol description vs_Baseline.y hits.y vs_Baseline.y ENSG00000210140 MT-TC mitochondrially encoded tRNA cysteine NA 1.17 −1.16 [Source: HGNC Symbol; Acc: HGNC: 7477] ENSG00000229344 1.58 2.02 NA ENSG00000225972 MTND1P23 MT-ND1 pseudogene 23 [Source: HGNC 1.06 1.22 NA Symbol; Acc: HGNC: 42092] ENSG00000122585 NPY neuropeptide Y [Source: HGNC NA NA 1.07 Symbol; Acc: HGNC: 7955] ENSG00000198840 MT-ND3 mitochondrially encoded NADH dehydrogenase 3 NA 1.54 −1.01 [Source: HGNC Symbol; Acc: HGNC: 7458] ENSG00000210174 MT-TR mitochondrially encoded tRNA arginine NA 1.67 −1.01 [Source: HGNC Symbol; Acc: HGNC: 7496] ENSG00000210191 MT-TL2 mitochondrially encoded tRNA leucine 2 (CUN) NA 1.36 −1.02 [Source: HGNC Symbol; Acc: HGNC: 7491] ENSG00000210156 MT-TK mitochondrially encoded tRNA lysine NA 1.65 −1.02 [Source: HGNC Symbol; Acc: HGNC: 7489] ENSG00000210049 MT-TF mitochondrially encoded tRNA phenylalanine NA 1.44 −1.08 [Source: HGNC Symbol; Acc: HGNC: 7481] ENSG00000210107 MT-TQ mitochondrially encoded tRNA glutamine NA 1.31 −1.10 [Source: HGNC Symbol; Acc: HGNC: 7495] ENSG00000210196 MT-TP mitochondrially encoded tRNA proline NA 1.43 −1.11 [Source: HGNC Symbol; Acc: HGNC: 7494] ENSG00000210100 MT-TI mitochondrially encoded tRNA isoleucine NA 1.72 −1.21 [Source: HGNC Symbol; Acc: HGNC: 7488] ENSG00000210194 MT-TE mitochondrially encoded tRNA glutamic acid NA 1.63 NA [Source: HGNC Symbol; Acc: HGNC: 7479] ENSG00000209082 MT-TL1 mitochondrially encoded tRNA leucine 1 (UUA/G) NA 1.60 NA [Source: HGNC Symbol; Acc: HGNC: 7490] ENSG00000210127 MT-TA mitochondrially encoded tRNA alanine NA 1.55 NA [Source: HGNC Symbol; Acc: HGNC: 7475] ENSG00000210195 MT-TT mitochondrially encoded tRNA threonine NA 1.54 NA [Source: HGNC Symbol; Acc: HGNC: 7499] ENSG00000210117 MT-TW mitochondrially encoded tRNA tryptophan NA 1.54 NA [Source: HGNC Symbol; Acc: HGNC: 7501] ENSG00000210077 MT-TV mitochondrially encoded tRNA valine NA 1.41 NA [Source: HGNC Symbol; Acc: HGNC: 7500] ENSG00000210176 MT-TH mitochondrially encoded tRNA histidine NA 1.41 NA [Source: HGNC Symbol; Acc: HGNC: 7487] ENSG00000198763 MT-ND2 mitochondrially encoded NADH dehydrogenase 2 NA 1.41 NA [Source: HGNC Symbol; Acc: HGNC: 7456] ENSG00000198938 MT-CO3 mitochondrially encoded cytochrome c oxidase III NA 1.35 NA [Source: HGNC Symbol; Acc: HGNC: 7422] ENSG00000198786 MT-NDS mitochondrially encoded NADH dehydrogenase 5 NA 1.34 NA [Source: HGNC Symbol; Acc: HGNC: 7461] ENSG00000225630 MTND2P28 MT-ND2 pseudogene 28 [Source: HGNC NA 1.34 NA Symbol; Acc: HGNC: 42129] ENSG00000198712 MT-CO2 mitochondrially encoded cytochrome c oxidase II NA 1.32 NA [Source: HGNC Symbol; Acc: HGNC: 7421] ENSG00000198727 MT-CYB mitochondrially encoded cytochrome b NA 1.31 NA [Source: HGNC Symbol; Acc: HGNC: 7427] ENSG00000198888 MT-ND1 mitochondrially encoded NADH dehydrogenase 1 NA 1.25 NA [Source: HGNC Symbol; Acc: HGNC: 7455] ENSG00000198804 MT-001 mitochondrially encoded cytochrome c oxidase I NA 1.23 NA [Source: HGNC Symbol; Acc: HGNC: 7419] ENSG00000198886 MT-ND4 mitochondrially encoded NADH dehydrogenase 4 NA 1.23 NA [Source: HGNC Symbol; Acc: HGNC: 7459] ENSG00000198899 MT-ATP6 mitochondrially encoded ATP synthase 6 NA 1.22 NA [Source: HGNC Symbol; Acc: HGNC: 7414] ENSG00000210184 MT-TS2 mitochondrially encoded tRNA serine 2 (AGU/C) NA 1.15 NA [Source: HGNC Symbol; Acc: HGNC: 7498] ENSG00000198695 MT-ND6 mitochondrially encoded NADH dehydrogenase 6 NA 1.12 NA [Source: HGNC Symbol; Acc: HGNC: 7462] ENSG00000210144 MT-TY mitochondrially encoded tRNA tyrosine NA 1.09 NA [Source: HGNC Symbol; Acc: HGNC: 7502] ENSG00000228253 MT-ATP8 mitochondrially encoded ATP synthase 8 NA 1.05 NA [Source: HGNC Symbol; Acc: HGNC: 7415] ENSG00000258696 NA 1.03 NA ENSG00000175646 PRM1 protamine 1 [Source: HGNC Symbol; NA NA 1.01 Acc: HGNC: 9447]

TABLE 30 Biomarkers that are differentially expressed in urine based on the level of head impact Ensembl_ID hgnc_symbol description Min_hitsp_vs_Baseline.y ENSG00000210140 MT-TC mitochondrially encoded tRNA cysteine −1.00 [Source: HGNC Symbol; Acc: HGNC: 7477] ENSG00000122585 NPY neuropeptide Y [Source: HGNC Symbol; 1.13 Acc: HGNC: 7955]

TABLE 31 Some biomarkers that are differentially expressed in plasma based on subjects' probability score for the risk of concussion hgnc_ X1_ X2_ X2_ X3_ X3_ X3_ Ensembl_ID symbol description vs_0.x vs_0.x vs_1.x vs_0.x vs_1.x vs_2.x ENSG00000229344 1.20 1.39 NA NA −1.25 −1.43 ENSG00000212338 Small nucleolar RNA SNORA67 −1.07 −1.09 NA −1.15 NA NA [Source:RFAM;Acc:RF00272] ENSG00000186453 FAM228 family with sequence similarity 228, member A −1.13 NA NA NA 1.37 1.07 A [Source:HGNC Symbol;Acc:HGNC:34418] ENSG00000239011 NA NA −1.02 −1.06 NA NA NA NA ENSG00000229775 −1.10 −1.15 NA NA NA NA ENSG00000252596 NA NA −1.36 −1.23 NA NA NA NA ENSG00000237731 RNGTT RNA guanylyltransferase and 5′-phosphatase −1.24 −1.48 NA NA NA NA P1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:39652] ENSG00000270683 FAM71 family with sequence similarity 71, member B NA −1.07 NA −1.02 NA NA BP1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:49805] ENSG00000225181 −1.22 −1.07 NA −1.07 NA NA ENSG00000163993 S100P S100 calcium binding protein P [Source:HGNC −1.26 NA NA −1.29 NA NA Symbol;Acc:HGNC:10504] ENSG00000237256 PGAM3 phosphoglycerate mutase 3, pseudogene −1.37 NA NA NA 1.13 NA P [Source:HGNC Symbol;Acc:HGNC:16557] ENSG00000227593 −1.20 NA NA NA 1.02 NA ENSG00000234723 NA −1.16 NA NA 1.02 1.80 ENSG00000249072 1.30 1.27 NA NA −1.06 −1.03 ENSG00000252670 NA NA 1.01 1.25 NA NA NA NA ENSG00000264386 MIR451 microRNA 4513 [Source:HGNC NA 1.07 NA NA NA NA 3 Symbol;Acc:HGNC:41855] ENSG00000185296 NA −1.01 NA NA NA NA ENSG00000221291 NA −1.04 NA NA NA NA ENSG00000256972 −1.09 −1.10 NA NA NA NA ENSG00000197568 HHLA3 HERV-H LTR-associating 3 [Source:HGNC NA −1.12 NA NA NA NA Symbol;Acc:HGNC:4906] ENSG00000230645 −1.47 −1.16 NA NA NA NA ENSG00000229031 NA −1.18 NA NA NA NA ENSG00000232578 −1.18 −1.18 NA NA NA NA ENSG00000231680 −1.25 −1.21 NA NA NA NA ENSG00000226939 NA −1.27 NA NA NA NA ENSG00000258088 NA −1.29 NA NA NA NA ENSG00000250392 −1.26 −1.35 NA NA NA NA ENSG00000215030 RPL13P ribosomal protein L13 pseudogene 12 [Source:HGNC NA NA 1.13 NA NA NA 12 Symbol;Acc:HGNC:35701] ENSG00000220505 EIF4EB eukaryotic translation initiation factor 4E binding protein P2P3 2 pseudogene 3 [Source:HGNC NA −1.55 −1.06 NA NA NA Symbol;Acc:HGNC:49318] ENSG00000158856 DMTN dematin actin binding protein [Source:HGNC NA NA NA 1.31 NA NA Symbol;Acc:HGNC:3382] ENSG00000100345 MYH9 myosin, heavy chain 9, non-muscle [Source:HGNC NA NA NA 1.08 NA NA Symbol;Acc:HGNC:7579] ENSG00000242716 NA NA NA NA NA 1.07 NA NA ENSG00000175602 CCDC8 coiled-coil domain containing 85B [Source:HGNC NA NA NA 1.03 NA NA 5B Symbol;Acc:HGNC:24926] ENSG00000225906 −1.01 NA NA −1.02 NA NA ENSG00000201271 RNU1- RNA, U1 small nuclear 112, pseudogene −1.14 −1.21 NA −1.04 NA NA 112P [Source:HGNC Symbol;Acc:HGNC:48454] ENSG00000265408 −1.10 NA NA −1.05 NA NA ENSG00000172594 SMPDL sphingomyelin phosphodiesterase, acid-like 3A -1.07 −1.24 NA −1.06 NA NA 3A [Source:HGNC Symbol;Acc:HGNC:17389] ENSG00000203691 NA NA −1.49 −1.37 NA −1.13 NA NA ENSG00000212564 RNU6- RNA, U6 small nuclear 1326, pseudogene NA −1.17 NA −1.13 NA NA 1326P [Source:HGNC Symbol;Acc:HGNC:48289] ENSG00000199470 Small nucleolar RNA SNORA64/SNORA10 family NA NA NA −1.17 NA NA [Source:RFAM;Acc:RF00264] ENSG00000264469 −1.01 −1.13 NA −1.18 NA NA ENSG00000267670 −1.47 NA NA −1.20 NA NA ENSG00000238763 NA NA −1.11 NA NA −1.35 NA NA ENSG00000270680 −1.13 NA NA NA 1.15 NA ENSG00000182393 IFNL1 interferon, lambda 1 [Source:HGNC NA NA NA NA 1.14 NA Symbol;Acc:HGNC:18363] ENSG00000249941 −1.12 NA NA NA 1.09 NA ENSG00000261665 TUBA8 tubulin, alpha 8 pseudogene 2 [Source:HGNC NA NA 1.00 NA 1.06 NA P2 Symbol;Acc:HGNC:44569] ENSG00000235186 −1.02 NA 1.04 NA 1.05 NA RBMXP RNA binding motif protein, X-linked pseudogene 4 −1.24 NA NA NA 1.05 NA ENSG00000249465 4 [Source:HGNC Symbol;Acc:HGNC:34028] ENSG00000219188 CACYB calcyclin binding protein pseudogene 3 [Source:HGNC NA −1.05 NA NA 1.06 1.31 PP3 Symbol;Acc:HGNC:45124] ENSG00000199287 NA NA NA −1.27 −1.10 NA NA 1.03 ENSG00000206848 RNU6- RNA, U6 small nuclear 890, pseudogene NA NA NA NA 1.01 1.01 890P [Source:HGNC Symbol;Acc:HGNC:47853] ENSG00000252672 NA NA NA NA 1.33 NA NA −1.26 ENSG00000200510 NA NA 1.95 2.01 NA NA −1.67 −1.72 ENSG00000263740 RN7SL4 RNA, 7SL, cytoplasmic 4, pseudogene [Source:HGNC NA 1.42 NA NA NA NA P Symbol;Acc:HGNC:10039] ENSG00000166086 JAM3 junctional adhesion molecule 3 [Source:HGNC 1.18 1.05 NA NA NA NA Symbol;Acc:HGNC:15532] ENSG00000272468 NA 1.02 NA NA NA NA ENSG00000232120 NA −1.01 NA NA NA NA ENSG00000251354 NA −1.01 NA NA NA NA ENSG00000183346 C10orf1 chromosome 10 open reading frame 107 NA −1.01 NA NA NA NA 07 [Source:HGNC Symbol;Acc:HGNC:28678] ENSG00000234683 NA −1.02 NA NA NA NA ENSG00000263774 NA −1.03 NA NA NA NA ENSG00000265946 NA −1.03 NA NA NA NA ENSG00000260229 NA −1.03 NA NA NA NA ENSG00000225785 NA −1.05 NA NA NA NA ENSG00000252164 RNA5S RNA, 5S ribosomal pseudogene 282 [Source:HGNC NA −1.07 NA NA NA NA P282 Symbol;Acc:HGNC:43182] ENSG00000226659 NA −1.07 NA NA NA NA ENSG00000266596 NA NA −1.05 −1.07 NA NA NA NA ENSG00000221083 Small nucleolar RNA SNORA77 −1.03 −1.09 NA NA NA NA [Source:RFAM;Acc:RF00599] ENSG00000219368 ZNF299 zinc finger protein 299, pseudogene [Source:HGNC −1.06 −1.10 NA NA NA NA P Symbol;Acc:HGNC:13088] ENSG00000251751 RN7SK RNA, 7SK small nuclear pseudogene 46 −1.00 −1.12 NA NA NA NA P46 [Source:HGNC Symbol;Acc:HGNC:45770] ENSG00000213144 −1.11 −1.12 NA NA NA NA ENSG00000147183 CPXCR CPX chromosome region, candidate 1 [Source:HGNC NA −1.12 NA NA NA NA 1 Symbol;Acc:HGNC:2332] ENSG00000266941 NA −1.12 NA NA NA NA ENSG00000231957 GNAI2P guanine nucleotide binding protein (G protein), alpha NA −1.13 NA NA NA NA 2 inhibiting activity polypeptide 2 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:45110] ENSG00000224924 LINC00 long intergenic non-protein coding RNA 320 −1.06 −1.13 NA NA NA NA 320 [Source:HGNC Symbol;Acc:HGNC:19690] ENSG00000225216 NA −1.14 NA NA NA NA ENSG00000266667 NA −1.14 NA NA NA NA ENSG00000224618 NA −1.16 NA NA NA NA ENSG00000241954 NA −1.18 NA NA NA NA ENSG00000253849 −1.04 −1.20 NA NA NA NA ENSG00000230589 IMP3P1 IMP3 pseudogene 1 [Source:HGNC −1.37 −1.21 NA NA NA NA Symbol;Acc:HGNC:49385] ENSG00000254845 NA NA −1.16 −1.24 NA NA NA NA ENSG00000204389 HSPA1 heat shock 70 kDa protein 1A [Source:HGNC −1.07 −1.29 NA NA NA NA A Symbol;Acc:HGNC:5232] ENSG00000224418 STK24- STK24 antisense RNA 1 [Source:HGNC −1.00 −1.30 NA NA NA NA AS1 Symbol;Acc:HGNC:39935] ENSG00000258642 NA −1.35 NA NA NA NA ENSG00000239791 −1.51 −1.50 NA NA NA NA ENSG00000171794 UTF1 undifferentiated embryonic cell transcription factor 1 NA NA 1.19 NA NA NA [Source:HGNC Symbol;Acc:HGNC:12634] ENSG00000232491 NA NA 1.12 NA NA NA ENSG00000226981 ABHD1 abhydrolase domain containing 17A pseudogene 6 NA NA 1.06 NA NA NA 7AP6 [Source:HGNC Symbol;Acc:HGNC:34044] ENSG00000215089 KRT18P keratin 18 pseudogene 11 [Source:HGNC NA NA 1.04 NA NA NA 11 Symbol;Acc:HGNC:6431] ENSG00000222524 RN7SK RNA, 7SK small nuclear pseudogene 109 −1.27 NA 1.02 NA NA NA P109 [Source:HGNC Symbol;Acc:HGNC:45833] ENSG00000250461 NA −1.13 −1.03 NA NA NA ENSG00000252497 RPPH1- ribonuclease P RNA component H1, 2 pseudogene NA −1.26 −1.09 NA NA NA 2P [Source:HGNC Symbol;Acc:HGNC:47029] ENSG00000221096 NA NA NA NA −1.12 NA NA NA ENSG00000168067 MAP4K mitogen-activated protein kinase kinase kinase kinase NA NA NA 1.06 NA NA 2 2 [Source:HGNC Symbol;Acc:HGNC:6864] ENSG00000239617 NA NA NA 1.01 NA NA ENSG00000230528 NOS2P nitric oxide synthase 2 pseudogene 3 [Source:HGNC −1.22 NA NA −1.01 NA NA 3 Symbol;Acc:HGNC:35124] ENSG00000236852 NA −1.09 NA −1.02 NA NA ENSG00000267513 NA NA NA −1.03 NA NA ENSG00000254683 SNRPC small nuclear ribonucleoprotein polypeptide C −1.02 NA NA −1.04 NA NA P6 pseudogene 6 [Source:HGNC Symbol;Acc:HGNC:49821] ENSG00000230019 YWHAQ YWHAQ pseudogene 9 [Source:HGNC NA −1.25 NA −1.04 NA NA P9 Symbol;Acc:HGNC:37688] ENSG00000253377 NA −1.04 NA −1.04 NA NA ENSG00000266187 RN7SL4 RNA, 7SL, cytoplasmic 480, pseudogene NA NA NA −1.07 NA NA 80P [Source:HGNC Symbol;Acc:HGNC:46496] ENSG00000264296 NA NA NA −1.09 NA NA ENSG00000261340 NA −1.02 NA −1.10 NA NA ENSG00000172769 OR5B3 olfactory receptor, family 5, subfamily B, member 3 −1.06 −1.09 NA −1.14 NA NA [Source:HGNC Symbol;Acc:HGNC:8324] ENSG00000238858 NA NA NA NA NA −1.15 NA NA ENSG00000257519 NA NA NA −1.24 NA NA ENSG00000224288 −1.01 −1.25 NA −1.25 NA NA ENSG00000270798 NA −1.28 NA −1.28 NA NA ENSG00000252863 RNU6- RNA, U6 small nuclear 1183, pseudogene −1.03 −1.12 NA −1.31 NA NA 1183P [Source:HGNC Symbol;Acc:HGNC:48146] ENSG00000223881 NA −1.45 NA −1.32 NA NA ENSG00000263253 −1.01 −1.24 NA −1.39 NA NA ENSG00000248891 NA NA NA −1.43 NA NA ENSG00000136872 ALDOB aldolase B, fructose-bisphosphate [Source:HGNC −1.66 −1.42 NA −1.48 NA NA Symbol;Acc:HGNC:417] ENSG00000270371 NA 1.16 1.09 1.19 1.12 NA ENSG00000273154 NA 1.21 1.11 1.18 1.08 NA ENSG00000233545 CYCSP cytochrome c, somatic pseudogene 33 [Source:HGNC −1.38 NA NA NA 1.06 NA 33 Symbol;Acc:HGNC:24407] ENSG00000231682 −1.14 NA NA NA 1.05 NA ENSG00000238460 NA NA NA −1.06 −1.00 NA ENSG00000270457 NA NA NA NA −1.12 NA ENSG00000268995 VN1R82 vomeronasal 1 receptor 82 pseudogene NA NA NA NA −1.12 NA P [Source:HGNC Symbol;Acc:HGNC:37402] ENSG00000198829 SUCNR succinate receptor 1 [Source:HGNC 1.02 NA NA NA −1.21 NA 1 Symbol;Acc:HGNC:4542] ENSG00000248538 NA −1.05 −1.03 −1.24 −1.22 NA ENSG00000243370 RN7SL7 RNA, 7SL, cytoplasmic 775, pseudogene −1.01 −1.41 NA NA 1.04 1.44 75P [Source:HGNC Symbol;Acc:HGNC:46791] ENSG00000259588 NA −1.19 NA NA NA 1.34 ENSG00000263493 NA NA NA −1.26 −1.09 NA NA 1.27 ENSG00000233265 MICF MHC class I polypeptide-related sequence F NA NA NA NA 1.42 1.24 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:16801] ENSG00000239547 RN7SL8 RNA, 7SL, cytoplasmic 843, pseudogene −1.08 NA NA NA 1.34 1.20 43P [Source:HGNC Symbol;Acc:HGNC:46859] ENSG00000240545 RN7SL4 RNA, 7SL, cytoplasmic 492, pseudogene NA −1.16 NA NA NA 1.16 92P [Source:HGNC Symbol;Acc:HGNC:46508] ENSG00000226104 NA NA NA −1.12 NA NA NA 1.11 ENSG00000257723 CHCHD coiled-coil-helix-coiled-coil-helix domain containing 3 NA −1.16 NA NA NA 1.10 3P2 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:44698] ENSG00000259411 HNRNP heterogeneous nuclear ribonucleoprotein A1 NA −1.10 NA NA NA 1.06 A1P45 pseudogene 45 [Source:HGNC Symbol;Acc:HGNC:48775] ENSG00000136457 CHAD chondroadherin [Source:HGNC −1.02 NA NA NA 1.35 1.06 Symbol;Acc:HGNC:1909] ENSG00000265334 −1.14 −1.01 NA NA 1.17 1.03 ENSG00000241757 RN7SL7 RNA, 7SL, cytoplasmic 714, pseudogene NA −1.02 NA NA NA 1.03 14P [Source:HGNC Symbol;Acc:HGNC:46730] ENSG00000159186 −1.02 −1.12 NA NA NA 1.03 ENSG00000238754 Small nucleolar RNA U109 NA NA −1.11 NA NA 1.01 [Source: RFAM ;Acc:RF01233] ENSG00000229196 −1.19 −1.17 NA NA 1.04 1.01 ENSG00000259604 −1.31 −1.35 NA NA NA 1.01 ENSG00000236876 TMSB4 thymosin beta 4, X-linked pseudogene 1 NA 1.24 NA NA NA −1.11 XP1 [Source:HGNC Symbol;Acc:HGNC:11883] ENSG00000244921 NA 1.03 NA NA NA −1.16 ENSG00000259145 NA NA NA NA NA −1.25 −1.01 −1.17 ENSG00000227468 NA 1.04 NA NA NA −1.20 ENSG00000269028 MTRNR MT-RNR2-like 12 [Source:HGNC NA NA NA NA −1.26 −1.22 2L12 Symbol;Acc:HGNC:37169] ENSG00000201955 RNY3P RNA, Ro-associated Y3 pseudogene 1 [Source:HGNC 1.00 1.06 NA NA −1.19 −1.24 1 Symbol;Acc:HGNC:42477] ENSG00000237973 MIR672 microRNA 6723 [Source:HGNC NA NA NA NA NA −1.27 3 Symbol;Acc:HGNC:50152] ENSG00000259045 NA 1.06 NA NA NA -1.37

TABLE 32 Biomarkers that are differentially expressed in urine based on subjects' probability score for the risk of concussion hgnc_ X1_ X2_ X2_ X3_ X3_ X3_ Ensembl_ID symbol description vs_0.y vs_0.y vs_1.y vs_0.y vs_1.y vs_2.y ENSG00000136689 IL1RN interleukin 1 receptor antagonist [Source:HGNC NA NA NA 1.03 NA 1.11 Symbol;Acc:HGNC:6000] ENSG00000124233 SEMG1 semenogelin I [Source:HGNC Symbol;Acc:HGNC:10742] 1.02 NA NA NA NA NA ENSG00000134240 HMGCS 3-hydroxy-3-methylglutaryl-CoA synthase 2 NA NA NA 1.06 NA NA 2 (mitochondrial) [Source:HGNC Symbol;Acc:HGNC:5008] ENSG00000242082 NA NA NA 1.00 NA NA ENSG00000181617 FDCSP follicular dendritic cell secreted protein [Source:HGNC NA NA NA −1.04 NA NA Symbol;Acc:HGNC:19215] ENSG00000214049 UCA1 urothelial cancer associated 1 (non-protein coding) NA NA NA NA NA 1.10 [Source:HGNC Symbol;Acc:HGNC:37126] ENSG00000153071 DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 NA NA NA NA NA 1.00 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:2662] ENSG00000224203 RPS23P ribosomal protein S23 pseudogene 10 [Source:HGNC NA NA NA NA NA −1.01 10 Symbol;Acc:HGNC:48342] ENSG00000212930 NA NA NA NA NA −1.01 ENSG00000240863 RN7SL6 RNA, 7SL, cytoplasmic 645, pseudogene [Source:HGNC NA NA NA NA NA −1.02 45P Symbol;Acc:HGNC:46661 ] ENSG00000237460 NA NA NA NA NA −1.02 ENSG00000236495 NA NA NA NA NA −1.02 ENSG00000226197 NA NA NA NA NA −1.02

TABLE 33 The markers listed discriminate between a subject who is exposed to frequent head impact (e.g. an athlete who plays contact sports) and subject with normal exposure to head impact (e.g. an athlete who does not play contact sports, like track and field) using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000001626 CFTR cystic fibrosis transmembrane conductance regulator (ATP- binding cassette sub-family C, member 7) [Source: HGNC Symbol; Acc: HGNC: 1884] ENSG00000003249 DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 [Source: HGNC Symbol; Acc: HGNC: 28455] ENSG00000106018 VIPR2 vasoactive intestinal peptide receptor 2 [Source: HGNC Symbol; Acc: HGNC: 12695] ENSG00000117411 B4GALT2 UDP-Gal: betaGIcNAc beta 1,4- galactosyltransferase, polypeptide 2 [Source: HGNC Symbol; Acc: HGNC: 925] ENSG00000119614 VSX2 visual system homeobox 2 [Source: HGNC Symbol; Acc: HGNC: 1975] ENSG00000122254 HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 [Source: HGNC Symbol; Acc: HGNC: 5195] ENSG00000122584 NXPH1 neurexophilin 1 [Source: HGNC Symbol; Acc: HGNC: 20693] ENSG00000124089 MC3R melanocortin 3 receptor [Source: HGNC Symbol; Acc: HGNC: 6931] ENSG00000130545 CRB3 crumbs family member 3 [Source: HGNC Symbol; Acc: HGNC: 20237] ENSG00000160161 CILP2 cartilage intermediate layer protein 2 [Source: HGNC Symbol; Acc: HGNC: 24213] ENSG00000169174 PCSK9 proprotein convertase subtilisin/kexin type 9 [Source: HGNC Symbol; Acc: HGNC: 20001] ENSG00000172780 RAB43 RAB43, member RAS oncogene family [Source: HGNC Symbol; Acc: HGNC: 19983] ENSG00000184154 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing [Source: HGNC Symbol; Acc: HGNC: 25033] ENSG00000185915 KLHL34 kelch-like family member 34 [Source: HGNC Symbol; Acc: HGNC: 26634] ENSG00000188833 ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 [Source: HGNC Symbol; Acc: HGNC: 24860] ENSG00000205765 C5orf51 chromosome 5 open reading frame 51 [Source: HGNC Symbol; Acc: HGNC: 27750] ENSG00000233421 ENSG00000234944 ENSG00000256463 SALL3 spalt-like transcription factor 3 [Source: HGNC Symbol; Acc: HGNC: 10527] ENSG00000258991 DUX4L19 double homeobox 4 like 19 [Source: HGNC Symbol; Acc: HGNC: 37718] ENSG00000266947 ENSG00000184194 GPR173 G protein-coupled receptor 173 [Source: HGNC Symbol; Acc: HGNC: 18186] ENSG00000176956 LY6H lymphocyte antigen 6 complex, locus H [Source: HGNC Symbol; Acc: HGNC: 6728] ENSG00000171606 ZNF274 zinc finger protein 274 [Source: HGNC Symbol; Acc: HGNC: 13068]

TABLE 34 The markers listed discriminate between a subject who is exposed to frequent head impact (e.g. an athlete who plays contact sports) and subject with normal exposure to head impact (e.g. an athlete who does not play contact sports, like track and field) using urine samples. Ensembl_ID HGNC_symbol Description ENSG00000065675 PRKCQ protein kinase C, theta [Source: HGNC Symbol; Acc: HGNC: 9410] ENSG00000105948 TTC26 tetratricopeptide repeat domain 26 [Source: HGNC Symbol; Acc: HGNC: 21882] ENSG00000116273 PHF13 PHD finger protein 13 [Source: HGNC Symbol; Acc: HGNC: 22983] ENSG00000138050 THUMPD2 THUMP domain containing 2 [Source: HGNC Symbol; Acc: HGNC: 14890] ENSG00000151093 OXSM 3-oxoacyl-ACP synthase, mitochondrial [Source: HGNC Symbol; Acc: HGNC: 26063] ENSG00000151623 NR3C2 nuclear receptor subfamily 3, group C, member 2 [Source: HGNC Symbol; Acc: HGNC: 7979] ENSG00000168491 CCDC110 coiled-coil domain containing 110 [Source: HGNC Symbol; Acc: HGNC: 28504] ENSG00000170989 S1PR1 sphingosine-1-phosphate receptor 1 [Source: HGNC Symbol; Acc: HGNC: 3165] ENSG00000175857 GAPT GRB2-binding adaptor protein, transmembrane [Source: HGNC Symbol; Acc: HGNC: 26588] ENSG00000188488 SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 [Source: HGNC Symbol; Acc: HGNC: 8723] ENSG00000198077 CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 [Source: HGNC Symbol; Acc: HGNC: 2611] ENSG00000198889 DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 [Source: HGNC Symbol; Acc: HGNC: 29395] ENSG00000204666 FLJ26850 protein [Source: EntrezGene; Acc: 400710] ENSG00000228506 ENSG00000229356 LRRC3-AS1 LRRC3 antisense RNA 1 (head to head) [Source: HGNC Symbol; Acc: HGNC: 43636] ENSG00000249465 RBMXP4 RNA binding motif protein, X-linked pseudogene 4 [Source: HGNC Symbol; Acc: HGNC: 34028] ENSG00000257242 C12orf79 chromosome 12 open reading frame 79 [Source: HGNC Symbol; Acc: HGNC: 27409] ENSG00000125630 POLR1B polymerase (RNA) I polypeptide B, 128 kDa [Source: HGNC Symbol; Acc: HGNC: 20454] ENSG00000198142 SOWAHC sosondowah ankyrin repeat domain family member C [Source: HGNC Symbol; Acc: HGNC: 26149] ENSG00000113360 DROSHA drosha, ribonuclease type III [Source: HGNC Symbol; Acc: HGNC: 17904] ENSG00000174899 C3orf55 chromosome 3 open reading frame 55 [Source: HGNC Symbol; Acc: HGNC: 25146] ENSG00000141034 GID4 GID complex subunit 4 [Source: HGNC Symbol; Acc: HGNC: 28453]

TABLE 35 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most frequent head impact and the subject's baseline using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000006114 NA NA ENSG00000074582 BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like [Source: HGNC Symbol; Acc: HGNC: 1020] ENSG00000084764 MAPRE3 microtubule-associated protein, RP/EB family, member 3 [Source: HGNC Symbol; Acc: HGNC: 6892] ENSG00000101098 RIMS4 regulating synaptic membrane exocytosis 4 [Source: HGNC Symbol; Acc: HGNC: 16183] ENSG00000128512 DOCK4 dedicator of cytokinesis 4 [Source: HGNC Symbol; Acc: HGNC: 19192] ENSG00000132535 DLG4 discs, large homolog 4 (Drosophila) [Source: HGNC Symbol; Acc: HGNC: 2903] ENSG00000163704 PRRT3 proline-rich transmembrane protein 3 [Source: HGNC Symbol; Acc: HGNC: 26591] ENSG00000164093 PITX2 paired-like homeodomain 2 [Source: HGNC Symbol; Acc: HGNC: 9005] ENSG00000172071 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 [Source: HGNC Symbol; Acc: HGNC: 3255] ENSG00000182552 RWDD4 RWD domain containing 4 [Source: HGNC Symbol; Acc: HGNC: 23750] ENSG00000182973 CNOT10 CCR4-NOT transcription complex, subunit 10 [Source: HGNC Symbol; Acc: HGNC: 23817] ENSG00000213414 ENSG00000228215 ENSG00000228327 ENSG00000232900 ENSG00000236540 ENSG00000243772 KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 [Source: HGNC Symbol; Acc: HGNC: 6331] ENSG00000243916 ENSG00000261398 ENSG00000266677 ENSG00000270696 ENSG00000272645 ENSG00000196268 ZNF493 zinc finger protein 493 [Source: HGNC Symbol; Acc: HGNC: 23708] ENSG00000181773 GPR3 G protein-coupled receptor 3 [Source: HGNC Symbol; Acc: HGNC: 4484]

TABLE 36 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most frequent head impact and a subject who is a contact sport athlete and experienced the least frequent head impact using a blood sample. Ensembl_ID HGNC_symbol Description ENSG00000100012 SEC14L3 SEC14-like 3 (S. cerevisiae) [Source: HGNC Symbol; Acc: HGNC: 18655] ENSG00000112852 PCDHB2 protocadherin beta 2 [Source: HGNC Symbol; Acc: HGNC: 8687] ENSG00000125734 GPR108 G protein-coupled receptor 108 [Source: HGNC Symbol; Acc: HGNC: 17829] ENSG00000130489 SCO2 SCO2 cytochrome c oxidase assembly protein [Source: HGNC Symbol; Acc: HGNC: 10604] ENSG00000143337 TOR1AIP1 torsin A interacting protein 1 [Source: HGNC Symbol; Acc: HGNC: 29456] ENSG00000151240 DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) [Source: HGNC Symbol; Acc: HGNC: 29150] ENSG00000154764 WNT7A wingless-type MMTV integration site family, member 7A [Source: HGNC Symbol; Acc: HGNC: 12786] ENSG00000166167 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase [Source: HGNC Symbol; Acc: HGNC: 1144] ENSG00000168280 KIF5C kinesin family member 5C [Source: HGNC Symbol; Acc: HGNC: 6325] ENSG00000172116 CD8B CD8b molecule [Source: HGNC Symbol; Acc: HGNC: 1707] ENSG00000180902 D2HGDH D-2-hydroxyglutarate dehydrogenase [Source: HGNC Symbol; Acc: HGNC: 28358] ENSG00000181722 ZBTB20 zinc finger and BTB domain containing 20 [Source: HGNC Symbol; Acc: HGNC: 13503] ENSG00000187556 NANOS3 nanos homolog 3 (Drosophila) [Source: HGNC Symbol; Acc: HGNC: 22048] ENSG00000196268 ZNF493 zinc finger protein 493 [Source: HGNC Symbol; Acc: HGNC: 23708] ENSG00000225492 GBP1P1 guanylate binding protein 1, interferon-inducible pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 39561] ENSG00000227892 OR5P4P olfactory receptor, family 5, subfamily P, member 4 pseudogene [Source: HGNC Symbol; Acc: HGNC: 15295] ENSG00000236445 LINC00608 long intergenic non-protein coding RNA 608 [Source: HGNC Symbol; Acc: HGNC: 27179] ENSG00000249831 ENSG00000257943 ENSG00000260288 ENSG00000261770 ENSG00000270275 ENSG00000270948 ENSG00000258071 ARL2BPP2 ADP-ribosylation factor-like 2 binding protein pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 31036]

TABLE 37 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most frequent head impact and a subject with normal exposure to head impact (e.g. an athlete who does not play contact sports, like track and field) using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000131759 RARA retinoic acid receptor, alpha [Source: HGNC Symbol; Acc: HGNC: 9864] ENSG00000140995 DEF8 differentially expressed in FDCP 8 homolog (mouse) [Source: HGNC Symbol; Acc: HGNC: 25969] ENSG00000143595 AQP10 aquaporin 10 [Source: HGNC Symbol; Acc: HGNC: 16029] ENSG00000177728 KIAA0195 KIAA0195 [Source: HGNC Symbol; Acc: HGNC: 28983] ENSG00000180613 GSX2 GS homeobox 2 [Source: HGNC Symbol; Acc: HGNC: 24959] ENSG00000181773 GPR3 G protein-coupled receptor 3 [Source: HGNC Symbol; Acc: HGNC: 4484] ENSG00000182636 NDN necdin, melanoma antigen (MAGE) family member [Source: HGNC Symbol; Acc: HGNC: 7675] ENSG00000183921 SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 [Source: HGNC Symbol; Acc: HGNC: 35414] ENSG00000184194 GPR173 G protein-coupled receptor 173 [Source: HGNC Symbol; Acc: HGNC: 18186] ENSG00000184502 GAST gastrin [Source: HGNC Symbol; Acc: HGNC: 4164] ENSG00000186868 MAPT microtubule-associated protein tau [Source: HGNC Symbol; Acc: HGNC: 6893] ENSG00000189223 PAX8-AS1 PAX8 antisense RNA 1 [Source: HGNC Symbol; Acc: HGNC: 49271] ENSG00000213152 RPL7AP60 ribosomal protein L7a pseudogene 60 [Source: HGNC Symbol; Acc: HGNC: 35859] ENSG00000221844 ENSG00000230989 HSBP1 heat shock factor binding protein 1 [Source: HGNC Symbol; Acc: HGNC: 5203] ENSG00000235979 ENSG00000237753 uncharacterized LOC400999 [Source: EntrezGene; Acc: 400999] ENSG00000244122 UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 [Source: HGNC Symbol; Acc: HGNC: 12539] ENSG00000244280 ECEL1P2 endothelin converting enzyme-like 1, pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 14019] ENSG00000251624 UNC93B7 unc-93 homolog B7 pseudogene (C. elegans) [Source: HGNC Symbol; Acc: HGNC: 44036] ENSG00000253318 TMCC1P1 transmembrane and coiled-coil domain family 1 pseudogene 1 [Source: HGNC Symbol; Acc: HGNC: 31901] ENSG00000254966 ENSG00000258071 ARL2BPP2 ADP-ribosylation factor-like 2 binding protein pseudogene 2 [Source: HGNC Symbol; Acc: HGNC: 31036] ENSG00000273382 ENSG00000260288

TABLE 38 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most frequent head impact and the subject's baseline using urine samples. Ensembl_ID HGNC_symbol Description ENSG00000061273 HDAC7 histone deacetylase 7 [Source: HGNC Symbol; Acc: HGNC: 14067] ENSG00000102287 GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon [Source: HGNC Symbol; Acc: HGNC: 4085] ENSG00000103152 MPG N-methylpurine-DNA glycosylase [Source: HGNC Symbol; Acc: HGNC: 7211] ENSG00000116984 MTR 5-methyltetrahydrofolate-homocysteine methyltransferase [Source: HGNC Symbol; Acc: HGNC: 7468] ENSG00000130349 C6orf203 chromosome 6 open reading frame 203 [Source: HGNC Symbol; Acc: HGNC: 17971] ENSG00000130829 DUSP9 dual specificity phosphatase 9 [Source: HGNC Symbol; Acc: HGNC: 3076] ENSG00000134215 VAV3 vav 3 guanine nucleotide exchange factor [Source: HGNC Symbol; Acc: HGNC: 12659] ENSG00000138639 ARHGAP24 Rho GTPase activating protein 24 [Source: HGNC Symbol; Acc: HGNC: 25361] ENSG00000144283 PKP4 plakophilin 4 [Source: HGNC Symbol; Acc: HGNC: 9026] ENSG00000169894 MUC3A mucin 3A, cell surface associated [Source: HGNC Symbol; Acc: HGNC: 7513] ENSG00000184454 NCMAP noncompact myelin associated protein [Source: HGNC Symbol; Acc: HGNC: 29332] ENSG00000188987 NA NA ENSG00000205927 OLIG2 oligodendrocyte lineage transcription factor 2 [Source: HGNC Symbol; Acc: HGNC: 9398] ENSG00000215070 XRCC6P5 X-ray repair complementing defective repair in Chinese hamster cells 6 pseudogene 5 [Source: HGNC Symbol; Acc: HGNC: 45187] ENSG00000234500 ENSG00000260896 ENSG00000264016 ENSG00000151623 NR3C2 nuclear receptor subfamily 3, group C, member 2 [Source: HGNC Symbol; Acc: HGNC: 7979] ENSG00000085415 SEH1L SEH1-like (S. cerevisiae) [Source: HGNC Symbol; Acc: HGNC: 30379] ENSG00000112679 DUSP22 dual specificity phosphatase 22 [Source: HGNC Symbol; Acc: HGNC: 16077]

TABLE 39 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most frequent head impact and a subject who is a contact sport athlete and experienced the least frequent head impact using a urine sample. Ensembl_ID HGNC_symbol Description ENSG00000085415 SEH1L SEH1-like (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:30379] ENSG00000088882 CPXM1 carboxypeptidase X (M14 family), member 1 [Source:HGNC Symbol;Acc:HGNC:15771] ENSG00000101276 SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 [Source:HGNC Symbol;Acc:HGNC:16187] ENSG00000105865 DUS4L dihydrouridine synthase 4-like (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:21517] ENSG00000110448 CD5 CD5 molecule [Source:HGNC Symbol;Acc:HGNC:1685] ENSG00000112941 PAPD7 PAP associated domain containing 7 [Source:HGNC Symbol;Acc:HGNC:16705] ENSG00000126500 FLRT1 fibronectin leucine rich transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:3760] ENSG00000127511 SIN3B SIN3 transcription regulator family member B [Source:HGNC Symbol;Acc:HGNC:19354] ENSG00000137802 MAPKBP1 mitogen-activated protein kinase binding protein 1 [Source:HGNC Symbol;Acc:HGNC:29536] ENSG00000164978 NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 [Source:HGNC Symbol;Acc:HGNC:8049] ENSG00000170929 OR1M1 olfactory receptor, family 1, subfamily M, member 1 [Source:HGNC Symbol;Acc:HGNC:8220] ENSG00000186318 BACE1 beta-site APP-cleaving enzyme 1 [Source:HGNC Symbol;Acc:HGNC:933] ENSG00000188508 KRTDAP keratinocyte differentiation-associated protein [Source:HGNC Symbol;Acc:HGNC:16313] ENSG00000197177 GPR123 G protein-coupled receptor 123 [Source:HGNC Symbol;Acc:HGNC:13838] ENSG00000203620 ENSG00000225365 ENSG00000226070 ENSG00000235816 PRELID1P3 PRELI domain containing 1 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:43888] ENSG00000236969 GGT8P gamma-glutamyltransferase 8 pseudogene [Source:HGNC Symbol;Acc:HGNC:33438] ENSG00000242159 ABCF2P1 ATP-binding cassette, sub-family F (GCN20), member 2 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:48841] ENSG00000243810 ENSG00000260664 ENSG00000267028 ENSG00000184454 NCMAP noncompact myelin associated protein [Source:HGNC Symbol;Acc:HGNC:29332]

TABLE 40 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most forceful head impact and the subject's baseline using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000091181 IL5RA interleukin 5 receptor, alpha [Source:HGNC Symbol;Acc:HGNC:6017] ENSG00000103429 BFAR bifunctional apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:17613] ENSG00000124256 ZBP1 Z-DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:16176] ENSG00000136274 NACAD NAC alpha domain containing [Source:HGNC Symbol;Acc:HGNC:22196] ENSG00000138081 FBXO11 F-box protein 11 [Source:HGNC Symbol;Acc:HGNC:13590] ENSG00000146242 TPBG trophoblast glycoprotein [Source:HGNC Symbol;Acc:HGNC:12004] ENSG00000151689 INPP1 inositol polyphosphate-1-phosphatase [Source:HGNC Symbol;Acc:HGNC:6071] ENSG00000163497 FEV FEV (ETS oncogene family) [Source:HGNC Symbol;Acc:HGNC:18562] ENSG00000164022 AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 [Source:HGNC Symbol;Acc:HGNC:10648] ENSG00000164616 FBXL21 F-box and leucine-rich repeat protein 21 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:13600] ENSG00000166987 MBD6 methyl-CpG binding domain protein 6 [Source:HGNC Symbol;Acc:HGNC:20445] ENSG00000168032 ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 [Source:HGNC Symbol;Acc:HGNC:3365] ENSG00000181837 OR5D17P olfactory receptor, family 5, subfamily D, member 17 pseudogene [Source:HGNC Symbol;Acc:HGNC:15284] ENSG00000197322 C17orf102 chromosome 17 open reading frame 102 [Source:HGNC Symbol;Acc:HGNC:34412] ENSG00000204682 CASC10 cancer susceptibility candidate 10 [Source:HGNC Symbol;Acc:HGNC:31448] ENSG00000213759 UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 [Source:HGNC Symbol;Acc:HGNC:12545] ENSG00000226149 ENSG00000250391 ENSG00000254537 ENSG00000255189 GLYATL1P1 glycine-N-acyltransferase-like 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:37866] ENSG00000259675 ENSG00000261351 ENSG00000264515 ENSG00000138286 FAM149B1 family with sequence similarity 149, member B1 [Source:HGNC Symbol;Acc:HGNC:29162]

TABLE 41 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most forceful head impact and a subject who is a contact sport athlete and experienced the least forceful head impact using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000091138 SLC26A3 solute carrier family 26 (anion exchanger), member 3 [Source:HGNC Symbol;Acc:HGNC:3018] ENSG00000107262 BAG1 BCL2-associated athanogene [Source:HGNC Symbol;Acc:HGNC:937] ENSG00000117501 MROH9 maestro heat-like repeat family member 9 [Source:HGNC Symbol;Acc:HGNC:26287] ENSG00000128606 LRRC17 leucine rich repeat containing 17 [Source:HGNC Symbol;Acc:HGNC:16895] ENSG00000132507 EIF5A eukaryotic translation initiation factor 5A [Source:HGNC Symbol;Acc:HGNC:3300] ENSG00000136155 SCEL sciellin [Source:HGNC Symbol;Acc:HGNC:10573] ENSG00000138286 FAM149B1 family with sequence similarity 149, member B1 [Source:HGNC Symbol;Acc:HGNC:29162] ENSG00000143341 HMCN1 hemicentin 1 [Source:HGNC Symbol;Acc:HGNC:19194] ENSG00000152034 MCHR2 melanin-concentrating hormone receptor 2 [Source:HGNC Symbol;Acc:HGNC:20867] ENSG00000173250 GPR151 G protein-coupled receptor 151 [Source:HGNC Symbol;Acc:HGNC:23624] ENSG00000175164 ABO ABO blood group (transferase A, alpha 1-3-N- acetylgalactosaminyltransferase; transferase B, alpha 1-3- galactosyltransferase) [Source:HGNC Symbol;Acc:HGNC:79] ENSG00000177106 EPS8L2 EPS8-like 2 [Source:HGNC Symbol;Acc:HGNC:21296] ENSG00000177352 CCDC71 coiled-coil domain containing 71 [Source:HGNC Symbol;Acc:HGNC:25760] ENSG00000215853 RPTN repetin [Source:HGNC Symbol;Acc:HGNC:26809] ENSG00000225361 PPP1R26-AS1 PPP1R26 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:48717] ENSG00000227036 LINC00511 long intergenic non-protein coding RNA 511 [Source:HGNC Symbol;Acc:HGNC:43564] ENSG00000230173 ENSG00000230925 ENSG00000231852 CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 [Source:HGNC Symbol;Acc:HGNC:2600] ENSG00000236596 ENSG00000247381 PDX1-AS1 PDX1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:43698] ENSG00000253374 ENSG00000253706 ENSG00000259293

TABLE 42 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most forceful head impact and a subject with normal exposure to head impact (e.g. an athlete who does not play contact sports, like track and field) using blood samples. Ensembl_ID HGNC_symbol description ENSG00000028203 VEZT vezatin, adherens junctions transmembrane protein [Source:HGNC Symbol;Acc:HGNC:18258] ENSG00000063169 GLTSCR1 glioma tumor suppressor candidate region gene 1 [Source:HGNC Symbol;Acc:HGNC:4332] ENSG00000100258 LMF2 lipase maturation factor 2 [Source:HGNC Symbol;Acc:HGNC:25096] ENSG00000113396 SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 [Source:HGNC Symbol;Acc:HGNC:11000] ENSG00000113946 CLDN16 claudin 16 [Source:HGNC Symbol;Acc:HGNC:2037] ENSG00000120322 PCDHB8 protocadherin beta 8 [Source:HGNC Symbol;Acc:HGNC:8693] ENSG00000136021 SCYL2 SCY1-1ike 2 (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:19286] ENSG00000157322 CLEC18A C-type lectin domain family 18, member A [Source:HGNC Symbol;Acc:HGNC:30388] ENSG00000161912 ADCY10P1 adenylate cyclase 10 (soluble) pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44143] ENSG00000162040 HS3ST6 heparan sulfate (glucosamine) 3-0-sulfotransferase 6 [Source:HGNC Symbol;Acc:HGNC:14178] ENSG00000166313 APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) [Source:HGNC Symbol;Acc:HGNC:581] ENSG00000166348 USP54 ubiquitin specific peptidase 54 [Source:HGNC Symbol;Acc:HGNC:23513] ENSG00000186625 KATNA1 katanin p60 (ATPase containing) subunit A 1 [Source:HGNC Symbol;Acc:HGNC:6216] ENSG00000188626 GOLGA8M golgin A8 family, member M [Source:HGNC Symbol;Acc:HGNC:44404] ENSG00000197582 GPX1P1 glutathione peroxidase pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:4560] ENSG00000198468 FLVCR1-AS1 FLVCR1 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:39077] ENSG00000198964 SGMS1 sphingomyelin synthase 1 [Source:HGNC Symbol;Acc:HGNC:29799] ENSG00000226820 ENSG00000236301 MRGPRG-AS1 MRGPRG antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:26691] ENSG00000254449 SF3A3P2 splicing factor 3a, subunit 3 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:23277] ENSG00000260423 ENSG00000260704 LINC00543 long intergenic non-protein coding RNA 543 [Source:HGNC Symbol;Acc:HGNC:43678] ENSG00000263551 ENSG00000266172 NA NA ENSG00000205765 C5orf51 chromosome 5 open reading frame 51 [Source:HGNC Symbol;Acc:HGNC:27750]

TABLE 43 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most forceful head impact and the subject's baseline using urine samples. Ensembl_ID HGNC_symbol Description ENSG00000101544 ADNP2 ADNP homeobox 2 [Source:HGNC Symbol;Acc:HGNC:23803] ENSG00000109133 TMEM33 transmembrane protein 33 [Source:HGNC Symbol;Acc:HGNC:25541] ENSG00000112679 DUSP22 dual specificity phosphatase 22 [Source:HGNC Symbol;Acc:HGNC:16077] ENSG00000128165 ADM2 adrenomedullin 2 [Source:HGNC Symbol;Acc:HGNC:28898] ENSG00000134779 TPGS2 tubulin polyglutamylase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:24561] ENSG00000137819 PAQR5 progestin and adipoQ receptor family member V [Source:HGNC Symbol;Acc:HGNC:29645] ENSG00000143190 POU2F1 POU class 2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9212] ENSG00000161281 COX7A1 cytochrome c oxidase subunit Vila polypeptide 1 (muscle) [Source:HGNC Symbol;Acc:HGNC:2287] ENSG00000161929 SCIMP SLP adaptor and CSK interacting membrane protein [Source:HGNC Symbol;Acc:HGNC:33504] ENSG00000165699 TSC1 tuberous sclerosis 1 [Source:HGNC Symbol;Acc:HGNC:12362] ENSG00000166225 FRS2 fibroblast growth factor receptor substrate 2 [Source:HGNC Symbol;Acc:HGNC:16971] ENSG00000178053 MLF1 myeloid leukemia factor 1 [Source:HGNC Symbol;Acc:HGNC:7125] ENSG00000179242 CDH4 cadherin 4, type 1, R-cadherin (retinal) [Source:HGNC Symbol;Acc:HGNC:1763] ENSG00000180818 HOXC10 homeobox C10 [Source:HGNC Symbol;Acc:HGNC:5122] ENSG00000183495 EP400 E1A binding protein p400 [Source:HGNC Symbol;Acc:HGNC:11958] ENSG00000183580 FBXL7 F-box and leucine-rich repeat protein 7 [Source:HGNC Symbol;Acc:HGNC:13604] ENSG00000203482 NA NA ENSG00000251192 ZNF674 zinc finger protein 674 [Source:HGNC Symbol;Acc:HGNC:17625] ENSG00000255306 ENSG00000130349 C6orf203 chromosome 6 open reading frame 203 [Source:HGNC Symbol;Acc:HGNC:17971] ENSG00000138639 ARHGAP24 Rho GTPase activating protein 24 [Source:HGNC Symbol;Acc:HGNC:25361] ENSG00000164327 RICTOR RPTOR independent companion of MTOR, complex 2 [Source:HGNC Symbol;Acc:HGNC:28611]

TABLE 44 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most forceful head impact and a subject who is a contact sport athlete and experienced the least forceful head impact using urine samples. Ensembl_ID HGNC_symbol Description ENSG00000102786 INTS6 integrator complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14879] ENSG00000103811 CTSH cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] ENSG00000108785 HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:5216] ENSG00000120910 PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme [Source:HGNC Symbol;Acc:HGNC:9316] ENSG00000156398 SFXN2 sideroflexin 2 [Source:HGNC Symbol;Acc:HGNC:16086] ENSG00000168209 DDIT4 DNA-damage-inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] ENSG00000178229 ZNF543 zinc finger protein 543 [Source:HGNC Symbol;Acc:HGNC:25281] ENSG00000185880 TRIM69 tripartite motif containing 69 [Source:HGNC Symbol;Acc:HGNC:17857] ENSG00000198108 CHSY3 chondroitin sulfate synthase 3 [Source:HGNC Symbol;Acc:HGNC:24293] ENSG00000198690 FAN1 FANCD2/FANCI-associated nuclease 1 [Source:HGNC Symbol;Acc:HGNC:29170] ENSG00000205002 AARD alanine and arginine rich domain containing protein [Source:HGNC Symbol;Acc:HGNC:33842] ENSG00000221972 C3orf36 chromosome 3 open reading frame 36 [Source:HGNC Symbol;Acc:HGNC:26170] ENSG00000224238 WARS2-IT1 WARS2 intronic transcript 1 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:41393] ENSG00000225944 RIOK3P1 RIO kinase 3 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:39714] ENSG00000228794 LINC01128 long intergenic non-protein coding RNA 1128 [Source:HGNC Symbol;Acc:HGNC:49377] ENSG00000229774 ENSG00000238040 SALL4P2 spalt-like transcription factor 4 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:39819] ENSG00000245060 LINC00847 long intergenic non-protein coding RNA 847 [Source:HGNC Symbol;Acc:HGNC:45050] ENSG00000249307 LINC01088 long intergenic non-protein coding RNA 1088 [Source:HGNC Symbol;Acc:HGNC:49148] ENSG00000253522 MIR146A microRNA 146a [Source:HGNC Symbol;Acc:HGNC:31533] ENSG00000257135 ENSG00000258120 KRT128P keratin 128 pseudogene [Source:HGNC Symbol;Acc:HGNC:48882] ENSG00000164978 NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 [Source:HGNC Symbol;Acc:HGNC:8049] ENSG00000128165 ADM2 adrenomedullin 2 [Source:HGNC Symbol;Acc:HGNC:28898] ENSG00000128534 LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:20471]

TABLE 45 The markers listed discriminate between a subject who is a contact sport athlete and experienced the most forceful head impact and a subject with normal exposure to head impact (e.g. an athlete who does not play contact sports, like track and field) using urine samples. Ensembl_ID HGNC_symbol Description ENSG00000101951 PAGE4 P antigen family, member 4 (prostate associated) [Source:HGNC Symbol;Acc:HGNC:4108] ENSG00000116701 NCF2 neutrophil cytosolic factor 2 [Source:HGNC Symbol;Acc:HGNC:7661] ENSG00000120068 HOXB8 homeobox B8 [Source:HGNC Symbol;Acc:HGNC:5119] ENSG00000121680 PEX16 peroxisomal biogenesis factor 16 [Source:HGNC Symbol;Acc:HGNC:8857] ENSG00000125630 POLR1B polymerase (RNA) I polypeptide B, 128 kDa [Source:HGNC Symbol;Acc:HGNC:20454] ENSG00000126790 L3HYPDH L-3-hydroxyproline dehydratase (trans-) [Source:HGNC Symbol;Acc:HGNC:20488] ENSG00000134962 KLB klotho beta [Source:HGNC Symbol;Acc:HGNC:15527] ENSG00000150433 TMEM218 transmembrane protein 218 [Source:HGNC Symbol;Acc:HGNC:27344] ENSG00000157884 CIB4 calcium and integrin binding family member 4 [Source:HGNC Symbol;Acc:HGNC:33703] ENSG00000163161 ERCC3 excision repair cross-complementation group 3 [Source:HGNC Symbol;Acc:HGNC:3435] ENSG00000167548 KMT2D lysine (K)-specific methyltransferase 2D [Source:HGNC Symbol;Acc:HGNC:7133] ENSG00000167552 TUBA1A tubulin, alpha 1a [Source:HGNC Symbol;Acc:HGNC:20766] ENSG00000170890 PLA2G1B phospholipase A2, group IB (pancreas) [Source:HGNC Symbol;Acc:HGNC:9030] ENSG00000171401 KRT13 keratin 13 [Source:HGNC Symbol;Acc:HGNC:6415] ENSG00000174083 NA NA ENSG00000176136 MC5R melanocortin 5 receptor [Source:HGNC Symbol;Acc:HGNC:6933] ENSG00000183199 HSP90AB3P heat shock protein 90 kDa alpha (cytosolic), class B member 3, pseudogene [Source:HGNC Symbol;Acc:HGNC:5259] ENSG00000198142 SOWAHC sosondowah ankyrin repeat domain family member C [Source:HGNC Symbol;Acc:HGNC:26149] ENSG00000204584 ENSG00000204622 HLA-J major histocompatibility complex, class I, J (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4967] ENSG00000229248 WBP2P1 WW domain binding protein 2 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:31695] ENSG00000261337 NA NA ENSG00000263731 ENSG00000221972 C3orf36 chromosome 3 open reading frame 36 [Source:HGNC Symbol;Acc:HGNC:26170]

TABLE 46 The markers listed discriminate between a subject who is a contact sport athlete and experienced the least frequent head impact and the subject's baseline using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000002745 WNT16 wingless-type MMTV integration site family, member 16 [Source:HGNC Symbol;Acc:HGNC:16267] ENSG00000006788 MYH13 myosin, heavy chain 13, skeletal muscle [Source:HGNC Symbol;Acc:HGNC:7571] ENSG00000054654 SYNE2 spectrin repeat containing, nuclear envelope 2 [Source:HGNC Symbol;Acc:HGNC:17084] ENSG00000101460 MAP1LC3A microtubule-associated protein 1 light chain 3 alpha [Source:HGNC Symbol;Acc:HGNC:6838] ENSG00000106261 ZKSCAN1 zinc finger with KRAB and SCAN domains 1 [Source:HGNC Symbol;Acc:HGNC:13101] ENSG00000115073 ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) [Source:HGNC Symbol;Acc:HGNC:168] ENSG00000137392 CLPS colipase, pancreatic [Source:HGNC Symbol;Acc:HGNC:2085] ENSG00000138650 PCDH10 protocadherin 10 [Source:HGNC Symbol;Acc:HGNC:13404] ENSG00000149136 SSRP1 structure specific recognition protein 1 [Source:HGNC Symbol;Acc:HGNC:11327] ENSG00000160446 ZDHHC12 zinc finger, DHHC-type containing 12 [Source:HGNC Symbol;Acc:HGNC:19159] ENSG00000160613 PCSK7 proprotein convertase subtilisin/kexin type 7 [Source:HGNC Symbol;Acc:HGNC:8748] ENSG00000164430 MB21D1 Mab-21 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21367] ENSG00000176034 CHDC2 calponin homology domain containing 2 [Source:HGNC Symbol;Acc:HGNC:26708] ENSG00000176956 LY6H lymphocyte antigen 6 complex, locus H [Source:HGNC Symbol;Acc:HGNC:6728] ENSG00000188107 EYS eyes shut homolog (Drosophila) [Source:HGNC Symbol;Acc:HGNC:21555] ENSG00000196228 SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 [Source:HGNC Symbol;Acc:HGNC:33543] ENSG00000196295 ENSG00000196549 MME membrane metallo-endopeptidase [Source:HGNC Symbol;Acc:HGNC:7154] ENSG00000197594 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:3356] ENSG00000228823 ENSG00000229622 MTND5P2 MT-NDS pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:41919] ENSG00000249066 ENSG00000261437 ENSG00000266998 ENSG00000257943

TABLE 47 The markers listed discriminate between a subject who is a contact sport athlete and experienced the least frequent head impact and a subject with normal exposure to head impact (e.g. an athlete who does not play contact sports, like track and field) using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000049239 H6PD hexose-6-phosphate dehydrogenase (glucose 1- dehydrogenase) [Source:HGNC Symbol;Acc:HGNC:4795] ENSG00000107937 GTPBP4 GTP binding protein 4 [Source:HGNC Symbol;Acc:HGNC:21535] ENSG00000115844 DLX2 distal-less homeobox 2 [Source:HGNC Symbol;Acc:HGNC:2915] ENSG00000118162 KPTN kaptin (actin binding protein) [Source:HGNC Symbol;Acc:HGNC:6404] ENSG00000139352 ASCL1 achaete-scute family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:738] ENSG00000141316 SPACA3 sperm acrosome associated 3 [Source:HGNC Symbol;Acc:HGNC:16260] ENSG00000144339 TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 [Source:HGNC Symbol;Acc:HGNC:11867] ENSG00000149179 C11orf49 chromosome 11 open reading frame 49 [Source:HGNC Symbol;Acc:HGNC:28720] ENSG00000166822 TMEM170A transmembrane protein 170A [Source:HGNC Symbol;Acc:HGNC:29577] ENSG00000169474 SPRR1A small proline-rich protein 1A [Source:HGNC Symbol;Acc:HGNC:11259] ENSG00000171606 ZNF274 zinc finger protein 274 [Source:HGNC Symbol;Acc:HGNC:13068] ENSG00000182173 TSEN54 TSEN54 tRNA splicing endonuclease subunit [Source:HGNC Symbol;Acc:HGNC:27561] ENSG00000187730 GABRD gamma-aminobutyric acid (GABA) A receptor, delta [Source:HGNC Symbol;Acc:HGNC:4084] ENSG00000197536 C5orf56 chromosome 5 open reading frame 56 [Source:HGNC Symbol;Acc:HGNC:33838] ENSG00000213780 GTF2H4 general transcription factor IIH, polypeptide 4, 52 kDa [Source:HGNC Symbol;Acc:HGNC:4658] ENSG00000213930 GALT galactose-1-phosphate uridylyltransferase [Source:HGNC Symbol;Acc:HGNC:4135] ENSG00000228876 ENSG00000238021 ARMC4P1 armadillo repeat containing 4 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44937] ENSG00000240040 ENSG00000244291 NA NA ENSG00000249215 ENSG00000269758 ENSG00000270127 protein kinase, X-linked, pseudogene 1 [Source:EntrezGene;Acc:441733] ENSG00000162040 HS3ST6 heparan sulfate (glucosamine) 3-0-sulfotransferase 6 [Source:HGNC Symbol;Acc:HGNC:14178] ENSG00000120875 DUSP4 dual specificity phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:3070]

TABLE 48 The markers listed discriminate between a subject who is a contact sport athlete and experienced the least frequent head impact and the subject's baseline using urine samples. Ensembl_ID HGNC_symbol Description ENSG00000066185 ZMYND12 zinc finger, MYND-type containing 12 [Source:HGNC Symbol;Acc:HGNC:21192] ENSG00000073169 selenoprotein 0 [Source:EntrezGene;Acc:83642] ENSG00000074590 NUAK1 NUAK family, SNF1-like kinase, 1 [Source:HGNC Symbol;Acc:HGNC:14311] ENSG00000115241 PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G [Source:HGNC Symbol;Acc:HGNC:9278] ENSG00000124839 RAB17 RAB17, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:16523] ENSG00000125827 TMX4 thioredoxin-related transmembrane protein 4 [Source:HGNC Symbol;Acc:HGNC:25237] ENSG00000136295 TTYH3 tweety family member 3 [Source:HGNC Symbol;Acc:HGNC:22222] ENSG00000143061 IGSF3 immunoglobulin superfamily, member 3 [Source:HGNC Symbol;Acc:HGNC:5950] ENSG00000144481 TRPM8 transient receptor potential cation channel, subfamily M, member 8 [Source:HGNC Symbol;Acc:HGNC:17961] ENSG00000156853 ZNF689 zinc finger protein 689 [Source:HGNC Symbol;Acc:HGNC:25173] ENSG00000164327 RICTOR RPTOR independent companion of MTOR, complex 2 [Source:HGNC Symbol;Acc:HGNC:28611] ENSG00000166173 LARP6 La ribonucleoprotein domain family, member 6 [Source:HGNC Symbol;Acc:HGNC:24012] ENSG00000166426 CRABP1 cellular retinoic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2338] ENSG00000168002 POLR2G polymerase (RNA) 11 (DNA directed) polypeptide G [Source:HGNC Symbol;Acc:HGNC:9194] ENSG00000169499 PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 [Source:HGNC Symbol;Acc:HGNC:14336] ENSG00000196335 STK31 serine/threonine kinase 31 [Source:HGNC Symbol;Acc:HGNC:11407] ENSG00000196409 NA NA ENSG00000196532 NA NA ENSG00000213963 ENSG00000226935 LINC00161 long intergenic non-protein coding RNA 161 [Source:HGNC Symbol;Acc:HGNC:17138] ENSG00000242732 RGAG4 retrotransposon gag domain containing 4 [Source:HGNC Symbol;Acc:HGNC:29430] ENSG00000247363 ENSG00000260163 ENSG00000140043 PTGR2 prostaglandin reductase 2 [Source:HGNC Symbol;Acc:HGNC:20149] ENSG00000253688

TABLE 49 The markers listed discriminate between a subject who is a contact sport athlete and experienced the least frequent head impact and a subject with normal exposure to head impact (e.g. an athlete who does not play contact sports, like track and field) using urine samples. Ensembl_ID HGNC_symbol Description ENSG00000082515 MRPL22 mitochondrial ribosomal protein L22 [Source:HGNC Symbol;Acc:HGNC:14480] ENSG00000100197 CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 [Source:HGNC Symbol;Acc:HGNC:2625] ENSG00000103528 SYT17 synaptotagmin XVII [Source:HGNC Symbol;Acc:HGNC:24119] ENSG00000105197 TIMM50 translocase of inner mitochondria! membrane 50 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23656] ENSG00000105989 WNT2 wingless-type MMTV integration site family member 2 [Source:HGNC Symbol;Acc:HGNC:12780] ENSG00000113360 DROSHA drosha, ribonuclease type III [Source:HGNC Symbol;Acc:HGNC:17904] ENSG00000122644 ARL4A ADP-ribosylation factor-like 4A [Source:HGNC Symbol;Acc:HGNC:695] ENSG00000124006 OBSL1 obscurin-like 1 [Source:HGNC Symbol;Acc:HGNC:29092] ENSG00000129003 VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23594] ENSG00000131435 PDLIM4 PDZ and LIM domain 4 [Source:HGNC Symbol;Acc:HGNC:16501] ENSG00000140043 PTGR2 prostaglandin reductase 2 [Source:HGNC Symbol;Acc:HGNC:20149] ENSG00000143493 INTS7 integrator complex subunit 7 [Source:HGNC Symbol;Acc:HGNC:24484] ENSG00000174899 C3orf55 chromosome 3 open reading frame 55 [Source:HGNC Symbol;Acc:HGNC:25146] ENSG00000182831 C16orf72 chromosome 16 open reading frame 72 [Source:HGNC Symbol;Acc:HGNC:30103] ENSG00000187626 ZKSCAN4 zinc finger with KRAB and SCAN domains 4 [Source:HGNC Symbol;Acc:HGNC:13854] ENSG00000198373 WWP2 WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:16804] ENSG00000205832 C16orf96 chromosome 16 open reading frame 96 [Source:HGNC Symbol;Acc:HGNC:40031] ENSG00000226067 long intergenic non-protein coding RNA 869 [Source:EntrezGene;Acc:57234] ENSG00000233896 ENSG00000242498 ARPIN actin-related protein 2/3 complex inhibitor [Source:HGNC Symbol;Acc:HGNC:28782] ENSG00000248445 SEMA6A-AS1 SEMA6A antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51110] ENSG00000270020 ENSG00000257242 C12orf79 chromosome 12 open reading frame 79 [Source:HGNC Symbol;Acc:HGNC:27409]

TABLE 50 The markers listed discriminate between a subject who is a contact sport athlete and experienced the least forceful head impact and the subject's baseline using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000073067 CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:20243] ENSG00000127329 PTPRB protein tyrosine phosphatase, receptor type, B [Source:HGNC Symbol;Acc:HGNC:9665] ENSG00000134138 MEIS2 Meis homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7001] ENSG00000141524 TMC6 transmembrane channel-like 6 [Source:HGNC Symbol;Acc:HGNC:18021] ENSG00000148795 CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:2593] ENSG00000151502 VPS26B vacuolar protein sorting 26 homolog B (S. pombe) [Source:HGNC Symbol;Acc:HGNC:28119] ENSG00000152128 TMEM163 transmembrane protein 163 [Source:HGNC Symbol;Acc:HGNC:25380] ENSG00000164237 CMBL carboxymethylenebutenolidase homolog (Pseudomonas) [Source:HGNC Symbol;Acc:HGNC:25090] ENSG00000166049 PASD1 PAS domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20686] ENSG00000173638 SLC19A1 solute carrier family 19 (folate transporter), member 1 [Source:HGNC Symbol;Acc:HGNC:10937] ENSG00000173699 SPATA3 spermatogenesis associated 3 [Source:HGNC Symbol;Acc:HGNC:17884] ENSG00000174705 SH3PXD2B 5H3 and PX domains 2B [Source:HGNC Symbol;Acc:HGNC:29242] ENSG00000181007 ZFP82 ZFP82 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:28682] ENSG00000196970 NXF4 nuclear RNA export factor 4 pseudogene [Source:HGNC Symbol;Acc:HGNC:8074] ENSG00000201148 RNA5SP42 RNA, 5S ribosomal pseudogene 42 [Source:HGNC Symbol;Acc:HGNC:42818] ENSG00000230484 OR51A10P olfactory receptor, family 51, subfamily A, member 10 pseudogene [Source:HGNC Symbol;Acc:HGNC:15185] ENSG00000231682 ENSG00000239670 ENSG00000250274 ENSG00000259358 ENSG00000259870 ENSG00000260721 ENSG00000196268 ZNF493 zinc finger protein 493 [Source:HGNC Symbol;Acc:HGNC:23708] ENSG00000236596 ENSG00000249066

TABLE 51 The markers listed discriminate between a subject who is a contact sport athlete and experienced the least forceful head impact and a subject with normal exposure to head impact (e.g. an athlete who does not play contact sports, like track and field) using blood samples. Ensembl_ID HGNC_symbol Description ENSG00000075945 KIFAP3 kinesin-associated protein 3 [Source:HGNC Symbol;Acc:HGNC:17060] ENSG00000099326 MZF1 myeloid zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13108] ENSG00000104047 DTWD1 DTW domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30926] ENSG00000118705 RPN2 ribophorin 11 [Source:HGNC Symbol;Acc:HGNC:10382] ENSG00000120875 DUSP4 dual specificity phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:3070] ENSG00000167110 GOLGA2 golgin A2 [Source:HGNC Symbol;Acc:HGNC:4425] ENSG00000170262 MRAP melanocortin 2 receptor accessory protein [Source:HGNC Symbol;Acc:HGNC:1304] ENSG00000170689 HOXB9 homeobox B9 [Source:HGNC Symbol;Acc:HGNC:5120] ENSG00000180316 PNPLA1 patatin-like phospholipase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21246] ENSG00000182057 OGFRP1 opioid growth factor receptor pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:50511] ENSG00000187166 H1FNT H1 histone family, member N, testis-specific [Source:HGNC Symbol;Acc:HGNC:24893] ENSG00000197863 ZNF790 zinc finger protein 790 [Source:HGNC Symbol;Acc:HGNC:33114] ENSG00000198814 GK glycerol kinase [Source:HGNC Symbol;Acc:HGNC:4289] ENSG00000214063 TSPAN4 tetraspanin 4 [Source:HGNC Symbol;Acc:HGNC:11859] ENSG00000215305 VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:14584] ENSG00000225972 MTND1P23 MT-ND1 pseudogene 23 [Source:HGNC Symbol;Acc:HGNC:42092] ENSG00000250986 ENSG00000253973 ENSG00000256612 CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene [Source:HGNC Symbol;Acc:HGNC:2616] ENSG00000259011 ENSG00000267023 LRRC37A16P leucine rich repeat containing 37, member A16, pseudogene [Source:HGNC Symbol;Acc:HGNC:43820] ENSG00000273096 ENSG00000166049 PASD1 PAS domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20686]

TABLE 52 The markers listed discriminate between a subject who is a contact sport athlete and experienced the least forceful head impact and the subject's baseline using urine samples. Ensembl_ID HGNC_symbol description ENSG00000080839 RBL1 retinoblastoma-like 1 [Source:HGNC Symbol;Acc:HGNC:9893] ENSG00000106948 AKNA AT-hook transcription factor [Source:HGNC Symbol;Acc:HGNC:24108] ENSG00000119737 GPR75 G protein-coupled receptor 75 [Source:HGNC Symbol;Acc:HGNC:4526] ENSG00000120051 CFAP58 cilia and flagella associated protein 58 [Source:HGNC Symbol;Acc:HGNC:26676] ENSG00000125810 CD93 CD93 molecule [Source:HGNC Symbol;Acc:HGNC:15855] ENSG00000128534 LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:20471] ENSG00000132640 BTBD3 BTB (POZ) domain containing 3 [Source:HGNC Symbol;Acc:HGNC:15854] ENSG00000137871 ZNF280D zinc finger protein 280D [Source:HGNC Symbol;Acc:HGNC:25953] ENSG00000138621 PPCDC phosphopantothenoylcysteine decarboxylase [Source:HGNC Symbol;Acc:HGNC:28107] ENSG00000141034 GID4 GID complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:28453] ENSG00000153015 CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:10664] ENSG00000160959 LRRC14 leucine rich repeat containing 14 [Source:HGNC Symbol;Acc:HGNC:20419] ENSG00000170873 MTSS1 metastasis suppressor 1 [Source:HGNC Symbol;Acc:HGNC:20443] ENSG00000182093 WRB tryptophan rich basic protein [Source:HGNC Symbol;Acc:HGNC:12790] ENSG00000184210 DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 [Source:HGNC Symbol;Acc:HGNC:23250] ENSG00000188266 HYKK hydroxylysine kinase [Source:HGNC Symbol;Acc:HGNC:34403] ENSG00000189433 GJB4 gap junction protein, beta 4, 30.3 kDa [Source:HGNC Symbol;Acc:HGNC:4286] ENSG00000198836 OPA1 optic atrophy 1 (autosomal dominant) [Source:HGNC Symbol;Acc:HGNC:8140] ENSG00000229323 DLEU1-AS1 DLEU1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:50496] ENSG00000233527 ZNF529-AS1 ZNF529 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51275] ENSG00000235524 ENSG00000253688 ENSG00000257531 ENSG00000172071 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] ENSG00000124839 RAB17 RAB17, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:16523]

TABLE 53 Markers with expression that is significant different across the different biological samples Change in Ensembl_ID HGNC_symbol Description Expression ENSG00000113889 KNG1 kininogen 1 [Source:HGNC Decrease Symbol;Acc:HGNC:6383] ENSG00000164825 DEFB1 defensin, beta 1 [Source:HGNC Decrease Symbol;Acc:HGNC:2766] ENSG00000165685 TMEM52B transmembrane protein 52B [Source:HGNC Decrease Symbol;Acc:HGNC:26438] ENSG00000169344 UMOD uromodulin [Source:HGNC Decrease Symbol;Acc:HGNC:12559] ENSG00000184908 CLCNKB chloride channel, voltage-sensitive Kb Decrease [Source:HGNC Symbol;Acc:HGNC:2027] ENSG00000270103 RNU11 RNA, U11 small nuclear [Source:HGNC Decrease Symbol;Acc:HGNC:10108] ENSG00000125652 ALKBH7 alkB, alkylation repair homolog 7 (E. coli) Increase [Source:HGNC Symbol;Acc:HGNC:21306] ENSG00000145113 MUC4 mucin 4, cell surface associated [Source:HGNC increase Symbol;Acc:HGNC:7514] ENSG00000153802 TMPRSS11D transmembrane protease, serine 11D Increase [Source:HGNC Symbol;Acc:HGNC:24059] ENSG00000196352 CD55 CD55 molecule, decay accelerating factor for Increase complement (Cromer blood group) [Source:HGNC Symbol;Acc:HGNC:2665] ENSG00000197674 OR51C1P olfactory receptor, family 51, subfamily C, member Increase 1 pseudogene [Source:HGNC Symbol;Acc:HGNC:15191] ENSG00000206652 RNU1-1 RNA, U1 small nuclear 1 [Source:HGNC Increase Symbol;Acc:HGNC:10120] ENSG00000210194 MT-TE mitochondrially encoded tRNA glutamic acid Increase [Source:HGNC Symbol;Acc:HGNC:7479] ENSG00000230140 Increase ENSG00000254325 Increase ENSG00000258406 Increase ENSG00000267706 Increase ENSG00000269364 LINC01233 long intergenic non-protein coding RNA 1233 Increase [Source:HGNC Symbol;Acc:HGNC:49756] ENSG00000271043 MTRNR2L2 MT-RNR2-like 2 [Source:HGNC Increase Symbol;Acc:HGNC:37156] 

What is claimed is:
 1. A method for determining the risk of a subject for developing mild traumatic brain injuries (mTBI) or the fitness of a subject for participating in an activity with increased chances of receiving a head impact, comprising: obtaining a biological sample from the subject after a head injury; obtaining a control biological sample, wherein the control biological sample is selected from the group consisting of: the baseline sample of the subject, a matched sample from a different subject that plays non-contact sports, and a predicted control sample calculated from the general population; measuring the biological sample with RNASeq for an amount of at least one extracellular RNA (exRNA) biomarker transcribed from a gene selected from the group consisting of ENSG00000163346, ENSG00000112941, ENSG00000087589, and ENSG00000160917; measuring the control biological sample with RNASeq for an amount of the at least one exRNA biomarker; and comparing the amount of the at least one exRNA biomarker in the biological sample with the amount of the at least one exRNA biomarker in the control biological sample, wherein a change in the amount of the at least one exRNA biomarker from the subject compared with the control biological sample is indicative of the subject having an increased risk for mTBI or being unfit for participating in the activity with increased chances of receiving a head impact; wherein decreased amounts of exRNA transcribed from the gene of ENSG00000112941 in a urine sample and/or ENSG00000087589 in a plasma sample and increased amounts of exRNA transcribed from the gene of ENSG00000160917 in a urine sample and/or ENSG00000163346 in a urine sample are indicative of the subject being at increased risk for mTBI or unfit for participating in the activity with increased chances of receiving a head impact.
 2. The method of claim 1, wherein the control biological sample is a matched sample from a different subject that plays non-contact sports.
 3. The method of claim 1, wherein the control biological sample is from the subject's baseline sample.
 4. The method of claim 1, wherein the biological sample from the subject is obtained within 48 hours after the subject received a head impact or is suspected of having a head impact.
 5. The method of claim 1, wherein at least two exRNA biomarkers are measured and compared, wherein a change in the amount of the at least two exRNA biomarkers from the subject compared with the control is indicative of the subject having an increased risk for mTBI or being unfit for participating in the activity with increased chances of receiving a head impact.
 6. The method of claim 1, wherein the at least one exRNA biomarker comprises exRNA transcribed from the gene of ENSG00000163346.
 7. The method of claim 1, wherein the biological sample from the subject is obtained within 24 hours after the subject received a head impact or is suspected of having a head impact. 